OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

Immunity

Volumn 15, Issue 3, 2001, Pages 445-455

  Rogers, Paul R ^a   Song, Jianxun ^a   Gramaglia, Irene ^a   Killeen, Nigel ^b   Croft, Michael ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CD28 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2; LIGAND; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN OX40; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DIVISION; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSDUCTION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REACTION TIME; RETROVIRUS; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0034812971     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00191-1     Document Type: Article

References (67)

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2. Phosphatidylinositol 3-kinase and NF-κ B/Rel are at the divergence of CD40-mediated proliferation and survival pathways
3. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB
4. Signaling through OX40 (CD134) breaks peripheral T cell tolerance
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23. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
24. IκB kinases serve as a target of CD28 signaling
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27. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
28. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
29. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-κB activation
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33. The origin and mechanism of the allograft reaction
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39. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion
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53. CD28, OX40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen
54. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors
55. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
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