Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis - CREB and NF-κB as key regulators

Immunity

Volumn 23, Issue 3, 2005, Pages 319-329

  Park, Jin Mo ^a,b   Greten, Florian R ^a,c   Wong, Athena ^d   Westrick, Randal J ^e   Arthur, J Simon C ^f   Otsu, Kinya ^g   Hoffmann, Alexander ^a   Montminy, Marc ^d   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 2; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTHRAX; APOPTOSIS; BACILLUS ANTHRACIS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; MACROPHAGES; MICE; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLASMINOGEN ACTIVATOR INHIBITOR 2; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION, GENETIC;

EID: 24944554790     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2005.08.010     Document Type: Article

References (57)

1. A. Aderem, and D.M. Underhill Mechanisms of phagocytosis in macrophages Annu. Rev. Immunol. 17 1999 593 623
2. S. Ahn, M. Olive, S. Aggarwal, D. Krylov, D.D. Ginty, and C. Vinson A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos Mol. Cell. Biol. 18 1998 967 977
3. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
4. T.M. Antalis, M. La Linn, K. Donnan, L. Mateo, J. Gardner, J.L. Dickinson, K. Buttigieg, and A. Suhrbier The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 protects against viral cytopathic effects by constitutive interferon α/β priming J. Exp. Med. 187 1998 1799 1811
5. A.A. Beg, W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB Nature 376 1995 167 169
6. B. Beutler Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263
7. J.M. Blander, and R. Medzhitov Regulation of phagosome maturation by signals from toll-like receptors Science 304 2004 1014 1018
8. A. Bonni, A. Brunet, A.E. West, S.R. Datta, M.A. Takasu, and M.E. Greenberg Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms Science 286 1999 1358 1362
9. M.N. Bradley, L. Zhou, and S.T. Smale C/EBPβ regulation in lipopolysaccharide-stimulated macrophages Mol. Cell. Biol. 23 2003 4841 4858
10. Y. Cao, G. Bonizzi, T. Seagroves, F. Greten, R. Johnson, E. Schmidt, and M. Karin IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development Cell 107 2001 763 775
11. B.E. Clausen, C. Burkhardt, W. Reith, R. Renkawitz, and I. Forster Conditional gene targeting in macrophages and granulocytes using LysMcre mice Transgenic Res. 8 1999 265 277
12. R.J. Collier, and J.A. Young Anthrax toxin Annu. Rev. Cell Dev. Biol. 19 2003 45 70
13. L.S. Collier-Hyams, H. Zeng, J. Sun, A.D. Tomlinson, Z.Q. Bao, H. Chen, J.L. Madara, K. Orth, and A.S. Neish Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway J. Immunol. 169 2002 2846 2850
14. K. Cunningham, D. Lacy, J. Mogridge, and R.J. Collier Characterization of membrane translocation by anthrax protective antigen Biochemistry 37 1998 15737 15746
15. M. Deak, A.D. Clifton, L.M. Lucocq, and D.R. Alessi Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB EMBO J. 17 1998 4426 4441
16. J.L. Dickinson, E.J. Bates, A. Ferrante, and T.M. Antalis Plasminogen activator inhibitor type 2 inhibitsTNFα-induced apoptosis. Evidence for an alternate biological function J. Biol. Chem. 270 1995 27894 27904
17. T.C. Dixon, M. Meselson, J. Guillemin, and P.C. Hanna Anthrax N. Engl. J. Med. 341 1999 815 826
18. K.M. Dougherty, J.M. Pearson, A.Y. Yang, R.J. Westrick, M.S. Baker, and D. Ginsburg The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival Proc. Natl. Acad. Sci. USA 96 1999 686 691
19. S.E. Doyle, R.M. O'Connell, G.A. Miranda, S.A. Vaidya, E.K. Chow, P.T. Liu, S. Suzuki, N. Suzuki, R.L. Modlin, and W.C. Yeh Toll-like receptors induce a phagocytic gene program through p38 J. Exp. Med. 199 2004 81 90
20. M. Enari, H. Hug, and S. Nagata Involvement of an ICE-like protease in Fas-mediated apoptosis Nature 375 1995 78 81
21. V. Gagliardini, P.A. Fernandez, R.K. Lee, H.C. Drexler, R.J. Rotello, M.C. Fishman, and J. Yuan Prevention of vertebrate neuronal death by the crmA gene Science 263 1994 826 828
22. H. Gan, G.W. Newman, and H.G. Remold Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4 J. Immunol. 155 1995 1304 1315
23. G.A. Gonzalez, and M.R. Montminy Cyclic AMP stimulates somatostain gene transcription by phosphorylation of CREB at serine 133 Cell 59 1989 675 680
24. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.-W. Li, L.J. Egan, M.F. Kagnoff, and M. Karin IKKβ links inflammation and tumorigenesis in a mouse model of colitis associated cancer Cell 118 2004 285 296
25. S. Hatakeyama, A. Hamasaki, I. Negishi, D.Y. Loh, F. Sendo, and K. Nakayama Multiple gene duplication and expression of mouse bcl-2-related genes, A1 Int. Immunol. 10 1998 631 637
26. L.C. Hsu, J.M. Park, K. Zhang, J.L. Luo, S. Maeda, R.J. Kaufman, L. Eckmann, D.G. Guiney, and M. Karin The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 Nature 428 2004 341 345
27. E. Hummler, T.J. Cole, J.A. Blendy, R. Ganss, A. Aguzzi, W. Schmid, F. Beermann, and G. Schutz Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors Proc. Natl. Acad. Sci. USA 91 1994 5647 5651
28. C. Janeway Jr., and R. Medzhitov Innate immune recognition Annu. Rev. Immunol. 20 2002 197 216
29. U.S. Jhala, G. Canettieri, R.A. Screaton, R.N. Kulkarni, S. Krajewski, J. Reed, J. Walker, X. Lin, M. White, and M. Montminy cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2 Genes Dev. 17 2003 1575 1580
30. M. Karin, and A. Lin NF-κB at the crossroads of life and death Nat. Immunol. 3 2002 221 227
31. J. Katsikis, H. Yu, F. Maurer, and R. Medcalf The molecular basis for the aberrant production of plasminogen activator inhibitor type 2 in THP-1 monocytes Thromb. Haemost. 84 2000 468 473
32. S. Kumar, and C. Baglioni Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2 J. Biol. Chem. 266 1991 20960 20964
33. Z.-W. Li, W. Chu, Y. Hu, M. Delhase, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin The IKKβ subunit of IκB kinase (IKK) is essential for NF-κB activation and prevention of apoptosis J. Exp. Med. 189 1999 1839 1845
34. N. Liu, T. Phillips, M. Zhang, Y. Wang, J.T. Opferman, R. Shah, and P.G. Ashton-Rickardt Serine protease inhibitor 2A is a protective factor for memory T cell development Nat. Immunol. 5 2004 919 926
35. B.E. Lonze, A. Riccio, S. Cohen, and D.D. Ginty Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB Neuron 34 2002 371 385
36. T. Mantamadiotis, T. Lemberger, S.C. Bleckmann, H. Kern, O. Kretz, A. Martin Villalba, F. Tronche, C. Kellendonk, D. Gau, and J. Kapfhammer Disruption of CREB function in brain leads to neurodegeneration Nat. Genet. 31 2002 47 54
37. P. Matzinger The danger model: a renewed sense of self Science 296 2002 301 305
38. B. Mayr, and M. Montminy Transcriptional regulation by the phosphorylation-dependent factor CREB Nat. Rev. Mol. Cell Biol. 2 2001 599 609
39. K. Nishida, O. Yamaguchi, S. Hirotani, S. Hikoso, Y. Higuchi, T. Watanabe, T. Takeda, S. Osuka, T. Morita, and G. Kondoh p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload Mol. Cell. Biol. 24 2004 10611 10620
40. H. Nishihara, M. Hwang, S. Kizaka-Kondoh, L. Eckmann, and P.A. Insel Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK J. Biol. Chem. 279 2004 26176 26183
41. K. Orth, L.E. Palmer, Z.Q. Bao, S. Stewart, A.E. Rudolph, J.B. Bliska, and J.E. Dixon Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector Science 285 1999 1920 1923
42. J.M. Park, F.R. Greten, Z.-W. Li, and M. Karin Macrophage apoptosis by Anthrax Lethal Factor and p38 MAP kinase inhibition Science 297 2002 2048 2051
43. J.M. Park, V.H. Ng, S. Maeda, R.F. Rest, and M. Karin Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists J. Exp. Med. 200 2004 1647 1655
44. J. Raingeaud, S. Gupta, J.S. Rogers, M. Dickens, J. Han, and R.J. Davis Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine J. Biol. Chem. 270 1995 7420 7426
45. C.A. Ray, R.A. Black, S.R. Kronheim, T.A. Greenstreet, P.R. Sleath, G.S. Salvesen, and D.J. Pickup Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme Cell 69 1992 597 604
46. A. Riccio, S. Ahn, C.M. Davenport, J.A. Blendy, and D.D. Ginty Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons Science 286 1999 2358 2361
47. D.A. Rubinson, C.P. Dillon, A.V. Kwiatkowski, C. Sievers, L. Yang, J. Kopinja, D.L. Rooney, M.M. Ihrig, M.T. McManus, and F.B. Gertler A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference Nat. Genet. 33 2003 401 406
48. S. Saccani, and G. Natoli Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes Genes Dev. 16 2002 2219 2224
49. S. Saccani, S. Pantano, and G. Natoli p38-dependent marking of inflammatory genes for increased NF-κB recruitment Nat. Immunol. 3 2002 69 75
50. K. Schesser, A.K. Spiik, J.M. Dukuzumuremyi, M.F. Neurath, S. Pettersson, and H. Wolf-Watz The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity Mol. Microbiol. 28 1998 1067 1079
51. K.B. Seamon, W. Padgett, and J.W. Daly Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells Proc. Natl. Acad. Sci. USA 78 1981 3363 3367
52. G.A. Silverman, P.I. Bird, R.W. Carrell, F.C. Church, P.B. Coughlin, P.G. Gettins, J.A. Irving, D.A. Lomas, C.J. Luke, and R.W. Moyer The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature J. Biol. Chem. 276 2001 33293 33296
53. Y. Tan, J. Rouse, A. Zhang, S. Cariati, P. Cohen, and M.J. Comb FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 EMBO J. 15 1996 4629 4642
54. M. Tewari, L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase Cell 81 1995 801 809
55. X.Z. Wang, and D. Ron Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase Science 272 1996 1347 1349
56. G.R. Wiggin, A. Soloaga, J.M. Foster, V. Murray-Tait, P. Cohen, and J.S. Arthur MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts Mol. Cell. Biol. 22 2002 2871 2881
57. C.-T. Yu, H.-m. Shih, and M.-Z. Lai Multiple signals required for cyclic AMP-responsiveness element binding protein (CREB) binding protein interaction induced by CD3/CD28 costimulation J. Immunol. 166 2001 284 292