OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ tregs

Transplantation

Volumn 85, Issue 11, 2008, Pages 1659-1662

  Chen, Ming ^a,b   Xiao, Xiang ^b   Demirci, Gulcin ^b   Li, Xian Chang ^b,c  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Costimulation; Islets; OX40; Tolerance; Transplantation

Indexed keywords

CD134 ANTIGEN; TRANSCRIPTION FACTOR FOXP3; CD27 ANTIGEN; CD40 LIGAND; FORKHEAD TRANSCRIPTION FACTOR; FOXP4 PROTEIN, MOUSE; MEMBRANE PROTEIN; TNFSF4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ALLOGRAFT; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; DONOR; EFFECTOR CELL; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE FUNCTION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; C3H MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; DBA MOUSE; DISEASE MODEL; DRUG ANTAGONISM; GRAFT SURVIVAL; IMMUNOLOGY; METABOLISM; PANCREAS ISLET TRANSPLANTATION; PATHOLOGY;

ANIMALS; ANTIGENS, CD27; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; ISLETS OF LANGERHANS TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTORS;

EID: 47049086314     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181726987     Document Type: Article

References (10)

1. Croft M. Co-stimulatory members of the TNFR family: Keys to effective T cell immunity? Nat Rev Immunol 2003; 3: 609.
2. Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T cell costimulatory molecule OX40. Nat Rev Immunol 2004; 4:420.
3. Taylor PA, Friedman TM, Korngold R, et al. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002; 99: 4601.
4. Vu MD, Xiao X, Gao W, et al. OX40 costimulation turns off Foxp3+ Tregs. Blood2007; 110: 2501.
5. Quezada SA, Jarvinen LZ, Lind EF, et al. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 2004; 22: 307.
6. Li XC, Roy-Chaudhury P, Hancock WW, et al. IL-2 and IL-4 double knockout mice reject islet allografts: A role for novel T cell growth factors in allograft rejection. J Immunol 1998; 161: 890.
7. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531.
8. + regulatory T Cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875.
9. Bansal-Pakala P, Jember AG, Croft M. Signaling through OX40 (CD134) breaks peripheral T cell tolerance. NatMed2001; 7: 907.
10. Demirci G, Amanullah F, Kewalaramani R, et al. Critical role of OX40 inCD28andCD154independentrejection.JImmunol2004; 172:1691.