Phosphorylation of serine 68 in the IκB Kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-α-induced NF-κB activity

Journal of Biological Chemistry

Volumn 283, Issue 1, 2008, Pages 76-86

  Palkowitsch, Lysann ^a   Leidner, Julia ^a   Ghosh, Sankar ^b   Marienfeld, Ralf B ^a  

^a UNIVERSITY OF ULM   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; FIBROBLASTS; PHOSPHORYLATION; PROTEINS;

AMINO-TERMINAL DIMERIZATION; BINDING DOMAIN; MURINE EMBRYONIC FIBROBLASTS;

TUMORS;

I KAPPA B; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TUMOR NECROSIS FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM;

ANIMALS; CELL LINE; CELLS, CULTURED; DIMERIZATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; I-KAPPA B KINASE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SERINE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 38049028109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708856200     Document Type: Article

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