-
1
-
-
0022930702
-
Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism
-
Sen, R.; Baltimore, D. Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism. Cell, 1986, 47, 921-928.
-
(1986)
Cell
, vol.47
, pp. 921-928
-
-
Sen, R.1
Baltimore, D.2
-
2
-
-
65549164068
-
Roles of NF-κB in health and disease: Mechanisms and therapeutic potential
-
Wong, E.T.; Tergaonkar, V. Roles of NF-κB in health and disease: mechanisms and therapeutic potential. Clin. Sci., 2009, 116, 451-465.
-
(2009)
Clin. Sci
, vol.116
, pp. 451-465
-
-
Wong, E.T.1
Tergaonkar, V.2
-
3
-
-
4444376712
-
Signaling to NF-κB
-
Hayden, M.S.; Ghosh, S. Signaling to NF-κB. Genes Dev., 2004, 15, 2195-2224.
-
(2004)
Genes Dev
, vol.15
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
4
-
-
33750466230
-
Introduction to NF-kappa B: Players, pathways, perspectives
-
Gilmore, T.D. Introduction to NF-kappa B: players, pathways, perspectives. Oncogene, 2006, 25, 6680-6684.
-
(2006)
Oncogene
, vol.25
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
5
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh, S.; Karin, M. Missing pieces in the NF-κB puzzle. Cell, 2002, 109(Suppl), S81-S96.
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
Ghosh, S.1
Karin, M.2
-
6
-
-
38849199203
-
Shared principles in NF-kappa B signaling
-
Hayden, M.S.; Ghosh, S. Shared principles in NF-kappa B signaling. Cell, 2008, 132, 344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
7
-
-
33750467991
-
Unravelling the complexities of the NFkappaB signalling pathway using mouse knockout and transgenic models
-
Gerondakis, S.; Grumont, R.; Gugasyan, R.; Wong, L.; Isomura, I.; Ho, W.; Banerjee, V. Unravelling the complexities of the NFkappaB signalling pathway using mouse knockout and transgenic models. Oncogene, 2006, 25, 6781-6799.
-
(2006)
Oncogene
, vol.25
, pp. 6781-6799
-
-
Gerondakis, S.1
Grumont, R.2
Gugasyan, R.3
Wong, L.4
Isomura, I.5
Ho, W.6
Banerjee, V.7
-
8
-
-
47149099552
-
NF-Kappa B in the pathogenesis and treatment of multiple myeloma
-
Li, Z.W.; Chen, H.; Campbell, R.A.; Bonavida, B.; Berenson, J.R. NF-kappa B in the pathogenesis and treatment of multiple myeloma. Curr. Opin. Hematol., 2008, 15, 391-399.
-
(2008)
Curr. Opin. Hematol
, vol.15
, pp. 391-399
-
-
Li, Z.W.1
Chen, H.2
Campbell, R.A.3
Bonavida, B.4
Berenson, J.R.5
-
9
-
-
0023853764
-
V-rel Oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells
-
Gilmore, T.D.; Temin, H.M. v-rel Oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells. J. Virol., 1988, 62, 703-714.
-
(1988)
J. Virol
, vol.62
, pp. 703-714
-
-
Gilmore, T.D.1
Temin, H.M.2
-
10
-
-
33645999999
-
Targeting NF-kappa B in hematologic malignancies
-
Braun, T.; Carvalho, G.; Fabre, C.; Grosjean, J.; Fenaux, P.; Kroemer, G. Targeting NF-kappa B in hematologic malignancies. Cell Death Differ., 2006, 13, 748-758.
-
(2006)
Cell Death Differ
, vol.13
, pp. 748-758
-
-
Braun, T.1
Carvalho, G.2
Fabre, C.3
Grosjean, J.4
Fenaux, P.5
Kroemer, G.6
-
11
-
-
31544448567
-
NFkappa B constitutes a potential therapeutic target in high-risk myelodysplastic syndrome
-
Braun, T.; Carvalho, G.; Coquelle, A.; Vozenin, M.C.; Lepelley, P.; Hirsch, F.; Kiladjian, J.J.; Ribrag, V.; Fenaux, P.; Kroemer, G. NFkappa B constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood, 2006, 107, 1156-1165.
-
(2006)
Blood
, vol.107
, pp. 1156-1165
-
-
Braun, T.1
Carvalho, G.2
Coquelle, A.3
Vozenin, M.C.4
Lepelley, P.5
Hirsch, F.6
Kiladjian, J.J.7
Ribrag, V.8
Fenaux, P.9
Kroemer, G.10
-
12
-
-
0035886024
-
Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
-
Guzman, M.L.; Neering, S.J.; Upchurch, D.; Grimes, B.; Howard, D.S.; Rizzieri, D.A.; Luger, S.M.; Jordan, C.T. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood, 2001, 98, 2301-2307.
-
(2001)
Blood
, vol.98
, pp. 2301-2307
-
-
Guzman, M.L.1
Neering, S.J.2
Upchurch, D.3
Grimes, B.4
Howard, D.S.5
Rizzieri, D.A.6
Luger, S.M.7
Jordan, C.T.8
-
13
-
-
36348988506
-
Nuclear factor kB as a target for new drug development in myeloid malignancies
-
Cilloni, D.; Martinelli, G.; Messa, F.; Baccarani, M.; Saglio, G. Nuclear factor kB as a target for new drug development in myeloid malignancies. Haematologica, 2007, 92, 1224-1229.
-
(2007)
Haematologica
, vol.92
, pp. 1224-1229
-
-
Cilloni, D.1
Martinelli, G.2
Messa, F.3
Baccarani, M.4
Saglio, G.5
-
14
-
-
70349289739
-
Nuclear factor-kappaB signaling: A contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
-
Reikvam, H.; Olsnes, A.M.; Gjertsen, B.T.; Ersvar, E.; Bruserud, O. Nuclear factor-kappaB signaling: A contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia. Crit. Rev. Oncog., 2009, 15, 1-41.
-
(2009)
Crit. Rev. Oncog
, vol.15
, pp. 1-41
-
-
Reikvam, H.1
Olsnes, A.M.2
Gjertsen, B.T.3
Ersvar, E.4
Bruserud, O.5
-
15
-
-
55949105242
-
Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia
-
Jenkins, C.; Hewamana, S.; Gilkes, A.; Neelakantan, S.; Crooks, P.; Mills, K.; Pepper, C.; Burnett, A. Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia. Br. J. Haematol., 2008, 143, 661-671.
-
(2008)
Br. J. Haematol
, vol.143
, pp. 661-671
-
-
Jenkins, C.1
Hewamana, S.2
Gilkes, A.3
Neelakantan, S.4
Crooks, P.5
Mills, K.6
Pepper, C.7
Burnett, A.8
-
16
-
-
0037111664
-
Tumor necrosis factor receptorassociated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: Analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis
-
Munzert, G.; Kirchner, D.; Stobbe, H.; Bergmann, L.; Schmid, R.M.; Döhner, H.; Heimpel, H. Tumor necrosis factor receptorassociated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood, 2002, 100, 3749-3756.
-
(2002)
Blood
, vol.100
, pp. 3749-3756
-
-
Munzert, G.1
Kirchner, D.2
Stobbe, H.3
Bergmann, L.4
Schmid, R.M.5
Döhner, H.6
Heimpel, H.7
-
17
-
-
2342641470
-
Constitutive NF-kappab/Rel activation in philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). Leuk
-
Munzert, G.; Kirchner, D.; Ottmann, O.; Bergmann, L.; Schmid, R.M. Constitutive NF-kappab/Rel activation in philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). Leuk. Lymphoma, 2004, 45, 1181-1184.
-
(2004)
Lymphoma
, vol.45
, pp. 1181-1184
-
-
Munzert, G.1
Kirchner, D.2
Ottmann, O.3
Bergmann, L.4
Schmid, R.M.5
-
18
-
-
0032034216
-
A requirement for NF-κB activation in Bcr-Ablmediated transformation
-
Reuther, J.Y.; Reuther, G.W.; Cortez, D.; Pendergast, A.M.; Baldwin, A.S. Jr. A requirement for NF-κB activation in Bcr-Ablmediated transformation. Genes Dev., 1998, 12, 968-981.
-
(1998)
Genes Dev
, vol.12
, pp. 968-981
-
-
Reuther, J.Y.1
Reuther, G.W.2
Cortez, D.3
Pendergast, A.M.4
Baldwin Jr., A.S.5
-
19
-
-
33749260717
-
Deregulated NFkappaB activity in haematological malignancies
-
Keutgens, A.; Robert, I.; Viatour, P.; Chariot, A. Deregulated NFkappaB activity in haematological malignancies. Biochem. Pharmacol., 2006, 72, 1069-1080.
-
(2006)
Biochem. Pharmacol
, vol.72
, pp. 1069-1080
-
-
Keutgens, A.1
Robert, I.2
Viatour, P.3
Chariot, A.4
-
20
-
-
58149355768
-
The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine
-
Hewamana, S.; Lin, T.T.; Jenkins, C.; Burnett, A.K.; Jordan, C.T.; Fegan, C.; Brennan, P.; Rowntree, C.; Pepper, C. The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clin. Cancer Res., 2008, 14, 8102-8111.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 8102-8111
-
-
Hewamana, S.1
Lin, T.T.2
Jenkins, C.3
Burnett, A.K.4
Jordan, C.T.5
Fegan, C.6
Brennan, P.7
Rowntree, C.8
Pepper, C.9
-
21
-
-
0742324492
-
NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors
-
Turco, M.C.; Romano, M.F.; Petrella, A.; Bisogni, R.; Tassone, P.; Venuta, S. NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors. Leukemia, 2004, 18, 11-17.
-
(2004)
Leukemia
, vol.18
, pp. 11-17
-
-
Turco, M.C.1
Romano, M.F.2
Petrella, A.3
Bisogni, R.4
Tassone, P.5
Venuta, S.6
-
22
-
-
27144476790
-
Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T-cell leukemia
-
Watanabe, M.; Ohsugi, T.; Shoda, M.; Ishida, T.; Aizawa, S.; Maruyama-Nagai, M.; Utsunomiya, A.; Koga, S.; Yamada, Y.; Kamihira, S.; Okayama, A.; Kikuchi, H.; Uozumi, K.; Yamaguchi, K.; Higashihara, M.; Umezawa, K.; Watanabe, T.; Horie, R. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood, 2005, 106, 2462-2471.
-
(2005)
Blood
, vol.106
, pp. 2462-2471
-
-
Watanabe, M.1
Ohsugi, T.2
Shoda, M.3
Ishida, T.4
Aizawa, S.5
Maruyama-Nagai, M.6
Utsunomiya, A.7
Koga, S.8
Yamada, Y.9
Kamihira, S.10
Okayama, A.11
Kikuchi, H.12
Uozumi, K.13
Yamaguchi, K.14
Higashihara, M.15
Umezawa, K.16
Watanabe, T.17
Horie, R.18
-
23
-
-
51249095557
-
The role of NF-κB in lymphoid malignancies
-
Packham, G. The role of NF-κB in lymphoid malignancies. Br. J. Haematol., 2008, 143, 3-15.
-
(2008)
Br. J. Haematol
, vol.143
, pp. 3-15
-
-
Packham, G.1
-
24
-
-
33947586159
-
Aberrant NF-kappaB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
-
Jost, P.J.; Ruland, J. Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood, 2007, 109, 2700-2707.
-
(2007)
Blood
, vol.109
, pp. 2700-2707
-
-
Jost, P.J.1
Ruland, J.2
-
25
-
-
70249122331
-
Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in follicular lymphoma
-
Green, M.R.; Gandhi, M.K.; Courtney, M.J.; Marlton, P.; Griffiths, L. Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in follicular lymphoma. Leuk. Res., 2009, 33, 1699-1702.
-
(2009)
Leuk. Res
, vol.33
, pp. 1699-1702
-
-
Green, M.R.1
Gandhi, M.K.2
Courtney, M.J.3
Marlton, P.4
Griffiths, L.5
-
26
-
-
0035725855
-
Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: Downregulation of NF-kappa B induces apoptosis
-
Ni, H.; Ergin, M.; Huang, Q.; Qin, J.Z.; Amin, H.M.; Martinez, R.L.; Saeed, S.; Barton, K.; Alkan, S. Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis. Br. J. Haematol., 2001, 115, 279-286.
-
(2001)
Br. J. Haematol
, vol.115
, pp. 279-286
-
-
Ni, H.1
Ergin, M.2
Huang, Q.3
Qin, J.Z.4
Amin, H.M.5
Martinez, R.L.6
Saeed, S.7
Barton, K.8
Alkan, S.9
-
27
-
-
0035207110
-
The role of nuclear factorkappaB in the biology and treatment of multiple myeloma
-
Berenson, J.R.; Ma, H.M.; Vescio, R. The role of nuclear factorkappaB in the biology and treatment of multiple myeloma. Semin. Oncol., 2001, 28, 626-633.
-
(2001)
Semin. Oncol
, vol.28
, pp. 626-633
-
-
Berenson, J.R.1
Ma, H.M.2
Vescio, R.3
-
28
-
-
14644413996
-
Regulation of NF-κB in multiple myeloma: Therapeutic implications
-
Feinman, R.; Siegel, D.S.; Berenson, J. Regulation of NF-κB in multiple myeloma: therapeutic implications. Clin. Adv. Hematol. Oncol., 2004, 2, 162-166.
-
(2004)
Clin. Adv. Hematol. Oncol
, vol.2
, pp. 162-166
-
-
Feinman, R.1
Siegel, D.S.2
Berenson, J.3
-
29
-
-
1842579486
-
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
-
Bharti, A.C.; Shishodia, S.; Reuben, J.M.; Weber, D.; Alexanian, R.; Raj-Vadhan, S.; Estrov, Z.; Talpaz, M.; Aggarwal, B.B. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood, 2004, 103, 3175-3184.
-
(2004)
Blood
, vol.103
, pp. 3175-3184
-
-
Bharti, A.C.1
Shishodia, S.2
Reuben, J.M.3
Weber, D.4
Alexanian, R.5
Raj-Vadhan, S.6
Estrov, Z.7
Talpaz, M.8
Aggarwal, B.B.9
-
30
-
-
35548984453
-
SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma
-
Lentzsch, S.; Elliott, G.; Roodman, G.D. SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma. Arch. Pharm. (Weinheim), 2007, 340, 511-516.
-
(2007)
Arch. Pharm. (Weinheim)
, vol.340
, pp. 511-516
-
-
Lentzsch, S.1
Elliott, G.2
Roodman, G.D.3
-
31
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata, C.M.; Davis, R.E.; Demchenko, Y.; Bellamy, W.; Gabrea, A.; Zhan, F.; Lenz, G.; Hanamura, I.; Wright, G.; Xiao, W.; Dave, S.; Hurt, E.M.; Tan, B.; Zhao, H.; Stephens, O.; Santra, M.; Williams, D.R.; Dang, L.; Barlogie, B.; Shaughnessy, J.D. Jr.; Kuehl, W.M.; Staudt, L.M. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell, 2007, 12, 115-130.
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
Dave, S.11
Hurt, E.M.12
Tan, B.13
Zhao, H.14
Stephens, O.15
Santra, M.16
Williams, D.R.17
Dang, L.18
Barlogie, B.19
Shaughnessy Jr., J.D.20
Kuehl, W.M.21
Staudt, L.M.22
more..
-
32
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
Keats, J.J.; Fonseca, R.; Chesi, M.; Schop, R.; Baker, A.; Chng, W.J.; Van Wier, S.; Tiedemann, R.; Shi, C.X.; Sebag, M.; Braggio, E.; Henry, T.; Zhu, Y.X.; Fogle, H.; Price-Troska, T.; Ahmann, G.; Mancini, C.; Brents, L.A.; Kumar, S.; Greipp, P.; Dispenzieri, A.; Bryant, B.; Mulligan, G.; Bruhn, L.; Barrett, M.; Valdez, R.; Trent, J.; Stewart, A.K.; Carpten, J.; Bergsagel, P.L. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell, 2007, 12, 131-144.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.J.6
van Wier, S.7
Tiedemann, R.8
Shi, C.X.9
Sebag, M.10
Braggio, E.11
Henry, T.12
Zhu, Y.X.13
Fogle, H.14
Price-Troska, T.15
Ahmann, G.16
Mancini, C.17
Brents, L.A.18
Kumar, S.19
Greipp, P.20
Dispenzieri, A.21
Bryant, B.22
Mulligan, G.23
Bruhn, L.24
Barrett, M.25
Valdez, R.26
Trent, J.27
Stewart, A.K.28
Carpten, J.29
Bergsagel, P.L.30
more..
-
33
-
-
0033596121
-
Activators and target genes of Rel/NF-kappaB transcription factors
-
Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene, 1999, 18, 6853-6866.
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
34
-
-
76449101970
-
Regulation of cyclin D1 gene expression
-
Witzell, I.I.; Koh, L.F.; Perkins, N.D. Regulation of cyclin D1 gene expression. Biochem. Soc. Trans., 2010, 38, 217-222.
-
(2010)
Biochem. Soc. Trans
, vol.38
, pp. 217-222
-
-
Witzell, I.I.1
Koh, L.F.2
Perkins, N.D.3
-
35
-
-
77349094234
-
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma
-
Xie, T.X.; Xia, Z.; Zhang, N.; Gong, W.; Huang, S. Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncol. Rep., 2010, 23, 725-732.
-
(2010)
Oncol. Rep
, vol.23
, pp. 725-732
-
-
Xie, T.X.1
Xia, Z.2
Zhang, N.3
Gong, W.4
Huang, S.5
-
36
-
-
77952941515
-
Sesamin manifests chemopreventive effects through the suppression of NF-kappaB-regulated cell survival, proliferation, invasion, and angiogenic gene products
-
Harikumar, K.B.; Sung, B.; Tharakan, S.T.; Pandey, M.P.; Joy, B.; Guha, S.; Krishnan, S.; Aggarwal, B.B. Sesamin manifests chemopreventive effects through the suppression of NF-kappaB-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol. Cancer Res., 2010, 8, 751-761.
-
(2010)
Mol. Cancer Res
, vol.8
, pp. 751-761
-
-
Harikumar, K.B.1
Sung, B.2
Tharakan, S.T.3
Pandey, M.P.4
Joy, B.5
Guha, S.6
Krishnan, S.7
Aggarwal, B.B.8
-
37
-
-
0037675869
-
NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants
-
Takebayashi, T.; Higashi, H.; Sudo, H.; Ozawa, H.; Suzuki, E.; Shirado, O.; Katoh, H.; Hatakeyama, M. NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants. J. Biol. Chem., 2003, 278, 14897-14905.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14897-14905
-
-
Takebayashi, T.1
Higashi, H.2
Sudo, H.3
Ozawa, H.4
Suzuki, E.5
Shirado, O.6
Katoh, H.7
Hatakeyama, M.8
-
38
-
-
0028903216
-
Members of the nuclear factor kappa B family transactivate the murine c-myb gene
-
Toth, C.R.; Hostutler, R.F.; Baldwin, A.S. Jr.; Bender, T.P. Members of the nuclear factor kappa B family transactivate the murine c-myb gene. J. Biol. Chem., 1995, 270, 7661-7671.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 7661-7671
-
-
Toth, C.R.1
Hostutler, R.F.2
Baldwin Jr., A.S.3
Bender, T.P.4
-
39
-
-
0026712227
-
Transactivation of the cmyc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B
-
Duyao, M.P.; Kessler, D.J.; Spicer, D.B.; Bartholomew, C.; Cleveland, J.L.; Siekevitz, M.; Sonenshein, G.E. Transactivation of the cmyc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B. J. Biol. Chem., 1992, 267, 16288-16291.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 16288-16291
-
-
Duyao, M.P.1
Kessler, D.J.2
Spicer, D.B.3
Bartholomew, C.4
Cleveland, J.L.5
Siekevitz, M.6
Sonenshein, G.E.7
-
40
-
-
0036009115
-
NF-kappaB at the crossroads of life and death
-
Karin, M.; Lin, A. NF-kappaB at the crossroads of life and death. Nat. Immunol., 2002, 3, 221-227.
-
(2002)
Nat. Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
41
-
-
0038103154
-
NF-kappa B2/p100 induces Bcl-2 expression
-
Viatour, P.; Bentires-Alj, M.; Chariot, A.; Deregowski, V.; de Leval, L.; Merville, M.P.; Bours, V. NF-kappa B2/p100 induces Bcl-2 expression. Leukemia, 2003, 17, 1349-1356.
-
(2003)
Leukemia
, vol.17
, pp. 1349-1356
-
-
Viatour, P.1
Bentires-Alj, M.2
Chariot, A.3
Deregowski, V.4
de Leval, L.5
Merville, M.P.6
Bours, V.7
-
42
-
-
0037427122
-
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells
-
Bentires-Alj, M.; Barbu, V.; Fillet, M.; Chariot, A.; Relic, B.; Jacobs, N.; Gielen, J.; Merville, M.P.; Bours, V. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene, 2003, 22, 90-97.
-
(2003)
Oncogene
, vol.22
, pp. 90-97
-
-
Bentires-Alj, M.1
Barbu, V.2
Fillet, M.3
Chariot, A.4
Relic, B.5
Jacobs, N.6
Gielen, J.7
Merville, M.P.8
Bours, V.9
-
43
-
-
0033596124
-
Aberrant rel/nfkb genes and activity in human cancer
-
Rayet, B.; Gelinas, C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene, 1999, 18, 6938-6947.
-
(1999)
Oncogene
, vol.18
, pp. 6938-6947
-
-
Rayet, B.1
Gelinas, C.2
-
44
-
-
0035950554
-
Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel
-
Gilmore, T.D.; Cormier, C.; Jean-Jacques, J.; Gapuzan, M.E. Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel. Oncogene, 2001, 20, 7098-7103.
-
(2001)
Oncogene
, vol.20
, pp. 7098-7103
-
-
Gilmore, T.D.1
Cormier, C.2
Jean-Jacques, J.3
Gapuzan, M.E.4
-
45
-
-
1842432464
-
The c-Rel transcription factor and B-cell proliferation: A deal with the devil
-
Gilmore, T.D.; Kalaitzidis, D.; Liang, M.C.; Starczynowski, D.T. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 2004, 23, 2275-2286.
-
(2004)
Oncogene
, vol.23
, pp. 2275-2286
-
-
Gilmore, T.D.1
Kalaitzidis, D.2
Liang, M.C.3
Starczynowski, D.T.4
-
46
-
-
0033596128
-
Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel
-
Gilmore, T.D. Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene, 1999, 22, 6925-6937.
-
(1999)
Oncogene
, vol.22
, pp. 6925-6937
-
-
Gilmore, T.D.1
-
47
-
-
0028804551
-
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
-
Sha, W.C.; Liou, H.C.; Tuomanen, E.I.; Baltimore, D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell, 1995, 80, 321-330.
-
(1995)
Cell
, vol.80
, pp. 321-330
-
-
Sha, W.C.1
Liou, H.C.2
Tuomanen, E.I.3
Baltimore, D.4
-
48
-
-
0029150389
-
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
-
Köntgen, F.; Grumont, R.J.; Strasser, A.; Metcalf, D.; Li, R.; Tarlinton, D.; Gerondakis, S. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev., 1995, 9, 1965-1977.
-
(1995)
Genes Dev
, vol.9
, pp. 1965-1977
-
-
Köntgen, F.1
Grumont, R.J.2
Strasser, A.3
Metcalf, D.4
Li, R.5
Tarlinton, D.6
Gerondakis, S.7
-
49
-
-
0031964855
-
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
-
Franzoso, G.; Carlson, L.; Poljak, L.; Shores, E.W.; Epstein, S.; Leonardi, A.; Grinberg, A.; Tran, T.; Scharton-Kersten, T.; Anver, M.; Love, P.; Brown, K.; Siebenlist, U. Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med., 1998, 187, 147-159.
-
(1998)
J. Exp. Med
, vol.187
, pp. 147-159
-
-
Franzoso, G.1
Carlson, L.2
Poljak, L.3
Shores, E.W.4
Epstein, S.5
Leonardi, A.6
Grinberg, A.7
Tran, T.8
Scharton-Kersten, T.9
Anver, M.10
Love, P.11
Brown, K.12
Siebenlist, U.13
-
50
-
-
0032568792
-
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
-
Yamaoka, S.; Courtois, G.; Bessia, C.; Whiteside, S.T.; Weil, R.; Agou, F.; Kirk, H.E.; Kay, R.J.; Israël, A. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell, 1998, 93, 1231-1240.
-
(1998)
Cell
, vol.93
, pp. 1231-1240
-
-
Yamaoka, S.1
Courtois, G.2
Bessia, C.3
Whiteside, S.T.4
Weil, R.5
Agou, F.6
Kirk, H.E.7
Kay, R.J.8
Israël, A.9
-
51
-
-
0032541657
-
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
-
Rothwarf, D.M.; Zandi, E.; Natoli, G.; Karin, M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature, 1998, 395, 297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
52
-
-
0032589935
-
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
-
Mercurio, F.; Murray B.W.; Shevchenko, A.; Bennett, B.L.; Young, D.B.; Li, J.W.; Pascual, G.; Motiwala, A.; Zhu, H.; Mann, M.; Manning, A.M. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol., 1999, 19, 1526-1538.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 1526-1538
-
-
Mercurio, F.1
Murray, B.W.2
Shevchenko, A.3
Bennett, B.L.4
Young, D.B.5
Li, J.W.6
Pascual, G.7
Motiwala, A.8
Zhu, H.9
Mann, M.10
Manning, A.M.11
-
53
-
-
61849127839
-
The IkappaB kinase complex: Master regulator of NF-kappaB signaling
-
Solt, L.A.; May, M.J. The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol. Res., 2008, 42, 3-18.
-
(2008)
Immunol. Res
, vol.42
, pp. 3-18
-
-
Solt, L.A.1
May, M.J.2
-
54
-
-
70350442569
-
NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation
-
Solt, L.A.; Madge, L.A.; May, M.J. NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. J. Biol. Chem., 2009, 284, 27596-27608.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 27596-27608
-
-
Solt, L.A.1
Madge, L.A.2
May, M.J.3
-
55
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation
-
Rahighi, S.; Ikeda, F.; Kawasaki, M.; Akutsu, M.; Suzuki, N.; Kato, R.; Kensche, T.; Uejima, T.; Bloor, S.; Komander, D.; Randow, F.; Wakatsuki, S.; Dikic, I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell, 2009, 136, 1098-1109.
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
Ikeda, F.2
Kawasaki, M.3
Akutsu, M.4
Suzuki, N.5
Kato, R.6
Kensche, T.7
Uejima, T.8
Bloor, S.9
Komander, D.10
Randow, F.11
Wakatsuki, S.12
Dikic, I.13
-
56
-
-
0033106149
-
A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways
-
Maniatis, T. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev., 1999, 13, 505-510.
-
(1999)
Genes Dev
, vol.13
, pp. 505-510
-
-
Maniatis, T.1
-
57
-
-
0034084163
-
Phosphorylation meets ubiquitination: The control of NFκB activity
-
Karin, M.; Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NFκB activity. Annu. Rev. Immunol., 2000, 18, 621-663.
-
(2000)
Annu. Rev. Immunol
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
58
-
-
33645703930
-
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation
-
Wu, C.J.; Conze, D.B.; Li, T.; Srinivasula, S.M.; Ashwell, J.D. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nat. Cell. Biol., 2006, 8, 398-406.
-
(2006)
Nat. Cell. Biol
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
59
-
-
38049028109
-
Phosphorylation of serine 68 in the IκB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-κB activity
-
Palkowitsch, L.; Leidner, J.; Ghosh, S.; Marienfeld, R.B. Phosphorylation of serine 68 in the IκB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-κB activity. J. Biol. Chem., 2008, 283, 76-86.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 76-86
-
-
Palkowitsch, L.1
Leidner, J.2
Ghosh, S.3
Marienfeld, R.B.4
-
60
-
-
33645271646
-
Advances in NF-κB signaling transduction and transcription. Cell. Mol
-
Xiao, W. Advances in NF-κB signaling transduction and transcription. Cell. Mol. Immunol., 2004, 1, 425-435.
-
(2004)
Immunol
, vol.1
, pp. 425-435
-
-
Xiao, W.1
-
61
-
-
24944489952
-
Stimulus specificity of gene expression programs determined by temporal control of IKK activity
-
Werner, S.L.; Barken, D.; Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science, 2005, 309, 1857-1861.
-
(2005)
Science
, vol.309
, pp. 1857-1861
-
-
Werner, S.L.1
Barken, D.2
Hoffmann, A.3
-
62
-
-
24944554790
-
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis: CREB and NF-κB as key regulators
-
Park, J.M.; Greten, F.R.; Wong, A.; Westrick, R.J.; Arthur, J.S.; Otsu, K.; Hoffmann, A.; Montminy, M.; Karin, M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis: CREB and NF-κB as key regulators. Immunity, 2005, 23, 319-329.
-
(2005)
Immunity
, vol.23
, pp. 319-329
-
-
Park, J.M.1
Greten, F.R.2
Wong, A.3
Westrick, R.J.4
Arthur, J.S.5
Otsu, K.6
Hoffmann, A.7
Montminy, M.8
Karin, M.9
-
63
-
-
24944586285
-
Achieving stability of lipopolysaccharide-induced NF-kappaB activation
-
Covert, M.W.; Leung, T.H.; Gaston, J.E.; Baltimore, D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science, 2005, 309, 1854-1857.
-
(2005)
Science
, vol.309
, pp. 1854-1857
-
-
Covert, M.W.1
Leung, T.H.2
Gaston, J.E.3
Baltimore, D.4
-
64
-
-
33750448661
-
Transcriptional regulation via the NF-κB signaling module
-
Hoffmann, A.; Natoli, G.; Ghosh, G. Transcriptional regulation via the NF-κB signaling module. Oncogene, 2006, 25, 6706-6716.
-
(2006)
Oncogene
, vol.25
, pp. 6706-6716
-
-
Hoffmann, A.1
Natoli, G.2
Ghosh, G.3
-
65
-
-
33645936634
-
Regulation of NF-κB transcriptional activity
-
Vermeulen, L.; Vanden Berghe, W.; Haegeman, G. Regulation of NF-κB transcriptional activity. Cancer Treat. Res., 2006, 130, 89-102.
-
(2006)
Cancer Treat. Res
, vol.130
, pp. 89-102
-
-
Vermeulen, L.1
Vanden, B.W.2
Haegeman, G.3
-
66
-
-
64849104716
-
Pulsatile stimulation determines timing and specificity of NF-κB-dependent transcription
-
Ashall, L.; Horton, C.A.; Nelson, D.E.; Paszek, P.; Harper, C.V.; Sillitoe, K.; Ryan, S.; Spiller, D.G.; Unitt, J.F.; Broomhead, D.S.; Kell, D.B.; Rand, D.A.; Sée, V.; White, M.R. Pulsatile stimulation determines timing and specificity of NF-κB-dependent transcription. Science, 2009, 324, 242-246.
-
(2009)
Science
, vol.324
, pp. 242-246
-
-
Ashall, L.1
Horton, C.A.2
Nelson, D.E.3
Paszek, P.4
Harper, C.V.5
Sillitoe, K.6
Ryan, S.7
Spiller, D.G.8
Unitt, J.F.9
Broomhead, D.S.10
Kell, D.B.11
Rand, D.A.12
Sée, V.13
White, M.R.14
-
67
-
-
59449108567
-
The roles of the classical and alternative nuclear factor-κB pathways: Potential implications for autoimmunity and rheumatoid arthritis
-
Brown, K.D.; Claudio, E.; Siebenlist, U. The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis. Res. Ther., 2008, 10, 212.
-
(2008)
Arthritis. Res. Ther
, vol.10
, pp. 212
-
-
Brown, K.D.1
Claudio, E.2
Siebenlist, U.3
-
68
-
-
35648958721
-
IκB kinase-β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NFκB pathway
-
Hutti, J.E.; Turk, B.E.; Asara, J.M.; Ma, A.; Cantley, L.C.; Abbott, D.W. IκB kinase-β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NFκB pathway. Mol. Cell. Biol., 2007, 27, 7451-7461.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 7451-7461
-
-
Hutti, J.E.1
Turk, B.E.2
Asara, J.M.3
Ma, A.4
Cantley, L.C.5
Abbott, D.W.6
-
69
-
-
77649230307
-
Turning off inflammation signaling
-
Sriskantharajah, S.; Ley, S.C. Turning off inflammation signaling. Science, 2010, 327, 1093-1094.
-
(2010)
Science
, vol.327
, pp. 1093-1094
-
-
Sriskantharajah, S.1
Ley, S.C.2
-
70
-
-
77649225756
-
Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes
-
Shembade, N.; Ma, A.; Harhaj, E.W. Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes. Science, 2010, 327, 1135-1139.
-
(2010)
Science
, vol.327
, pp. 1135-1139
-
-
Shembade, N.1
Ma, A.2
Harhaj, E.W.3
-
71
-
-
0036771765
-
Two pathways to NF-kappaB
-
Pomerantz, J.L.; Baltimore, D. Two pathways to NF-kappaB. Mol. Cell, 2002, 10, 693-695.
-
(2002)
Mol. Cell
, vol.10
, pp. 693-695
-
-
Pomerantz, J.L.1
Baltimore, D.2
-
72
-
-
17944378526
-
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben, U.; Cao, Y.; Xiao, G.; Greten, F.R.; Krähn, G.; Bonizzi, G.; Chen, Y.; Hu, Y.; Fong, A.; Sun, S.C.; Karin, M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science, 2001, 293, 1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
Greten, F.R.4
Krähn, G.5
Bonizzi, G.6
Chen, Y.7
Hu, Y.8
Fong, A.9
Sun, S.C.10
Karin, M.11
-
73
-
-
9144275033
-
-
Bonizzi, G.; Bebien, M.; Otero, D.C.; Johnson-Vroom, K.E.; Cao, Y.; Vu, D.; Jegga, A.G.; Aronow, B.J.; Ghosh, G.; Rickert, R.C.; Karin, M. EMBO J., 2004, 23, 4202-4210.
-
(2004)
EMBO J
, vol.23
, pp. 4202-4210
-
-
Bonizzi, G.1
Bebien, M.2
Otero, D.C.3
Johnson-Vroom, K.E.4
Cao, Y.5
Vu, D.6
Jegga, A.G.7
Aronow, B.J.8
Ghosh, G.9
Rickert, R.C.10
Karin, M.11
-
74
-
-
2342464085
-
The two NF-kappaB activation pathways and their role in innate and adaptive immunity
-
Bonizzi, G.; Karin, M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol., 2004, 25, 280-288.
-
(2004)
Trends Immunol
, vol.25
, pp. 280-288
-
-
Bonizzi, G.1
Karin, M.2
-
75
-
-
0242298578
-
CK2 Is a CTerminal IκB Kinase Responsible for NF-κB Activation during the UV Response
-
Kato, T. Jr.; Delhase, M.; Hoffmann, A.; Karin, M. CK2 Is a CTerminal IκB Kinase Responsible for NF-κB Activation during the UV Response. Mol. Cell, 2003, 12, 829-839.
-
(2003)
Mol. Cell
, vol.12
, pp. 829-839
-
-
Kato Jr., T.1
Delhase, M.2
Hoffmann, A.3
Karin, M.4
-
76
-
-
45149090556
-
Nuclear ubiquitin ligases, NF-κB degradation, and the control of inflammation
-
Natoli, G.; Chiocca, S. Nuclear ubiquitin ligases, NF-κB degradation, and the control of inflammation. Sci. Signal., 2008, 8, pe1.
-
(2008)
Sci. Signal
, vol.8
, pp. 1
-
-
Natoli, G.1
Chiocca, S.2
-
77
-
-
54449087372
-
Economic and clinical impact of multiple myeloma to managed care
-
Cook, R. Economic and clinical impact of multiple myeloma to managed care. J. Manag. Care Pharm., 2008, 14(Suppl. 7), S19-S25.
-
(2008)
J. Manag. Care Pharm
, vol.14
, Issue.7
-
-
Cook, R.1
-
78
-
-
72149121096
-
Novel therapies in the treatment of multiple myeloma
-
Laubach, J.P.; Mitsiades, C.S.; Mahindra, A.; Schlossman, R.L.; Hideshima, T.; Chauhan, D.; Carreau N.A.; Ghobrial I.M.; Raje, N.; Munshi, N.C.; Anderson, K.C; Richardson, P.G. Novel therapies in the treatment of multiple myeloma. J. Natl. Compr. Canc. Netw., 2009, 7, 947-960.
-
(2009)
J. Natl. Compr. Canc. Netw
, vol.7
, pp. 947-960
-
-
Laubach, J.P.1
Mitsiades, C.S.2
Mahindra, A.3
Schlossman, R.L.4
Hideshima, T.5
Chauhan, D.6
Carreau, N.A.7
Ghobrial, I.M.8
Raje, N.9
Munshi, N.C.10
Anderson, K.C.11
Richardson, P.G.12
-
79
-
-
0024541563
-
The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction
-
Paulie, S.; Rosen, A.; Ehlin-Henriksson, B.; Braesch-Andersen, S.; Jakobson, E.; Koho, H.; Perlmann, P. The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction. J. Immunol., 1989, 142, 590-595.
-
(1989)
J. Immunol
, vol.142
, pp. 590-595
-
-
Paulie, S.1
Rosen, A.2
Ehlin-Henriksson, B.3
Braesch-Andersen, S.4
Jakobson, E.5
Koho, H.6
Perlmann, P.7
-
80
-
-
0023108060
-
Augmentation of normal and malignant B-cell proliferation by monoclonal antibody to the B-cell-specific antigen BP50 (CDW40)
-
Ledbetter, J.A.; Shu, G.; Gallagher, M.; Clark, E.A. Augmentation of normal and malignant B-cell proliferation by monoclonal antibody to the B-cell-specific antigen BP50 (CDW40). J. Immunol., 1987, 138, 788-794.
-
(1987)
J. Immunol
, vol.138
, pp. 788-794
-
-
Ledbetter, J.A.1
Shu, G.2
Gallagher, M.3
Clark, E.A.4
-
81
-
-
0042591416
-
Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
-
Nowak, A.K.; Robinson, B.W.; Lake, R.A. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res., 2003, 63, 4490-4496.
-
(2003)
Cancer Res
, vol.63
, pp. 4490-4496
-
-
Nowak, A.K.1
Robinson, B.W.2
Lake, R.A.3
-
82
-
-
0034124140
-
CD40 expressed on human melanoma cells mediates T-cell co-stimulation and tumor cell growth
-
Pirozzi, G.; Lombari, V.; Zanzi, D.; Ionna, F.; Lombardi, M.L.; Errico, S.; Ruggiero, G.; Manzo, C. CD40 expressed on human melanoma cells mediates T-cell co-stimulation and tumor cell growth. Int. Immunol., 2000, 12, 787-795.
-
(2000)
Int. Immunol
, vol.12
, pp. 787-795
-
-
Pirozzi, G.1
Lombari, V.2
Zanzi, D.3
Ionna, F.4
Lombardi, M.L.5
Errico, S.6
Ruggiero, G.7
Manzo, C.8
-
83
-
-
0036757072
-
CD40 activation as potential tool in malignant neoplasms
-
Ottaiano, A.; Pisano, C.; De Chiara, A.; Ascierto, P.A.; Botti, G.; Barletta, E.; Apice, G.; Gridelli, C.; Iaffaioli, V.R. CD40 activation as potential tool in malignant neoplasms. Tumori, 2002, 88, 361-366.
-
(2002)
Tumori
, vol.88
, pp. 361-366
-
-
Ottaiano, A.1
Pisano, C.2
de Chiara, A.3
Ascierto, P.A.4
Botti, G.5
Barletta, E.6
Apice, G.7
Gridelli, C.8
Iaffaioli, V.R.9
-
84
-
-
33645060195
-
Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro
-
Villarroel Dorrego, M.; Whawell, S.A.; Speight, P.M.; Barrett, A.W. Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro. Clin. Exp. Dermatol., 2006, 31, 266-271.
-
(2006)
Clin. Exp. Dermatol
, vol.31
, pp. 266-271
-
-
Villarroel, D.M.1
Whawell, S.A.2
Speight, P.M.3
Barrett, A.W.4
-
85
-
-
34447637912
-
The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction
-
Pinzon-Charry, A.; Schmidt, C.W.; Lopez, J.A. The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction. Breast Cancer Res., 2006, 8, 402.
-
(2006)
Breast Cancer Res
, vol.8
, pp. 402
-
-
Pinzon-Charry, A.1
Schmidt, C.W.2
Lopez, J.A.3
-
86
-
-
16544387516
-
Determinations of B cell fate in immunity and autoimmunity
-
Noelle, R.J.; Erickson, L.D. Determinations of B cell fate in immunity and autoimmunity. Curr. Dis. Autoimmun., 2005, 8, 1-24.
-
(2005)
Curr. Dis. Autoimmun
, vol.8
, pp. 1-24
-
-
Noelle, R.J.1
Erickson, L.D.2
-
87
-
-
33749472033
-
Chemotherapeutic agents enhance AAV2-mediated gene transfer into breast cancer cells promoting CD40 ligand-based immunotherapy
-
Koppold, B.; Sauer, G.; Buening, H.; Hallek, M.; Kreienberg, R.; Deissler, H.; Kurzeder, C. Chemotherapeutic agents enhance AAV2-mediated gene transfer into breast cancer cells promoting CD40 ligand-based immunotherapy. J. Cancer Res. Clin. Oncol., 2006, 132, 787-794.
-
(2006)
J. Cancer Res. Clin. Oncol
, vol.132
, pp. 787-794
-
-
Koppold, B.1
Sauer, G.2
Buening, H.3
Hallek, M.4
Kreienberg, R.5
Deissler, H.6
Kurzeder, C.7
-
88
-
-
34248153303
-
Expression of CD40 and CD40L on tumor cells: The role of their interaction and new approach to immunotherapy
-
Bereznaya, N.M.; Chekhun, V.F. Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy. Exp. Oncol., 2007, 29, 2-12.
-
(2007)
Exp. Oncol
, vol.29
, pp. 2-12
-
-
Bereznaya, N.M.1
Chekhun, V.F.2
-
89
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
Lomaga, M.A.; Yeh, W.C.; Sarosi, I.; Duncan, G.S.; Furlonger, C.; Ho, A.; Morony, S.; Capparelli, C.; Van, G.; Kaufman, S.; van der Heiden, A.; Itie, A.; Wakeham, A.; Khoo, W., Sasaki, T.; Cao, Z.; Penninger, J.M.; Paige, C.J.; Lacey, D.L.; Dunstan, C.R.; Boyle, W.J., Goeddel, D.V.; Mak, T.W. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev., 1999, 13, 1015-1024.
-
(1999)
Genes Dev
, vol.13
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
Duncan, G.S.4
Furlonger, C.5
Ho, A.6
Morony, S.7
Capparelli, C.8
Van, G.9
Kaufman, S.10
van der Heiden, A.11
Itie, A.12
Wakeham, A.13
Khoo, W.14
Sasaki, T.15
Cao, Z.16
Penninger, J.M.17
Paige, C.J.18
Lacey, D.L.19
Dunstan, C.R.20
Boyle, W.J.21
Goeddel, D.V.22
Mak, T.W.23
more..
-
90
-
-
14544286868
-
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
-
Hauer, J.; Püschner, S.; Ramakrishnan, P.; Simon, U.; Bongers, M.; Federle, C.; Engelmann, H. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc. Natl. Acad. Sci. USA, 2005, 102, 2874-2879.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2874-2879
-
-
Hauer, J.1
Püschner, S.2
Ramakrishnan, P.3
Simon, U.4
Bongers, M.5
Federle, C.6
Engelmann, H.7
-
91
-
-
33750208645
-
Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis
-
Chen, H.; Li, M.; Campbell, R.A.; Burkhardt, K.; Zhu, D.; Li, S.G.; Lee, H.J.; Wang, C.; Zeng, Z.; Gordon, M.S.; Bonavida, B.; Berenson, J.R. Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis. Oncogene, 2006, 25, 6520-6527.
-
(2006)
Oncogene
, vol.25
, pp. 6520-6527
-
-
Chen, H.1
Li, M.2
Campbell, R.A.3
Burkhardt, K.4
Zhu, D.5
Li, S.G.6
Lee, H.J.7
Wang, C.8
Zeng, Z.9
Gordon, M.S.10
Bonavida, B.11
Berenson, J.R.12
-
92
-
-
2942731516
-
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptorassociated factor 3-induced degradation
-
Liao, G.; Zhang, M.; Harhaj, E.W.; Sun, S.C. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptorassociated factor 3-induced degradation. J. Biol. Chem., 2004, 279, 26243-26250.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 26243-26250
-
-
Liao, G.1
Zhang, M.2
Harhaj, E.W.3
Sun, S.C.4
-
93
-
-
77951719556
-
Classical and/or alternative NFκB pathway activation in multiple myeloma
-
Demchenko, Y.N.; Glebov, O.K.; Zingone, A.; Keats, J.J.; Bergsagel, P.L.; Kuehl, W.M. Classical and/or alternative NFκB pathway activation in multiple myeloma. Blood, 2010, 115, 3541-3552.
-
(2010)
Blood
, vol.115
, pp. 3541-3552
-
-
Demchenko, Y.N.1
Glebov, O.K.2
Zingone, A.3
Keats, J.J.4
Bergsagel, P.L.5
Kuehl, W.M.6
-
94
-
-
0035896422
-
Defective lymphotoxin-beta receptorinduced NF-kappaB transcriptional activity in NIK-deficient mice
-
Yin, L.; Wu, L.; Wesche, H.; Arthur, C.D.; White, J.M.; Goeddel, D.V.; Schreiber, R.D. Defective lymphotoxin-beta receptorinduced NF-kappaB transcriptional activity in NIK-deficient mice. Science, 2001, 291, 2162-2165.
-
(2001)
Science
, vol.291
, pp. 2162-2165
-
-
Yin, L.1
Wu, L.2
Wesche, H.3
Arthur, C.D.4
White, J.M.5
Goeddel, D.V.6
Schreiber, R.D.7
-
95
-
-
0036794398
-
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells
-
Claudio, E.; Brown, K.; Park, S.; Wang, H.; Siebenlist, U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat. Immunol., 2002, 3, 958-965.
-
(2002)
Nat. Immunol
, vol.3
, pp. 958-965
-
-
Claudio, E.1
Brown, K.2
Park, S.3
Wang, H.4
Siebenlist, U.5
-
96
-
-
0037107399
-
CD40 regulates the processing of NFkappaB2 p100 to p52
-
Coope, H.J.; Atkinson, P.G.; Huhse, B.; Belich, M.; Janzen, J.; Holman, M.J.; Klaus, G.G.; Johnston, L.H.; Ley, S.C.; Klaus, G.G.; Johnston, L.H.; Ley, S.C. CD40 regulates the processing of NFkappaB2 p100 to p52. EMBO J., 2002, 21, 5375-5385.
-
(2002)
EMBO J
, vol.21
, pp. 5375-5385
-
-
Coope, H.J.1
Atkinson, P.G.2
Huhse, B.3
Belich, M.4
Janzen, J.5
Holman, M.J.6
Klaus, G.G.7
Johnston, L.H.8
Ley, S.C.9
Klaus, G.G.10
Johnston, L.H.11
Ley, S.C.12
-
97
-
-
5644302162
-
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase
-
Ramakrishnan, P.; Wang, W.; Wallach, D. Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity, 2004, 21, 477-489.
-
(2004)
Immunity
, vol.21
, pp. 477-489
-
-
Ramakrishnan, P.1
Wang, W.2
Wallach, D.3
-
98
-
-
0030611595
-
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
-
Woronicz, J.D.; Gao, X.; Cao, Z.; Rothe, M.; Goeddel, D.V. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science, 1997, 278, 866-869.
-
(1997)
Science
, vol.278
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
99
-
-
0033621618
-
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions
-
O'Mahony, A.; Lin, X.; Geleziunas, R.; Greene, W.C. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol. Cell. Biol., 2000, 20, 1170-1178.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1170-1178
-
-
O'Mahony, A.1
Lin, X.2
Geleziunas, R.3
Greene, W.C.4
-
100
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
-
Brummelkamp, T.R.; Nijman, S.M.; Dirac, A.M.; Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature, 2003, 424, 797-801.
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
101
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko, A.; Chable-Bessia, C.; Cantarella, G.; Israël, A.; Wallach, D.; Courtois, G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature, 2003, 424, 801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israël, A.4
Wallach, D.5
Courtois, G.6
-
102
-
-
0346333095
-
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor
-
Regamey, A.; Hohl, D.; Liu, J.W.; Roger, T.; Kogerman, P.; Toftgard, R.; Huber, M. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. J. Exp. Med., 2003, 198, 1959-1964.
-
(2003)
J. Exp. Med
, vol.198
, pp. 1959-1964
-
-
Regamey, A.1
Hohl, D.2
Liu, J.W.3
Roger, T.4
Kogerman, P.5
Toftgard, R.6
Huber, M.7
-
103
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
-
Trompouki, E.; Hatzivassiliou, E.; Tsichritzis, T.; Farmer, H.; Ashworth, A.; Mosialos, G. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature, 2003, 424, 793-796.
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
Farmer, H.4
Ashworth, A.5
Mosialos, G.6
-
104
-
-
33646531810
-
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
-
Massoumi, R.; Chmielarska, K.; Hennecke, K.; Pfeifer, A.; Fässler, R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell, 2006, 125, 665-677.
-
(2006)
Cell
, vol.125
, pp. 665-677
-
-
Massoumi, R.1
Chmielarska, K.2
Hennecke, K.3
Pfeifer, A.4
Fässler, R.5
-
105
-
-
0029595282
-
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe, M.; Pan, M.G.; Henzel, W.J.; Ayres, T.M.; Goeddel, D.V. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell, 1995, 83, 1243-1252.
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
106
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li, X.; Yang, Y.; Ashwell, J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature, 2002, 416, 345-347.
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
107
-
-
45449112944
-
Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells
-
Gerlo, S.; Haegeman, G.; Vanden Berghe, W. Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells. Cell. Signal., 2008, 20, 1489-1496.
-
(2008)
Cell. Signal
, vol.20
, pp. 1489-1496
-
-
Gerlo, S.1
Haegeman, G.2
Vanden, B.W.3
-
108
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
-
Chauhan, D.; Uchiyama, H.; Akbarali, Y.; Urashima, M.; Yamamoto, K.; Libermann, T.A.; Anderson, K.C. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood, 1996, 87, 1104-1112.
-
(1996)
Blood
, vol.87
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
Urashima, M.4
Yamamoto, K.5
Libermann, T.A.6
Anderson, K.C.7
-
109
-
-
0028952405
-
Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group
-
Pelliniemi, T.T.; Irjala, K.; Mattila, K.; Pulkki, K.; Rajamäki, A.; Tienhaara, A.; Laakso, M.; Lahtinen, R.; Laakso, M.; Lahtinen, R. Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group. Blood, 1995, 85, 765-771.
-
(1995)
Blood
, vol.85
, pp. 765-771
-
-
Pelliniemi, T.T.1
Irjala, K.2
Mattila, K.3
Pulkki, K.4
Rajamäki, A.5
Tienhaara, A.6
Laakso, M.7
Lahtinen, R.8
Laakso, M.9
Lahtinen, R.10
-
110
-
-
0030057701
-
Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group
-
Pulkki, K.; Pelliniemi, T.T.; Rajamäki, A.; Tienhaara, A.; Laakso, M.; Lahtinen, R. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group. Br. J. Haematol., 1996, 92, 370-374.
-
(1996)
Br. J. Haematol
, vol.92
, pp. 370-374
-
-
Pulkki, K.1
Pelliniemi, T.T.2
Rajamäki, A.3
Tienhaara, A.4
Laakso, M.5
Lahtinen, R.6
-
111
-
-
0028331014
-
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
-
Fattori, E.; Della Rocca, C.; Costa, P.; Giorgio, M.; Dente, B.; Pozzi, L.; Ciliberto, G. Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood, 1994, 83, 2570-2579.
-
(1994)
Blood
, vol.83
, pp. 2570-2579
-
-
Fattori, E.1
della Rocca, C.2
Costa, P.3
Giorgio, M.4
Dente, B.5
Pozzi, L.6
Ciliberto, G.7
-
112
-
-
0025139463
-
NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene
-
Schreck, R.; Baeuerle, P.A. NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol. Cell. Biol., 1990, 10, 1281-1286.
-
(1990)
Mol. Cell. Biol
, vol.10
, pp. 1281-1286
-
-
Schreck, R.1
Baeuerle, P.A.2
-
113
-
-
0025633094
-
Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells
-
Zhang, X.G.; Bataille, R.; Jourdan, M.; Saeland, S.; Banchereau, J.; Mannoni, P.; Klein B. Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells. Blood, 1990, 76, 2599-2605.
-
(1990)
Blood
, vol.76
, pp. 2599-2605
-
-
Zhang, X.G.1
Bataille, R.2
Jourdan, M.3
Saeland, S.4
Banchereau, J.5
Mannoni, P.6
Klein, B.7
-
114
-
-
0031686759
-
Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity
-
Villunger, A.; Egle, A.; Kos, M.; Egle, D.; Tinhofer, I.; Henn, T.; Uberall, F.; Maly, K.; Greil, R. Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity. Br. J. Haematol., 1998, 102, 1069-1080.
-
(1998)
Br. J. Haematol
, vol.102
, pp. 1069-1080
-
-
Villunger, A.1
Egle, A.2
Kos, M.3
Egle, D.4
Tinhofer, I.5
Henn, T.6
Uberall, F.7
Maly, K.8
Greil, R.9
-
115
-
-
0027442070
-
Cytokine gene expression in human multiple myeloma
-
Portier, M.; Zhang, X.G.; Ursule, E.; Lees, D.; Jourdan, M.; Bataille, R.; Klein, B. Cytokine gene expression in human multiple myeloma. Br. J. Haematol., 1993, 85, 514-520.
-
(1993)
Br. J. Haematol
, vol.85
, pp. 514-520
-
-
Portier, M.1
Zhang, X.G.2
Ursule, E.3
Lees, D.4
Jourdan, M.5
Bataille, R.6
Klein, B.7
-
116
-
-
0942298590
-
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: A mechanism for growth and survival
-
Novak, A.J.; Darce, J.R.; Arendt, B.K.; Harder, B.; Henderson, K.; Kindsvogel, W.; Gross, J.A.; Greipp, P.R.; Jelinek, D.F. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood, 2004, 103, 689-694.
-
(2004)
Blood
, vol.103
, pp. 689-694
-
-
Novak, A.J.1
Darce, J.R.2
Arendt, B.K.3
Harder, B.4
Henderson, K.5
Kindsvogel, W.6
Gross, J.A.7
Greipp, P.R.8
Jelinek, D.F.9
-
117
-
-
33746122751
-
Role of B-cellactivating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment
-
Tai, Y.T.; Li, X.F.; Breitkreutz, I.; Song, W.; Neri, P.; Catley, L.; Podar, K.; Hideshima, T.; Chauhan, D.; Raje, N.; Schlossman, R.; Richardson, P.; Munshi, N.C.; Anderson, K.C. Role of B-cellactivating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Cancer Res., 2006, 66, 6675-6682.
-
(2006)
Cancer Res
, vol.66
, pp. 6675-6682
-
-
Tai, Y.T.1
Li, X.F.2
Breitkreutz, I.3
Song, W.4
Neri, P.5
Catley, L.6
Podar, K.7
Hideshima, T.8
Chauhan, D.9
Raje, N.10
Schlossman, R.11
Richardson, P.12
Munshi, N.C.13
Anderson, K.C.14
-
118
-
-
33748614845
-
Chemokines in multiple myeloma
-
Aggarwal, R.; Ghobrial, I.M.; Roodman, G.D. Chemokines in multiple myeloma. Exp. Hematol., 2006, 34, 1289-1295.
-
(2006)
Exp. Hematol
, vol.34
, pp. 1289-1295
-
-
Aggarwal, R.1
Ghobrial, I.M.2
Roodman, G.D.3
-
119
-
-
58149185114
-
Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
-
Abe, M.; Hiura, K.; Ozaki, S.; Kido, S.; Matsumoto, T. Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production. J. Bone Miner. Metab., 2009, 27, 16-23.
-
(2009)
J. Bone Miner. Metab
, vol.27
, pp. 16-23
-
-
Abe, M.1
Hiura, K.2
Ozaki, S.3
Kido, S.4
Matsumoto, T.5
-
120
-
-
0028899112
-
Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line
-
Lee, H.; Arsura, M.; Wu, M.; Duyao, M.; Buckler, A.J.; Sonenshein, G.E. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J. Exp. Med., 1995, 181, 1169-1177.
-
(1995)
J. Exp. Med
, vol.181
, pp. 1169-1177
-
-
Lee, H.1
Arsura, M.2
Wu, M.3
Duyao, M.4
Buckler, A.J.5
Sonenshein, G.E.6
-
121
-
-
0032588186
-
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge, D.C.; Albanese, C.; Reuther, J.Y.; Pestell, RG.; Baldwin, A.S. Jr. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol., 1999, 19, 5785-5799.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin Jr., A.S.5
-
122
-
-
0032588170
-
NF-kappaB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition
-
Hinz, M.; Krappmann, D.; Eichten, A.; Heder, A.; Scheidereit, C.; Strauss, M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol., 1999, 19, 2690-2698.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 2690-2698
-
-
Hinz, M.1
Krappmann, D.2
Eichten, A.3
Heder, A.4
Scheidereit, C.5
Strauss, M.6
-
123
-
-
0033520458
-
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
-
Joyce, D.; Bouzahzah, B.; Fu, M.; Albanese, C.; D'Amico, M.; Steer, J.; Klein, J.U.; Lee, R.J.; Segall, J.E.; Westwick, J.K.; Der, C.J.; Pestell, R.G. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J. Biol. Chem., 1999, 274, 25245-25249.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 25245-25249
-
-
Joyce, D.1
Bouzahzah, B.2
Fu, M.3
Albanese, C.4
D'Amico, M.5
Steer, J.6
Klein, J.U.7
Lee, R.J.8
Segall, J.E.9
Westwick, J.K.10
Der, C.J.11
Pestell, R.G.12
-
124
-
-
0034744949
-
NF-kappaB and cell-cycle regulation: The cyclin connection
-
Joyce, D.; Albanese, C.; Steer, J.; Fu, M.; Bouzahzah, B.; Pestell, R.G. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev., 2001, 12, 73-90.
-
(2001)
Cytokine Growth Factor Rev
, vol.12
, pp. 73-90
-
-
Joyce, D.1
Albanese, C.2
Steer, J.3
Fu, M.4
Bouzahzah, B.5
Pestell, R.G.6
-
125
-
-
16544395502
-
Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6)
-
Ogasawara, T.; Katagiri, M.; Yamamoto, A.; Hoshi, K.; Takato, T.; Nakamura, K.; Tanaka, S.; Okayama, H.; Kawaguchi, H. Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). J. Bone Miner. Res., 2004, 19, 1128-1136.
-
(2004)
J. Bone Miner. Res
, vol.19
, pp. 1128-1136
-
-
Ogasawara, T.1
Katagiri, M.2
Yamamoto, A.3
Hoshi, K.4
Takato, T.5
Nakamura, K.6
Tanaka, S.7
Okayama, H.8
Kawaguchi, H.9
-
126
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
Bergsagel P.L.; Kuehl, W.M.; Zhan, F.; Sawyer, J.; Barlogie, B.; Shaughnessy, J. Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood, 2005, 106, 296-303.
-
(2005)
Blood
, vol.106
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy Jr., J.6
-
127
-
-
0033529416
-
NF-κBmediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
-
Lee, H.H.; Dadgostar, H.; Cheng, Q.; Shu, J.; Cheng, G. NF-κBmediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. USA, 1999, 96, 9136-9141.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9136-9141
-
-
Lee, H.H.1
Dadgostar, H.2
Cheng, Q.3
Shu, J.4
Cheng, G.5
-
128
-
-
0032490670
-
Nuclear factor (NF)-kappaB-regulated Xchromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
-
Stehlik, C.; de Martin, R.; Kumabashiri, I.; Schmid, J.A.; Binder, B.R.; Lipp, J. Nuclear factor (NF)-kappaB-regulated Xchromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med., 1998, 188, 211-216.
-
(1998)
J. Exp. Med
, vol.188
, pp. 211-216
-
-
Stehlik, C.1
de Martin, R.2
Kumabashiri, I.3
Schmid, J.A.4
Binder, B.R.5
Lipp, J.6
-
129
-
-
0032531994
-
Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells
-
Hu, X.; Yee, E.; Harlan, J.M.; Wong, F.; Karsan, A. Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood, 1998, 92, 2759-2765.
-
(1998)
Blood
, vol.92
, pp. 2759-2765
-
-
Hu, X.1
Yee, E.2
Harlan, J.M.3
Wong, F.4
Karsan, A.5
-
130
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang, C.Y.; Mayo, M.W.; Korneluk, R.G.; Goeddel, D.V.; Baldwin, A.S. Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science, 1998, 281, 1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin Jr., A.S.5
-
131
-
-
1842425016
-
Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies
-
Panwalkar, A.; Verstovsek, S.; Giles, F. Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies. Cancer, 2004, 100, 1578-1589.
-
(2004)
Cancer
, vol.100
, pp. 1578-1589
-
-
Panwalkar, A.1
Verstovsek, S.2
Giles, F.3
-
132
-
-
43249117703
-
NF-kappaBdependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
-
Benayoun, B.; Baghdiguian, S.; Lajmanovich, A.; Bartoli, M.; Daniele, N.; Gicquel, E.; Bourg, N.; Raynaud, F.; Pasquier, M.A.; Suel, L.; Lochmuller, H.; Lefranc, G.; Richard, I. NF-kappaBdependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J., 2008, 22, 1521-1529.
-
(2008)
FASEB J
, vol.22
, pp. 1521-1529
-
-
Benayoun, B.1
Baghdiguian, S.2
Lajmanovich, A.3
Bartoli, M.4
Daniele, N.5
Gicquel, E.6
Bourg, N.7
Raynaud, F.8
Pasquier, M.A.9
Suel, L.10
Lochmuller, H.11
Lefranc, G.12
Richard, I.13
-
133
-
-
13244252299
-
A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo
-
Watanabe, M.; Dewan, M.Z.; Okamura, T.; Sasaki, M.; Itoh, K.; Higashihara, M.; Mizoguchi, H; Honda, M.; Sata, T.; Watanabe, T.; Yamamoto, N.; Umezawa, K.; Horie, R. A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo. Int. J. Cancer, 2005, 114, 32-38.
-
(2005)
Int. J. Cancer
, vol.114
, pp. 32-38
-
-
Watanabe, M.1
Dewan, M.Z.2
Okamura, T.3
Sasaki, M.4
Itoh, K.5
Higashihara, M.6
Mizoguchi, H.7
Honda, M.8
Sata, T.9
Watanabe, T.10
Yamamoto, N.11
Umezawa, K.12
Horie, R.13
-
134
-
-
33750589355
-
IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes
-
Nakagawa, Y.; Abe, S.; Kurata, M.; Hasegawa, M.; Yamamoto, K.; Inoue, M.; Takemura, T.; Suzuki, K.; Kitagawa, M. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am. J. Hematol., 2006, 81, 824-831.
-
(2006)
Am. J. Hematol
, vol.81
, pp. 824-831
-
-
Nakagawa, Y.1
Abe, S.2
Kurata, M.3
Hasegawa, M.4
Yamamoto, K.5
Inoue, M.6
Takemura, T.7
Suzuki, K.8
Kitagawa, M.9
-
135
-
-
0037207872
-
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
-
Akiyama, M.; Hideshima, T.; Hayashi, T.; Tai, Y.T.; Mitsiades, C.S.; Mitsiades, N.; Chauhan, D.; Richardson, P.; Munshi, N.C.; Anderson, K.C. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res., 2003, 63, 18-21.
-
(2003)
Cancer Res
, vol.63
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
Tai, Y.T.4
Mitsiades, C.S.5
Mitsiades, N.6
Chauhan, D.7
Richardson, P.8
Munshi, N.C.9
Anderson, K.C.10
-
136
-
-
47549118123
-
Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
-
Shammas, M.A.; Koley, H.; Bertheau, R.C.; Neri, P.; Fulciniti, M.; Tassone, P.; Blotta, S.; Protopopov, A.; Mitsiades, C.; Batchu, R.B.; Anderson, K.C.; Chin, A.; Gryaznov, S.; Munshi, N.C. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia, 2008, 22, 1410-1418.
-
(2008)
Leukemia
, vol.22
, pp. 1410-1418
-
-
Shammas, M.A.1
Koley, H.2
Bertheau, R.C.3
Neri, P.4
Fulciniti, M.5
Tassone, P.6
Blotta, S.7
Protopopov, A.8
Mitsiades, C.9
Batchu, R.B.10
Anderson, K.C.11
Chin, A.12
Gryaznov, S.13
Munshi, N.C.14
-
137
-
-
0037442674
-
VEGF expression in human macrophages is NFkappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinasedefective form of the IkappaB kinase 2
-
Kiriakidis, S.; Andreakos, E.; Monaco, C.; Foxwell, B.; Feldmann, M.; Paleolog, E. VEGF expression in human macrophages is NFkappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinasedefective form of the IkappaB kinase 2. J. Cell. Sci., 2003, 116, 665-674.
-
(2003)
J. Cell. Sci
, vol.116
, pp. 665-674
-
-
Kiriakidis, S.1
Andreakos, E.2
Monaco, C.3
Foxwell, B.4
Feldmann, M.5
Paleolog, E.6
-
138
-
-
26844516068
-
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
-
Cramer, M.; Nagy, I.; Murphy, B.J.; Gassmann, M.; Hottiger, M.O.; Georgiev, O.; Schaffner, W. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol. Chem., 2005, 386, 865-872.
-
(2005)
Biol. Chem
, vol.386
, pp. 865-872
-
-
Cramer, M.1
Nagy, I.2
Murphy, B.J.3
Gassmann, M.4
Hottiger, M.O.5
Georgiev, O.6
Schaffner, W.7
-
139
-
-
28844501340
-
The role of nuclear factor kappaB on angiogenesis regulation through monocyte chemotactic protein-1 in myeloma
-
Stifter, S. The role of nuclear factor kappaB on angiogenesis regulation through monocyte chemotactic protein-1 in myeloma. Med. Hypotheses, 2006, 66, 384-386.
-
(2006)
Med. Hypotheses
, vol.66
, pp. 384-386
-
-
Stifter, S.1
-
140
-
-
10144233477
-
Expression of adhesion molecules on myeloma cells
-
Tatsumi, T.; Shimazaki, C.; Goto, H.; Araki, S.; Sudo, Y.; Yamagata, N.; Ashihara, E.; Inaba, T.; Fujita, N.; Nakagawa, M. Expression of adhesion molecules on myeloma cells. Jpn. J. Cancer Res., 1996, 87, 837-842.
-
(1996)
Jpn. J. Cancer Res
, vol.87
, pp. 837-842
-
-
Tatsumi, T.1
Shimazaki, C.2
Goto, H.3
Araki, S.4
Sudo, Y.5
Yamagata, N.6
Ashihara, E.7
Inaba, T.8
Fujita, N.9
Nakagawa, M.10
-
141
-
-
0034981119
-
VLA-4-dependent myeloma cell adhesion
-
Sanz-Rodríguez, F.; Teixidó, J. VLA-4-dependent myeloma cell adhesion. Leuk. Lymphoma, 2001, 41, 239-245.
-
(2001)
Leuk. Lymphoma
, vol.41
, pp. 239-245
-
-
Sanz-Rodríguez, F.1
Teixidó, J.2
-
142
-
-
0032508674
-
Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-kappa B
-
Bond, M.; Fabunmi, R.P.; Baker, A.H.; Newby, A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett., 1998, 435, 29-34.
-
(1998)
FEBS Lett
, vol.435
, pp. 29-34
-
-
Bond, M.1
Fabunmi, R.P.2
Baker, A.H.3
Newby, A.C.4
-
143
-
-
0031596140
-
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts
-
Vincenti, M.P.; Coon, C.I.; Brinckerhoff, C.E. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum., 1998, 41, 1987-1994.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1987-1994
-
-
Vincenti, M.P.1
Coon, C.I.2
Brinckerhoff, C.E.3
-
144
-
-
39449098165
-
Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)
-
Hecht, M.; von Metzler, I.; Sack, K.; Kaiser, M.; Sezer, O. Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Exp. Cell. Res., 2008, 314, 1082-1093.
-
(2008)
Exp. Cell. Res
, vol.314
, pp. 1082-1093
-
-
Hecht, M.1
von Metzler, I.2
Sack, K.3
Kaiser, M.4
Sezer, O.5
-
145
-
-
0038780897
-
Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities
-
Delaissé, J.M.; Andersen, T.L.; Engsig, M.T.; Henriksen, K.; Troen, T.; Blavier, L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc. Res. Tech., 2003, 61, 504-513.
-
(2003)
Microsc. Res. Tech
, vol.61
, pp. 504-513
-
-
Delaissé, J.M.1
Andersen, T.L.2
Engsig, M.T.3
Henriksen, K.4
Troen, T.5
Blavier, L.6
-
146
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima, T.; Chauhan, D.; Richardson, P.; Mitsiades, C.; Mitsiades, N.; Hayashi, T.; Munshi, N.; Dang, L.; Castro, A.; Palombella, V.; Adams, J.; Anderson, K.C. NF-kappa B as a therapeutic target in multiple myeloma. J. Biol. Chem., 2002, 277, 16639-16647.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
Munshi, N.7
Dang, L.8
Castro, A.9
Palombella, V.10
Adams, J.11
Anderson, K.C.12
-
147
-
-
0036624741
-
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: Therapeutic applications
-
Mitsiades, N.; Mitsiades, C.S.; Poulaki, V.; Chauhan, D.; Richardson, P.G.; Hideshima, T.; Munshi, N.; Treon, S.P.; Anderson, K.C. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood, 2002, 99, 4079-4086.
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.7
Treon, S.P.8
Anderson, K.C.9
-
148
-
-
1642278407
-
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
-
Dai, Y.; Pei, X.Y.; Rahmani, M.; Conrad, D.H.; Dent, P.; Grant, S. Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood, 2004, 103, 2761-2770.
-
(2004)
Blood
, vol.103
, pp. 2761-2770
-
-
Dai, Y.1
Pei, X.Y.2
Rahmani, M.3
Conrad, D.H.4
Dent, P.5
Grant, S.6
-
149
-
-
33750283069
-
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo
-
Hideshima, T.; Neri, P.; Tassone, P.; Yasui, H.; Ishitsuka, K.; Raje, N.; Chauhan, D.; Podar, K.; Mitsiades, C.; Dang, L.; Munshi, N.; Richardson, P.; Schenkein, D.; Anderson, K.C. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin. Cancer Res., 2006, 12, 5887-5894.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5887-5894
-
-
Hideshima, T.1
Neri, P.2
Tassone, P.3
Yasui, H.4
Ishitsuka, K.5
Raje, N.6
Chauhan, D.7
Podar, K.8
Mitsiades, C.9
Dang, L.10
Munshi, N.11
Richardson, P.12
Schenkein, D.13
Anderson, K.C.14
-
150
-
-
35948980027
-
Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL
-
Romagnoli, M.; Desplanques, G.; Maïga, S.; Legouill, S.; Dreano, M.; Bataille, R.; Barillé-Nion, S. Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL. Clin. Cancer Res., 2007, 13, 6010-6018.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 6010-6018
-
-
Romagnoli, M.1
Desplanques, G.2
Maïga, S.3
Legouill, S.4
Dreano, M.5
Bataille, R.6
Barillé-Nion, S.7
-
151
-
-
34250855679
-
Targeting NF kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth
-
Jourdan, M.; Moreaux, J.; Vos, J.D.; Hose, D.; Mahtouk, K.; Abouladze, M.; Robert, N.; Baudard, M.; Rème, T.; Romanelli, A.; Goldschmidt, H.; Rossi, J.F.; Dreano, M.; Klein, B. Targeting NF kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth. Br. J. Haematol., 2007, 138, 160-168.
-
(2007)
Br. J. Haematol
, vol.138
, pp. 160-168
-
-
Jourdan, M.1
Moreaux, J.2
Vos, J.D.3
Hose, D.4
Mahtouk, K.5
Abouladze, M.6
Robert, N.7
Baudard, M.8
Rème, T.9
Romanelli, A.10
Goldschmidt, H.11
Rossi, J.F.12
Dreano, M.13
Klein, B.14
-
152
-
-
54049149951
-
Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells
-
Malara, N.; Focà, D.; Casadonte, F.; Sesto, M.F.; Macrina, L.; Santoro, L.; Scaramuzzino, M.; Terracciano, R.; Savino, R. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell Cycle, 2008, 7, 3235-3245.
-
(2008)
Cell Cycle
, vol.7
, pp. 3235-3245
-
-
Malara, N.1
Focà, D.2
Casadonte, F.3
Sesto, M.F.4
Macrina, L.5
Santoro, L.6
Scaramuzzino, M.7
Terracciano, R.8
Savino, R.9
-
153
-
-
8444220061
-
Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells
-
Yinjun, L.; Jie, J.; Yungui, W. Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells. Leuk. Res., 2005, 29, 99-105.
-
(2005)
Leuk. Res
, vol.29
, pp. 99-105
-
-
Yinjun, L.1
Jie, J.2
Yungui, W.3
-
154
-
-
33646355210
-
Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide
-
Wang, X.; Matta, R.; Shen, G.; Nelin, L.D.; Pei, D.; Liu, Y. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J. Mol. Med., 2006, 84, 405-415.
-
(2006)
J. Mol. Med
, vol.84
, pp. 405-415
-
-
Wang, X.1
Matta, R.2
Shen, G.3
Nelin, L.D.4
Pei, D.5
Liu, Y.6
-
155
-
-
33845868505
-
The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages
-
Bao, X.; Cui, J.; Wu, Y.; Han, X.; Gao, C.; Hua, Z.; Shen, P. The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages. J. Mol. Med., 2007, 85, 85-98.
-
(2007)
J. Mol. Med
, vol.85
, pp. 85-98
-
-
Bao, X.1
Cui, J.2
Wu, Y.3
Han, X.4
Gao, C.5
Hua, Z.6
Shen, P.7
-
156
-
-
65449174330
-
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-{kappa}B with anti-myeloma activity in vitro and in vivo
-
Tiedemann, R.E.; Schmidt, J.; Keats, J.J.; Shi, C.X.; Zhu, Y.X.; Palmer, S.E.; Mao, X.; Schimmer, A.D.; Stewart, A.K. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-{kappa}B with anti-myeloma activity in vitro and in vivo. Blood, 2009, 113, 4027-4037.
-
(2009)
Blood
, vol.113
, pp. 4027-4037
-
-
Tiedemann, R.E.1
Schmidt, J.2
Keats, J.J.3
Shi, C.X.4
Zhu, Y.X.5
Palmer, S.E.6
Mao, X.7
Schimmer, A.D.8
Stewart, A.K.9
-
157
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams, J. The proteasome: a suitable antineoplastic target. Nat. Rev. Cancer, 2004, 4, 349-360.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
158
-
-
0345447210
-
Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy
-
Kane, R.C.; Bross, P.F.; Farrell, A.T.; Pazdur, R. Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy. Oncologist, 2003, 8, 508-513.
-
(2003)
Oncologist
, vol.8
, pp. 508-513
-
-
Kane, R.C.1
Bross, P.F.2
Farrell, A.T.3
Pazdur, R.4
-
159
-
-
33744832401
-
United States Food and Drug Administration approval summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy
-
Kane, R.C.; Farrell, A.T.; Sridhara, R.; Pazdur, R. United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin. Cancer Res., 2006, 12, 2955-2960.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 2955-2960
-
-
Kane, R.C.1
Farrell, A.T.2
Sridhara, R.3
Pazdur, R.4
-
160
-
-
34247846013
-
Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma
-
Richardson, P.G.; Sonneveld, P.; Schuster, M.W.; Irwin, D.; Stadtmauer, E.A; Facon, T.; Harousseau, J.L.; Ben-Yehuda, D.; Lonial, S.; San Miguel, J.F.; Cavenagh, J.D; Anderson, K.C. Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma. Br. J. Haematol., 2007, 137, 429-435.
-
(2007)
Br. J. Haematol
, vol.137
, pp. 429-435
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
Harousseau, J.L.7
Ben-Yehuda, D.8
Lonial, S.9
San, M.J.F.10
Cavenagh, J.D.11
Anderson, K.C.12
-
161
-
-
36749069842
-
From the bench to the bedside: Emerging new treatments in multiple myeloma
-
Mitsiades, C.S.; Hayden, P.J.; Anderson, K.C.; Richardson, P.G. From the bench to the bedside: emerging new treatments in multiple myeloma. Best Pract. Res. Clin. Haematol., 2007, 20, 797-816.
-
(2007)
Best Pract. Res. Clin. Haematol
, vol.20
, pp. 797-816
-
-
Mitsiades, C.S.1
Hayden, P.J.2
Anderson, K.C.3
Richardson, P.G.4
-
162
-
-
43249127114
-
Targeting proteasomes as therapy in multiple myeloma
-
Chauhan, D.; Hideshima, T.; Anderson, K.C. Targeting proteasomes as therapy in multiple myeloma. Adv. Exp. Med. Biol., 2008, 615, 251-260.
-
(2008)
Adv. Exp. Med. Biol
, vol.615
, pp. 251-260
-
-
Chauhan, D.1
Hideshima, T.2
Anderson, K.C.3
-
163
-
-
20044396543
-
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
-
Goy, A.; Younes, A.; McLaughlin, P.; Pro, B.; Romaguera, J.E.; Hagemeister, F.; Fayad, L.; Dang, N.H.; Samaniego, F.; Wang, M.; Broglio, K.; Samuels, B.; Gilles, F.; Sarris, A.H.; Hart, S.; Trehu, E.; Schenkein, D.; Cabanillas, F.; Rodriguez, A.M. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J. Clin. Oncol., 2005, 23, 667-675.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 667-675
-
-
Goy, A.1
Younes, A.2
McLaughlin, P.3
Pro, B.4
Romaguera, J.E.5
Hagemeister, F.6
Fayad, L.7
Dang, N.H.8
Samaniego, F.9
Wang, M.10
Broglio, K.11
Samuels, B.12
Gilles, F.13
Sarris, A.H.14
Hart, S.15
Trehu, E.16
Schenkein, D.17
Cabanillas, F.18
Rodriguez, A.M.19
-
164
-
-
20044376092
-
Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma
-
O'Connor, O.A.; Wright, J.; Moskowitz, C.; Muzzy, J.; MacGregor-Cortelli, B.; Stubblefield, M.; Straus, D.; Portlock, C.; Hamlin, P.; Choi, E.; Dumetrescu, O.; Esseltine, D.; Trehu, E.; Adams, J.; Schenkein, D.; Zelenetz, A.D. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J. Clin. Oncol., 2005, 23, 676-684.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 676-684
-
-
O'Connor, O.A.1
Wright, J.2
Moskowitz, C.3
Muzzy, J.4
Macgregor-Cortelli, B.5
Stubblefield, M.6
Straus, D.7
Portlock, C.8
Hamlin, P.9
Choi, E.10
Dumetrescu, O.11
Esseltine, D.12
Trehu, E.13
Adams, J.14
Schenkein, D.15
Zelenetz, A.D.16
-
165
-
-
43049115407
-
Bortezomib in mantle cell lymphoma
-
Suh, K.S.; Gay, A. Bortezomib in mantle cell lymphoma. Future Oncol., 2008, 4, 149-168.
-
(2008)
Future Oncol
, vol.4
, pp. 149-168
-
-
Suh, K.S.1
Gay, A.2
-
166
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima, T.; Richardson, P.; Chauhan, D.; Palombella, V.J.; Elliott, P.J.; Adams, J.; Anderson, K.C. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res., 2001, 61, 3071-3076.
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.J.4
Elliott, P.J.5
Adams, J.6
Anderson, K.C.7
-
167
-
-
70349243697
-
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells
-
Hideshima, T.; Ikeda, H.; Chauhan, D.; Okawa, Y.; Raje, N.; Podar, K.; Mitsiades, C.; Munshi, N.C.; Richardson, P.G.; Carrasco, R.D.; Anderson, K.C. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. Blood, 2009, 114, 1046-1052.
-
(2009)
Blood
, vol.114
, pp. 1046-1052
-
-
Hideshima, T.1
Ikeda, H.2
Chauhan, D.3
Okawa, Y.4
Raje, N.5
Podar, K.6
Mitsiades, C.7
Munshi, N.C.8
Richardson, P.G.9
Carrasco, R.D.10
Anderson, K.C.11
-
168
-
-
0037455147
-
Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
-
Feling, R.H.; Buchanan, G.O.; Mincer, T.J.; Kauffman, C.A.; Jensen, P.R.; Fenical, W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew. Chem. Int. Ed. Engl., 2003, 42, 355-357.
-
(2003)
Angew. Chem. Int. Ed. Engl
, vol.42
, pp. 355-357
-
-
Feling, R.H.1
Buchanan, G.O.2
Mincer, T.J.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
169
-
-
20044397059
-
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
-
Macherla, V.R.; Mitchell, S.S.; Manam, R.R.; Reed, K.A.; Chao, T.H.; Nicholson, B.; Deyanat-Yazdi, G.; Mai, B.; Jensen, P.R.; Fenical, W.F.; Neuteboom, S.T.; Lam, K.S.; Palladino, M.A.; Potts, B.C. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem., 2005, 48, 3684-3687.
-
(2005)
J. Med. Chem
, vol.48
, pp. 3684-3687
-
-
Macherla, V.R.1
Mitchell, S.S.2
Manam, R.R.3
Reed, K.A.4
Chao, T.H.5
Nicholson, B.6
Deyanat-Yazdi, G.7
Mai, B.8
Jensen, P.R.9
Fenical, W.F.10
Neuteboom, S.T.11
Lam, K.S.12
Palladino, M.A.13
Potts, B.C.14
-
170
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
Chauhan, D.; Catley, L.; Li, G.; Podar, K.; Hideshima, T.; Velankar, M.; Mitsiades, C.; Mitsiades, N.; Yasui, H.; Letai, A.; Ovaa, H.; Berkers, C.; Nicholson, B.; Chao, T.H.; Neuteboom, S.T.; Richardson, P.; Palladino, M.A.; Anderson, K.C. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell, 2005, 8, 407-419.
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
Ovaa, H.11
Berkers, C.12
Nicholson, B.13
Chao, T.H.14
Neuteboom, S.T.15
Richardson, P.16
Palladino, M.A.17
Anderson, K.C.18
-
171
-
-
33750209537
-
A novel proteasome inhibitor NPI-0052 as an anticancer therapy
-
Chauhan, D.; Hideshima, T.; Anderson, K.C. A novel proteasome inhibitor NPI-0052 as an anticancer therapy. Br. J. Cancer, 2006, 95, 961-965.
-
(2006)
Br. J. Cancer
, vol.95
, pp. 961-965
-
-
Chauhan, D.1
Hideshima, T.2
Anderson, K.C.3
-
172
-
-
33846253586
-
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
-
Williamson, M.J.; Blank, J.L.; Bruzzese, F.J.; Cao, Y.; Daniels, J.S.; Dick, L.R.; Labutti, J.; Mazzola, A.M.; Patil, A.D.; Reimer, C.L.; Solomon, M.S.; Stirling, M.; Tian, Y.; Tsu, C.A.; Weatherhead, G.S.; Zhang, J.X.; Rolfe, M. Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib. Mol. Cancer Ther., 2006, 5, 3052-3061.
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 3052-3061
-
-
Williamson, M.J.1
Blank, J.L.2
Bruzzese, F.J.3
Cao, Y.4
Daniels, J.S.5
Dick, L.R.6
Labutti, J.7
Mazzola, A.M.8
Patil, A.D.9
Reimer, C.L.10
Solomon, M.S.11
Stirling, M.12
Tian, Y.13
Tsu, C.A.14
Weatherhead, G.S.15
Zhang, J.X.16
Rolfe, M.17
-
173
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan, D.; Singh, A.; Brahmandam, M.; Podar, K.; Hideshima, T.; Richardson, P. Munshi, N., Palladino, M.A., Anderson, K.C. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood, 2008, 111, 1654-1664.
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
Podar, K.4
Hideshima, T.5
Richardson, P.6
Munshi, N.7
Palladino, M.A.8
Anderson, K.C.9
-
174
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo, S.D., Kirk, C.J.; Aujay, M.A.; Buchholz, T.J.; Dajee, M.; Ho, M.N.; Jiang, J.; Laidig, G.J.; Lewis, E.R.; Parlati, F.; Shenk, K.D.; Smyth, M.S.; Sun, C.M.; Vallone, M.K.; Woo, T.M.; Molineaux, C.J.; Bennett, M.K. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res., 2007, 67, 6383-6391.
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
Buchholz, T.J.4
Dajee, M.5
Ho, M.N.6
Jiang, J.7
Laidig, G.J.8
Lewis, E.R.9
Parlati, F.10
Shenk, K.D.11
Smyth, M.S.12
Sun, C.M.13
Vallone, M.K.14
Woo, T.M.15
Molineaux, C.J.16
Bennett, M.K.17
-
175
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
Kuhn, D.J.; Chen, Q.; Voorhees, P.M.; Strader, J.S.; Shenk, K.D.; Sun, C.M.; Sun, C.M.; Demo, S.D.; Bennett, M.K.; van Leeuwen, F.W.; Chanan-Khan, A.A.; Orlowski, R.Z. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood, 2007, 110, 3281-3290.
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
Strader, J.S.4
Shenk, K.D.5
Sun, C.M.6
Sun, C.M.7
Demo, S.D.8
Bennett, M.K.9
van Leeuwen, F.W.10
Chanan-Khan, A.A.11
Orlowski, R.Z.12
-
176
-
-
41549133200
-
Proteasome inhibitors in cancer therapy: Lessons from the first decade
-
Orlowski, R.Z.; Kuhn, D.J. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin. Cancer. Res., 2008, 14, 1649-1657.
-
(2008)
Clin. Cancer. Res
, vol.14
, pp. 1649-1657
-
-
Orlowski, R.Z.1
Kuhn, D.J.2
-
177
-
-
39749143840
-
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
-
Dorsey, B.D.; Iqbal, M.; Chatterjee, S.; Menta, E.; Bernardini, R.; Bernareggi, A.; Cassarà, P.G.; D'Arasmo, G.; Ferretti, E.; De Munari, S.; Oliva, A.; Pezzoni, G.; Allievi, C.; Strepponi, I.; Ruggeri, B., Ator, M.A.; Williams, M.; Mallamo, J.P. Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J. Med. Chem., 2008, 51, 1068-1072.
-
(2008)
J. Med. Chem
, vol.51
, pp. 1068-1072
-
-
Dorsey, B.D.1
Iqbal, M.2
Chatterjee, S.3
Menta, E.4
Bernardini, R.5
Bernareggi, A.6
Cassarà, P.G.7
D'Arasmo, G.8
Ferretti, E.9
de Munari, S.10
Oliva, A.11
Pezzoni, G.12
Allievi, C.13
Strepponi, I.14
Ruggeri, B.15
Ator, M.A.16
Williams, M.17
Mallamo, J.P.18
-
178
-
-
41949110089
-
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
-
Piva, R.; Ruggeri, B.; Williams, M.; Costa, G.; Tamagno, I.; Ferrero, D.; Giai, V.; Coscia, M.; Peola, S.; Massaia, M.; Pezzoni, G.; Allievi, C.; Pescalli, N.; Cassin, M.; di Giovine, S.; Nicoli, P.; de Feudis, P.; Strepponi, I.; Roato, I.; Ferracini, R.; Bussolati, B.; Camussi, G.; Jones-Bolin, S.; Hunter, K.; Zhao, H.; Neri, A.; Palumbo, A.; Berkers, C.; Ovaa, H.; Bernareggi, A.; Inghirami, G. CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood, 2008, 111, 2765-2775.
-
(2008)
Blood
, vol.111
, pp. 2765-2775
-
-
Piva, R.1
Ruggeri, B.2
Williams, M.3
Costa, G.4
Tamagno, I.5
Ferrero, D.6
Giai, V.7
Coscia, M.8
Peola, S.9
Massaia, M.10
Pezzoni, G.11
Allievi, C.12
Pescalli, N.13
Cassin, M.14
Di Giovine, S.15
Nicoli, P.16
de Feudis, P.17
Strepponi, I.18
Roato, I.19
Ferracini, R.20
Bussolati, B.21
Camussi, G.22
Jones-Bolin, S.23
Hunter, K.24
Zhao, H.25
Neri, A.26
Palumbo, A.27
Berkers, C.28
Ovaa, H.29
Bernareggi, A.30
Inghirami, G.31
more..
-
179
-
-
0021022219
-
Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers
-
Demerson, C.A.; Humber, L.G.; Abraham, N.A.; Schilling, G.; Martel, R.R.; Pace-Asciak, C. Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers. J. Med. Chem., 1983, 26, 1778-1780.
-
(1983)
J. Med. Chem
, vol.26
, pp. 1778-1780
-
-
Demerson, C.A.1
Humber, L.G.2
Abraham, N.A.3
Schilling, G.4
Martel, R.R.5
Pace-Asciak, C.6
-
180
-
-
0022486909
-
Etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid): A potent antiinflammatory drug. Conformation and absolute configuration of its active enantiomer
-
Humber, L.G.; Demerson, C.A. Swaminathan, P.; Bird, P.H. Etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid): a potent antiinflammatory drug. Conformation and absolute configuration of its active enantiomer. J. Med. Chem., 1986, 29, 871-874.
-
(1986)
J. Med. Chem
, vol.29
, pp. 871-874
-
-
Humber, L.G.1
Demerson, C.A.2
Swaminathan, P.3
Bird, P.H.4
-
181
-
-
22144481007
-
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma
-
Yasui, H.; Hideshima, T.; Hamasaki, M.; Roccaro, A.M.; Shiraishi, N.; Kumar, S.; Tassone, P.; Ishitsuka, K.; Raje, N.; Tai, Y.T.; Podar, K.; Chauhan, D.; Leoni, L.M.; Kanekal, S.; Elliott, G.; Munshi, N.C.; Anderson, K.C. SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma. Blood, 2005, 106, 706-712.
-
(2005)
Blood
, vol.106
, pp. 706-712
-
-
Yasui, H.1
Hideshima, T.2
Hamasaki, M.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Tassone, P.7
Ishitsuka, K.8
Raje, N.9
Tai, Y.T.10
Podar, K.11
Chauhan, D.12
Leoni, L.M.13
Kanekal, S.14
Elliott, G.15
Munshi, N.C.16
Anderson, K.C.17
-
182
-
-
33744806416
-
In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells
-
Neri, P.; Yasui, H.; Hideshima, T.; Tassone, P.; Raje, N.; Catley, L.P.; Ishitsuka, K.; Blotta, S.; Kiziltepe, T.; Ocio, E.M.; Fulciniti, M.; Kanekal, S.; Elliott, G.T.; Munshi, N.C.; Anderson, K.C. In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells. Br. J. Haematol., 2006, 134, 37-44.
-
(2006)
Br. J. Haematol
, vol.134
, pp. 37-44
-
-
Neri, P.1
Yasui, H.2
Hideshima, T.3
Tassone, P.4
Raje, N.5
Catley, L.P.6
Ishitsuka, K.7
Blotta, S.8
Kiziltepe, T.9
Ocio, E.M.10
Fulciniti, M.11
Kanekal, S.12
Elliott, G.T.13
Munshi, N.C.14
Anderson, K.C.15
-
183
-
-
33847364101
-
SDX-308, a nonsteroidal antiinflammatory agent, inhibits NF-kappaB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth
-
Feng, R.; Anderson, G.; Xiao, G.; Elliott, G.; Leoni, L.; Mapara, M.Y.; Roodman, G.D.; Lentzsch, S. SDX-308, a nonsteroidal antiinflammatory agent, inhibits NF-kappaB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood, 2007, 109, 2130-2138.
-
(2007)
Blood
, vol.109
, pp. 2130-2138
-
-
Feng, R.1
Anderson, G.2
Xiao, G.3
Elliott, G.4
Leoni, L.5
Mapara, M.Y.6
Roodman, G.D.7
Lentzsch, S.8
-
184
-
-
51349150407
-
The role of non-steroidal antiinflammatory drugs in the risk of development and treatment of hematologic malignancies
-
Robak, P.; Smolewski, P.; Robak, T. The role of non-steroidal antiinflammatory drugs in the risk of development and treatment of hematologic malignancies. Leuk. Lymphoma, 2008, 49, 1452-1462.
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 1452-1462
-
-
Robak, P.1
Smolewski, P.2
Robak, T.3
-
185
-
-
33847187070
-
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of betacatenin/TCF pathway
-
Yasui, H.; Hideshima, T.; Ikeda, H.; Ocio, E.M.; Kiziltepe, T.; Vallet, S.; Okawa, Y.; Neri, P.; Sukhdeo, K.; Podar, K.; Chauhan, D.; Richardson, P.G.; Raje, N.; Carrasco, D.R.; Anderson, K.C. Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of betacatenin/TCF pathway. Leukemia, 2007, 21, 535-540.
-
(2007)
Leukemia
, vol.21
, pp. 535-540
-
-
Yasui, H.1
Hideshima, T.2
Ikeda, H.3
Ocio, E.M.4
Kiziltepe, T.5
Vallet, S.6
Okawa, Y.7
Neri, P.8
Sukhdeo, K.9
Podar, K.10
Chauhan, D.11
Richardson, P.G.12
Raje, N.13
Carrasco, D.R.14
Anderson, K.C.15
-
186
-
-
34250333058
-
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia
-
Fabre, C.; Carvalho, G.; Tasdemir, E.; Braun, T.; Adès, L.; Grosjean, J.; Boehrer, S.; Métivier, D.; Souquère, S.; Pierron, G.; Fenaux, P.; Kroemer, G. NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene, 2007, 26, 4071-4083.
-
(2007)
Oncogene
, vol.26
, pp. 4071-4083
-
-
Fabre, C.1
Carvalho, G.2
Tasdemir, E.3
Braun, T.4
Adès, L.5
Grosjean, J.6
Boehrer, S.7
Métivier, D.8
Souquère, S.9
Pierron, G.10
Fenaux, P.11
Kroemer, G.12
-
187
-
-
34147131297
-
Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia
-
Carvalho, G.; Fabre, C.; Braun, T.; Grosjean, J.; Ades, L.; Agou, F.; Tasdemir, E.; Boehrer, S.; Israel, A.; Véron, M.; Fenaux, P.; Kroemer, G. Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene, 2007, 26, 2299-2307.
-
(2007)
Oncogene
, vol.26
, pp. 2299-2307
-
-
Carvalho, G.1
Fabre, C.2
Braun, T.3
Grosjean, J.4
Ades, L.5
Agou, F.6
Tasdemir, E.7
Boehrer, S.8
Israel, A.9
Véron, M.10
Fenaux, P.11
Kroemer, G.12
-
188
-
-
61349144249
-
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
-
Grosjean-Raillard, J.; Tailler, M.; Adès, L.; Perfettini, J.L.; Fabre, C.; Braun, T.; De Botton, S.; Fenaux, P.; Kroemer, G. ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene, 2009, 28, 1099-1109.
-
(2009)
Oncogene
, vol.28
, pp. 1099-1109
-
-
Grosjean-Raillard, J.1
Tailler, M.2
Adès, L.3
Perfettini, J.L.4
Fabre, C.5
Braun, T.6
de Botton, S.7
Fenaux, P.8
Kroemer, G.9
-
189
-
-
74849125276
-
The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation
-
Zanotto-Filho, A.; Delgado-Cañedo, A.; Schröder, R.; Becker, M.; Klamt, F.; Moreira, J.C. The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. Cancer Lett., 2010, 288, 192-203.
-
(2010)
Cancer Lett
, vol.288
, pp. 192-203
-
-
Zanotto-Filho, A.1
Delgado-Cañedo, A.2
Schröder, R.3
Becker, M.4
Klamt, F.5
Moreira, J.C.6
-
190
-
-
58149327371
-
Nuclear factor-kappaB modulation in patients undergoing induction chemotherapy for acute myelogenous leukemia
-
Strair, R.K.; Gharibo, M.; Schaar, D.; Rubin, A.; Harrison, J.; Aisner, J.; Lin, H.C.; Lin, Y.; Goodell, L.; Anand, M.; Balsara, B.; Dudek, L.; Rabson, A.; Medina, D.J. Nuclear factor-kappaB modulation in patients undergoing induction chemotherapy for acute myelogenous leukemia. Clin. Cancer Res., 2008, 14, 7564-7568.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 7564-7568
-
-
Strair, R.K.1
Gharibo, M.2
Schaar, D.3
Rubin, A.4
Harrison, J.5
Aisner, J.6
Lin, H.C.7
Lin, Y.8
Goodell, L.9
Anand, M.10
Balsara, B.11
Dudek, L.12
Rabson, A.13
Medina, D.J.14
-
191
-
-
0028986985
-
The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NFkappa B transcription factor in acute myeloblastic leukemia cells
-
Dokter, W.H.; Tuyt, L.; Sierdsema, S.J.; Esselink, M.T.; Vellenga, E. The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NFkappa B transcription factor in acute myeloblastic leukemia cells. Leukemia, 1995, 9, 425-432.
-
(1995)
Leukemia
, vol.9
, pp. 425-432
-
-
Dokter, W.H.1
Tuyt, L.2
Sierdsema, S.J.3
Esselink, M.T.4
Vellenga, E.5
-
192
-
-
0036771841
-
Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts
-
Baumgartner, B.; Weber, M.; Quirling, M.; Fischer, C.; Page, S.; Adam, M.; Von Schilling, C.; Waterhouse, C.; Schmid, C.; Neumeier, D.; Brand, K. Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia, 2002, 16, 2062-2071.
-
(2002)
Leukemia
, vol.16
, pp. 2062-2071
-
-
Baumgartner, B.1
Weber, M.2
Quirling, M.3
Fischer, C.4
Page, S.5
Adam, M.6
von Schilling, C.7
Waterhouse, C.8
Schmid, C.9
Neumeier, D.10
Brand, K.11
-
193
-
-
0038040499
-
Effect of NF-kappaB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells
-
Romano, M.F.; Petrella, A.; Bisogni, R.; Turco, M.C.; Venuta, S. Effect of NF-kappaB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells. Leukemia, 2003, 17, 1190-1192.
-
(2003)
Leukemia
, vol.17
, pp. 1190-1192
-
-
Romano, M.F.1
Petrella, A.2
Bisogni, R.3
Turco, M.C.4
Venuta, S.5
-
194
-
-
0042744823
-
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells
-
Estrov, Z.; Shishodia, S.; Faderl, S.; Harris, D.; Van, Q.; Kantarjian, H.M.; Talpaz, M.; Aggarwal, B.B. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood, 2003, 102, 987-995.
-
(2003)
Blood
, vol.102
, pp. 987-995
-
-
Estrov, Z.1
Shishodia, S.2
Faderl, S.3
Harris, D.4
Van, Q.5
Kantarjian, H.M.6
Talpaz, M.7
Aggarwal, B.B.8
-
195
-
-
10744224210
-
Expression of constitutively active nuclearkappa B RelA transcription factor in blasts of acute myeloid leukemia
-
Bueso-Ramos, C.E.; Rocha, F.C.; Shishodia, S.; Medeiros, L.J.; Kantarjian, H.M.; Vadhan-Raj, S.; Estrov, Z.; Smith, T.L.; Nguyen, M.H.; Aggarwal, B.B. Expression of constitutively active nuclearkappa B RelA transcription factor in blasts of acute myeloid leukemia. Hum. Pathol., 2004, 35, 246-253.
-
(2004)
Hum. Pathol
, vol.35
, pp. 246-253
-
-
Bueso-Ramos, C.E.1
Rocha, F.C.2
Shishodia, S.3
Medeiros, L.J.4
Kantarjian, H.M.5
Vadhan-Raj, S.6
Estrov, Z.7
Smith, T.L.8
Nguyen, M.H.9
Aggarwal, B.B.10
-
196
-
-
43549095276
-
HO-1 underlies resistance of AML cells to TNF-induced apoptosis
-
Rushworth, S.A.; MacEwan, D.J. HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood, 2008, 111, 3793-3801.
-
(2008)
Blood
, vol.111
, pp. 3793-3801
-
-
Rushworth, S.A.1
Macewan, D.J.2
-
197
-
-
77950819906
-
NFkappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction
-
Rushworth, S.A.; Bowles, K.M.; Raninga, P.; MacEwan, D.J. NFkappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. Cancer Res., 2010, 70, 2973-2983.
-
(2010)
Cancer Res
, vol.70
, pp. 2973-2983
-
-
Rushworth, S.A.1
Bowles, K.M.2
Raninga, P.3
Macewan, D.J.4
-
198
-
-
77951241720
-
Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway
-
Rosato, R.R.; Kolla, S.S.; Hock, S.K.; Almenara, J.A.; Patel, A.; Amin, S.; Atadja, P.; Fisher, P.B.; Dent, P.; Grant, S. Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. J. Biol. Chem., 2010, 285, 10064-10077.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 10064-10077
-
-
Rosato, R.R.1
Kolla, S.S.2
Hock, S.K.3
Almenara, J.A.4
Patel, A.5
Amin, S.6
Atadja, P.7
Fisher, P.B.8
Dent, P.9
Grant, S.10
-
199
-
-
1042278138
-
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
-
Takada, Y.; Aggarwal, B.B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J. Biol. Chem., 2004, 279, 4750-4759.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 4750-4759
-
-
Takada, Y.1
Aggarwal, B.B.2
-
200
-
-
4844224868
-
Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol
-
Gao, N.; Dai, Y.; Rahmani, M.; Dent, P.; Grant, S. Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. Mol. Pharmacol., 2004, 66, 956-963.
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 956-963
-
-
Gao, N.1
Dai, Y.2
Rahmani, M.3
Dent, P.4
Grant, S.5
-
201
-
-
77950620888
-
Exploiting cellular pathways to develop new treatment strategies for AML
-
Fathi, A.T.; Grant, S.; Karp, J.E. Exploiting cellular pathways to develop new treatment strategies for AML. Cancer Treat. Rev., 2010, 36, 142-150.
-
(2010)
Cancer Treat. Rev
, vol.36
, pp. 142-150
-
-
Fathi, A.T.1
Grant, S.2
Karp, J.E.3
-
202
-
-
0037059012
-
Preferential induction of apoptosis for primary human leukemic stem cells
-
Guzman, M.L.; Swiderski, C.F.; Howard, D.S.; Grimes, B.A.; Rossi, R.M.; Szilvassy, S.J.; Jordan, C.T. Preferential induction of apoptosis for primary human leukemic stem cells. Proc. Natl. Acad. Sci. USA, 2002, 99, 16220-16225.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16220-16225
-
-
Guzman, M.L.1
Swiderski, C.F.2
Howard, D.S.3
Grimes, B.A.4
Rossi, R.M.5
Szilvassy, S.J.6
Jordan, C.T.7
-
203
-
-
16844363378
-
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
-
Guzman, M.L.; Rossi, R.M.; Karnischky, L.; Li, X.; Peterson, D.R.; Howard, D.S.; Jordan, C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood, 2005, 105, 4163-4169.
-
(2005)
Blood
, vol.105
, pp. 4163-4169
-
-
Guzman, M.L.1
Rossi, R.M.2
Karnischky, L.3
Li, X.4
Peterson, D.R.5
Howard, D.S.6
Jordan, C.T.7
-
204
-
-
47049105891
-
Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data
-
Hassane, D.C.; Guzman, M.L.; Corbett, C.; Li, X.; Abboud, R.; Young, F.; Liesveld, J.L.; Carroll, M.; Jordan, C.T. Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood, 2008, 111, 5654-5662.
-
(2008)
Blood
, vol.111
, pp. 5654-5662
-
-
Hassane, D.C.1
Guzman, M.L.2
Corbett, C.3
Li, X.4
Abboud, R.5
Young, F.6
Liesveld, J.L.7
Carroll, M.8
Jordan, C.T.9
-
205
-
-
0036081355
-
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
-
Edgar, R.; Domrachev, M.; Lash, A.E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res., 2002, 30, 207-210.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
206
-
-
0033597234
-
4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis
-
Page, S.; Fischer, C.; Baumgartner, B.; Haas, M.; Kreusel, U.; Loidl, G.; Hayn, M.; Ziegler-Heitbrock, H.W.; Neumeier, D.; Brand, K. 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis. J. Biol. Chem., 1999, 274, 11611-11618.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 11611-11618
-
-
Page, S.1
Fischer, C.2
Baumgartner, B.3
Haas, M.4
Kreusel, U.5
Loidl, G.6
Hayn, M.7
Ziegler-Heitbrock, H.W.8
Neumeier, D.9
Brand, K.10
-
207
-
-
0035947678
-
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal
-
Ji, C.; Kozak, K.R.; Marnett, L.J. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J. Biol. Chem., 2001, 276, 18223-18228.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18223-18228
-
-
Ji, C.1
Kozak, K.R.2
Marnett, L.J.3
-
208
-
-
0037411282
-
4-Hydroxy-2-nonenal: A product and mediator of oxidative stress
-
Uchida, K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res., 2003, 42, 318-343.
-
(2003)
Prog. Lipid Res
, vol.42
, pp. 318-343
-
-
Uchida, K.1
-
209
-
-
19544390715
-
Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects
-
Setty, A.R.; Sigal, L.H. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin. Arthritis Rheum., 2005, 34, 773-784.
-
(2005)
Semin. Arthritis Rheum
, vol.34
, pp. 773-784
-
-
Setty, A.R.1
Sigal, L.H.2
-
210
-
-
33750008443
-
Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid
-
Lee, J.H.; Koo, T.H.; Yoon, H.; Jung, H.S.; Jin, H.Z.; Lee, K.; Hong, Y.S.; Lee, J.J. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem. Pharmacol., 2006, 72, 1311-1321.
-
(2006)
Biochem. Pharmacol
, vol.72
, pp. 1311-1321
-
-
Lee, J.H.1
Koo, T.H.2
Yoon, H.3
Jung, H.S.4
Jin, H.Z.5
Lee, K.6
Hong, Y.S.7
Lee, J.J.8
-
211
-
-
33646406554
-
Celastrol, a triterpene extracted from the Chinese Thunder of God Vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
-
Yang, H.; Chen, D.; Cui, Q.C.; Yuan, X.; Dou, Q.P. Celastrol, a triterpene extracted from the Chinese Thunder of God Vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res., 2006, 66, 4758-4765.
-
(2006)
Cancer Res
, vol.66
, pp. 4758-4765
-
-
Yang, H.1
Chen, D.2
Cui, Q.C.3
Yuan, X.4
Dou, Q.P.5
-
212
-
-
0037711690
-
Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation
-
Kirchner, D.; Duyster, J.; Ottmann, O.; Schmid, R.M.; Bergmann, L.; Munzert, G. Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation. Exp. Hematol., 2003, 31, 504-511.
-
(2003)
Exp. Hematol
, vol.31
, pp. 504-511
-
-
Kirchner, D.1
Duyster, J.2
Ottmann, O.3
Schmid, R.M.4
Bergmann, L.5
Munzert, G.6
-
213
-
-
0242493856
-
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571
-
Yu, C.; Rahmani, M.; Conrad, D.; Subler, M.; Dent, P.; Grant, S. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood, 2003, 102, 3765-3774.
-
(2003)
Blood
, vol.102
, pp. 3765-3774
-
-
Yu, C.1
Rahmani, M.2
Conrad, D.3
Subler, M.4
Dent, P.5
Grant, S.6
-
214
-
-
3142554015
-
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and-independent mechanisms
-
Dai, Y.; Rahmani, M.; Pei, X.Y.; Dent, P.; Grant, S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and-independent mechanisms. Blood, 2004, 104, 509-518.
-
(2004)
Blood
, vol.104
, pp. 509-518
-
-
Dai, Y.1
Rahmani, M.2
Pei, X.Y.3
Dent, P.4
Grant, S.5
-
215
-
-
35648974809
-
AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
-
Dell'Eva, R.; Ambrosini, C.; Vannini, N.; Piaggio, G.; Albini, A.; Ferrari, N. AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies. Cancer, 2007, 110, 2007-2011.
-
(2007)
Cancer
, vol.110
, pp. 2007-2011
-
-
Dell'Eva, R.1
Ambrosini, C.2
Vannini, N.3
Piaggio, G.4
Albini, A.5
Ferrari, N.6
-
216
-
-
54049094848
-
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation
-
Monteghirfo, S.; Tosetti, F.; Ambrosini, C.; Stigliani, S.; Pozzi, S.; Frassoni, F.; Fassina, G.; Soverini, S.; Albini, A.; Ferrari, N. Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation. Mol. Cancer Ther., 2008, 7, 2692-2702.
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 2692-2702
-
-
Monteghirfo, S.1
Tosetti, F.2
Ambrosini, C.3
Stigliani, S.4
Pozzi, S.5
Frassoni, F.6
Fassina, G.7
Soverini, S.8
Albini, A.9
Ferrari, N.10
-
217
-
-
70249121052
-
The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NFkappaB pathway
-
Wei, Y.L.; Liang, Y.; Xu, L.; Zhao, X.Y. The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NFkappaB pathway. Anat. Rec. (Hoboken), 2009, 292, 945-950.
-
(2009)
Anat. Rec. (Hoboken)
, vol.292
, pp. 945-950
-
-
Wei, Y.L.1
Liang, Y.2
Xu, L.3
Zhao, X.Y.4
-
218
-
-
65249094734
-
Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo
-
Wei, Y.L.; Xu, L.; Liang, Y.; Xu, X.H.; Zhao, X.Y. Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo. Acta Pharmacol. Sin., 2009, 30, 451-457.
-
(2009)
Acta Pharmacol. Sin
, vol.30
, pp. 451-457
-
-
Wei, Y.L.1
Xu, L.2
Liang, Y.3
Xu, X.H.4
Zhao, X.Y.5
-
219
-
-
67349250886
-
Berbamine derivatives: A novel class of compounds for antileukemia activity
-
Xie, J.; Ma, T.; Gu, Y.; Zhang, X.; Qiu, X.; Zhang, L.; Xu, R.; Yu, Y. Berbamine derivatives: a novel class of compounds for antileukemia activity. Eur. J. Med. Chem., 2009, 44, 3293-3298.
-
(2009)
Eur. J. Med. Chem
, vol.44
, pp. 3293-3298
-
-
Xie, J.1
Ma, T.2
Gu, Y.3
Zhang, X.4
Qiu, X.5
Zhang, L.6
Xu, R.7
Yu, Y.8
-
220
-
-
67449094298
-
NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutants
-
Lounnas, N.; Frelin, C.; Gonthier, N.; Colosetti, P.; Sirvent, A.; Cassuto, J.P.; Berthier, F.; Sirvent, N.; Rousselot, P.; Dreano, M.; Peyron, J.F.; Imbert, V. NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutants. Int. J. Cancer, 2009, 125, 308-317.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 308-317
-
-
Lounnas, N.1
Frelin, C.2
Gonthier, N.3
Colosetti, P.4
Sirvent, A.5
Cassuto, J.P.6
Berthier, F.7
Sirvent, N.8
Rousselot, P.9
Dreano, M.10
Peyron, J.F.11
Imbert, V.12
-
221
-
-
33947608617
-
Animal models for chronic lymphocytic leukemia
-
Pekarsky, Y.; Zanesi, N.; Aqeilan, R.I.; Croce, C.M. Animal models for chronic lymphocytic leukemia. J. Cell. Biochem., 2007, 100, 1109-1118.
-
(2007)
J. Cell. Biochem
, vol.100
, pp. 1109-1118
-
-
Pekarsky, Y.1
Zanesi, N.2
Aqeilan, R.I.3
Croce, C.M.4
-
222
-
-
73949158411
-
High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia
-
Herling, M.; Patel, K.A.; Weit, N.; Lilienthal, N.; Hallek, M.; Keating, M.J.; Jones, D. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood, 2009, 114, 4675-4686.
-
(2009)
Blood
, vol.114
, pp. 4675-4686
-
-
Herling, M.1
Patel, K.A.2
Weit, N.3
Lilienthal, N.4
Hallek, M.5
Keating, M.J.6
Jones, D.7
-
223
-
-
0032147205
-
Triggering of CD40 antigen inhibits fludarabineinduced apoptosis in B chronic lymphocytic leukemia cells
-
Romano, M.F.; Lamberti, A.; Tassone, P.; Alfinito, F.; Costantini, S.; Chiurazzi, F.; Defrance, T.; Bonelli, P.; Tuccillo, F.; Turco, M.C.; Venuta, S. Triggering of CD40 antigen inhibits fludarabineinduced apoptosis in B chronic lymphocytic leukemia cells. Blood, 1998, 92, 990-995.
-
(1998)
Blood
, vol.92
, pp. 990-995
-
-
Romano, M.F.1
Lamberti, A.2
Tassone, P.3
Alfinito, F.4
Costantini, S.5
Chiurazzi, F.6
Defrance, T.7
Bonelli, P.8
Tuccillo, F.9
Turco, M.C.10
Venuta, S.11
-
224
-
-
0033621706
-
CD40 and B chronic lymphocytic leukemia cell response to fludarabine: The influence of NF-kappaB/Rel transcription factors on chemotherapyinduced apoptosis
-
Romano, M.F.; Lamberti, A.; Turco, M.C.; Venuta, S. CD40 and B chronic lymphocytic leukemia cell response to fludarabine: the influence of NF-kappaB/Rel transcription factors on chemotherapyinduced apoptosis. Leuk. Lymphoma, 2000, 36, 255-262.
-
(2000)
Leuk. Lymphoma
, vol.36
, pp. 255-262
-
-
Romano, M.F.1
Lamberti, A.2
Turco, M.C.3
Venuta, S.4
-
225
-
-
4344664011
-
A sustained activation of PI3K/NFkappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells
-
Cuní, S.; Pérez-Aciego, P.; Pérez-Chacón, G.; Vargas, J.A.; Sánchez, A.; Martín-Saavedra, F.M.; Ballester, S.; García-Marco, J.; Jordá, J.; Durántez, A. A sustained activation of PI3K/NFkappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia, 2004, 18, 1391-1400.
-
(2004)
Leukemia
, vol.18
, pp. 1391-1400
-
-
Cuní, S.1
Pérez-Aciego, P.2
Pérez-Chacón, G.3
Vargas, J.A.4
Sánchez, A.5
Martín-Saavedra, F.M.6
Ballester, S.7
García-Marco, J.8
Jordá, J.9
Durántez, A.10
-
226
-
-
17144430972
-
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells
-
Farahani, M.; Treweeke, A.T.; Toh, C.H.; Till, K.J.; Harris, R.J.; Cawley, J.C.; Zuzel, M.; Chen, H. Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia, 2005, 19, 524-530.
-
(2005)
Leukemia
, vol.19
, pp. 524-530
-
-
Farahani, M.1
Treweeke, A.T.2
Toh, C.H.3
Till, K.J.4
Harris, R.J.5
Cawley, J.C.6
Zuzel, M.7
Chen, H.8
-
227
-
-
77149154324
-
NF-kappaB as a therapeutic target in chronic lymphocytic leukemia
-
Lopez-Guerra, M.; Colomer, D. NF-kappaB as a therapeutic target in chronic lymphocytic leukemia. Expert Opin. Ther. Targets, 2010, 14, 275-288.
-
(2010)
Expert Opin. Ther. Targets
, vol.14
, pp. 275-288
-
-
Lopez-Guerra, M.1
Colomer, D.2
-
228
-
-
0034005455
-
CD40 ligand in CLL pathogenesis and therapy
-
Schattner, E.J. CD40 ligand in CLL pathogenesis and therapy. Leuk. Lymphoma, 2000, 37, 461-472.
-
(2000)
Leuk. Lymphoma
, vol.37
, pp. 461-472
-
-
Schattner, E.J.1
-
229
-
-
33750454819
-
Mutations in the NF-kappaB signaling pathway: Implications for human disease
-
Courtois, G.; Gilmore, T.D. Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene, 2006, 25, 6831-6843.
-
(2006)
Oncogene
, vol.25
, pp. 6831-6843
-
-
Courtois, G.1
Gilmore, T.D.2
-
230
-
-
0034651739
-
Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells
-
Furman, R.R.; Asgary, Z.; Mascarenhas, J.O.; Liou, H.C.; Schattner, E.J. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J. Immunol., 2000, 164, 2200-2206.
-
(2000)
J. Immunol
, vol.164
, pp. 2200-2206
-
-
Furman, R.R.1
Asgary, Z.2
Mascarenhas, J.O.3
Liou, H.C.4
Schattner, E.J.5
-
231
-
-
34547130063
-
CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis
-
Mineva, N.D.; Rothstein, T.L.; Meyers, J.A.; Lerner, A.; Sonenshein, G.E. CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. J. Biol. Chem., 2007, 282, 17475-17485.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 17475-17485
-
-
Mineva, N.D.1
Rothstein, T.L.2
Meyers, J.A.3
Lerner, A.4
Sonenshein, G.E.5
-
232
-
-
2542527768
-
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
-
Zarnegar, B.; He, J.Q.; Oganesyan, G.; Hoffmann, A.; Baltimore, D.; Cheng, G. Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc. Natl. Acad. Sci. USA, 2004, 101, 8108-8113.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 8108-8113
-
-
Zarnegar, B.1
He, J.Q.2
Oganesyan, G.3
Hoffmann, A.4
Baltimore, D.5
Cheng, G.6
-
233
-
-
34547114509
-
Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells
-
Ougolkov, A.V.; Bone, N.D.; Fernandez-Zapico, M.E.; Kay, N.E.; Billadeau, D.D. Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood, 2007, 110, 735-742.
-
(2007)
Blood
, vol.110
, pp. 735-742
-
-
Ougolkov, A.V.1
Bone, N.D.2
Fernandez-Zapico, M.E.3
Kay, N.E.4
Billadeau, D.D.5
-
234
-
-
36849078197
-
Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration
-
Chen, H.; Yang, S.; Yang, Z.; Ma, L.; Jiang, D.; Mao, J.; Jiao, B.; Cai, Z. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J. Cell. Biochem., 2007, 102, 1281-1289.
-
(2007)
J. Cell. Biochem
, vol.102
, pp. 1281-1289
-
-
Chen, H.1
Yang, S.2
Yang, Z.3
Ma, L.4
Jiang, D.5
Mao, J.6
Jiao, B.7
Cai, Z.8
-
235
-
-
47149090375
-
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
-
Hewamana, S.; Alghazal, S.; Lin, T.T.; Clement, M.; Jenkins, C.; Guzman, M.L.; Jordan C.T.; Neelakantan, S.; Crooks, P.A.; Burnett, A.K.; Pratt, G.; Fegan, C.; Rowntree, C.; Brennan, P.; Pepper, C. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood, 2008, 111, 4681-4689.
-
(2008)
Blood
, vol.111
, pp. 4681-4689
-
-
Hewamana, S.1
Alghazal, S.2
Lin, T.T.3
Clement, M.4
Jenkins, C.5
Guzman, M.L.6
Jordan, C.T.7
Neelakantan, S.8
Crooks, P.A.9
Burnett, A.K.10
Pratt, G.11
Fegan, C.12
Rowntree, C.13
Brennan, P.14
Pepper, C.15
-
236
-
-
33847185843
-
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells
-
Pickering, B.M.; de Mel, S.; Lee, M.; Howell, M.; Habens, F.; Dallman, C.L.; Neville, L.A.; Potter, K.N.; Mann, J.; Mann, D.A.; Johnson, P.W.; Stevenson, F.K.; Packham, G. Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. Oncogene, 2007, 26, 1166-1177.
-
(2007)
Oncogene
, vol.26
, pp. 1166-1177
-
-
Pickering, B.M.1
de Mel, S.2
Lee, M.3
Howell, M.4
Habens, F.5
Dallman, C.L.6
Neville, L.A.7
Potter, K.N.8
Mann, J.9
Mann, D.A.10
Johnson, P.W.11
Stevenson, F.K.12
Packham, G.13
-
237
-
-
0037166268
-
Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNAbinding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes
-
Lee, J.H.; Koo, T.H.; Hwang, B.Y.; Lee, J.J. Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNAbinding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes. J. Biol. Chem., 2002, 277, 18411-18420.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 18411-18420
-
-
Lee, J.H.1
Koo, T.H.2
Hwang, B.Y.3
Lee, J.J.4
-
238
-
-
0035869378
-
CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia
-
Matrai, Z.; Lin, K.; Dennis, M.; Sherrington, P.; Zuzel, M.; Pettitt, A.R.; Cawley, J.C. CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia. Blood, 2001, 97, 1902-1903.
-
(2001)
Blood
, vol.97
, pp. 1902-1903
-
-
Matrai, Z.1
Lin, K.2
Dennis, M.3
Sherrington, P.4
Zuzel, M.5
Pettitt, A.R.6
Cawley, J.C.7
-
239
-
-
65249086258
-
P65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541
-
López-Guerra, M.; Roué, G.; Pérez-Galán, P.; Alonso, R.; Villamor, N.; Montserrat, E.; Campo, E.; Colomer, D. P65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541. Clin. Cancer Res., 2009, 15, 2767-2776.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 2767-2776
-
-
López-Guerra, M.1
Roué, G.2
Pérez-Galán, P.3
Alonso, R.4
Villamor, N.5
Montserrat, E.6
Campo, E.7
Colomer, D.8
-
240
-
-
33845922019
-
Preclinical assessment of curcumin as a potential therapy for BCLL
-
Everett, P.C.; Meyers, J.A.; Makkinje, A.; Rabbi, M.; Lerner, A. Preclinical assessment of curcumin as a potential therapy for BCLL. Am. J. Hematol., 2007, 82, 23-30.
-
(2007)
Am. J. Hematol
, vol.82
, pp. 23-30
-
-
Everett, P.C.1
Meyers, J.A.2
Makkinje, A.3
Rabbi, M.4
Lerner, A.5
-
241
-
-
63149189848
-
Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG
-
Ghosh, A.K.; Kay, N.E.; Secreto, C.R.; Shanafelt, T.D. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin. Cancer Res., 2009, 15, 1250-1258.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 1250-1258
-
-
Ghosh, A.K.1
Kay, N.E.2
Secreto, C.R.3
Shanafelt, T.D.4
-
242
-
-
68449098158
-
Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leuk
-
Hayun, R.; Okun, E.; Berrebi, A.; Shvidel, L.; Bassous, L.; Sredni, B.; Nir, U. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leuk. Lymphoma, 2009, 50, 625-632.
-
(2009)
Lymphoma
, vol.50
, pp. 625-632
-
-
Hayun, R.1
Okun, E.2
Berrebi, A.3
Shvidel, L.4
Bassous, L.5
Sredni, B.6
Nir, U.7
-
243
-
-
20244368521
-
AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: Interference with the Akt/NF-kappaB survival pathway
-
Escobar-Díaz, E.; López-Martín, E.M.; Hernández del Cerro, M.; Puig-Kroger, A.; Soto-Cerrato, V.; Montaner, B.; Giralt, E.; García-Marco, J.A.; Pérez-Tomás, R.; Garcia-Pardo, A. AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway. Leukemia, 2005, 19, 572-579.
-
(2005)
Leukemia
, vol.19
, pp. 572-579
-
-
Escobar-Díaz, E.1
López-Martín, E.M.2
del Cerro, H.M.3
Puig-Kroger, A.4
Soto-Cerrato, V.5
Montaner, B.6
Giralt, E.7
García-Marco, J.A.8
Pérez-Tomás, R.9
Garcia-Pardo, A.10
-
244
-
-
0035324928
-
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
-
Hinz, M.; Löser, P.; Mathas, S.; Krappmann, D.; Dörken, B.; Scheidereit, C. Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells. Blood, 2001, 97, 2798-2807.
-
(2001)
Blood
, vol.97
, pp. 2798-2807
-
-
Hinz, M.1
Löser, P.2
Mathas, S.3
Krappmann, D.4
Dörken, B.5
Scheidereit, C.6
-
245
-
-
20544465128
-
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts
-
Nonaka, M.; Horie, R.; Itoh, K.; Watanabe, T.; Yamamoto, N.; Yamaoka, S. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene, 2005, 24, 3976-3986.
-
(2005)
Oncogene
, vol.24
, pp. 3976-3986
-
-
Nonaka, M.1
Horie, R.2
Itoh, K.3
Watanabe, T.4
Yamamoto, N.5
Yamaoka, S.6
-
246
-
-
33947526496
-
IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells
-
Watanabe, M.; Dewan, M.Z.; Taira, M.; Shoda, M.; Honda, M.; Sata, T.; Higashihara, M.; Kadin, M.E.; Watanabe, T.; Yamamoto, N.; Umezawa, K.; Horie, R. IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab. Invest., 2007, 87, 372-382.
-
(2007)
Lab. Invest
, vol.87
, pp. 372-382
-
-
Watanabe, M.1
Dewan, M.Z.2
Taira, M.3
Shoda, M.4
Honda, M.5
Sata, T.6
Higashihara, M.7
Kadin, M.E.8
Watanabe, T.9
Yamamoto, N.10
Umezawa, K.11
Horie, R.12
-
247
-
-
70349459622
-
TNF receptor-associated factor 1 is a positive regulator of the NFkappaB alternative pathway
-
Lavorgna, A.; De Filippi, R.; Formisano, S.; Leonardi, A. TNF receptor-associated factor 1 is a positive regulator of the NFkappaB alternative pathway. Mol. Immunol., 2009, 46, 3278-3282.
-
(2009)
Mol. Immunol
, vol.46
, pp. 3278-3282
-
-
Lavorgna, A.1
de Filippi, R.2
Formisano, S.3
Leonardi, A.4
-
248
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
-
Compagno, M.; Lim, W.K.; Grunn, A.; Nandula, S.V.; Brahmachary, M.; Shen, Q.; Bertoni, F.; Ponzoni, M.; Scandurra, M.; Califano, A.; Bhagat, G.; Chadburn, A.; Dalla-Favera, R.; Pasqualucci, L. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature, 2009, 459, 717-721.
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
Shen, Q.6
Bertoni, F.7
Ponzoni, M.8
Scandurra, M.9
Califano, A.10
Bhagat, G.11
Chadburn, A.12
Dalla-Favera, R.13
Pasqualucci, L.14
-
249
-
-
57049183997
-
Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies
-
Pavan, A.; Spina, M.; Canzonieri, V.; Sansonno, S.; Toffoli, G.; De Re, V. Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies. Leuk. Lymphoma, 2008, 49, 2048-2058.
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 2048-2058
-
-
Pavan, A.1
Spina, M.2
Canzonieri, V.3
Sansonno, S.4
Toffoli, G.5
de Re, V.6
-
250
-
-
19944405795
-
Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively
-
Tracey, L.; Pérez-Rosado, A.; Artiga, M.J.; Camacho, F.I.; Rodríguez, A.; Martínez, N.; Ruiz-Ballesteros, E.; Mollejo, M.; Martinez, B.; Cuadros, M.; Garcia, J.F.; Lawler, M.; Piris, M.A. Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively. J. Pathol., 2005, 206, 123-134.
-
(2005)
J. Pathol
, vol.206
, pp. 123-134
-
-
Tracey, L.1
Pérez-Rosado, A.2
Artiga, M.J.3
Camacho, F.I.4
Rodríguez, A.5
Martínez, N.6
Ruiz-Ballesteros, E.7
Mollejo, M.8
Martinez, B.9
Cuadros, M.10
Garcia, J.F.11
Lawler, M.12
Piris, M.A.13
-
251
-
-
19944428834
-
Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
-
Lam, L.T.; Davis, R.E.; Pierce, J.; Hepperle, M.; Xu, Y.; Hottelet, M.; Nong, Y.; Wen, D.; Adams, J.; Dang, L.; Staudt, L.M. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin. Cancer Res., 2005, 11, 28-40.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 28-40
-
-
Lam, L.T.1
Davis, R.E.2
Pierce, J.3
Hepperle, M.4
Xu, Y.5
Hottelet, M.6
Nong, Y.7
Wen, D.8
Adams, J.9
Dang, L.10
Staudt, L.M.11
-
252
-
-
43949131788
-
Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells
-
Mackenzie, G.G.; Queisser, N.; Wolfson, M.L.; Fraga, C.G.; Adamo, A.M.; Oteiza, P.I. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int. J. Cancer, 2008, 123, 56-65.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 56-65
-
-
Mackenzie, G.G.1
Queisser, N.2
Wolfson, M.L.3
Fraga, C.G.4
Adamo, A.M.5
Oteiza, P.I.6
-
253
-
-
23044479821
-
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
-
Shishodia, S.; Amin, H.M.; Lai, R.; Aggarwal, B.B. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem. Pharmacol., 2005, 70, 700-713.
-
(2005)
Biochem. Pharmacol
, vol.70
, pp. 700-713
-
-
Shishodia, S.1
Amin, H.M.2
Lai, R.3
Aggarwal, B.B.4
-
254
-
-
40649105973
-
Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations
-
Mackenzie, G.G.; Adamo, A.M.; Decker, N.P.; Oteiza, P.I. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. Biochem. Pharmacol., 2008, 75, 1461-1471.
-
(2008)
Biochem. Pharmacol
, vol.75
, pp. 1461-1471
-
-
Mackenzie, G.G.1
Adamo, A.M.2
Decker, N.P.3
Oteiza, P.I.4
-
255
-
-
33749257325
-
Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: Effect of (-)-epicatechin
-
Mackenzie, G.G.; Oteiza, P.I. Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin. Free Radic. Res., 2006, 40, 1086-1094.
-
(2006)
Free Radic. Res
, vol.40
, pp. 1086-1094
-
-
Mackenzie, G.G.1
Oteiza, P.I.2
-
256
-
-
33846476267
-
Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
-
Roué, G.; Pérez-Galán, P.; López-Guerra, M.; Villamor, N.; Campo, E.; Colomer, D. Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. J. Immunol., 2007, 178, 1923-1930.
-
(2007)
J. Immunol
, vol.178
, pp. 1923-1930
-
-
Roué, G.1
Pérez-Galán, P.2
López-Guerra, M.3
Villamor, N.4
Campo, E.5
Colomer, D.6
-
257
-
-
38949181015
-
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma downregulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents
-
Sors, A.; Jean-Louis, F.; Bégué, E.; Parmentier, L.; Dubertret, L.; Dreano, M.; Courtois, G.; Bachelez, H.; Michel, L. Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma downregulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents. Clin. Cancer Res., 2008, 14, 901-911.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 901-911
-
-
Sors, A.1
Jean-Louis, F.2
Bégué, E.3
Parmentier, L.4
Dubertret, L.5
Dreano, M.6
Courtois, G.7
Bachelez, H.8
Michel, L.9
-
258
-
-
33748935149
-
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma
-
Horie, R.; Watanabe, T.; Umezawa, K. Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. Drug News Perspect., 2006, 19, 201-209.
-
(2006)
Drug News Perspect
, vol.19
, pp. 201-209
-
-
Horie, R.1
Watanabe, T.2
Umezawa, K.3
-
259
-
-
0033929398
-
Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel-specific decoy oligodeoxynucleotides
-
Romano, M.F.; Lamberti, A.; Bisogni, R.; Tassone, P.; Pagnini, D.; Storti, G.; Del Vecchio, L.; Turco, M.C.; Venuta, S. Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel-specific decoy oligodeoxynucleotides. Gene Ther., 2000, 7, 1234-1237.
-
(2000)
Gene Ther
, vol.7
, pp. 1234-1237
-
-
Romano, M.F.1
Lamberti, A.2
Bisogni, R.3
Tassone, P.4
Pagnini, D.5
Storti, G.6
Del Vecchio, L.7
Turco, M.C.8
Venuta, S.9
-
260
-
-
0030855813
-
In vivo transfection of cis element decoy against nuclear factor-kappaB binding site prevents myocardial infarction
-
Morishita, R.; Sugimoto, T.; Aoki, M.; Kida, I.; Tomita, N.; Moriguchi, A.; Maeda, K.; Sawa, Y.; Kaneda, Y.; Higaki, J.; Ogihara, T. In vivo transfection of cis element decoy against nuclear factor-kappaB binding site prevents myocardial infarction. Nat. Med., 1997, 3, 894-899.
-
(1997)
Nat. Med
, vol.3
, pp. 894-899
-
-
Morishita, R.1
Sugimoto, T.2
Aoki, M.3
Kida, I.4
Tomita, N.5
Moriguchi, A.6
Maeda, K.7
Sawa, Y.8
Kaneda, Y.9
Higaki, J.10
Ogihara, T.11
-
261
-
-
0141953974
-
Transcription factors as molecular targets: Molecular mechanisms of decoy ODN and their design
-
Tomita, N.; Ogihara, T.; Morishita, R. Transcription factors as molecular targets: molecular mechanisms of decoy ODN and their design. Curr. Drug Targets, 2003, 4, 603-608.
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 603-608
-
-
Tomita, N.1
Ogihara, T.2
Morishita, R.3
-
262
-
-
34548569075
-
Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus
-
Osako, M.K.; Tomita, N.; Nakagami, H.; Kunugiza, Y.; Yoshino, M.; Yuyama, K.; Tomita, T.; Yoshikawa, H.; Ogihara, T.; Morishita, R. Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus. J. Gene Med., 2007, 9, 812-819.
-
(2007)
J. Gene Med
, vol.9
, pp. 812-819
-
-
Osako, M.K.1
Tomita, N.2
Nakagami, H.3
Kunugiza, Y.4
Yoshino, M.5
Yuyama, K.6
Tomita, T.7
Yoshikawa, H.8
Ogihara, T.9
Morishita, R.10
-
263
-
-
22144448580
-
Dissecting role of regulatory factors in NF-kappaB pathway with siRNA
-
Guo, J.; Fu, Y.C.; Becerra, C.R. Dissecting role of regulatory factors in NF-kappaB pathway with siRNA. Acta Pharmacol. Sin., 2005, 26, 780-788.
-
(2005)
Acta Pharmacol. Sin
, vol.26
, pp. 780-788
-
-
Guo, J.1
Fu, Y.C.2
Becerra, C.R.3
-
264
-
-
44049094771
-
Clinical gene therapy using recombinant adeno-associated virus vectors
-
Mueller, C.; Flotte, T.R. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Ther., 2008, 15, 858-863.
-
(2008)
Gene Ther
, vol.15
, pp. 858-863
-
-
Mueller, C.1
Flotte, T.R.2
-
265
-
-
68949202566
-
Transient transfection methods for clinical adenoassociated viral vector production
-
Wright, J.F. Transient transfection methods for clinical adenoassociated viral vector production. Hum. Gene Ther., 2009, 20, 698-706.
-
(2009)
Hum. Gene Ther
, vol.20
, pp. 698-706
-
-
Wright, J.F.1
-
266
-
-
48949098577
-
Gene therapy progress and prospects: Synthetic polymer-based systems
-
Schaffert, D.; Wagner, E. Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther., 2008, 15, 1131-1138.
-
(2008)
Gene Ther
, vol.15
, pp. 1131-1138
-
-
Schaffert, D.1
Wagner, E.2
-
267
-
-
65249105506
-
Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons
-
Bonoiu, A.C.; Mahajan, S.D.; Ding, H.; Roy, I.; Yong, K.T.; Kumar, R.; Hu, R.; Bergey, E.J.; Schwartz, S.A.; Prasad, P.N. Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. Proc. Natl. Acad. Sci. USA, 2009, 106, 5546-5550.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5546-5550
-
-
Bonoiu, A.C.1
Mahajan, S.D.2
Ding, H.3
Roy, I.4
Yong, K.T.5
Kumar, R.6
Hu, R.7
Bergey, E.J.8
Schwartz, S.A.9
Prasad, P.N.10
-
268
-
-
33745128099
-
Aptamer mediated siRNA delivery
-
Chu, T.C.; Twu, K.Y.; Ellington, A.D.; Levy, M. Aptamer mediated siRNA delivery. Nucleic Acids Res., 2006, 34, e73.
-
(2006)
Nucleic Acids Res
, vol.e73
, pp. 34
-
-
Chu, T.C.1
Twu, K.Y.2
Ellington, A.D.3
Levy, M.4
-
269
-
-
33747031960
-
Cell type-specific dfelivery of siRNAs with aptamer-siRNA chimeras
-
McNamara, J.O. 2nd; Andrechek, E.R.; Wang, Y.; Viles, K.D.; Rempel, R.E.; Gilboa, E.; Sullenger, B.A.; Giangrande, P.H. Cell type-specific dfelivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol., 2006, 24, 1005-1015.
-
(2006)
Nat. Biotechnol
, vol.24
, pp. 1005-1015
-
-
McNamara, J.O.1
Andrechek, E.R.2
Wang, Y.3
Viles, K.D.4
Rempel, R.E.5
Gilboa, E.6
Sullenger, B.A.7
Giangrande, P.H.8
-
270
-
-
48349105059
-
Novel dual inhibitory function aptamer-siRNA delivery systems for HIV-1 therapy
-
Zhou, J.; Li, H.; Li, S.; Zaia, J.; Rossi, J.J. Novel dual inhibitory function aptamer-siRNA delivery systems for HIV-1 therapy. Mol. Ther., 2008, 16, 1481-1489.
-
(2008)
Mol. Ther
, vol.16
, pp. 1481-1489
-
-
Zhou, J.1
Li, H.2
Li, S.3
Zaia, J.4
Rossi, J.J.5
-
271
-
-
0028869690
-
Diversity of oligonucleotide functions
-
Gold, L.; Polisky, B.; Uhlenbeck, O.; Yarus, M. Diversity of oligonucleotide functions. Annu. Rev. Biochem., 1995, 64, 763-797.
-
(1995)
Annu. Rev. Biochem
, vol.64
, pp. 763-797
-
-
Gold, L.1
Polisky, B.2
Uhlenbeck, O.3
Yarus, M.4
-
272
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
Semple, S.C.; Akinc, A.; Chen, J.; Sandhu, A.P.; Mui, B.L.; Cho, C.K.; Sah, D.W.; Stebbing, D.; Crosley, E.J.; Yaworski, E.; Hafez, I.M.; Dorkin, J.R.; Qin, J.; Lam, K.; Rajeev, K.G.; Wong, K.F.; Jeffs, L.B.; Nechev, L.; Eisenhardt, M.L.; Jayaraman, M.; Kazem, M.; Maier, M.A.; Srinivasulu, M.; Weinstein, M.J.; Chen, Q.; Alvarez, R.; Barros S.A.; De, S.; Klimuk, S.K.; Borland, T.; Kosovrasti, V.; Cantley, W.L.; Tam, Y.K.; Manoharan, M.; Ciufolini, M.A.; Tracy, M.A.; de Fougerolles, A.; MacLachlan, I.; Cullis, P.R.; Madden, T.D.; Hope, M.J. Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol., 2010, 28, 172-176.
-
(2010)
Nat. Biotechnol
, vol.28
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
Sandhu, A.P.4
Mui, B.L.5
Cho, C.K.6
Sah, D.W.7
Stebbing, D.8
Crosley, E.J.9
Yaworski, E.10
Hafez, I.M.11
Dorkin, J.R.12
Qin, J.13
Lam, K.14
Rajeev, K.G.15
Wong, K.F.16
Jeffs, L.B.17
Nechev, L.18
Eisenhardt, M.L.19
Jayaraman, M.20
Kazem, M.21
Maier, M.A.22
Srinivasulu, M.23
Weinstein, M.J.24
Chen, Q.25
Alvarez, R.26
Barros, S.A.27
De, S.28
Klimuk, S.K.29
Borland, T.30
Kosovrasti, V.31
Cantley, W.L.32
Tam, Y.K.33
Manoharan, M.34
Ciufolini, M.A.35
Tracy, M.A.36
de Fougerolles, A.37
Maclachlan, I.38
Cullis, P.R.39
Madden, T.D.40
Hope, M.J.41
more..
-
273
-
-
70449102637
-
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation
-
Stilmann, M.; Hinz, M.; Arslan, S.C.; Zimmer, A.; Schreiber, V.; Scheidereit, C. A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Mol. Cell, 2009, 36, 365-378.
-
(2009)
Mol. Cell
, vol.36
, pp. 365-378
-
-
Stilmann, M.1
Hinz, M.2
Arslan, S.C.3
Zimmer, A.4
Schreiber, V.5
Scheidereit, C.6
-
274
-
-
23744494993
-
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
-
Avellino, R.; Romano, S.; Parasole, R.; Bisogni, R.; Lamberti, A.; Poggi, V.; Venuta, S.; Romano, M.F. Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood, 2005, 106, 1400-1406.
-
(2005)
Blood
, vol.106
, pp. 1400-1406
-
-
Avellino, R.1
Romano, S.2
Parasole, R.3
Bisogni, R.4
Lamberti, A.5
Poggi, V.6
Venuta, S.7
Romano, M.F.8
|