Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Immunity

Volumn 30, Issue 5, 2009, Pages 636-645

  Shevach, Ethan M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOLYSIS; DENDRITIC CELL; HUMAN; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MAST CELL; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; FIBRINOGEN; FORKHEAD TRANSCRIPTION FACTORS; GALECTIN 1; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2; MICE; NEUROPILINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 65549136983     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.04.010     Document Type: Review

References (67)

1. + regulatory T cells confer infectious tolerance in a TGF-β-dependent manner. J. Exp. Med. 205 (2008) 1975-1981
2. + regulatory T cells do not constitutively express IL-35. J. Immunol. 181 (2008) 6898-6905
3. Belkaid Y. Regulatory T cells and infection: A dangerous necessity. Nat. Rev. Immunol. 7 (2007) 875-888
4. + Treg cells: Hydrolysis of extracellular ATP and immune suppression. Blood 110 (2007) 1225-1232
5. Cao X., Cai S.F., Fehniger T.A., Song J., Collins L.I., Piwnica D.R., and Ley T.J. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 27 (2007) 635-646
6. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
7. Chen M.-L., Pittet M.J., Gorelik L., Flavell R.A., Weissleder R., von Boehmer H., and Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc. Natl. Acad. Sci. USA 102 (2005) 419-424
8. Collison L.W., Workman C.J., Kuo T.T., Boyd K., Vignali K.M., Cross R., Sehy D., Blumberg R.S., and Vignali D.A.A. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450 (2007) 566-571
9. + T regulatory cells. J. Immunol. 175 (2005) 8051-8059
10. Deaglio S., Dwyer K.M., Gao W., Friedman D., Asheva A., Erat A., Chen J.-F., Enjypoji E., Linden J., Oukka M., et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204 (2007) 1257-1265
11. + T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J. Immunol. 175 (2005) 7135-7142
12. + regulatory T cells prevent autoimmunty by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 179 (2007) 4685-4693
13. + regulatory T cells. J. Exp. Med. 201 (2005) 737-746
14. + T cells. Blood 109 (2007) 2058-2065
15. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174 (2005) 1783-1786
16. + regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interactions. Immunity 29 (2008) 771-781
17. Grohmann U., Orabona C., Fallarino F., Vacca C., Calcinaro F., Falorni A., Candeloro P., Belladona M.L., Bianchi R., Fiorettie M.C., et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3 (2002) 1097-1101
18. Grossman W.J., Verbsky J.W., Barchet W., Colonna M., Atkinson J.P., and Ley T.J. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21 (2004) 589-601
19. Joly E., and Hudriser D. What is trogocytosis and what is its purpose?. Nat. Immunol. 4 (2003) 815-816
20. Klein L., Khazaie K., and von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100 (2003) 8886-8891
21. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169 (2002) 4712-4716
22. + regulatory T cells: Proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 110 (2007) 1550-1558
23. Li M.O., Wan Y.S.Y., and Flavell R.A. T cell-produced transforming growth factor-beta 1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26 (2007) 579-591
24. Liang B.T., Workman C., Lee J., Chew C., Dale B.M., Colonna L., Flores M., Li N.Y., Schweighoffer E., Greenberg S., et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J. Immunol. 180 (2008) 5916-5926
25. + regulatory T cells. Proc. Natl. Acad. Sci. USA 103 (2006) 7048-7053
26. + regulatory T cells. Nat. Immunol. 6 (2008) 632-640
27. +regulatory T cells independent of autocrine TGF-β1. Blood 103 (2002) 4594-4601
28. + regulatory T cells. J. Exp. Med. 201 (2005) 1061-1067
29. - precursor cells in the absence of interleukin 10. Nat. Immunol. 8 (2007) 931-941
30. + regulatory T cells within the central nervous system. J. Immunol. 175 (2005) 3025-3032
31. Mempel T.R., Pittet M.J., Khazaie K., Weninger W., Weissleder R., von Boehmer H., and von Adrian U.H. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25 (2006) 129-141
32. + T cells restrain the maturation and antigen-presenting function of dendritic cells. J. Immunol. 172 (2004) 4676-4680
33. + T cells is mediated by cell surface-bound transforming growth factor-β. J. Exp. Med. 194 (2001) 629-644
34. + regulatory T cells: Independence of IL-2 consumption, TGF-β, and various inhibitors of TCR signaling. J. Immunol. 179 (2007) 3578-3587
35. + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 105 (2008) 10113-10118
36. + T cells. Nat. Immunol. 8 (2007) 1353-1362
37. + T cell-mediated suppression by dendritic cells. Science 299 (2003) 1033-1036
38. Paust S., and Cantor H. Regulatory T cells and autoimmune disease. Immunol. Rev. 204 (2005) 195-207
39. Pesu M., Watford W.T., Wei L., Xu L.L., Fuss I., Strober W., Andersson J., Shevach E.M., Quezado M., Bouladoux N., et al. T cell expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 455 (2008) 246-251
40. + immunoregulatory cells. J. Immunol. 167 (2002) 1137-1140
41. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor-β1 production and responsiveness. J. Exp. Med. 196 (2002) 1-10
42. Piconese S., Valzasina B., and Colombo M.P. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205 (2008) 825-839
43. Qureshi O.S., Zheng Y., Manzotti C.N., Walker L.S., and Samsom D.M. Regulatory T cells use CRTLA-4 to remove CD86 from the surface of dendritic cells. Immunology 125 Supplement (2008) 99
44. + regulatory T cells abrogates their function in vivo. J. Immunol. 177 (2006) 4376-4383
45. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J. Immunol. 155 (1995) 1151-1164
46. + regulatory T cells in the regional lymph node. J. Exp. Med. 202 (2005) 771-782
47. Sarris M., Anderson K.G., Randow F., Mayr L., and Betz A.G. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 28 (2008) 402-413
48. + cells controlling pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression and tissue invasion. J. Immunol. 5 (2004) 2942-2951
49. + T cells. Immunity 19 (2003) 877-889
50. Shalev I., Liu H., Koscik C., Bartczak A., Javadi M., Wong K.M., Maknojia A., He W., Liu M.F., Diao J., et al. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J. Immunol. 180 (2008) 249-260
51. Sutmuller R.P., Morgan M.E., Netea M.G., Grauer O., and Adema G.J. Toll-like receptors on regulatory T cells: Expanding immune regulation. Trends Immunol. 27 (2006) 387-393
52. Shevach E.M., and Stephens G.L. The GITR-GITRL interaction: Costimulation or contrasuppression of regulatory activity. Nat. Rev. Immunol. 6 (2006) 613-618
53. + T cells and dendritic cells in vivo. J. Exp. Med. 203 (2006) 505-511
54. + naturally anergic and autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10 (1998) 1969-1980
55. Tang Q., Adams J.Y., Tooley A.J., Bi M.Y., Fife B.T., Serra P., Santamaria P., Locksley R.M., Krummel M.F., and Bluestone J.A. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7 (2006) 83-92
56. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188 (1998) 287-296
57. + immunoregulatory T cells is antigen-nonspecific. J. Immunol. 164 (2000) 183-190
58. + T cell suppressor function. J. Immunol. 172 (2004) 6519-6523
59. + T cell suppressor function. Eur. J. Immunol. 34 (2004) 366-376
60. + regulatory T cells allows for their purification from expansion cultures. Blood (2009) 10.1182/blood-2009-01-199950 in press. Published online March 18, 2009
61. + regulatory T cell suppressor function. J. Immunol. 182 (2009) 2929-2938
62. + T cells during cure of colitis. J. Immunol. 177 (2006) 5852-5860
63. + regulatory T cells in vivo. J. Exp. Med. 198 (2003) 249-258
64. + regulatory cell function. Science 322 (2008) 271-275
65. + T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR. Blood 105 (2005) 2845-2851
66. Yu A.X., Zhu L.J., Altman N.H., and Malek T.R. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. (2009). Immunity 30 (2009) 204-217
67. + regulatory T cells selectively kill B lymphocytes. Blood 107 (2006) 3925-3932