OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology

Advances in Immunology

Volumn 105, Issue C, 2010, Pages 63-98

  Ishii, Naoto ^a   Takahashi, Takeshi ^a   Soroosh, Pejman ^b   Sugamura, Kazuo ^a,c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c Miyagi Cancer Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CYCLOSPORIN; IMMUNOGLOBULIN; METHOTREXATE; OX40 IMMUNOGLOBULIN; OX40 LIGAND; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; INTERLEUKIN 7; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CARDIOVASCULAR DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; EFFECTOR CELL; GENETIC ASSOCIATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; INFLAMMATION; INFLAMMATORY DISEASE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MAST CELL; MEMORY T LYMPHOCYTE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; ANIMAL; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MOUSE; REVIEW; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; INTERLEUKIN-7; MICE; OX40 LIGAND; RECEPTORS, OX40; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 77955965216     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/S0065-2776(10)05003-0     Document Type: Chapter

References (145)

1. Ahmadzadeh M., Hussain S.F., Farber D.L. Heterogeneity of the memory CD4 T cell response: Persisting effectors and resting memory T cells. J. Immunol. 2001, 166:926-935.
2. Ahmed R., Gray D. Immunological memory and protective immunity: Understanding their relation. Science 1996, 272:54-60.
3. Ahmed R., Bevan M.J., Reiner S.L., Fearon D.T. The precursors of memory: Models and controversies. Nat. Rev. Immunol. 2009, 9:662-668.
4. Akiba H., Miyahira Y., Atsuta M., Takeda K., Nohara C., Futagawa T., Matsuda H., Aoki T., Yagita H., Okumura K. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 2000, 191:375-380.
5. Apostolou I., von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 2004, 199:1401-1408.
6. Bansal-Pakala P., Halteman B.S., Cheng M.H., Croft M. Costimulation of CD8 T cell responses by OX40. J. Immunol. 2004, 172:4821-4825.
7. Baum P.R., Gayle R.B., Ramsdell F., Srinivasan S., Sorensen R.A., Watson M.L., Seldin M.F., Baker E., Sutherland G.R., Clifford K.N., et al. Molecular characterization of murine and human OX40/OX40 ligand systems: Identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994, 13:3992-4001.
8. Becker T.C., Wherry E.J., Boone D., Murali-Krishna K., Antia R., Ma A., Ahmed R. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 2002, 195:1541-1548.
9. Belghith M., Bluestone J.A., Barriot S., Megret J., Bach J.F., Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 2003, 9:1202-1208.
10. Benson M.J., Pino-Lagos K., Rosemblatt M., Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 2007, 204:1765-1774.
11. Blattman J.N., Antia R., Sourdive D.J., Wang X., Kaech S.M., Murali-Krishna K., Altman J.D., Ahmed R. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 2002, 195:657-664.
12. Borst J., Hendriks J., Xiao Y. CD27 and CD70 in T cell and B cell activation. Curr. Opin. Immunol. 2005, 17:275-281.
13. Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E., Noelle R.J., Fell H.P. Cloning of mouse Ox40: A T cell activation marker that may mediate T-B cell interactions. J. Immunol. 1993, 151:5261-5271.
14. Chang J.T., Palanivel V.R., Kinjyo I., Schambach F., Intlekofer A.M., Banerjee A., Longworth S.A., Vinup K.E., Mrass P., Oliaro J., Killeen N., Orange J.S., et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007, 315:1687-1691.
15. Chang Y.K., Yang W., Zhao M., Mok C.C., Chan T.M., Wong R.W., Lee K.W., Mok M.Y., Wong S.N., Ng I.O., Lee T.L., Ho M.H., et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2009, 10:414-420.
16. Chen A.I., McAdam A.J., Buhlmann J.E., Scott S., Lupher M.L., Greenfield E.A., Baum P.R., Fanslow W.C., Calderhead D.M., Freeman G.J., Sharpe A.H. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 1999, 11:689-698.
17. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
18. Chen M., Xiao X., Demirci G., Li X.C. OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ Tregs. Transplantation 2008, 85:1659-1662.
19. Cobbold S.P., Castejon R., Adams E., Zelenika D., Graca L., Humm S., Waldmann H. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 2004, 172:6003-6010.
20. Coyle A.J., Gutierrez-Ramos J.C. The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2001, 2:203-209.
21. Croft M. Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?. Nat. Rev. Immunol. 2003, 3:609-620.
22. Croft M., So T., Duan W., Soroosh P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 2009, 229:173-191.
23. Cunninghame Graham D.S., Graham R.R., Manku H., Wong A.K., Whittaker J.C., Gaffney P.M., Moser K.L., Rioux J.D., Altshuler D., Behrens T.W., Vyse T.J. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat. Genet. 2008, 40:83-89.
24. Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004, 10:942-949.
25. Curotto de Lafaille M.A., Lafaille J.J. Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?. Immunity 2009, 30:626-635.
26. Damayanti T., Kikuchi T., Zaini J., Daito H., Kanehira M., Kohu K., Ishii N., Satake M., Sugamura K., Nukiwa T. Serial OX40 engagement on CD4+ T cells and NKT cells causes allergic airway inflammation. Am. J. Respir. Crit. Care Med. 2009.
27. Dawicki W., Bertram E.M., Sharpe A.H., Watts T.H. 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J. Immunol. 2004, 173:5944-5951.
28. De Smedt T., Smith J., Baum P., Fanslow W., Butz E., Maliszewski C. Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol. 2002, 168:661-670.
29. Delgado-Vega A.M., Abelson A.K., Sanchez E., Witte T., D'Alfonso S., Galeazzi M., Jimenez-Alonso J., Pons-Estel B.A., Martin J., Alarcon-Riquelme M.E. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun. 2009, 10:248-253.
30. Duan W., So T., Croft M. Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells. J. Immunol. 2008, 181:8650-8659.
31. Dutton R.W., Bradley L.M., Swain S.L. T cell memory. Annu. Rev. Immunol. 1998, 16:201-223.
32. Fantini M.C., Becker C., Tubbe I., Nikolaev A., Lehr H.A., Galle P., Neurath M.F. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006, 55:671-680.
33. Flynn S., Toellner K.M., Raykundalia C., Goodall M., Lane P. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 1998, 188:297-304.
34. Ghiringhelli F., Puig P.E., Roux S., Parcellier A., Schmitt E., Solary E., Kroemer G., Martin F., Chauffert B., Zitvogel L. Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J. Exp. Med. 2005, 202:919-929.
35. Godfrey W.R., Fagnoni F.F., Harara M.A., Buck D., Engleman E.G. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J. Exp. Med. 1994, 180:757-762.
36. Goldrath A.W., Sivakumar P.V., Glaccum M., Kennedy M.K., Bevan M.J., Benoist C., Mathis D., Butz E.A. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 2002, 195:1515-1522.
37. Gramaglia I., Weinberg A.D., Lemon M., Croft M. Ox-40 ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 1998, 161:6510-6517.
38. Gramaglia I., Jember A., Pippig S.D., Weinberg A.D., Killeen N., Croft M. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 2000, 165:3043-3050.
39. Gri G., Piconese S., Frossi B., Manfroi V., Merluzzi S., Tripodo C., Viola A., Odom S., Rivera J., Colombo M.P., Pucillo C.E. CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008, 29:771-781.
40. Haxhinasto S., Mathis D., Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 2008, 205:565-574.
41. Hendriks J., Xiao Y., Rossen J.W., van der Sluijs K.F., Sugamura K., Ishii N., Borst J. During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J. Immunol. 2005, 175:1665-1676.
42. Hirschhorn-Cymerman D., Rizzuto G.A., Merghoub T., Cohen A.D., Avogadri F., Lesokhin A.M., Weinberg A.D., Wolchok J.D., Houghton A.N. OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. J. Exp. Med. 2009, 206:1103-1116.
43. Homann D., Teyton L., Oldstone M.B. Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat. Med. 2001, 7:913-919.
44. Humphreys I.R., Walzl G., Edwards L., Rae A., Hill S., Hussell T. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. J. Exp. Med. 2003, 198:1237-1242.
45. Humphreys I.R., Loewendorf A., de Trez C., Schneider K., Benedict C.A., Munks M.W., Ware C.F., Croft M. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: A CD4-dependent mechanism. J. Immunol. 2007, 179:2195-2202.
46. Imura A., Hori T., Imada K., Ishikawa T., Tanaka Y., Maeda M., Imamura S., Uchiyama T. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 1996, 183:2185-2195.
47. Ishii N., Ndhlovu L.C., Murata K., Sato T., Kamanaka M., Sugamura K. OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses. Eur. J. Immunol. 2003, 33:2372-2381.
48. Ito T., Wang Y.H., Duramad O., Hori T., Delespesse G.J., Watanabe N., Qin F.X., Yao Z., Cao W., Liu Y.J. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 2005, 202:1213-1223.
49. Itoh M., Takahashi T., Sakaguchi N., Kuniyasu Y., Shimizu J., Otsuka F., Sakaguchi S. Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999, 162:5317-5326.
50. Jenkins S.J., Perona-Wright G., Worsley A.G., Ishii N., MacDonald A.S. Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J. Immunol. 2007, 179:3515-3523.
51. Jordan M.S., Boesteanu A., Reed A.J., Petrone A.L., Holenbeck A.E., Lerman M.A., Naji A., Caton A.J. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001, 2:301-306.
52. Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
53. Joshi N.S., Cui W., Chandele A., Lee H.K., Urso D.R., Hagman J., Gapin L., Kaech S.M. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 2007, 27:281-295.
54. Kashiwakura J., Yokoi H., Saito H., Okayama Y. T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: Comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J. Immunol. 2004, 173:5247-5257.
55. Kim M.Y., Gaspal F.M., Wiggett H.E., McConnell F.M., Gulbranson-Judge A., Raykundalia C., Walker L.S., Goodall M.D., Lane P.J. CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Immunity 2003, 18:643-654.
56. Komatsu N., Mariotti-Ferrandiz M.E., Wang Y., Malissen B., Waldmann H., Hori S. Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA 2009, 106:1903-1908.
57. Kopf M., Ruedl C., Schmitz N., Gallimore A., Lefrang K., Ecabert B., Odermatt B., Bachmann M.F. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 1999, 11:699-708.
58. Kretschmer K., Apostolou I., Hawiger D., Khazaie K., Nussenzweig M.C., von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 2005, 6:1219-1227.
59. Kumanogoh A., Wang X., Lee I., Watanabe C., Kamanaka M., Shi W., Yoshida K., Sato T., Habu S., Itoh M., Sakaguchi N., Sakaguchi S., et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development. J. Immunol. 2001, 166:353-360.
60. Kunitomi A., Hori T., Imura A., Uchiyama T. Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system. J. Leukoc. Biol. 2000, 68:111-118.
61. Lenschow D.J., Walunas T.L., Bluestone J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996, 14:233-258.
62. Linton P.J., Bautista B., Biederman E., Bradley E.S., Harbertson J., Kondrack R.M., Padrick R.C., Bradley L.M. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J. Exp. Med. 2003, 197:875-883.
63. Liu Y.J. TSLP in epithelial cell and dendritic cell cross talk. Adv. Immunol. 2009, 101:1-25.
64. Liu H., Komai-Koma M., Xu D., Liew F.Y. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2006, 103:7048-7053.
65. Liu V.C., Wong L.Y., Jang T., Shah A.H., Park I., Yang X., Zhang Q., Lonning S., Teicher B.A., Lee C. Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: Role of tumor-derived TGF-beta. J. Immunol. 2007, 178:2883-2892.
66. Liyanage U.K., Moore T.T., Joo H.G., Tanaka Y., Herrmann V., Doherty G., Drebin J.A., Strasberg S.M., Eberlein T.J., Goedegebuure P.S., Linehan D.C. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 2002, 169:2756-2761.
67. Luo X., Tarbell K.V., Yang H., Pothoven K., Bailey S.L., Ding R., Steinman R.M., Suthanthiran M. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2007, 104:2821-2826.
68. Marschner A., Rothenfusser S., Hornung V., Prell D., Krug A., Kerkmann M., Wellisch D., Poeck H., Greinacher A., Giese T., Endres S., Hartmann G. CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur. J. Immunol. 2005, 35:2347-2357.
69. Mashimo Y., Suzuki Y., Hatori K., Tabara Y., Miki T., Tokunaga K., Katsuya T., Ogihara T., Yamada M., Takahashi N., Makita Y., Nakayama T., et al. Association of TNFRSF4 gene polymorphisms with essential hypertension. J. Hypertens. 2008, 26:902-913.
70. Masopust D., Vezys V., Marzo A.L., Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 2001, 291:2413-2417.
71. Matsumura Y., Hori T., Kawamata S., Imura A., Uchiyama T. Intracellular signaling of gp34, the OX40 ligand: Induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor, OX40. J. Immunol. 1999, 163:3007-3011.
72. Mempel T.R., Henrickson S.E., Von Andrian U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004, 427:154-159.
73. Miller M.J., Safrina O., Parker I., Cahalan M.D. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J. Exp. Med. 2004, 200:847-856.
74. Miura S., Ohtani K., Numata N., Niki M., Ohbo K., Ina Y., Gojobori T., Tanaka Y., Tozawa H., Nakamura M., et al. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol. Cell Biol. 1991, 11:1313-1325.
75. Moon J.J., Chu H.H., Pepper M., McSorley S.J., Jameson S.C., Kedl R.M., Jenkins M.K. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 2007, 27:203-213.
76. Mousavi S.F., Soroosh P., Takahashi T., Yoshikai Y., Shen H., Lefrancois L., Borst J., Sugamura K., Ishii N. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J. Immunol. 2008, 181:5990-6001.
77. Mueller D.L., Jenkins M.K., Schwartz R.H. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 1989, 7:445-480.
78. Murata K., Ishii N., Takano H., Miura S., Ndhlovu L.C., Nose M., Noda T., Sugamura K. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 2000, 191:365-374.
79. Murata K., Nose M., Ndhlovu L.C., Sato T., Sugamura K., Ishii N. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J. Immunol. 2002, 169:4628-4636.
80. Nakae S., Suto H., Iikura M., Kakurai M., Sedgwick J.D., Tsai M., Galli S.J. Mast cells enhance T cell activation: Importance of mast cell costimulatory molecules and secreted TNF. J. Immunol. 2006, 176:2238-2248.
81. Nishioka T., Nishida E., Iida R., Morita A., Shimizu J. In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules. Immunol. Lett. 2008, 121:97-104.
82. Nolte M.A., van Olffen R.W., van Gisbergen K.P., van Lier R.A. Timing and tuning of CD27-CD70 interactions: The impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol. Rev. 2009, 229:216-231.
83. Obar J.J., Khanna K.M., Lefrancois L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity 2008, 28:859-869.
84. Obst R., van Santen H.M., Mathis D., Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J. Exp. Med. 2005, 201:1555-1565.
85. Ohshima Y., Tanaka Y., Tozawa H., Takahashi Y., Maliszewski C., Delespesse G. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 1997, 159:3838-3848.
86. Ohshima Y., Yang L.P., Uchiyama T., Tanaka Y., Baum P., Sergerie M., Hermann P., Delespesse G. OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 1998, 92:3338-3345.
87. Pandiyan P., Zheng L., Ishihara S., Reed J., Lenardo M.J. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat. Immunol. 2007, 8:1353-1362.
88. Piconese S., Valzasina B., Colombo M.P. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 2008, 205:825-839.
89. Piconese S., Gri G., Tripodo C., Musio S., Gorzanelli A., Frossi B., Pedotti R., Pucillo C.E., Colombo M.P. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation. Blood 2009, 114:2639-2648.
90. Pippig S.D., Pena-Rossi C., Long J., Godfrey W.R., Fowell D.J., Reiner S.L., Birkeland M.L., Locksley R.M., Barclay A.N., Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 1999, 163:6520-6529.
91. Reinhardt R.L., Khoruts A., Merica R., Zell T., Jenkins M.K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 2001, 410:101-105.
92. Ria M., Eriksson P., Boquist S., Ericsson C.G., Hamsten A., Lagercrantz J. Human genetic evidence that OX40 is implicated in myocardial infarction. Biochem. Biophys. Res. Commun. 2006, 339:1001-1006.
93. Rogers P.R., Croft M. CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol. 2000, 164:2955-2963.
94. Rogers P.R., Song J., Gramaglia I., Killeen N., Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001, 15:445-455.
95. Ruby C.E., Yates M.A., Hirschhorn-Cymerman D., Chlebeck P., Wolchok J.D., Houghton A.N., Offner H., Weinberg A.D. Cutting edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J. Immunol. 2009, 183:4853-4857.
96. Sabbagh L., Snell L.M., Watts T.H. TNF family ligands define niches for T cell memory. Trends Immunol. 2007, 28:333-339.
97. Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
98. Salek-Ardakani S., Croft M. Regulation of CD4 T cell memory by OX40 (CD134). Vaccine 2006, 24:872-883.
99. Salek-Ardakani S., Song J., Halteman B.S., Jember A.G., Akiba H., Yagita H., Croft M. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J. Exp. Med. 2003, 198:315-324.
100. Salek-Ardakani S., Moutaftsi M., Crotty S., Sette A., Croft M. OX40 drives protective vaccinia virus-specific CD8 T cells. J. Immunol. 2008, 181:7969-7976.
101. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401:708-712.
102. Sarkar S., Teichgraber V., Kalia V., Polley A., Masopust D., Harrington L.E., Ahmed R., Wherry E.J. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J. Immunol. 2007, 179:6704-6714.
103. Sato T., Ishii N., Murata K., Kikuchi K., Nakagawa S., Ndhlovu L.C., Sugamura K. Consequences of OX40-OX40 ligand interactions in langerhans cell function: Enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur. J. Immunol. 2002, 32:3326-3335.
104. Scheffold A., Huhn J., Hofer T. Regulation of CD4+CD25+ regulatory T cell activity: It takes (IL-)two to tango. Eur. J. Immunol. 2005, 35:1336-1341.
105. Seder R.A., Ahmed R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 2003, 4:835-842.
106. Setoguchi R., Hori S., Takahashi T., Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 2005, 201:723-735.
107. Shakhar G., Lindquist R.L., Skokos D., Dudziak D., Huang J.H., Nussenzweig M.C., Dustin M.L. Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat. Immunol. 2005, 6:707-714.
108. Sharpe A.H., Freeman G.J. The B7-CD28 superfamily. Nat. Rev. Immunol. 2002, 2:116-126.
109. Shevach E.M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
110. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 2002, 3:135-142.
111. So T., Croft M. Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells. J. Immunol. 2007, 179:1427-1430.
112. Song J., Salek-Ardakani S., Rogers P.R., Cheng M., Van Parijs L., Croft M. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 2004, 5:150-158.
113. Song J., So T., Cheng M., Tang X., Croft M. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 2005, 22:621-631.
114. Soroosh P., Ine S., Sugamura K., Ishii N. OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J. Immunol. 2006, 176:5975-5987.
115. Soroosh P., Ine S., Sugamura K., Ishii N. Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. J. Immunol. 2007, 179:5014-5023.
116. Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Homey B., Gilliet M., Ho S., Antonenko S., Lauerma A., Smith K., Gorman D., et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 2002, 3:673-680.
117. Stephens G.L., McHugh R.S., Whitters M.J., Young D.A., Luxenberg D., Carreno B.M., Collins M., Shevach E.M. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J. Immunol. 2004, 173:5008-5020.
118. Stuber E., Neurath M., Calderhead D., Fell H.P., Strober W. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 1995, 2:507-521.
119. Sugamura K., Ishii N., Weinberg A.D. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat. Rev. Immunol. 2004, 4:420-431.
120. Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity 2008, 29:848-862.
121. Takahashi T., Kuniyasu Y., Toda M., Sakaguchi N., Itoh M., Iwata M., Shimizu J., Sakaguchi S. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998, 10:1969-1980.
122. Takahashi T., Tagami T., Yamazaki S., Uede T., Shimizu J., Sakaguchi N., Mak T.W., Sakaguchi S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000, 192:303-310.
123. Takeda I., Ine S., Killeen N., Ndhlovu L.C., Murata K., Satomi S., Sugamura K., Ishii N. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J. Immunol. 2004, 172:3580-3589.
124. Tanaka Y., Inoi T., Tozawa H., Yamamoto N., Hinuma Y. A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I). Int. J. Cancer 1985, 36:549-555.
125. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998, 188:287-296.
126. Tsuji M., Komatsu N., Kawamoto S., Suzuki K., Kanagawa O., Honjo T., Hori S., Fagarasan S. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 2009, 323:1488-1492.
127. Valzasina B., Guiducci C., Dislich H., Killeen N., Weinberg A.D., Colombo M.P. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR. Blood 2005, 105:2845-2851.
128. Valzasina B., Piconese S., Guiducci C., Colombo M.P. Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent. Cancer Res. 2006, 66:4488-4495.
129. van Wanrooij E.J., van Puijvelde G.H., de Vos P., Yagita H., van Berkel T.J., Kuiper J. Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27:204-210.
130. Vu M.D., Xiao X., Gao W., Degauque N., Chen M., Kroemer A., Killeen N., Ishii N., Chang Li X. OX40 costimulation turns off Foxp3+ Tregs. Blood 2007, 110:2501-2510.
131. Wang X., Ria M., Kelmenson P.M., Eriksson P., Higgins D.C., Samnegard A., Petros C., Rollins J., Bennet A.M., Wiman B., de Faire U., Wennberg C., et al. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat. Genet. 2005, 37:365-372.
132. Wang Y.H., Ito T., Homey B., Watanabe N., Martin R., Barnes C.J., McIntyre B.W., Gilliet M., Kumar R., Yao Z., Liu Y.J. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006, 24:827-838.
133. Wang L., Pino-Lagos K., de Vries V.C., Guleria I., Sayegh M.H., Noelle R.J. Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2008, 105:9331-9336.
134. Wang C., Lin G.H., McPherson A.J., Watts T.H. Immune regulation by 4-1BB and 4-1BBL: Complexities and challenges. Immunol. Rev. 2009, 229:192-215.
135. Weinberg A.D., Wallin J.J., Jones R.E., Sullivan T.J., Bourdette D.N., Vandenbark A.A., Offner H. Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J. Immunol. 1994, 152:4712-4721.
136. Weinberg A.D., Bourdette D.N., Sullivan T.J., Lemon M., Wallin J.J., Maziarz R., Davey M., Palida F., Godfrey W., Engleman E., Fulton R.J., Offner H., et al. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 1996, 2:183-189.
137. Weinberg A.D., Wegmann K.W., Funatake C., Whitham R.H. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 1999, 162:1818-1826.
138. Whitmire J.K., Ahmed R. The economy of T-cell memory: CD4+ recession in times of CD8+ stability?. Nat. Med. 2001, 7:892-893.
139. Wolf A.M., Wolf D., Steurer M., Gastl G., Gunsilius E., Grubeck-Loebenstein B. Increase of regulatory T cells in the peripheral blood of cancer patients. Clin. Cancer Res. 2003, 9:606-612.
140. Woo E.Y., Chu C.S., Goletz T.J., Schlienger K., Yeh H., Coukos G., Rubin S.C., Kaiser L.R., June C.H. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 2001, 61:4766-4772.
141. Xiao X., Kroemer A., Gao W., Ishii N., Demirci G., Li X.C. OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J. Immunol. 2008, 181:3193-3201.
142. Zaini J., Andarini S., Tahara M., Saijo Y., Ishii N., Kawakami K., Taniguchi M., Sugamura K., Nukiwa T., Kikuchi T. OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J. Clin. Invest. 2007, 117:3330-3338.
143. Zhou G., Levitsky H.I. Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance. J. Immunol. 2007, 178:2155-2162.
144. Zhou X., Bailey-Bucktrout S.L., Jeker L.T., Penaranda C., Martinez-Llordella M., Ashby M., Nakayama M., Rosenthal W., Bluestone J.A. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 2009, 10:1000-1007.
145. Zingoni A., Sornasse T., Cocks B.G., Tanaka Y., Santoni A., Lanier L.L. Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. J. Immunol. 2004, 173:3716-3724.