Effect of NF-κB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells [3]

Leukemia

Volumn 17, Issue 6, 2003, Pages 1190-1192

  Romano, M F ^c   Petrella, A ^c   Bisogni, R ^c   Turco, M C ^a   Venuta, S ^b  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CD34 ANTIGEN; CYTARABINE; ETOPOSIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PROTEASOME INHIBITOR; TRANSCRIPTION FACTOR; ANTINEOPLASTIC AGENT; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR REL;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER COMBINATION CHEMOTHERAPY; CARCINOGENESIS; CELL SURVIVAL; DOWN REGULATION; GENE TARGETING; HUMAN; IMMUNOMODULATION; LETTER; LEUKEMIA CELL LINE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL; UMBILICAL CORD BLOOD; ACUTE DISEASE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FETUS BLOOD; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY;

ACUTE DISEASE; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ETOPOSIDE; FETAL BLOOD; HUMANS; JURKAT CELLS; NF-KAPPA B; OLIGONUCLEOTIDES; PROTO-ONCOGENE PROTEINS C-REL; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0038040499     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402953     Document Type: Letter

References (12)

1. White MK, McCubrey JA. Suppression of apoptosis: role in cell growth and neoplasia. Leukemia 2001; 15: 1011-1021.
2. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 2001; 107: 241-246.
3. Romano MF, Lamberti A, Tassone P, Alfinito F, Costantini S, Chiurazzi F et al. Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells. Blood 1998; 92: 990-995.
4. Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol 2000; 164: 2200-2206.
5. Romano MF, Lamberti A, Bisogni R, Tassone P, Pagnini D, Storti G et al. Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-κB/Rel-specific decoy oligodeoxynucleotides. Gene Therapy 2000; 7: 1234-1237.
6. Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301-2307.
7. Pyatt DW, Stillman WS, Yang Y, Gross S, Zheng JH, Irons RD. An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. Blood 1999; 93: 3302-3308.
8. Romano MF, Lamberti A, Bisogni R, Garbi C, Pagnano AM, Auletta P et al. Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-κB/Rel transcription factors. Blood 1999; 94: 4060-4066.
9. Adams J. Proteasome inhibition: a novel approach to cancer therapy. Trends Mol Med 2002; 8: S49-S54.
10. Wang CY, Cusack Jr JC, Liu R, Baldwin Jr AS. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med 1999; 5: 412-417.
11. Lamberti A, Romano MF, Agosti V, Garbi C, Sun S-C, Turco MC et al. Regulation of cell survival in CD95-incluced T cell apoptosis: role of NF-κB/Rel factors. Apoptosis 1999; 4: 179-185.
12. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139: 271-279.