The costimulation-regulated duration of PKB activation controls T cell longevity

Nature Immunology

Volumn 5, Issue 2, 2004, Pages 150-158

  Song, Jianxun ^a   Salek Ardakani, Shahram ^a   Rogers, Paul R ^a   Cheng, Mary ^a   Van Parijs, Luk ^a,b   Croft, Michael ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD4 ANTIGEN; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CELL DIVISION; CELL SURVIVAL; INFLAMMATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 1142263117     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1030     Document Type: Article

References (48)

1. Weiss, A., Shields, R., Newton, M., Manger, B. & Imboden, J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J. Immunol. 138, 2169-2176 (1987).
2. Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8, 89-95 (1998).
3. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423-429 (2001).
4. Croft, M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3, 609-620 (2003).
5. Gramaglia, I. et al. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 165, 3043-3050 (2000).
6. L and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15, 445-455 (2001).
7. Cooper, D., Bansal-Pakala, P. & Croft, M. 41BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur. J. Immunol. 32, 521-529 (2002).
8. L. Immunity 3, 87-98 (1995).
9. L restores cell survival, but not proliferation or effector differentiation, in CD28-deficient T lymphocytes. J. Exp. Med. 191, 2031-2038 (2000).
10. Van Parijs, L. et al. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11, 281-288 (1999).
11. Salek-Ardakani, S. et al. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J. Exp. Med. 198, 315-324 (2003).
12. Gramaglia, I., Weinberg, A.D., Lemon, M. & Croft, M. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161, 6510-6517 (1998).
13. Ohshima, Y. et al. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159, 3838-3848 (1997).
14. Dudek, H. et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665 (1997).
15. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689 (1997).
16. Parsons, M.J. et al. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. J. Immunol. 167, 42-48 (2001).
17. L levels in vivo. J. Exp. Med. 191, 1721-1734 (2000).
18. Rathmell, J.C., Elstrom, R.L., Cinalli, R.M. & Thompson, C.B. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur. J. Immunol. 33, 2223-2232 (2003).
19. Parry, R.V. et al. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur. J. Immunol. 27, 2495-2501 (1997).
20. H2 cytokines. Nat. Immunol. 2, 37-44 (2001).
21. Jones, R.G. et al. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J. Exp. Med. 196, 335-348 (2002).
22. Ahmed, N.N., Grimes, H.L., Bellacosa, A., Chan, T.O. & Tsichlis, P.N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94, 3627-3632 (1997).
23. Kelly, E., Won, A., Refaeli, Y. & Van Parijs, L. IL-2 and related cytokines can promote T cell survival by activating AKT. J. Immunol. 168, 597-603 (2002).
24. Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M. & Hemmings, B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789 (1995).
25. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
26. Franke, T.F., Kaplan, D.R., Cantley, L.C. & Toker, A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-668 (1997).
27. Songyang, Z., Baltimore, D., Cantley, L.C., Kaplan, D.R. & Franke, T.F. Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. USA 94, 11345-11350 (1997).
28. Jember, A.G., Zuberi, R., Liu, F.T. & Croft, M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 193, 387-392 (2001).
29. Gunzer, M. et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13, 323-332 (2000).
30. Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869-1873 (2002).
31. Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002).
32. Linton, P.J. et al. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J. Exp. Med. 197, 875-883 (2003).
33. +CD3- accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Immunity 18, 643-654 (2003).
34. h cells and regulates their responses. Int. Immunol. 14, 555-566 (2002).
35. Pugazhenthi, S. et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275, 10761-10766 (2000).
36. Burgering, B.M. & Kops, G.J. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci, 27, 352-360 (2002).
37. Pap, M. & Cooper, G.M, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 273, 19929-19932 (1998).
38. Datta, S.R., Brunet, A. & Greenberg, M.E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
39. Stahl, M. et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 168, 5024-5031 (2002).
40. Dijkers, P.F. et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156, 531-542 (2002).
41. Datta, S.R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
42. Plas, D.R., Talapatra, S., Edinger, A.L., Rathmell, J.C. & Thompson, C.B. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276, 12041-12048 (2001).
43. Frauwirth, K.A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002).
44. + T cells in vivo by IL-15. Immunity 8, 591-599 (1998).
45. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426-432 (2000).
46. + memory T cells by opposing cytokines. Science 288, 675-678 (2000).
47. Seddon, B., Tomlinson, P. & Zamoyska, R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4, 680-686 (2003).
48. Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34-40 (1998).