CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response

Molecular Cell

Volumn 12, Issue 4, 2003, Pages 829-839

  Kato Jr , Tomohisa ^a   Delhase, Mireille ^a   Hoffmann, Alexander ^b   Karin, Michael ^a  

^a University of California San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN FUNCTION; STRUCTURE ANALYSIS; ULTRAVIOLET RADIATION;

ANIMALIA; MAMMALIA;

EID: 0242298578     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00358-7     Document Type: Article

References (41)

1. Ahmed K., Gerber D.A., Cochet C. Joining the cell survival squad. an emerging role for protein kinase CK2 Trends Cell Biol. 12:2002;226-230.
2. Allende J.E., Allende C.C. Protein kinases. 4. Protein kinase CK2. an enzyme with multiple substrates and a puzzling regulation FASEB J. 9:1995;313-323.
3. Barroga C.F., Stevenson J.K., Schwarz E.M., Verma I.M. Constitutive phosphorylation of IκBα by casein kinase II. Proc. Natl. Acad. Sci. USA. 92:1995;7637-7641.
4. Beg A.A., Sha W.C., Bronson R.T., Baltimore D. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα - deficient mice. Genes Dev. 9:1995;2736-2746.
5. Bender K., Gottlicher M., Whiteside S., Rahmsdorf H.J., Herrlich P. Sequential DNA damage-independent and -dependent activation of NF-κB by UV. EMBO J. 17:1998;5170-5181.
6. Cavigelli M., Dolfi F., Claret F.X., Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 14:1995;5957-5964.
7. Delhase M., Hayakawa M., Chen Y., Karin M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science. 284:1999;309-313.
8. Dérijard B., Hibi M., Wu I.-H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1. a protein kinase stimulated by uv light and ha-ras that binds and phosphorylates the c-jun activation domain Cell. 76:1994;1025-1037.
9. Devary Y., Gottlieb R.A., Lau L., Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11:1991;2804-2811.
10. Devary Y., Rosette C., DiDonato J.A., Karin M. NF-κB activation by ultraviolet light not dependent on a nuclear signal. Science. 261:1993;1442-1445.
11. DiDonato J.A., Mercurio F., Rosette C., Wu-li J., Suyang H., Ghosh S., Karin M. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16:1996;1295-1304.
12. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature. 388:1997;548-554.
13. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
14. Fenwick C., Na S.Y., Voll R.E., Zhong H., Im S.Y., Lee J.W., Ghosh S. A subclass of Ras proteins that regulate the degradation of IκB. Science. 287:2000;869-873.
15. Friedberg E.C. DNA Repair and Mutagenesis. 1995;ASM Press, Washington, DC.
16. Ghosh S., May M.J., Kopp E.B. NF-κB and Rel proteins. evolutionarily conserved mediators of immune responses Annu. Rev. Immunol. 16:1998;225-260.
17. Herrlich P., Blattner C., Knebel A., Bender K., Rahmsdorf H.J. Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants. Biol. Chem. 378:1997;1217-1229.
18. Hibi M., Lin A., Smeal T., Minden A., Karin M. Identification of an oncoprotein-responsive and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:1993;2135-2148.
19. Huang T.T., Feinberg S.L., Suryanarayanan S., Miyamoto S. The zinc finger domain of NEMO is selectively required for NF-κB activation by UV radiation and topoisomerase inhibitors. Mol. Cell. Biol. 22:2002;5813-5825.
20. Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination. the control of NF-κB activity Annu. Rev. Immunol. 18:2000;621-663.
21. Karin M., Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 3:2002;221-227.
22. Keller D.M., Zeng X., Wang Y., Zhang Q.H., Kapoor M., Shu H., Goodman R., Lozano G., Zhao Y., Lu H. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell. 7:2001;283-292.
23. Li N., Karin M. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms. Proc. Natl. Acad. Sci. USA. 95:1998;13012-13017.
24. Lin R.T., Beauparlant P., Makris C., Meloche S., Hiscott J. Phosphorylation of IκBα in the C-terminal pest domain by casein kinase II affects intrinsic protein stability. Mol. Cell. Biol. 16:1996;1401-1409.
25. Litchfield D.W. Protein kinase CK2. structure, regulation and role in cellular decisions of life and death Biochem. J. 369:2003;1-15.
26. Litchfield D.W., Dobrowolska G., Krebs E.G. Regulation of casein kinase II by growth factors. a reevaluation Cell. Mol. Biol. Res. 40:1994;373-381.
27. Liu Z.-G., Baskaran R., Lea-Chou E.T., Wood L.D., Chen Y., Karin M., Wang J.Y.J. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 384:1996;273-276.
28. McElhinny J.A., Trushin S.A., Bren G.D., Chester N., Paya C.V. Casein kinase II phosphorylates IκBα At S-283, S-289, S-293, and T-291 and is required for its degradation. Mol. Cell. Biol. 16:1996;899-906.
29. Naviaux R.K., Costanzi E., Haas M., Verma I.M. The pCL vector system. rapid production of helper-free, high-titer, recombinant retroviruses J. Virol. 70:1996;5701-5705.
30. Pando M.P., Verma I.M. Signal-dependent and -independent degradation of free and NF-κB-bound IκBα J. Biol. Chem. 275:2000;21278-21286.
31. Pinna L.A. Casein kinase 2. an "eminence grise" in cellular regulation? Biochim. Biophys. Acta. 1054:1990;267-284.
32. Sayed M., Kim S.O., Salh B.S., Issinger O.G., Pelech S.L. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. J. Biol. Chem. 275:2000;16569-16573.
33. Schwarz E.M., Vanantwerp D., Verma I.M. Constitutive phosphorylation of IκBα cy casein kinase II occurs preferentially at serine 293 - requirement for degradation of free IκBα Mol. Cell. Biol. 16:1996;3554-3559.
34. Shaulian E., Schreiber M., Piu F., Beeche M., Wagner E.F., Karin M. The mammalian UV response. c-Jun induction is required for exit from the p53-imposed checkpoint Cell. 103:2000;897-907.
35. Stein B., Rahmsdorf H.J., Steffan A., Litfin M., Herrlich P. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos., and metallothionein. Mol. Cell. Biol. 9:1989;5169-5181.
36. Tamura K., Sudo T.U., Senftleben U., Dadak A.M., Johnson R., Karin M. Requirement for p38α in erythropoietin expression. a role for stress kinases in erythropoiesis Cell. 102:2000;221-231.
37. Teitz T., Eli D., Penner M., Bakhanashvili M., Naiman T., Timme T.L., Wood C.M., Moses R.E., Canaani D. Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. Mutat. Res. 236:1990;85-97.
38. Tergaonkar V., Pando M., Vafa O., Wahl G., Verma I. p53 stabilization is decreased upon NF-κB activation. a role for NF-κB in acquisition of resistance to chemotherapy Cancer Cell. 1:2002;493-503.
39. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 288:2000;870-874.
40. Wang C.-Y., Mayo M.W., Baldwin A.S. Jr. TNF- and cancer therapy-induced apoptosis. potentiation by inhibition of NF-κB Science. 274:1996;784-787.
41. Zandi E., Rothwarf D.M., Delhase M., Hayakawa M., Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell. 91:1997;243-252.