Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases

Journal of Immunology

Volumn 169, Issue 8, 2002, Pages 4628-4636

  Murata, Kazuko ^a   Nose, Masato ^a   Ndhlovu, Lishomwa C ^a   Sato, Takayuki ^a   Sugamura, Kazuo ^a   Ishii, Naoto ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; DNA ANTIBODY; HEMOCYANIN; LIGAND; OX40 LIGAND; RAG2 PROTEIN; SUPERANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENTERITIS; FEMALE; IMMUNIZATION; IMMUNOREGULATION; INFLAMMATORY DISEASE; INTERSTITIAL PNEUMONIA; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0037108529     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.8.4628     Document Type: Article

References (57)

1. Janeway, C. A., Jr., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
2. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
3. Chambers, C. A. 2001. The expanding world of co-stimulation: the two-signal model revisited. Trends Immunol. 22:217.
4. Coyle, A. J., and J. C. Gutierrez-Ramos. 2001. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2:203.
5. Mauri, D. N., R. Ebner, R. I. Montgomery, K. D. Kochel, T. C. Cheung, G. L. Yu, S. Ruben, M. Murphy, R. J. Eisenberg, G. H. Cohen, et al. 1998. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpes-virus entry mediator. Immunity 8:21.
6. Watts, T. H., and M. A. DeBenedette. 1999. T cell co-stimulatory molecules other than CD28. Curr. Opin. Immunol. 11:286.
7. Miura, S., K. Ohtani, N. Numata, M. Niki, K. Ohbo, Y. Ina, T. Gojobori, Y. Tanaka, H. Tozawa, M. Nakamura, and K. Sugamura. 1991. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol. Cell. Biol. 11:1313.
8. Tanaka, Y., I. Tashiro, H. Tozawa, N. Yamamoto, and Y. Hinuma. 1985. A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T cell leukemia virus type-1 (HTLV-1). Int. J. Cancer 36:549.
9. Baum, P. R., R. B. Gayle III, F. Ramsdell, S. Srinivasan, R. A. Sorensen, M. L. Watson, M. F. Seldin, E. Baker, G. R. Sutherland, K. N. Clifford, et al. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 13:3992.
10. Pippig, S. D., C. Pena-Rossi, J. Long, W. R. Godfrey, D. J. Fowell, S. L. Reiner, M. L. Birkeland, R. M. Locksley, A. N. Barclay, and N. Killeen. 1999. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 163:6520.
11. Takasawa, N., N. Ishii, N. Higashimura, K. Murata, Y. Tanaka, M. Nakamura, T. Sasaki, and K. Sugamura. 2001. Expression of gp34 (OX40 ligand) and OX40 on human T cell clones. Jpn. J. Cancer Res. 92:377.
12. Stüber, E., M. Neurath, D. Calderhead, H. P. Fell, and W. Strober. 1995. Crosslinking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity. 2:507.
13. Stüber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med. 183:979.
14. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159:3838.
15. Brocker, T., A. Gulbranson-Judge, S. Flynn, M. Riedinger, C. Raykundalia, and P. Lane. 1999. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur. J. Immunol. 29:1610.
16. Murata, K., N. Ishii, H. Takano, S. Miura, L. C. Ndhlovu, M. Nose, T. Noda, and K. Sugamura. 2000. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 191:365.
17. Imura, A., T. Hori, K. Imada, T. Ishikawa, Y. Tanaka, M. Maeda, S. Imamura, and T. Uchiyama. 1996. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 183:2185.
18. r detected only on CD4 positive T blasts. Mol. Immunol. 24:1281.
19. Mallett, S., S. Fossum, and A. N. Barclay. 1990. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor. EMBO J. 9:1063.
20. Chen, A. I., A. J. McAdam, J. E. Buhlmann, S. Scott, M. L. Lupher, Jr., E. A. Greenfield, P. R. Baum, W. C. Fanslow, D. M. Calderhead, G. J. Freeman, and A. H. Sharpe. 1999. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 11:689.
21. Maxwell, J. R., A. Weinberg, R. A. Prell, and A. T. Vella. 2000. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J. Immunol. 164:107.
22. Gramaglia, I., A. Jember, S. D. Pippig, A. D. Weinberg, N. Killeen, and M. Croft. 2000. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 165:3043.
23. L and Bcl-2 expression and is essential for long-survival of CD4 T cells. Immunity 15:445.
24. Ndhlovu, L. C., N. Ishii, K. Murata, T. Sato, and K. Sugamura. 2001. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J. Immunol. 167:2991.
25. Bansal-Pakala, P. B., A. G. H. Jember, and M. Croft. 2001. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat. Med. 7:907.
26. Weinberg, A. D., J. J. Wallin, R. E. Jones, T. J. Sullivan, D. N. Bourdette, A. A. Vandenbark, and H. Offner. 1994. Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J. Immunol. 152:4712.
27. Weinberg, A. D., D. N. Bourdette, T. J. Sullivan, M. Lemon, J. J. Wallin, R. Maziarz, M. Davey, F. Palida, W. Godfrey, E. Engleman, et al. 1996. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 2:183.
28. Weinberg, A. D., K. W. Wegmann, C. Funatake, and R. H. Whitham. 1999. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 162:1818.
29. Higgins, L. M., S. A. McDonald, N. Whittle, N. Crockett, J. G. Shields, and T. T. MacDonald. 1999. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel diseases with OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 162:486.
30. Malmström, V., D. Shipton, B. Singh, A. Al-Shamkhani, M. J. Puklavec, A. N. Barclay, and F. Powrie. 2001. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 166:6972.
31. Tittle, T., A. D. Weinberg, C. N. Steinkeler, and R. T. Maziarz. 1997. Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease. Blood 89:4652.
32. Stüber, E., A. Von Freier, D. Marinescu, and U. R. Folsch. 1998. Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease. Gastroenterology 115:1205.
33. +) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation. Blood 98:3162.
34. Aten, J., A. Roos, N. Claessen, E. J. Schilder-Tol, I. J. Ten Berge, and J. J. Weening. 2000. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J. Am. Soc. Nephrol. 11:1426.
35. Yoshioka, T., A. Nakajima, H. Akiba, T. Ishiwata, G. Asano, S. Yoshino, H. Yagita, and K. Okumura. 2000. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur. J. Immunol. 30:2815.
36. Giacomelli, R., A. Passacantando, R. Perricone, I. Parzanese, M. Rascente, G. Minisola, and G. Tonietti. 2001. T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen. Clin. Exp. Rheumatol. 19:2317.
37. 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patient with inflammatory bowel disease. Gut 45:856.
38. Stüber, E., A. Buschenfeld, J. Luttges, A. Von Freier, T. Arendt, and U. R. Folsch. 2000. The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac diseases, Crohn's disease, ulcerative colitis). Eur. J. Clin. Invest. 30:594.
39. Tateyama, M., K. Fujihara, N. Ishii, K. Sugamura, Y. Onodera, and Y. Itoyama. 2002. Expression of OX40 in muscles of polymyositis and granulomatous myopathy. J. Neurol. Sci. 194:29.
40. Onodera, J., T. Nagata, K. Fujihara, M. Ohuchi, N. Ishii, K. Sugamura, and Y. Itoyama. 2000. Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus. Acta Neurol. Scand. 102:236.
41. Tsukada, N., H. Akiba, T. Kobata, Y. Aizawa, H. Yagita, and K. Okumura. 2000. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host diseases in a murine model of allogeneic bone marrow transplantation. Blood 95:2434.
42. Jember, A. G., R. Zuberi, F. T. Liu, and M. Croft. 2001. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 193:387.
43. Garvin, A. M., K. M. Abraham, A. Forbush, A. G. Farr, B. L. Davison, and R. M. Permutter. 1990. Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int. Immunol. 2:173.
44. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245.
45. Russell, J. H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 90:4409.
46. Shultz, L. D., D. R. Coman, B. L. Lyons, C. L. Sidman, and S. Taylor. 1987. Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice. Am. J. Pathol. 127:38.
47. Marrack, P., J. Kappler, and B. L. Kotzin. 2001. Autoimmune disease: why and where it occurs. Nat. Med. 7:899.
48. Goodnow, C. C. 2001. Pathways for self-tolerance and the treatment of autoimmune diseases. Lancet 357:2115.
49. Sharpe, A. H., and G. J. Freeman. 2002. The B7-CD28 superfamily. Nat. Rev. Immunol. 2:116.
50. Van Parijs, L., and A. K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280:243.
51. + T cells into high IL-4-producing effectors. Blood 92:3338.
52. Tanaka, H., C. E. Demeure, M. Rubio, G. Delespesse, and M. Sarfati. 2000. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio. J. Exp. Med. 192:405.
53. Flynn, S., K. M. Toellner, C. Raykundalia, M. Goodall, and P. M. Lane. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 188:297.
54. Arens, R., K. Tesselaar, P. A. Baars, G. M. van Schijndel, J. Hendriks, S. T. Pals, P. Krimpenfort, J. Borst, M. H. van Oers, and R. A. van Lier. 2001. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN γ-mediated B cell depletion. Immunity 15:801.
55. Kikuchi, T., Y. Saijo, T. Sakai, T. Abe, K. Ohnuma, F. Tezuka, H. Terunuma, K. Ogata, and T. Nukiwa. 1996. Human T-cell lymphotropic virus type I (HTLV-I) carrier with clinical manifestations characteristic of diffuse panbronchiolitis. Intern. Med. 35:305.
56. Sugimoto, M., M. Kitaichi, A. Ikeda, S. Nagai, and T. Izumi. 1998. Chronic bronchioloalveolitis associated with human T-cell lymphotrophic virus type I infection. Curr. Opin. Pulm. Med. 4:98.
57. Sugisaki, K., T. Tsuda, T. Kumamoto, and S. Akizuki. 1998. Clinicopathologic characteristics of the lung of patients with human T cell lymphotropic virus type I-associated myelopathy. Am. J. Trop. Med. Hyg. 58:721.