메뉴 건너뛰기




Volumn 23, Issue 3, 2010, Pages 725-732

Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma

Author keywords

Glioblastoma; IL 8; NF B; Tumor angiogenesis; VEGF

Indexed keywords

I KAPPA B ALPHA; I KAPPA B ALPHA M; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MUTANT PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; MESSENGER RNA; VASCULOTROPIN A;

EID: 77349094234     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000690     Document Type: Article
Times cited : (124)

References (41)
  • 2
    • 45349096041 scopus 로고    scopus 로고
    • Available at
    • American Cancer Society: Cancer Facts and Figures. 2008. Available at: http://www.cancer.org.
    • (2008) Cancer Facts and Figures
  • 4
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheuma rheumatoid and other disease
    • Folkman J: Angiogenesis in cancer, vascular, rheuma rheumatoid and other disease. Nat Med 1: 27-31, 1995.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 6
    • 67650713544 scopus 로고    scopus 로고
    • Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas
    • Wong ML, Prawira A, Kaye AH and Hovens CM: Tumour angiogenesis: its mechanism and therapeutic implications in malignant gliomas. J Clin Neurosci 16: 1119-1130, 2009.
    • (2009) J Clin Neurosci , vol.16 , pp. 1119-1130
    • Wong, M.L.1    Prawira, A.2    Kaye, A.H.3    Hovens, C.M.4
  • 9
    • 0026846928 scopus 로고
    • The role of angiogenesis in tumor growth
    • Folkman J: The role of angiogenesis in tumor growth. Semin Cancer Biol 3: 65-71, 1992.
    • (1992) Semin Cancer Biol , vol.3 , pp. 65-71
    • Folkman, J.1
  • 10
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis (mini review)
    • Fidler IJ and Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis (mini review). Cell 79: 185-188, 1994.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 11
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS and Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983-985, 1983.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 12
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WH, Goeddel DV and Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309, 1989.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.H.3    Goeddel, D.V.4    Ferrara, N.5
  • 15
    • 0023942368 scopus 로고
    • Surgery in advanced ovarian carcinoma: Is there proof to show the benefit?
    • Heintz APM: Surgery in advanced ovarian carcinoma: is there proof to show the benefit? Eur J Oncol 14: 91-99, 1988.
    • (1988) Eur J Oncol , vol.14 , pp. 91-99
    • Heintz, A.P.M.1
  • 17
    • 0028032360 scopus 로고
    • Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2)
    • Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P and Giaccia AJ: Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res 54: 5273-5279, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5273-5279
    • Koong, A.C.1    Chen, E.Y.2    Mivechi, N.F.3    Denko, N.C.4    Stambrook, P.5    Giaccia, A.J.6
  • 19
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues
    • Koong AC, Chen EY and Giaccia AJ: Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 54: 1425-1430, 1994.
    • (1994) Cancer Res , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 20
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
    • Madrid LV, Mayo MW, Reuther JY and Baldwin AS Jr: Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276: 18934-18940, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin Jr, A.S.4
  • 21
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA and Makarov SS: NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401: 86-90, 1999.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 22
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM and Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85, 1999.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 23
    • 0037192829 scopus 로고    scopus 로고
    • PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    • Mayo MW, Madrid LV, Westerheide SD, et al: PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J Biol Chem 277: 11116-11125, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 11116-11125
    • Mayo, M.W.1    Madrid, L.V.2    Westerheide, S.D.3
  • 24
    • 0036235624 scopus 로고    scopus 로고
    • Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma
    • Nagai S, Washiyama K, Kurimoto M, Takaku A, Endo S and Kumanishi T: Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. J Neurosurg 96: 909-917, 2002.
    • (2002) J Neurosurg , vol.96 , pp. 909-917
    • Nagai, S.1    Washiyama, K.2    Kurimoto, M.3    Takaku, A.4    Endo, S.5    Kumanishi, T.6
  • 25
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
    • Wang H, Wang H, Zhang W, Huang HJ, Liao WS and Fuller GN: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest 84: 941-951, 2004.
    • (2004) Lab Invest , vol.84 , pp. 941-951
    • Wang, H.1    Wang, H.2    Zhang, W.3    Huang, H.J.4    Liao, W.S.5    Fuller, G.N.6
  • 26
    • 0033623902 scopus 로고    scopus 로고
    • Nuclear factor-kB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice
    • Huang S, DeGuzman A, Bucana CD and Fidler IJ: Nuclear factor-kB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res 6: 2573-2581, 2000.
    • (2000) Clin Cancer Res , vol.6 , pp. 2573-2581
    • Huang, S.1    DeGuzman, A.2    Bucana, C.D.3    Fidler, I.J.4
  • 27
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of NF-κB signalling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8
    • Huang S, Robinson JB, DeGuzman A, Bucana CD and Fidler IJ: Blockade of NF-κB signalling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Cancer Res 60: 5334-5339, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    DeGuzman, A.3    Bucana, C.D.4    Fidler, I.J.5
  • 28
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway C, Uehara H, Bucana CD and Fidler IJ: Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20: 4188-4197, 2001.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 29
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary K R and Chiao PJ: The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 31
    • 0033960389 scopus 로고    scopus 로고
    • An implantable guide-screw system for brain tumor studies in small animals
    • Lal S, Lacroix M, Tofilon P, Fuller GN, Sawaya R and Lang FF: An implantable guide-screw system for brain tumor studies in small animals. J Neurosurg 92: 326-333, 2000.
    • (2000) J Neurosurg , vol.92 , pp. 326-333
    • Lal, S.1    Lacroix, M.2    Tofilon, P.3    Fuller, G.N.4    Sawaya, R.5    Lang, F.F.6
  • 33
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights (review)
    • Baldwin AS Jr: The NF-κB and IκB proteins: New discoveries and insights (review). Annu Rev Immunol 14: 649-683, 1996.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr, A.S.1
  • 35
    • 0033565217 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant inhibitor-κBα of NF-κB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression and tumor growth in vivo
    • Duffey DC, Chen Z, Dong G, Ondrey FG, Wolf JS, Brown K, Siebenlist U and Waes CV: Expression of a dominant-negative mutant inhibitor-κBα of NF-κB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression and tumor growth in vivo. Cancer Res 59: 3468-3474, 1999.
    • (1999) Cancer Res , vol.59 , pp. 3468-3474
    • Duffey, D.C.1    Chen, Z.2    Dong, G.3    Ondrey, F.G.4    Wolf, J.S.5    Brown, K.6    Siebenlist, U.7    Waes, C.V.8
  • 36
    • 0033558155 scopus 로고    scopus 로고
    • Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs
    • Bentires-Alj M, Hellin AC, Ameyar M, Chouaib S, Merville MP and Bours V: Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs. Cancer Res 59: 811-815, 1999.
    • (1999) Cancer Res , vol.59 , pp. 811-815
    • Bentires-Alj, M.1    Hellin, A.C.2    Ameyar, M.3    Chouaib, S.4    Merville, M.P.5    Bours, V.6
  • 37
    • 0033578993 scopus 로고    scopus 로고
    • Inhibition of NF-κB, clonogenicity, and radiosensitivity of human cancer cells
    • Pajonk F, Pajonk K and McBride WH: Inhibition of NF-κB, clonogenicity, and radiosensitivity of human cancer cells. J Natl Cancer Inst 91: 1956-1960, 1999.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1956-1960
    • Pajonk, F.1    Pajonk, K.2    McBride, W.H.3
  • 39
    • 0033549875 scopus 로고    scopus 로고
    • Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated relA
    • Wang W, Abbruzzese JL, Evans DB and Chiao PJ: Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated relA. Oncogene, 18: 4554-4563, 1999.
    • (1999) Oncogene , vol.18 , pp. 4554-4563
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Chiao, P.J.4
  • 41
    • 0030014964 scopus 로고    scopus 로고
    • Involvement of the transcription factor NF-κB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress
    • Shono T, Ono M, Izumi H, Jimi SI, Matsushima K, Okamoto T, Kohro K and Kuwano M: Involvement of the transcription factor NF-κB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress. Mol Cell Biol 16: 4231-4239, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 4231-4239
    • Shono, T.1    Ono, M.2    Izumi, H.3    Jimi, S.I.4    Matsushima, K.5    Okamoto, T.6    Kohro, K.7    Kuwano, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.