Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity

Cancer Research

Volumn 59, Issue 20, 1999, Pages 5294-5298

  Gosink, Eric C ^a   Chong, Miriam J ^a   McKinnon, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ARTICLE; ASTROCYTE; ATAXIA TELANGIECTASIA; CANCER SUSCEPTIBILITY; CELL AGING; CELL CYCLE; CELL GROWTH; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RADIOSENSITIVITY;

ANIMALS; ASTROCYTES; ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0032697807     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Sedgwick, R. P., and Boder, E. Ataxia-Telangiectasia. In: P. Vinken, G. Bruyn, and H. Klawans (eds.), Handbook of Clinical Neurology, Vol. 60, pp. 347-423. New York: Elsevier, 1991.
2. Rotman, G., and Shiloh, Y. ATM: from gene to function. Hum. Mol. Genet., 7: 1555-1563, 1998.
3. Lavin, M. F., and Shiloh, Y. The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol., 15: 177-202, 1997.
4. Jackson, S. P. DNA damage detection by DNA dependent protein kinase and related enzymes. Cancer Surv., 28: 261-279, 1996.
5. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C., and Abraham, R. T. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev., 13: 152-157, 1999.
6. McKinnon, P. J. Ataxia-telangiectasia: an inherited disorder of ionizing radiation sensitivity in man. Hum. Genet., 75: 197-208, 1987.
7. Khanna, K. K., and Lavin, M. F. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene, 8: 3307-3312, 1993.
8. Khanna, K. K., Beamish, H., Yan, J., Hobson, K., Williams, R., Dunn, I., and Lavin, M. F. Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. Oncogene, 11: 609-618, 1995.
9. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell, 71: 587-597, 1992.
10. Artuso, M., Esteve, A., Bresil, H., Vuillaume, M., and Hall, J. The role of the ataxia telangiectasia gene in the p53, WAF1/CIP1(p21), and GADD45-mediated response to DNA damage produced by ionizing radiation. Oncogene, 11: 1427-1435, 1995.
11. Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., and Kastan, M. B. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev., 11: 3471-3481, 1997.
12. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (Washington DC), 281: 1674-1677, 1998.
13. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (Washington DC), 281: 1677-1679, 1998.
14. Nakagawa, K., Taya, Y., Tamai, K., and Yamaizumi, M. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol. Cell Biol., 19: 2828-2834, 1999.
15. Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S., Gatei, M., Hobson, K., Taya, Y., Gabrielli, B., Chan, D., Lees-Miller, S. P., and Lavin, M. F. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat. Genet., 20: 398-400, 1998.
16. Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91: 325-334, 1997.
17. Lane, D. Awakening angels. Nature (Lond.), 394: 616-617, 1998.
18. Waterman, M. J., Stavridi, E. S., Waterman, J. L., and Halazonetis, T. D. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet., 19: 175-178, 1998.
19. Shieh, S. Y., Taya, Y., and Prives, C. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J., 18: 1815-1823, 1999.
20. Ashcroft, M., Kubbutat, M. H., and Vousden, K. H. Regulation of p53 function and stability by phosphorylation. Mol. Cell Biol., 19: 1751-1758, 1999.
21. Houldsworth, J., and Lavin, M. F. Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells. Nucleic Acids Res., 8: 3709-3720, 1980.
22. Beamish, H., Williams, R., Chen, P., and Lavin, M. F. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J. Biol. Chem., 271: 20486-20493, 1996.
23. Morgan, S. E., and Kastan, M. B. p53 and ATM: cell cycle, cell death, and cancer. Adv. Cancer Res., 71: 1-25, 1997.
24. Paules, R. S., Levedakou, E. N., Wilson, S. J., Innes, C. L., Rhodes, N., Tlsty, T. D., Galloway, D. A., Donehower, L. A., Tainsky, M. A., and Kaufmann, W. K. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res., 55: 1763-1773, 1995.
25. Guillouf, C., Rosselli, F., Krishnaraju, K., Moustacchi, E., Hoffman, B., and Liebermann, D. A. p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis. Oncogene, 10: 2263-2270, 1995.
26. Chen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K., and Lavin, M. F. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells. Oncogene, 18: 249-256, 1999.
27. Blasina, A., de Weyer, I. V., Laus, M. C., Luyten, W., Parker, A. E., and McGowan, C. H. A human homologue of the checkpoint kinase cds1 directly inhibits cdc25 phosphalase. Curr. Biol., 9: 1-10, 1999.
28. Matsuoka, S., Huang, M., and Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (Washington DC), 282: 1893-1897, 1998.
29. Morgan, S. E., and Kastan, M. B. Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. Cancer Res., 57: 3386-3389, 1997.
30. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D., and Wynshaw-Boris, A. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell, 86: 159-171, 1996.
31. Kamijo, T., van de Kamp, E., Chong, M. J., Zindy, F., Diehl, J. A., Sherr, C. J., and McKinnon, P. J. Loss of the ARF tumor supressor reverses premature senescence but not radiation hypersensitivity arising from disabled Atm function. Cancer Res., 59: 2464-2469, 1999.
32. Xu, Y., and Baltimore, D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev., 10: 2401-2410, 1996.
33. Herzog, K. H., Chong, M. J., Kapsetaki, M., Morgan, J. I., and McKinnon, P. J. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science (Washington DC), 280: 1089-1091, 1998.
34. Kueng, W., Silber, E., and Eppenberger, U. Quantification of cells cultured on 96-well plates. Anal. Biochem., 182: 16-19, 1989.
35. Barlow, C., Brown, K. D., Deng, C. X., Tagle, D. A., and Wynshaw-Boris, A. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat. Genet., 17: 453-456, 1997.
36. Westphal, C. H., Schmaltz, C., Rowan, S., Elson, A., Fisher, D. E., and Leder, P. Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. Cancer Res., 57: 1564-1667, 1997.
37. Slichenmyer, W. J., Nelson, W. G., Slebos, R. J., and Kastan, M. B. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res., 53: 4164-4168, 1993.
38. Westphal, C. H., Rowan, S., Schmaltz, C., Elson, A., Fisher, D. E., and Leder, P. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat. Genet., 16: 397-401, 1997.
39. Giaccia, A. J., and Kastan, M. B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev., 12: 2973-2983, 1998.
40. Elson, A., Wang, Y., Daugherty, C. J., Morton, C. C., Zhou, F., Campos-Torres, J., and Leder, P. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. USA, 93: 13084-13089, 1996.
41. Wang, Y. A., Elson, A., and Leder, P. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA, 94: 14590-14595, 1997.
42. Packer, R. J. Childhood tumors. Curr. Opin. Pediatr., 9: 551-557, 1997.
43. Prados, M. D., and Russo, C. Chemotherapy of brain tumors. Semin. Surg. Oncol., 14: 88-95, 1998.
44. Tarbell, N. J., and Loeffler, J. S. Recent trends in the radiotherapy of pediatric gliomas. J. Neurooncol., 28: 233-244, 1996.