Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance

Journal of Immunology

Volumn 178, Issue 4, 2007, Pages 2155-2162

  Zhou, Gang ^a   Levitsky, Hyam I ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ CD25+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMUS;

EID: 33846913897     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.4.2155     Document Type: Article

References (32)

1. + regulatory T cells in tumor immunity. Curr. Top. Microbiol. Immunol. 293: 287-302.
2. Zou, W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6: 295-307.
3. Curiel, T. J., G. Coukos, L. Zou, X. Alvarez, P. Cheng, P. Mottram, M. Evdemon-Hogan, J. R. Conejo-Garcia, L. Zhang, M. Burow, et al. 2004. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10: 942-949.
4. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163: 5211-5218.
5. Turk, M. J., J. A. Guevara-Patino, G. A. Rizzuto, M. E. Engelhorn, and A. N. Houghton. 2004. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J. Exp. Med. 200: 771-782.
6. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194: 823-832.
7. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3: 253-257.
8. Jonuleit, H., and E. Schmitt. 2003. The regulatory T cell family: distinct subsets and their interrelations. J. Immunol. 171: 6323-6327.
9. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
10. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22: 329-341.
11. + T cell receptors. Immunity 21: 267-277.
12. + regulatory T cells and their ligands: implications for immunotherapy. Immunity 20: 107-118.
13. Vigouroux, S., E. Yvon, E. Biagi, and M. K. Brenner. 2004. Antigen-induced regulatory T cells. Blood 104: 26-33.
14. + regulatory T cells in vivo. J. Exp. Med. 198: 249-258.
15. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
16. Zhou, G., C. G. Drake, and H. I. Levitsky. 2006. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 107: 628-636.
17. Bynoe, M. S., J. T. Evans, C. Viret, and C. A. Janeway, Jr. 2003. Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis. Immunity 19: 317-328.
18. Apostolou, I., and H. Von Boehmer. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199: 1401-1408.
19. Akbari, O., R. H. DeKruyff, and D. T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2: 725-731.
20. Rudensky, A. Y., M. Gavin, and Y. Zheng. 2006. FOXP3 and NFAT: partners in tolerance. Cell 126: 253-256.
21. Levitsky, H. I., J. Montgomery, M. Ahmadzadeh, O. C. K. Staveley, F. Guarnieri, D. L. Longo, and L. W. Kwak. 1996. Immunization with granulocyte-macrophage colony-stimulating factor- transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J. Immunol. 156: 3858-3865.
22. Staveley-O'Carroll, K., E. Sotomayor, J. Montgomery, I. Borrello, L. Hwang, S. Fein, D. Pardoll, and H. Levitsky. 1998. Induction of antigen-specific T cell anergy: an early event in the course of tumor progression. Proc. Natl. Acad. Sci. USA 95: 1178-1183.
23. Kim, R., M. Emi, K. Tanabe, and K. Arihiro. 2006. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res. 66: 5527-5536.
24. Pardoll, D. 2003. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21: 807-839.
25. Zou, W. 2005. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5: 263-274.
26. Sotomayor, E. M., I. Borrello, F. M. Rattis, A. G. Cuenca, J. Abrams, K. Staveley-O'Carroll, and H. I. Levitsky. 2001. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood 98: 1070-1077.
27. Cuenca, A., F. Cheng, H. Wang, J. Brayer, P. Horna, L. Gu, H. Bien, I. M. Borrello, H. I. Levitsky, and E. M. Sotomayor. 2003. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res. 63: 9007-9015.
28. + regulatory T cell proliferation. J. Exp. Med. 202: 919-929.
29. Cobbold, S., and H. Waldmann. 1998. Infectious tolerance. Curr. Opin. Immunol. 10: 518-524.
30. + T helper cells. J. Exp. Med. 196: 255-260.
31. Ochando, J. C., C. Homma, Y. Yang, A. Hidalgo, A. Garin, F. Tacke, V. Angeli, Y. Li, P. Boros, Y. Ding, et al. 2006. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat. Immunol. 7: 652-662.
32. Alpan, O., E. Bachelder, E. Isil, H. Arnheiter, and P. Matzinger. 2004. 'Educated' dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol. 5: 615-622.