OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses

European Journal of Immunology

Volumn 33, Issue 9, 2003, Pages 2372-2381

  Ishii, Naoto ^a   Ndhlovu, Lishomwa C ^a   Murata, Kazuko ^a   Sato, Takayuki ^a   Kamanaka, Masahito ^a   Sugamura, Kazuo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Costimulatory signal; OX40 ligand; Th2 response

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CD134 ANTIGEN; LIGAND;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IN VIVO STUDY; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, DIFFERENTIATION; LEISHMANIA MAJOR; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; TH2 CELLS; TUMOR NECROSIS FACTORS;

EID: 0141539378     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324031     Document Type: Article

References (47)

1. Janeway Jr., C. A. and Bottomly, K., Signals and signs for lymphocyte responses. Cell 1994. 76: 275-285
2. Lenschow, D. J., Walunas, T. L. and Bluestone, J. A., CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996. 14: 233-258.
3. Coyle, A. J. and Gutierrez-Ramos, J. C., The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2001. 2: 203-209.
4. Sharpe, A. H. and Freeman, G. J., The B7-CD28 surperfamily. Nat. Rev. Immunol. 2002. 2: 116-126.
5. Paterson, D. J., Jefferies, W. A., Green, J. R., Brandon, M. R., Corthesy, P., Puklavec, M. and Williams, A. F., Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 1987. 24: 1281-1290.
6. Mallett, S., Fossum, S. and Barclay, A. N., Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes-a molecule related to nerve growth factor receptor. EMBO J. 1990. 9: 1063-1068.
7. Calderhead, D. M., Buhlmann, J. E., Van der Eetwegh, A. J. M., Claasen, E., Noelle, R. J. and Fell, H. P., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B interactions. J. Immunol. 1993. 151: 5261-5271.
8. Baum, P. R., Gayle, R. B., Ramsdell, F., Srinivasan, S., Sorensen, R. A., Watson, M. L., Seldin, M. F., Baker, E., Sutherland, G. R. and Clifford, K. N., Molecular characterization of murine and human OX-40/OX-40 ligand systems: identification of a human OX-40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994. 13: 3992-4001.
9. Miura, S., Ohtani, K., Numata, N., Niki, M., Ohbo, K., Ina, Y., Gojobori, T., Tanaka, Y., Tozawa, H., Nakamura, M. and Sugamura, K., Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T cell leukemia virus type I transactivator p40tax. Mol. Cell. Biol. 1991. 11: 1313-1325.
10. + T cells with homology to tumor necrosis factor. J. Exp. Med. 1994. 180: 757-762.
11. Ohshima, Y., Tanaka, Y., Tozawa, H., Takahashi,, Y. Maliszewiski, C. and Delespesse, G., Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 1997. 159: 3838-3848.
12. Brocker, T., Gulbranson-Judge, A., Flynn, S., Riedinger, M., Raykundalia, C. and Lane, P., CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur. J. Immunol. 1999. 29: 1610-1616.
13. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H. and Okumura, K., CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 1999. 162: 7058-7066.
14. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T. and Sugamura, K., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 2000. 191: 365-374.
15. Chen, A. I., McAdam, A. J., Buhlmann, J. E., Scott, S., Lupher, M. L., Jr., Greenfield, E. A., Baum, P. R., Fanslow, W. C., Calderhead, D. M., Freeman, G. J. and Sharpe, A. H., OX40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 1999. 11: 689-698.
16. Kopf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B. and Bachmann, M. F., OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 1999. 11: 699-708.
17. Gramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N. and Croft, M., The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 2000. 165: 3043-3050.
18. Weinberg, A. D., Bourdette, D. N., Sullivan, T. J., Lemon, M., Wallin, J. J., Maziarz, R., Davey, M., Palida, F., Godfrey, W., Engleman, E., Fulton, R. J., Offner, H. and Vandenbark, A. A., Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 1996. 2: 183-189.
19. Weinberg, A. D., Wegmann, K. W., Funatake, C. and Whitham, R. H., Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 1999. 162: 1818-1826.
20. Malmström, V., Shipton, D., Singh, B., Al-Shamkhani, A., Puklavec, M. J., Barclay, A. N. and Powrie, F., CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 2001. 166: 6972-6981.
21. Higgins, L., McDonald, S. A. C., Whittle, N., Crockett, N., Shields, J. G. and MacDonald, T. T., Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel diseases with OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 1999. 162: 486-493.
22. Stüber, E., von Freier, A., Marinescu, D. and Folsch, U. R., Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease. Gastroenterology 1998. 115:, 1205-1215.
23. Tsukada, N., Akiba, H., Kobata, T., Aizawa, Y., Yagita, H. and Okumura, K., Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood 2000. 95: 2434-2439.
24. Ndhlovu, L. C., Ishii, N., Murata, K., Sato, T. and Sugamura, K., Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J. Immunol. 2001. 167: 2991-2999.
25. Jember, A. G., Zuberi, R., Liu, F. T. and Croft, M., Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 2001. 193: 387-392.
26. Akiba, H., Miyahira, Y., Atsuta, M., Takeda, K., Nohara, C., Futagawa, T., Matsuda, H., Aoki, T., Yagita, H. and Okumura, K., Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 2000. 191: 375-380.
27. Maxwell, J. R., Weinberg, A., Prell, R. A. and Vella, A. T., Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J. Immunol. 2000. 164: 107-112.
28. Rogers, P. R., Song, J., Gramaglia, I., Killeen, N. and Croft, M., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001. 15: 445-455.
29. Murata, K., Nose, M., Ndhlovu, L.C., Sato, T., Sugamura, K. and Ishii, N., Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J. Immunol. 2002. 169: 4628-4636.
30. Flynn, S., Toellner, K-M., Raykundalia, C., Goodall, M. and Lane, P., CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 1998. 188: 297-304.
31. + T cells into high IL-4-producing effectors. Blood 1998. 92: 3338-3345.
32. Tanaka, H., Demeure, C.E., Rubio, M., Delespesse, G. and Sarfati, M., Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio. J. Exp. Med. 2000. 192: 405-412.
33. Rogers, P. R. and Croft, M., CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol. 2000. 164: 2955-2963.
34. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 13: 151-177.
35. Solbach, W. and Laskay, T., The host response to Leishmania infection. Adv. Immunol. 2000. 74: 275-317.
36. Sacks, D. and Noben-Trauth, N., The immunology of susceptibility and resistance to Leishmania major in mice. Nat. Rev. Immunol. 2002. 2: 845-858.
37. Pippig, S. D., Pena-Rossi, C., Long, J., Godfrey, W. R., Fowell, D. J., Reiner, S. L., Birkeland, M. L., Locksley, R. M., Barclay, A. N. and Killeen, N., Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 1999. 163: 6520-6529.
38. Titus, R. G., Marchand, M., Boon, T. and Louis, J. A., A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 1985. 7: 545-555.
39. Weinberg, A. D., Rivera, M., Prell, R., Morris, A., Ramstad, T., Vetto, J. T., Urba, W. J., Alvord, G., Bunce, C. and Shields, J., Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J. Immunol. 2000. 164: 2160-2169.
40. De Smedt, T., Smith, J., Baum, P., Fanslow, W., Butz, E. and Maliszewski, C., Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol. 2002. 168: 661-670.
41. Pulendrart, B., Smith, J. L., Jenkins, M., Schoenborn, M., Maraskovsky, E. and Maliszewski, C. R., Prevention of peripheral tolerance by a dendritic cell growth factor: Flt3 ligand as an adjuvant. J. Exp. Med. 1998. 188: 2075-2982.
42. Sato, T., Ishii, N., Murata, K., Kikuchi, K., Nakagawa, S., Ndhlovu, L.C. and Sugamura, K., Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur. J. Immunol. 2002. 32: 3326-3335.
43. Tang, A., Judge, T. A., Nickoloff, B. J. and Turka, L. A., Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand. J. Immunol. 1996. 157: 117-125.
44. Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., Fernandez-Sueiro, J. L., Balish, E. and Hammer, R. E., The germ-free state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 1994. 180: 2359-2364.
45. Dianda, L., Hanby, A. M., Wright, N. A., Sebesteny, A., Hayday, A. C. and Owen, M. J., T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 1997. 150: 91-97.
46. Ishii, N., Owada, Y., Yamada, M., Miura, S., Murata, K., Asao, H., Kondo, H. and Sugamura, K., Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Mol. Cell. Biol. 2001. 21: 8626-8637.
47. Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimoto, T. and Kikutani, H., Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996. 4: 275-281.