Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo

Leukemia

Volumn 22, Issue 7, 2008, Pages 1410-1418

  Shammas, M A ^a,b,c   Koley, H ^a,c   Bertheau, R C ^a,b,c   Neri, P ^b,c   Fulciniti, M ^a,b,c   Tassone, P ^a,b,c   Blotta, S ^a,b,c   Protopopov, A ^b,c   Mitsiades, C ^b,c   Batchu, R B ^a,c   Anderson, K C ^b,c   Chin, A ^d   Gryaznov, S ^d   Munshi, N C ^a,b,c  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d GERON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRN 163L; OLIGONUCLEOTIDE; TANESPIMYCIN; TELOMERASE; TELOMERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL DEATH; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENTIATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TELOMERE;

ANIMALS; APOPTOSIS; BENZOQUINONES; CELL LINE, TUMOR; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; MICE, SCID; MULTIPLE MYELOMA; OLIGONUCLEOTIDES; OLIGOPEPTIDES; TELOMERASE; TELOMERE;

EID: 47549118123     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.81     Document Type: Article

References (35)

1. Day JP, Marder BA, Morgan WF. Telomeres and their possible role in chromosome stabilization. Environ Mol Mutagen 1993; 22: 245-249.
2. Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N et al. Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature 1988; 332: 656-659.
3. Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD et al A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988; 85: 6622-6626.
4. Cong YS, Wright WE, Shay JW. Human telomerase and its regulation. Microbiol Mol Biol Rev 2002; 66: 407-425, table of contents.
5. Hayflick L. The cellular basis for biological aging. In: Finch CE, Hayflick L (eds). Handbook of the Biology of Aging. Van Nostrand Reinhold Co.: NY, 1977, pp 159-186.
6. Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin Jr WG, Levrero M et al The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399: 806-809.
7. Stiewe T, Putzer BM. p73 in apoptosis. Apoptosis 2001; 6: 447-452.
8. Blackburn EH, Greider CW, Henderson E, Lee MS, Shampay J, Shippen-Lentz D. Recognition and elongation of telomeres by telomerase. Genome 1989; 31: 553-560.
9. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992; 11: 1921-1929.
10. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
11. Lord RV, Salonga D, Danenberg KD, Peters JH, DeMeester TR, Park JM et al. Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointest Surg 2000; 4: 135-142.
12. Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995; 92 9082-9086.
13. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787-791.
14. Shay JW. Telomerase in human development and cancer. J Cell Physiol 1997; 173: 266-270.
15. Shay JW, Wright WE. The reactivation of telomerase activity in cancer progression. Trends Genet 1996; 12: 129-131.
16. Bodnar AG, Ouellette M, Frolkis M, Holt SF, Chiu CP, Morin GB et al Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
17. Bechter OE, Eisterer W, Pall G, Hilbe W, Kuhr T, Thaler J. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. Cancer Res 1998; 58: 4918-4922.
18. Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T et al. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Molecular Cancer Therapeutics 2003; 2: 825-833.
19. Fu W, Begley JG, Killen MW, Mattson MP. Anti-apoptotic role of telomerase in pheochromocytoma cells. J Biol Chem 1999; 274: 7264-7271.
20. Nakajima A, Tauchi T, Sashida G, Sumi M, Abe K, Yamamoto K et al. Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy. Leukemia 2003; 17: 560-567.
21. Sumi M, Tauchi T, Sashida G, Nakajima A, Gotoh A, Shin-Ya K et al. A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia. Int J Oncol 2004; 24: 1481-1487.
22. Tauchi T, Shin-Ya K, Sashida G, Sumi M, Nakajima A, Shimamoto T et al Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways. Oncogene 2003; 22 5338-5347.
23. Seimiya H, Oh-hara T, Suzuki T, Naasani I, Shimazaki T, Tsuchiya K et al. Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol Cancer Ther 2002; 1: 657-665.
24. Shammas MA, Koley H, Beer DG, Li C, Goyal RK, Munshi NC. Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology 2004; 126: 1337-1346.
25. Shammas MA, Reis RJ, Li C, Koley H, Hurley LH, Anderson KC et al. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res 2004; 10: 770-776.
26. Akiyama M, Hideshima T, Shammas MA, Hayashi T, Hamasaki M, Tai YT et al. Effects of oligonucleotide N3′-P5′ thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells. Cancer Res 2003; 63: 6187-6194.
27. Shammas MA, Liu X, Gavory G, Raney KD, Balasubramanian S, Shmookler Reis RJ. Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell growth and induces apoptosis of human immortal cells. Exp Cell Res 2004; 295: 204-214.
28. Shammas MA, Simmons CG, Corey DR, Reis RJ. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene 1999; 18: 6191-6200.
29. Shammas MA, Koley H, Batchu RB, Bertheau RC, Protopopov A, Munshi NC et al. Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: Mechanism and therapeutic potential. Mol Cancer 2005; 4: 24.
30. Yatabe N, Kyo S,.Kondo S, Kanaya T, Wang Z, Maida Y et al. 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells. Cancer Gene Ther 2002; 9: 624-630.
31. Shammas MA, Simmons CG, Corey DR, Shmookler Reis RJ. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene 1999; 18: 6191-6200.
32. Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC et al. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res 2004; 10: 770-776.
33. Workman P. Overview: Translating Hsp90 biology into Hsp90 drugs. Curr Cancer Drug Targets 2003; 3: 297-300.
34. Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N et al. Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Biochem Biophys Res Commun 2006; 351: 658-663.
35. Powers MV, Workman P. Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer 2006; 13 (Suppl 1): S125-S135.