Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB

Blood

Volumn 87, Issue 3, 1996, Pages 1104-1112

  Chauhan, Dharminder ^b   Uchiyama, Hiroshi ^b   Akbarali, Yasmin ^b   Urashima, Mitsuyoshi ^b   Yamamoto, Ken Ichi ^b   Libermann, Towia A ^b   Anderson, Kenneth C ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE MARROW CELL; CANCER CELL CULTURE; CELL ADHESION; HUMAN; HUMAN CELL; MESSENGER RNA SYNTHESIS; MULTIPLE MYELOMA; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; TUMOR GROWTH;

EID: 0030041147     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.3.1104.bloodjournal8731104     Document Type: Article

References (65)

1. Anderson KC, Bates MP, Slaughenhoupt B, Pinkus G, Schlossman SF, Nadler LN: Expression of human B cell associated antigens on leukemias and lymphomas: A model of human B-cell differentiation. Blood 63:1424, 1984
2. Anderson KC, Boyd AW, Fisher DC, Leslie D, Schlossman SF, Nadler LM: Hairy cell leukemia: A tumor of preplasma cells. Blood 65:620, 1985
3. Anderson KC, Jones RC, Morimoto C, Leavitt P, Barut, B: Response of purified myeloma cells to hematopoietic growth factors. Blood 73:1915, 1989
4. Barut BM, Cochran M, O'Hara C, Anderson KC: Response patterns of purified hairy cell leukemia tumor cells to mitogens and recombinant growth factors. Blood 76:2091, 1990
5. Paul SD, Barut BA, Cochran MA, Anderson KC: Lack of a role of interleukin-11 in the growth of multiple myeloma. Leuk Res 16:247, 1992
6. Barut BA, Zon LI, Cochran MK, Paul SR, Chauhan D, Mohrbacher A, Fingeroth J, Anderson KC: Role of interleukin-6 in the growth of myeloma derived cell lines. Leuk Res 16:951, 1992
7. Barut BA, Chauhan D, Uchiyama H, Anderson KC: Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia. J Clin Invest 92:2346, 1993
8. Taylor CW, Grogan TM, Salmon SE: Effects of interleukin-4 on the in vitro growth of human lymphoid and plasma cell neoplasms. Blood 75:1114, 1990
9. Herrmann F, Andreef M, Gruss H-J, Brach MA, Lubbert M, Mertelsmann R: Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression. Blood 78:2070, 1991
10. Klein B, Zhang XG, Yang LZ, Bataille R: Interleukin-6 in human multiple myeloma. Blood 85:863, 1995
11. Klein B, Zhang X, Jourdan M, Content J, Houssiau F, Aarden L, Piechaczyk M, Bataille R: Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73:517, 1989
12. Lichtenstein A, Berenson J, Norman D, Chang M-P, Carlile A. Production of cytokines by bone marrow cells obtained from patients with multiple myeloma. Blood 74:1266, 1989
13. Kawano M, Tanaka H, Ishikawa H, Nobuyoshi M, Iwato K, Asaoku H, Tanabe O, Kuramoto A: Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma. Blood 73:2145, 1989
14. Caligaris-Cappio F, Bergui L, Gregoretti MG, Gaidano G, Gaboli M, Schena M, Zallone AZ, Marchisio PC: Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 77:2688, 1991
15. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T: Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83, 1988
16. Freeman GJ, Freedman AS, Rabinowe SN, Segil JM, Horowitz J, Rosen K, Whitman JF, Nadler LM: Interleukin-6 gene expression in normal and neoplastic B cells. J Clin Invest 83:1512, 1989
17. Hata H, Xiao H, Petrucci MT, Woodliff J, Chang R, Epstein J: Interieukin-6 gene expression in multiple myeloma: A characteristic of immature tumor cells. Blood 81:3357, 1993
18. Jackson N, Lowe J, Ball J, Bromidge E, Ling NR, Larkins S, Griffith MJ, Franklin IM: Two new IgA1-k plasma cell leukaemia cell lines (JJN-1 & JJN-2) which proliferate in response to B cell stimulatory factor 2. Clin Exp Immunol 75:93, 1989
19. Hitzler J, Martinez-Valdez H, Bergsagel D, Minden M, Messner H: Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-MY 1 to 7 established from patients with advanced stage of the disease. Blood 78:1996, 1991
20. Schwab G, Siegall C, Aarden L, Neckers L, Nordan RP: Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587, 1991
21. Levy Y, Tsapis A, Brouet J-C: Interleukin-6 antisense oligomicleotides inhibit the growth of human myeloma cell lines J Clin Invest 88:696, 1991
22. Zhang XG, Gaillard JP, Robillard N, Lu AY, Gu ZJ, Jourdan M Boiron JM, Bataille R, Klein B: Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 83:3654, 1994
23. Westendorf, JJ, Ahmann GJ, Armitage RJ, Spriggs MK, Lust JA, Greipp PR, Katzmann JA, Jelinek DF: CD40 expression in malignant plasma cells: Role in stimulation of autocrine IL-6 secretion by a human myeloma cell line. J Immunol 152:117, 1994
24. Urashima M, Chauhan D, Uchiyama H, Freeman G, Anderson KC: CD40 ligand triggered interleukin-6 secretion in multiple myeloma. Blood 85:1903, 1995
25. Tong AW, Zhang BQ, Mues G, Solano M, Hanson T, Stone MJ: Anti-CD40 antibody binding modulates human multiple myeloma clonogenicity in vitro. Blood 84:3026, 1994
26. Hamilton MS, Ball J, Bromidge E, Franklin IM: Surface antigen expression of human neoplastic plasma cells includes molecules associated with lymphocyte recirculation and adhesion. Br J Haematol 78:60, 1991
27. Ahsmann EJM, Lokhorst HM, Dekker AW, Bloem AC: Lymphocyte function-associated antigen-1 expression on plasma cells correlates with tumor growth in multiple myeloma. Blood 79:2068, 1992
28. Uchiyama H, Barut BA, Chauhan D, Cannistra SA, Anderson KC: Characterization of adhesion molecules on human myeloma cell lines. Blood 80:2306, 1992
29. Uchiyama H, Barut B, Mohrbacher A, Chauhan D, Anderson KC: Adhesion of human myeloma-derived cell lines to bone marrow stroma stimulates IL-6 secretion. Blood 82:3712, 1993
30. Kim I, Uchiyama H, Chauhan D, Anderson KC: Cell surface expression and functional significance of adhesion molecules on human myeloma-derived cell lines. Br J Haematol 87:483, 1994
31. Lokhorst HM, Lamme T, deSmet M, Klein S, de Weger RA, van Oers R, Bloem AC: Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 84:2269, 1994
32. Huang H, Kawano MM, Mahmoud MS, Mihara K, Tsujimoto T, Niwa O, Kuramoto A: Expression of CD 21 antigen on myeloma cells and its involvement in their adhesion to bone marrow stromal cells. Blood 85:3704, 1995
33. Huang N, Kawano MM, Harada H, Harada Y, Sakai A, Kuramoto A, Niwa O: Heterogeneous expression of a novel MPC-1 antigen on myeloma cells: Possible involvement of MPC-1 antigen in the adhesion of mature myeloma cells to bone marrow stromal cells. Blood 82:3721, 1993
34. Ridley RC, Xiao H, Hata H, Woodliff J, Epstein J, Sanderson RD: Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen. Blood 81:767, 1993
35. Barillé S, Collette M, Bataille R, Amiot M: Myeloma cells upregulate IL-6 but downregulate osteocalcin production by osteoblastic cells through cell-cell-contact. Blood 86:3151, 1995
36. Chauhan D, Kharbanda S, Uchiyama H, Urashima M, Sen J, Fuguso R, Kufe DW, Anderson KC. Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen. Blood 84:2243, 1994
37. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirshner MW. Number and evolutionary conservation of a and β tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes. Cell 20:95, 1980
38. Shimizu H, Mitomo K, Watanabe T, Okamoto S, Yamamoto K-I: Involvement of NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol 10:561, 1990
39. Chauhan D, Kharbanda SM, Uchiyama H, Sukhatme VP, Kufe DW, Anderson KC: Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells. Cancer Res 54:2234, 1994
40. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:475, 1983
41. Ray A, Tatter SB, May LT, Sehgal PB: Activation of the human β2-interferon/hepatocyte-stimulating factor/interleukin 6 promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci USA 85:6700, 1988
42. Libermann TA, Baltimore D: Activation of interleukin-6 gene expression through the NF-κ transcription factor. Mol Cell Biol 10:2327, 1990
43. Walther Z, May LT, Sehgal PB: Transcriptional regulation of the interferon β2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol 140:974, 1988
44. Yasukawa K, Hirano T, Watanabe Y, Muratani T, Matsuda SN, Kishimoto T: Structure and expression of human B cell stimulatory factor-2 (BSF-2/1L-6) gene. EMBO J 6:2939, 1987
45. Brach MA, Heranann F, Kufe DW: Activation of the AP-1 transcription factor by 1-β-D arabinofuranosylcytosine in myeloid leukemia cells. Blood 79:728, 1992
46. Devary Y, Gottlieb RA, Lau LF, Karin M: Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11:2804, 1991
47. Isshiki H, Akira S, Tanabe O, Nakajima T, Shimamoto T, Hirano T, Kishimoto T: Constitutive and IL-1 inducible factors interact with the IL-1 responsive element in the IL-6 gene. Mol Cell Biol 10:2757, 1990
48. Ulrich D, Oettgen P, Libermann TA: Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol Cell Biol 14:4443, 1994
49. Matsusaka T, Fujikawa K, Nishio N, Mukaida K, Matsushima K, Kishimoto T, Akira S: Transcription factor NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin-6 and interleukin-8. Proc Natl Acad Sci USA 90:10193, 1993
50. Muraguchi A, Hirano T, Tang B, Matsuda T, Horii Y, Nakajima K, Kishimoto T: The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med 167:332, 1988
51. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda S, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324:73, 1986
52. Van Damme J, Opdenakker G, Simpson RJ, Rubira MR, Cayphas S, Vink A, Billiau A, van Snick J: Identification of the human 26-kD protein, interferon b2 (IFN-b2), as a B cell hybridoma/ plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 165:914, 1987
53. Bataille R, Jourdan M, Zhang XG, Klein B: Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias. J Clin Invest 84:2008, 1989
54. Bell JBG, Montes A, Gooding R, Riches P, Cunningham D, Millar BC: Comparison of interleukin-6 levels in the bone marrow of multiple myeloma patients with disease severity and clonogenicity m vitro. Leukemia 5:958, 1991
55. Ludwig H, Nachbaur DM, Fritz E, Krainer M, Huber H: Interleukin-6 is a prognostic factor in multiple myeloma. Blood 77:2794, 1991
56. Solary E, Guiguet M, Zeller V, Casanovas R-O, Caillot D, Chavant P, Guy H, Mack G: Radioimmunoassay for the measurement of serum IL-6 and its correlation with tumour cell mass parameters in multiple myeloma. Am J Hematol 39:163, 1992
57. Pelliniemi T-T, Irjala K, Mattila K, Pulkki K, Rajamäki A, Tienhaara A, Laakso M, Lahtinen R: Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Blood 85:765, 1995
58. Klein B, Wijdenes J, Zhang XG, Jourdan M, Boiron JM, Brochier J, Liautard J, Merlin M, Clement C, Morel-Fournier B, Lu Z-Y, Mannoni P, Sany J, Bataille R: Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78:1198, 1991
59. Bataille R, Barlogie B, Lu ZY, Rossi JF, Lavabre-Bertrand T, Beck T, Wijdenes J, Brochier J, Klein B: Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86:685, 1995
60. Ballester OF, Moscinski LC, Lyman GH, Chaney JV, Saba HI, Spiers ASD, Klein B: High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood 83:1903, 1994
61. Ray A, LaForge S, Sehgal PB : On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: Enhancer, TATA Box, and RNA start site (Inr Motif) occlusion. Mol Cell Biol 10:5736, 1990
62. Santhanam U, Ray A, Sehgal PB: Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci USA 88:7605, 1991
63. Zhang Y, Lin J-X, Vilcek J: Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB-like sequence. Mol Cell Biol 10:3818, 1990
64. Ogata A, Anderson KC: Therapeutic strategies for inhibition of interleukin-6 mediated multiple myeloma cell growth. Leuk Res (in press)
65. LeClair KP, Blanar MA, Sharp PA: The p50 subunit of NKκB associates with the NF-IL6 transcription factor. Proc Natl Acad Sci USA 89:8145, 1992