Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path?

Trends in Neurosciences

Volumn 24, Issue 1, 2001, Pages 25-31

  Copani, A ^a   Uberti, D ^a   Sortino, M A ^a   Bruno, V ^a   Nicoletti, F ^a   Memo, M ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; CELL CYCLE PROTEIN; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 3; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN G; CYCLINE; DNA NUCLEOTIDYLEXOTRANSFERASE; EXCITOTOXIN; FLAVOPIRIDOL; HOMEODOMAIN PROTEIN; NERVE GROWTH FACTOR; OLOMOUCINE; PROTEIN P53; RETINOBLASTOMA PROTEIN; ROSCOVITINE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; CELL PROLIFERATION; DNA DAMAGE; DNA STRAND BREAKAGE; HYPOXIA; ISCHEMIA; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL DEATH; DNA DAMAGE; HUMANS; NERVE DEGENERATION; NEURONS; NEUROTOXINS; OLIGONUCLEOTIDES, ANTISENSE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035058466     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01663-5     Document Type: Review

References (64)

1. Apoptosis, neurotrophic factors and neurodegeneration
2. Regulation of p53 tumor suppressor protein
3. Analysis of cell-related gene expression in post-mitotic neurons: Selective induction of cyclin D1 during programmed cell death
4. Cyclin-dependent kinase inhibitors and dominant-negative cyclin-dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
5. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
6. A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum
7. Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation and oxidative stress
8. Neurons from mouse embryos with a null mutation in the tumor suppressor gene p53 undergo normal cell death in the absence of neurotrophins
9. Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation
10. P53 protein in sympathetic neurons: Cytoplasmic localization and no apparent function in apoptosis
11. P53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors
12. R-deprenyl and R-2-heptyl-N-methylpropargylamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
13. +-induced apoptosis
14. The role of free radicals and p53 in neuron apoptosis in vivo
15. A matter of life and cell death
16. The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity
17. Cyclin D1 and p21/waf1 are both involved in p53 growth suppression
18. Eukaryotic DNA polymerases, a growing family
19. The fidelity of DNA polymerase β during distributive and processive DNA synthesis
20. G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis
21. P53 expression induces apoptosis in hippocampal pyramidal neuron cultures
22. P53 expression in brain after middle cerebral artery occlusion in the rat
23. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
24. Hippocampal Myc and p53 expression following transient global ischemia
25. Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia
26. Increased expression of cyclin G1 and p21WAF/CIP1 in neurons following transient forebrain ischemia: Comparison with early DNA damage
27. Increased cyclin D1 in vulnerable neurons in the hippocampus after ischemia and epilepsy: A modulator of in vivo programmed cell death?
28. Focal ischemia induces expression of the DNA damage-inducible gene GADD45 in the rat brain
29. Activation of p53 and its target genes p21 waf1/cip1 and PAG608/Wig-1 in ischemic preconditioning
30. P53 induction is associated with neuronal damage in the central nervous system
31. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation
32. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death
33. Induction of tumor suppressor phosphoprotein p53 in the apoptosis of cultured cerebellar neurons triggered by excitatory amino acids
34. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway
35. Contribution of NF-κb and p53 in the glutamate-induced apoptosis
36. Kainate-induced apoptosis in cultured murine cerenellar granule cells elevates expression of cell cycle gene cyclin D1
37. Formation of the base modification 8-hydroxyl-2′-deoxy guanosine and DNA fragmentation following seizure induced by systemic kainic acid in the rat
38. Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain
39. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
40. Abnormal expression of the cell cycle regulators p16 and cdk4 in Alzheimer's disease
41. Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions
42. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
43. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
44. Apoptosis-related protein expression in the hippocampus in Alzheimer's disease
45. The cell division cycle and the pathophysiology of Alzheimer's disease
46. Translating cell biology into therapeutic advances in Alzheimer's disease
47. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and EF2-DP, in β-amyloid-induced neuronal death
48. Mitotic signaling by β-amyloid causes neuronal death
49. Soluble products released by activated microglia induce cell cycling and death in cultured cortical neurons
50. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
51. Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome
52. Changes of p53 in the brains of patients with Alzheimer's disease
53. Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments
54. E2F1 mediates death of (-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3
55. Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons
56. APE/Ref-1 responses to ischemia in rat brain
57. Cycling, stress-out and nervous: Cellular functions of c-Abl
58. The p53 network
59. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo
60. Distinct roles for E2F proteins in cell growth control and apoptosis
61. Expression of cyclin-dependent kinase 5 and its activator p35 in rat brain after middle cerebral artery occlusion
62. Detection of a cdc2-related kinase associated with Alzheimer paired helical filaments
63. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
64. In vivo viability of postmitotic Purkinje neurons requires pRb family member function