CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen

Journal of Immunology

Volumn 164, Issue 6, 2000, Pages 2955-2963

  Rogers, Paul R ^a   Croft, Michael ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MODEL; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

EID: 0034654529     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.6.2955     Document Type: Article

References (50)

1. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680.
2. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
3. Kersh, G. J., E. N. Kersh, D. H. Fremont, and P. M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9:817.
4. Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285:221.
5. Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89.
6. Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82.
7. Rogers, P. R., H. M. Grey, and M. Croft. 1998. Modulation of naive CD4 T cell activation with altered peptide ligands: the nature of the peptidc and presentation in the context of costimulation are critical for a sustained response. J. Immunol. 160:3698.
8. Gramaglia, I., A. D. Weinberg, M. Lemon, and M. Croft. 1998. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161:6510.
9. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
10. Rogers, P. R., and M. Croft. 1999. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J. Immunol. 163:1205.
11. Kumar, V., V. Bhardwaj, L. Soares, J. Alexander, A. Sette, and B. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
12. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
13. Schountz, T., J. P. Kasselman, F. A. Martinson, L. Brown, and J. S. Murray. 1996. MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo. J. Immunol. 157:3893.
14. 2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485.
15. + T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4237.
16. Grakoui, A., D. L. Donermeyer, O. Kanagawa, K. M. Murphy, and P. M. Allen. 1999. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization. J. Immunol. 162:1923.
17. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X. Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
18. Ranger, A. M., M. P. Das, V. K. Kuchroo, and L. H. Glimcher. 1996. B7-2 (CD86) is essential for the development of IL-4-producing T cells. Int. Immunol. 8:1549.
19. Rulifson, I. C., A. I. Sperling, P. E. Fields, F. W. Fitch, and J. A. Bluestone. 1997. CD28 costimulation promotes the production of Th2 cytokines. J. Immunol. 158: 658.
20. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28 -B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
21. Brown, D. R., N. H. Moskowitz, N. Killeen, and S. L. Reiner. 1997. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186:101.
22. Fowell, D. J., J. Magram, C. W. Turck, N. Killeen, and R. M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity 6:559.
23. Flynn, S., K. M. Toellner, C. Raykundalia, M. Goodall, and P. Lane. 1998. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, blr-1. J. Exp. Med. 188:297.
24. + T cells into high IL-4-producing effectors. Blood 92:3338.
25. Salomon, B., and J. A. Bluestone. 1998. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J. Immunol. 161:5138.
26. Luksch, C. R., O. Winqvist, M. E. Ozaki, L. Karlsson, M. R. Jackson, P. A. Peterson, and S. R. Webb. 1999. Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc. Natl. Acad. Sci. USA 96:3023.
27. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
28. + T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med 176:1431.
29. Jaiswal, A. I., and M. Croft. 1997. CD40 ligand induction on T cell subsets by peptide-presenting B cells: implications for development of the primary T and B cell response. J. Immunol. 159:2282.
30. Croft, M., S. B. Joseph, and K. T. Miner. 1997. Partial activation of naive CD4 T cells and tolerance induction in response to peptide presenled by resting B cells. J. Immunol. 159:3257.
31. -) to TCR/CD8 signaling in response to antigen. J. Immunol. 160:3236.
32. + T cells via signal 1 alone. J. Immunol. 161:5226.
33. Croft, M., and C. Dubey. 1997. Accessory molecule and costimulation requirements for CD4 T cell response. Crit. Rev. Immunol. 17:89.
34. Bachmann, M. F., K. McKall-Faienza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7:549.
35. Hampl, J., Y. H. Chien, and M. M. Davis. 1997. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7:379.
36. Viola, A., M. Salio, L. Tuoslo, S. Linkert, O. Acuto, and A. Lanzavecchia. 1997. Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J. Exp. Med. 186:1775.
37. Madrenas, J., L. A. Chau, J. Smith, J. A. Bluestone, and R. N. Germain. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/ partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185: 219.
38. Rudd, C. E. 1996. Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity 4:527.
39. Berridge, M. J. 1997. Lymphocyte activation in health and disease. Crit. Rev. Immunol. 17:155.
40. 2-Integrin LFA-1 signaling through phospholipase C-γ1 activation. Proc. Natl. Acad. Sci. USA 90:7099.
41. Ni, H. T., M. J. Deeths, W. Li, D. L. Mueller, and M. F. Mescher. 1991. Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation. J. Immunol. 162:5183.
42. Arch, R. H., and C. B. Thompson. 1998. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB. Mol. Cell. Biol. 18:558.
43. Lin, X., E. T. Cunningham, Jr., Y. Mu, R. Geleziunas, and W. C. Greene. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271.
44. Croft, M., and S. L. Swain. 1995. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J. Immunol. 154:4269.
45. Bradley, L. M., D. K. Dalton, and M. Croft. 1996. A direct role for IFN-γ in regulation of Th1 cell development. J. Immunol. 157:1350.
46. Demeure, C. E., L. P. Yang, D. G. Byun, H. Ishihara, N. Vezzio, and G. Delespesse. 1995. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur. J. Immunol. 25:2722.
47. + T cell differentiation. J. Immunol. 159:5956.
48. Kamogawa, Y., L. A. Minasi, S. R. Carding, K. Bottomly, and R. A. Flavell. 1993. The relationship of IL-4- and IFN γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75:985.
49. lck tyrosine kinase activation in Th subset differentiation. Int. Immunol. 10:577.
50. Yamashita, M., M. Kimura, M. Kubo, C. Shimizu, T. Tada, R. M. Perlmutter, and T. Nakayama. 1999. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. USA 96:1024.