메뉴 건너뛰기




Volumn 2, Issue 2, 2002, Pages 116-126

The B7-CD28 superfamily

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BUTYROPHILIN; CD28 ANTIGEN; CD40 LIGAND; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ABATACEPT; ANTIBODY CONJUGATE; APOPTOSIS REGULATORY PROTEIN; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; INDUCIBLE T CELL CO STIMULATOR; INDUCIBLE T-CELL CO-STIMULATOR; LEUKOCYTE ANTIGEN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; PDCD1 PROTEIN, HUMAN; T LYMPHOCYTE ANTIGEN;

EID: 0036484220     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri727     Document Type: Review
Times cited : (1476)

References (118)
  • 1
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • Bretscher, P. & Cohn, M. A theory of self-nonself discrimination. Science 169, 1042-1049 (1970).
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 2
    • 0033524482 scopus 로고    scopus 로고
    • A two-step, two-signal model for the primary activation of precursor helper T cells
    • Bretscher, P. A. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc. Natl Acad. Sci. USA 96, 185-190 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 185-190
    • Bretscher, P.A.1
  • 3
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 4
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104-106 (1996).
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 5
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J., Evavold, B. D. & Allen, P. M. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363, 156-159 (1993).
    • (1993) Nature , vol.363 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 6
  • 8
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7:CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon, B. & Bluestone, J. A. Complexities of CD28/B7:CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 9
    • 0033770215 scopus 로고    scopus 로고
    • CD28, CTLA-4 and their ligands: Who does what and to whom?
    • Sansom, D. M. CD28, CTLA-4 and their ligands: who does what and to whom? Immunology 101, 169-177 (2000).
    • (2000) Immunology , vol.101 , pp. 169-177
    • Sansom, D.M.1
  • 10
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers, C. A., Kuhns, M. S., Egen, J. G. & Allison, J. P. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19, 565-594 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3    Allison, J.P.4
  • 11
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263-266 (1999). Identifies ICOS as a CD28 homologue on activated human T cells and shows that, in conjunction with a TCR signal, ICOS crosslinking upregulates cytokine production, particularly of IL-10 but not of IL-2.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1
  • 12
    • 0032580809 scopus 로고    scopus 로고
    • Prediction of the coding sequence of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
    • Isikawa, K. et al. Prediction of the coding sequence of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5, 169-176 (1998).
    • (1998) DNA Res. , vol.5 , pp. 169-176
    • Isikawa, K.1
  • 13
    • 0033212778 scopus 로고    scopus 로고
    • B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
    • Swallow, M. M., Wallin, J. J. & Sha, W. C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα. Immunity 11, 423-432 (1999).
    • (1999) Immunity , vol.11 , pp. 423-432
    • Swallow, M.M.1    Wallin, J.J.2    Sha, W.C.3
  • 14
    • 0034651694 scopus 로고    scopus 로고
    • Cutting edge: Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
    • Ling, V. et al. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J. Immunol. 164, 1653-1657 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 1653-1657
    • Ling, V.1
  • 15
    • 0033576707 scopus 로고    scopus 로고
    • T-cell co-stimulation through B7RP-1 and ICOS
    • Yoshinaga, S. K. et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402, 827-832 (1999). Identifies a B7 homologue as the ligand for ICOS and shows an important role for the ICOS pathway in regulating T-cell help for antibody production.
    • (1999) Nature , vol.402 , pp. 827-832
    • Yoshinaga, S.K.1
  • 16
    • 0034704760 scopus 로고    scopus 로고
    • LICOS, a primordial costimulatory ligand?
    • Brodie, D. et al. LICOS, a primordial costimulatory ligand? Curr. Biol. 10, 333-336 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 333-336
    • Brodie, D.1
  • 17
    • 0034667688 scopus 로고    scopus 로고
    • Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
    • Wang, S. et al. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 96, 2808-2813 (2000).
    • (2000) Blood , vol.96 , pp. 2808-2813
    • Wang, S.1
  • 18
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida, Y., Agata, Y., Shibahara, K. & Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887-3895 (1992).
    • (1992) EMBO J. , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 19
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1-9 (2000). Identifies a B7 homologue as the receptor for PD-1 and shows that, in conjunction with a TCR signal, this ligand can inhibit T-cell activation and cytokine production.
    • (2000) J. Exp. Med. , vol.192 , pp. 1-9
    • Freeman, G.J.1
  • 20
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion
    • Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nature Med. 5, 1365-1369 (1999). Identifies a B7 homologue, shows that it is expressed on activated T cells and APCs, and reports the stimulation of T-cell proliferation and cytokine production, particularly of IL-10.
    • (1999) Nature Med. , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 21
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman, Y. et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunol. 2, 261-268 (2001). Identifies a B7 homologue as a second receptor for PD-1 and shows expression on activated APCs, some non-lymphoid tissues and breast tumours. Shows inhibition of T-cell activation and cytokine production in an antigen-specific system via recruitment of SHP-2.
    • (2001) Nature Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1
  • 22
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng, S. Y. et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193, 839-846 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 839-846
    • Tseng, S.Y.1
  • 23
    • 0025873393 scopus 로고
    • Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7
    • Freeman, G. J. et al. Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J. Exp. Med. 174, 625-631 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 625-631
    • Freeman, G.J.1
  • 24
    • 0023636171 scopus 로고
    • B7, a B cell restricted antigen which identifies pre-activated B cells
    • Freedman, A. S. et al. B7, a B cell restricted antigen which identifies pre-activated B cells. J. Immunol. 137, 3260-3267 (1987).
    • (1987) J. Immunol. , vol.137 , pp. 3260-3267
    • Freedman, A.S.1
  • 25
    • 0020069605 scopus 로고
    • Lymphoblastoid antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid lines, and Burkitt's lymphomas
    • Yokochi, T., Holly, R. D. & Clark, E. A. Lymphoblastoid antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid lines, and Burkitt's lymphomas. J. Immunol. 128, 823-827 (1982).
    • (1982) J. Immunol. , vol.128 , pp. 823-827
    • Yokochi, T.1    Holly, R.D.2    Clark, E.A.3
  • 26
    • 0027767762 scopus 로고
    • Cloning of B7-2: A CTLA4 counter-receptor that costimulates human T cell proliferation
    • Freeman, G. J. et al. Cloning of B7-2: a CTLA4 counter-receptor that costimulates human T cell proliferation. Science 262, 909-911 (1993).
    • (1993) Science , vol.262 , pp. 909-911
    • Freeman, G.J.1
  • 27
    • 0027360332 scopus 로고
    • Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin-2 production
    • Freeman, G. J. et al. Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin-2 production. J. Exp. Med. 178, 2185-2192 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 2185-2192
    • Freeman, G.J.1
  • 28
    • 0027362823 scopus 로고
    • B70 antigen is a second ligand for CTLA-4 and CD28
    • Azuma, M. et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 386, 76-79 (1993).
    • (1993) Nature , vol.386 , pp. 76-79
    • Azuma, M.1
  • 29
    • 0023514599 scopus 로고
    • Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system
    • Aruffo, A. & Seed, B. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl Acad. Sci. USA 84, 8573-8577 (1987).
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8573-8577
    • Aruffo, A.1    Seed, B.2
  • 30
    • 0025273486 scopus 로고
    • The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression
    • Gross, J. A., St John, T. & Allison, J. P. The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J. Immunol. 144, 3201-3210 (1990).
    • (1990) J. Immunol. , vol.144 , pp. 3201-3210
    • Gross, J.A.1    St. John, T.2    Allison, J.P.3
  • 31
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily - CTLA-4
    • Brunet, J. F. et al. A new member of the immunoglobulin superfamily - CTLA-4. Nature 328, 267-270 (1987).
    • (1987) Nature , vol.328 , pp. 267-270
    • Brunet, J.F.1
  • 32
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • Linsley, P. et al. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174, 561-569 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 561-569
    • Linsley, P.1
  • 33
    • 0027937702 scopus 로고
    • Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    • Peach, R. J. et al. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J. Exp. Med. 180, 2049-2058 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 2049-2058
    • Peach, R.J.1
  • 34
    • 0026486220 scopus 로고
    • Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
    • Linsley, P. S. et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176, 1595-1604 (1992).
    • (1992) J. Exp. Med. , vol.176 , pp. 1595-1604
    • Linsley, P.S.1
  • 35
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors
    • Linsley, P. S. et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors. Immunity 1, 793-801 (1994).
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1
  • 36
    • 0026649765 scopus 로고
    • Identification and distribution of the costimulatory receptor CD28 in the mouse
    • Gross, J., Callas, E. & Allison, J. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149, 380-388 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 380-388
    • Gross, J.1    Callas, E.2    Allison, J.3
  • 37
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA4 and focal localization towards sites of TCR engagement
    • Linsley, P. et al. Intracellular trafficking of CTLA4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.1
  • 38
    • 0028337459 scopus 로고
    • Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
    • Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P. & Hodes, R. J. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180, 631-640 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 631-640
    • Hathcock, K.S.1    Laszlo, G.2    Pucillo, C.3    Linsley, P.4    Hodes, R.J.5
  • 39
    • 0031727486 scopus 로고    scopus 로고
    • The role of B7 costimulation in activation and differentiation of CD4 and CD8 T cells
    • McAdam, A., Schweitzer, A. & Sharpe, A. H. The role of B7 costimulation in activation and differentiation of CD4 and CD8 T cells. Immunol. Rev. 165, 231-247 (1998).
    • (1998) Immunol. Rev. , vol.165 , pp. 231-247
    • McAdam, A.1    Schweitzer, A.2    Sharpe, A.H.3
  • 41
    • 0033534678 scopus 로고    scopus 로고
    • From TCR engagement to T cell activation: A kinetic view of T cell behavior
    • Lanzavecchia, A., Lezzi, G. & Viola, A. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96, 1-4 (1999).
    • (1999) Cell , vol.96 , pp. 1-4
    • Lanzavecchia, A.1    Lezzi, G.2    Viola, A.3
  • 42
    • 0000324490 scopus 로고
    • CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines
    • Thompson, C. B. et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl Acad. Sci. USA 86, 1333-1337 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1333-1337
    • Thompson, C.B.1
  • 43
    • 0029031023 scopus 로고
    • Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response
    • Lucas, P. J. et al. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154, 5757-5768 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5757-5768
    • Lucas, P.J.1
  • 44
    • 0027281691 scopus 로고
    • Differential T cell costimulatory requirements in CD28-deficient mice
    • Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612 (1993).
    • (1993) Science , vol.261 , pp. 609-612
    • Shahinian, A.1
  • 45
    • 0030293443 scopus 로고    scopus 로고
    • CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
    • Sperling, A. I. et al. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J. Immunol. 151, 3909-3917 (1996).
    • (1996) J. Immunol. , vol.151 , pp. 3909-3917
    • Sperling, A.I.1
  • 46
    • 0029163387 scopus 로고
    • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xl
    • Boise, L., Minn, A., Noel, P. & Thompson, C. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xl. Immunity 3, 87-98 (1995).
    • (1995) Immunity , vol.3 , pp. 87-98
    • Boise, L.1    Minn, A.2    Noel, P.3    Thompson, C.4
  • 47
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas, T. L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1
  • 48
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas, T. L., Bakker, C. Y. & Bluestone, J. A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 49
    • 0029120245 scopus 로고
    • CD28 and CTLA4 have opposing effects on the response of T cells to stimulation
    • Krummel, M. & Allison, J. CD28 and CTLA4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-466 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 459-466
    • Krummel, M.1    Allison, J.2
  • 50
    • 0033563271 scopus 로고    scopus 로고
    • CTLA-4 mediates inhibition of early events of T cell proliferation
    • Brunner, M., Chambers, C. & Allison, J. CTLA-4 mediates inhibition of early events of T cell proliferation. J. Immunol. 162, 5813-5820 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5813-5820
    • Brunner, M.1    Chambers, C.2    Allison, J.3
  • 52
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988 (1995).
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 53
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.1
  • 54
    • 0033579816 scopus 로고    scopus 로고
    • B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    • Mandelbrot, D. A., McAdam, A. J. & Sharpe, A. H. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189, 435-440 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 435-440
    • Mandelbrot, D.A.1    McAdam, A.J.2    Sharpe, A.H.3
  • 55
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
    • (1997) Immunity , vol.6 , pp. 411-417
    • Perez, V.1
  • 56
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA4 blockade
    • Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA4 blockade. Science 271, 1734-1736 (1996).
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 57
    • 0030586626 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
    • Perrin, P. J., Maldonado, J. H., Davis, T. A., June, C. H. & Racke, M. K. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157, 1333-1336 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 1333-1336
    • Perrin, P.J.1    Maldonado, J.H.2    Davis, T.A.3    June, C.H.4    Racke, M.K.5
  • 58
    • 0034532630 scopus 로고    scopus 로고
    • The T cell activation molecule H4 and the CD28-like molecule ICOS are identical
    • Buonfiglio, D. et al. The T cell activation molecule H4 and the CD28-like molecule ICOS are identical. Eur. J. Immunol. 30, 3463-3467 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3463-3467
    • Buonfiglio, D.1
  • 59
    • 0034675217 scopus 로고    scopus 로고
    • Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family
    • Tezuka, K. et al. Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family. Biochem. Biophys. Res. Commun. 276, 335-345 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 335-345
    • Tezuka, K.1
  • 60
    • 0034533085 scopus 로고    scopus 로고
    • Induction, binding specificity and function of human ICOS
    • Beier, K. C. et al. Induction, binding specificity and function of human ICOS. Eur. J. Immunol. 30, 3707-3717 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3707-3717
    • Beier, K.C.1
  • 61
    • 0033696961 scopus 로고    scopus 로고
    • The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
    • Coyle, A. J. et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13, 95-105 (2000).
    • (2000) Immunity , vol.13 , pp. 95-105
    • Coyle, A.J.1
  • 63
    • 0033999501 scopus 로고    scopus 로고
    • Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand
    • Mages, H. W. et al. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur. J. Immunol. 30, 1040-1047 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1040-1047
    • Mages, H.W.1
  • 64
    • 0034327808 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Immunol. 165, 5035-5040 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 5035-5040
    • McAdam, A.J.1
  • 65
    • 0034193043 scopus 로고    scopus 로고
    • Characterization of human inducible costimulator ligand expression and function
    • Aicher, A. et al. Characterization of human inducible costimulator ligand expression and function. J. Immunol. 164, 4689-4696 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 4689-4696
    • Aicher, A.1
  • 66
    • 0034600567 scopus 로고    scopus 로고
    • Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
    • H1 models.
    • (2000) J. Exp. Med. , vol.192 , pp. 53-61
    • Kopf, M.1
  • 67
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40 mediated antibody class switching
    • McAdam, A. et al. ICOS is critical for CD40 mediated antibody class switching. Nature 409, 102-105 (2001). Shows a crucial role for ICOS in regulating immunoglobulin isotype class switching and germinal centre formation, by evaluating ICOS-deficient mice (similar to REFS 68,70). Shows that the defects in class switching in ICOS-deficient mice could be overcome by CD40 stimulation, indicating important interactions between these pathways
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.1
  • 68
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T cell activation and function
    • Dong, C. et al. ICOS co-stimulatory receptor is essential for T cell activation and function. Nature 409, 97-101 (2001).
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1
  • 69
    • 0035869525 scopus 로고    scopus 로고
    • Cutting edge: Critical role of inducible costimulator in germinal center reactions
    • Dong, C., Temann, U. A. & Flavell, R. A. Cutting edge: critical role of inducible costimulator in germinal center reactions. J. Immunol. 166, 3659-3662 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3659-3662
    • Dong, C.1    Temann, U.A.2    Flavell, R.A.3
  • 70
    • 0035804269 scopus 로고    scopus 로고
    • ICOS is essential for effective T helper cell responses
    • Tafuri, A. et al. ICOS is essential for effective T helper cell responses. Nature 409, 105-109 (2001).
    • (2001) Nature , vol.409 , pp. 105-109
    • Tafuri, A.1
  • 71
    • 0033809736 scopus 로고    scopus 로고
    • Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS
    • Yoshinaga, S. K. et al. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int. Immunol. 12, 1439-1447 (2000).
    • (2000) Int. Immunol. , vol.12 , pp. 1439-1447
    • Yoshinaga, S.K.1
  • 72
    • 0035824664 scopus 로고    scopus 로고
    • + progenitor cells during differentiation into antigen presenting cells
    • + progenitor cells during differentiation into antigen presenting cells. J. Biol. Chem. 276, 45686-45693 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 45686-45693
    • Richter, G.1
  • 73
    • 0035871758 scopus 로고    scopus 로고
    • ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement
    • Riley, J. L. et al. ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement. J. Immunol. 166, 4943-4948 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 4943-4948
    • Riley, J.L.1
  • 74
    • 0035881247 scopus 로고    scopus 로고
    • H2 differentiation, in a model of allergic airway disease
    • H2 differentiation, in a model of allergic airway disease. J. Immunol. 167, 1996-2003 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1996-2003
    • Tesciuba, A.G.1
  • 75
    • 0034912364 scopus 로고    scopus 로고
    • ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
    • H effector responses.
    • (2001) Nature Immunol. , vol.2 , pp. 597-604
    • Gonzalo, J.A.1
  • 76
    • 0034862368 scopus 로고    scopus 로고
    • Costimulation of memory T-cells by ICOS: A potential therapeutic target for autoimmunity?
    • Sporici, R. A. & Perrin, P. J. Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity? Clin. Immunol. 100, 263-269 (2001).
    • (2001) Clin. Immunol. , vol.100 , pp. 263-269
    • Sporici, R.A.1    Perrin, P.J.2
  • 77
    • 0034872458 scopus 로고    scopus 로고
    • ICOS costimulation: Is it the key to selective immunotherapy?
    • Sperling, A. I. ICOS costimulation: is it the key to selective immunotherapy? Clin. Immunol. 100, 261-262 (2001).
    • (2001) Clin. Immunol. , vol.100 , pp. 261-262
    • Sperling, A.I.1
  • 78
    • 0034917195 scopus 로고    scopus 로고
    • Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    • Ozkaynak, E. et al. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nature Immunol. 2, 591-596 (2001). Identifies a role for ICOS in acute and chronic rejection using cardiac allograft models. Shows that a combination of anti-ICOS antibody and cyclosporin can lead to long-term graft survival.
    • (2001) Nature Immunol. , vol.2 , pp. 591-596
    • Ozkaynak, E.1
  • 79
    • 0033888919 scopus 로고    scopus 로고
    • Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2
    • Furukawa, Y., Mandelbrot, D. A., Libby, P., Sharpe, A. H. & Mitchell, R. N. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am. J. Pathol. 157, 473-484 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 473-484
    • Furukawa, Y.1    Mandelbrot, D.A.2    Libby, P.3    Sharpe, A.H.4    Mitchell, R.N.5
  • 80
    • 0035101515 scopus 로고    scopus 로고
    • CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: Differential role of B7-1 in initiation versus progression of graft arteriosclerosis
    • Kim, K. S. et al. CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis. Am. J. Pathol. 158, 977-986 (2001).
    • (2001) Am. J. Pathol. , vol.158 , pp. 977-986
    • Kim, K.S.1
  • 81
    • 0030936275 scopus 로고    scopus 로고
    • B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    • Borriello, F. et al. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6, 303-313 (1997).
    • (1997) Immunity , vol.6 , pp. 303-313
    • Borriello, F.1
  • 82
    • 0034922160 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
    • Rottman, J. B. et al. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nature Immunol. 2, 605-611 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 605-611
    • Rottman, J.B.1
  • 83
    • 0034870102 scopus 로고    scopus 로고
    • ICOS ligand costimulation is required for T-cell encephalitogenicity
    • H1-mediated disease EAE and that ICOSL blockade after the onset of EAE can ameliorate clinical disease.
    • (2001) Clin. Immunol. , vol.100 , pp. 277-288
    • Sporici, R.A.1
  • 84
    • 0032843342 scopus 로고    scopus 로고
    • Studies in B7-deficient mice reveal a critical role for B7 costimulation in both the initiation and effector phases of EAE
    • Chang, T. C., Jabs, C., Sobel, R. A., Kuchroo, V. K. & Sharpe, A. H. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both the initiation and effector phases of EAE. J. Exp. Med. 190, 733-740 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 733-740
    • Chang, T.C.1    Jabs, C.2    Sobel, R.A.3    Kuchroo, V.K.4    Sharpe, A.H.5
  • 85
    • 0033109039 scopus 로고    scopus 로고
    • Experimental autoimmune meningitis: A novel neurological disease in CD28-deficient mice
    • Perrin, P. J., Lavi, E., Rumbley, C. A., Zekavat, S. A. & Phillips, S. M. Experimental autoimmune meningitis: a novel neurological disease in CD28-deficient mice. Clin. Immunol. 91, 41-49 (1999).
    • (1999) Clin. Immunol. , vol.91 , pp. 41-49
    • Perrin, P.J.1    Lavi, E.2    Rumbley, C.A.3    Zekavat, S.A.4    Phillips, S.M.5
  • 86
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal, B.M., Dwyer, B. K. & Shevach, E. M. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187, 537-546 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 87
    • 0032193696 scopus 로고    scopus 로고
    • IL-10 is is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
    • Bettelli, E. et al. IL-10 is is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161, 3299-3306 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 3299-3306
    • Bettelli, E.1
  • 89
    • 0028081358 scopus 로고
    • Structure and chromosomal localization of the human PD-1 gene (PPCP1)
    • Shinohara, T. Taniwaki, M., Ishida, Y., Kawaichi, M. & Honjo, T. Structure and chromosomal localization of the human PD-1 gene (PPCP1). Genomics 23, 704-706 (1994).
    • (1994) Genomics , vol.23 , pp. 704-706
    • Shinohara, T.1    Taniwaki, M.2    Ishida, Y.3    Kawaichi, M.4    Honjo, T.5
  • 90
    • 0031562690 scopus 로고    scopus 로고
    • Activation-induced expression of human programmed death-1 gene in T-lymphocytes
    • Vibhakar, R., Juan, G., Traganos, F., Darzynkiewicz, Z. & Finger, L. R. Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp. Cell Res. 232, 25-28 (1997).
    • (1997) Exp. Cell Res. , vol.232 , pp. 25-28
    • Vibhakar, R.1    Juan, G.2    Traganos, F.3    Darzynkiewicz, Z.4    Finger, L.R.5
  • 91
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996).
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1
  • 93
    • 0034610980 scopus 로고    scopus 로고
    • Facilitation of β selection and modification of positive selection in the thymus of PD-1 deficient mice
    • Nishimura, H., Honjo, T. & Minato, N. Facilitation of β selection and modification of positive selection in the thymus of PD-1 deficient mice. J. Exp. Med. 191, 891-898 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 891-898
    • Nishimura, H.1    Honjo, T.2    Minato, N.3
  • 94
    • 0034844763 scopus 로고    scopus 로고
    • Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product
    • Bieul, C. C. & Boehm, T. Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur. J. Immunol. 31, 2497-2503 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2497-2503
    • Bieul, C.C.1    Boehm, T.2
  • 95
    • 0036549835 scopus 로고    scopus 로고
    • Expression and regulation of the PD-L1 immuno-inhibitory molecule on microvascular endothelial cells
    • in the press
    • Eppihimer, M. et al. Expression and regulation of the PD-L1 immuno-inhibitory molecule on microvascular endothelial cells. Microcirculation (in the press).
    • Microcirculation
    • Eppihimer, M.1
  • 96
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
    • Nishimura, H., Minato, N., Nakano, T. & Honjo, T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10, 1563-1572 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 97
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • + TCR transgenic mice that escape thymic deletion become activated in the periphery and cause graft-versus-host-like disease.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 98
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice
    • Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice. Science 291, 319-322 (2001).
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1
  • 99
    • 0036207926 scopus 로고    scopus 로고
    • + T cells and is overcome by IL-2
    • in the press
    • + T cells and is overcome by IL-2. Eur. J. Immunol. (in the press).
    • Eur. J. Immunol.
    • Carter, L.L.1
  • 101
    • 0035869569 scopus 로고    scopus 로고
    • B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
    • Tamura, H. et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809-1816 (2001).
    • (2001) Blood , vol.97 , pp. 1809-1816
    • Tamura, H.1
  • 102
    • 0035923535 scopus 로고    scopus 로고
    • PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting Src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    • Okazaki, T., Nishimura, H. & Honjo, T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting Src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA 98, 13866-13871 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13866-13871
    • Okazaki, T.1    Nishimura, H.2    Honjo, T.3
  • 103
    • 0035340798 scopus 로고    scopus 로고
    • CD150 association with either the SH2-containing inositol-phosphate or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A
    • Shlapatska, L. M. et al. CD150 association with either the SH2-containing inositol-phosphate or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A J. Immunol. 166, 5480-5487 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5480-5487
    • Shlapatska, L.M.1
  • 104
    • 5844252552 scopus 로고    scopus 로고
    • B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
    • + T-cell proliferation, IFN-γ production, and CD8 lytic activity.
    • (2001) Nature Immunol. , vol.2 , pp. 269-274
    • Chapoval, A.1
  • 105
    • 0030330828 scopus 로고    scopus 로고
    • Structural organization and mammary-specific expression of the butyrophilin gene
    • Ogg, S. L., Komaragiri, M. V. & Mather, I. H. Structural organization and mammary-specific expression of the butyrophilin gene. Mamm. Genome 7, 900-905 (1996).
    • (1996) Mamm. Genome , vol.7 , pp. 900-905
    • Ogg, S.L.1    Komaragiri, M.V.2    Mather, I.H.3
  • 106
    • 0035251711 scopus 로고    scopus 로고
    • The cluster of BTN genes in the extended major histocompatibility complex
    • Rhodes, D. A., Stammers, M., Malcherek, G., Beck, S. & Trowsdale, J. The cluster of BTN genes in the extended major histocompatibility complex. Genomics 71, 351-362 (2001).
    • (2001) Genomics , vol.71 , pp. 351-362
    • Rhodes, D.A.1    Stammers, M.2    Malcherek, G.3    Beck, S.4    Trowsdale, J.5
  • 107
    • 0034073345 scopus 로고    scopus 로고
    • BTL-II: A polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse
    • Stammers, M., Rowen, L., Rhodes, D., Trowsdale, J. & Beck, S. BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics 51, 373-382 (2000).
    • (2000) Immunogenetics , vol.51 , pp. 373-382
    • Stammers, M.1    Rowen, L.2    Rhodes, D.3    Trowsdale, J.4    Beck, S.5
  • 109
    • 0034132921 scopus 로고    scopus 로고
    • A review and proposed nomenclature for major proteins of the milk-fat globule membrane
    • Mather I. H. A review and proposed nomenclature for major proteins of the milk-fat globule membrane. J. Dairy Sci. 83, 203-247 (2000).
    • (2000) J. Dairy Sci. , vol.83 , pp. 203-247
    • Mather, I.H.1
  • 110
    • 0032512739 scopus 로고    scopus 로고
    • Butyrophilin is expressed in mammary epithelial cells from a single-sized messenger RNA as a type I membrane glycoprotein
    • Banghart, L. R. et al. Butyrophilin is expressed in mammary epithelial cells from a single-sized messenger RNA as a type I membrane glycoprotein. J. Biol. Chem. 273, 4171-4179 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 4171-4179
    • Banghart, L.R.1
  • 111
    • 0033135464 scopus 로고    scopus 로고
    • Protein fold analysis of the B30.2-like domain
    • Seto, M. H., Liu, H. L., Zajchowski, D. A. & Whitlow, M. Protein fold analysis of the B30.2-like domain. Proteins 35, 235-249 (1999).
    • (1999) Proteins , vol.35 , pp. 235-249
    • Seto, M.H.1    Liu, H.L.2    Zajchowski, D.A.3    Whitlow, M.4
  • 112
    • 0028973205 scopus 로고
    • Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane
    • Ishii, T. et al. Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Biochim. Biophys. Acta 1245, 285-292 (1995).
    • (1995) Biochim. Biophys. Acta , vol.1245 , pp. 285-292
    • Ishii, T.1
  • 113
    • 0031697191 scopus 로고    scopus 로고
    • Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants
    • Peterson, J. A. et al. Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants. Pediatr. Res. 44, 499-506 (1998).
    • (1998) Pediatr. Res. , vol.44 , pp. 499-506
    • Peterson, J.A.1
  • 114
    • 0034283668 scopus 로고    scopus 로고
    • Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis
    • Stefferl, A. et al. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J. Immunol. 165, 2859-2865 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 2859-2865
    • Stefferl, A.1
  • 116
    • 0033971597 scopus 로고    scopus 로고
    • Structure and dimerization of a soluble form of B7-1
    • Ikemizu, S. et al. Structure and dimerization of a soluble form of B7-1. Immunity 12, 51-60 (2000).
    • (2000) Immunity , vol.12 , pp. 51-60
    • Ikemizu, S.1
  • 117
    • 0035967157 scopus 로고    scopus 로고
    • Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
    • Schwartz, J. C., Zhang, X., Fedorov, A. A., Nathenson, S. G. & Almo, S. C. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature 410, 604-608 (2001).
    • (2001) Nature , vol.410 , pp. 604-608
    • Schwartz, J.C.1    Zhang, X.2    Fedorov, A.A.3    Nathenson, S.G.4    Almo, S.C.5
  • 118
    • 0035967146 scopus 로고    scopus 로고
    • Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
    • Stamper, C. C. et al. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 410, 608-611 (2001).
    • (2001) Nature , vol.410 , pp. 608-611
    • Stamper, C.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.