Loss of base excision repair in aging rat neurons and its restoration by DNA polymerase β

Molecular Brain Research

Volumn 85, Issue 1-2, 2000, Pages 251-259

  Rao, Kalluri Subba ^a   Annapurna, V V ^a   Raji, N S ^a   Harikrishna, T ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

Aging; DNA polymerase ; Mismatch base excision; Neuron; Primer extension

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; EXONUCLEASE; MAGNESIUM; MANGANESE; OLIGODEOXYNUCLEOTIDE; PHOSPHORUS 32; PRIMER DNA;

ADOLESCENT; AGED; ANIMAL CELL; ARTICLE; BASE MISPAIRING; BRAIN CELL; CELL AGING; DNA DEGRADATION; DNA SEQUENCE; DNA TEMPLATE; ENZYME ACTIVITY; EXCISION REPAIR; FEMALE; MALE; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; BASE PAIR MISMATCH; DNA POLYMERASE BETA; DNA POLYMERASE I; DNA PRIMERS; DNA REPAIR; ESCHERICHIA COLI; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; FEMALE; LIVER; MALE; NEURONS; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY; THYMUS GLAND;

EID: 0034727887     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00266-7     Document Type: Article

References (33)

1. An error-correcting proof-reading exonuclease-polymerase that copurifies with DNA polymerase-α-primase
2. DNA mismatch repair and DNA methylation in adult brain neurons
3. The roles of the eukaryotic DNA polymerases in DNA repair synthesis
4. Human correxonuclease. Purification and properties of a DNA repair exonuclease from placenta
5. Exodeoxyribonuclease from rat brain specific for single stranded DNA
6. Instability and decay of the primary structure of DNA
7. Rate of depurination in native DNA
8. Excision of deoxyribose phosphate residues by DNA polymerase β during DNA repair
9. Interaction of mammalian deoxyribonuclease V, a double strand 3′ to 5′ and 5′ to 3′ exonuclease, with deoxyribonucleic acid polymerase-β from the Novikoff hepatoma
10. Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α
11. Hydrolysis of 3′-terminal mispairs in vitro by the 3′-5′ exonuclease of DNA polymerase δ permits subsequent extension by DNA polymerase α
12. DNA polymerases δ and ε in developing and aging rat brain
13. Improved DNA repair parameters in PHA stimulated peripheral blood lymphocytes of human subjects with low body mass index
14. Genomic damage and its repair in young and aging brain
15. DNA damage and repair in brain: Relationship to aging
16. On the 'active' molecules of DNA polymerase β in aging rat brain
17. Free radicals, DNA-damage and aging
18. The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA
19. External proof-reading of DNA replication errors and mammalian autonomous 3′-5′ exonuclease
20. Developmental activity profile of DNA polymerases delta and α in rat neurons suggests a coordinated in vivo function
21. On the type of DNA polymerase activity in neuronal, astroglial and oligodendroglial cell fractions from young, adult and old rat brains
22. Ultraviolet light-induced unscheduled DNA synthesis in isolated neurons of rat brain of different ages
23. Effect of a 3′→5′ exonuclease with a proof-reading function on the fidelity of error-prone DNA polymerase α from regenerating liver of aged rats
24. Procedure for isolation of neuron- and astrocyte-enriched fractions from chick brain of different ages
25. DNA-repair and RNA synthesis in isolated rat cerebral cortex nuclei: Effect of age and UV irradiation
26. Specificity of the catalytic interactions of human DNA polymerase β with nucleic acid substrates
27. Eukaryotic DNA polymerases
28. DNA polymerase β from brain neurons is a repair enzyme
29. Life without DNA repair
30. Mammalian base excision repair and DNA-polymerase β
31. DNA repair in eukaryotes
32. Which DNA polymerases are used for DNA repair in eukaryotes?
33. Developmental activity variations of DNA polymerase α, δ, ε in mouse forebrains and spleens