TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

Journal of Experimental Medicine

Volumn 202, Issue 9, 2005, Pages 1213-1223

  Ito, Tomoki ^a   Wang, Yui Hsi ^a   Duramad, Omar ^a,b   Hori, Toshiyuki ^c   Delespesse, Guy J ^d   Watanabe, Norihiko ^a   Qin, F Xiao Feng ^a   Yao, Zhengbin ^e   Cao, Wei ^a   Liu, Yong Jun ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c KYOTO UNIVERSITY   (Japan)

^d NOTRE DAME HOSPITAL   (Canada)

^e Tanox Biosystems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; THYMIC STROMAL LYMPHOPOIETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL POLARITY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

EID: 27744510433     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20051135     Document Type: Article

References (43)

1. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 8:275-283.
2. Mosmann, T.R., and R.L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
3. Borish, L., A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, and S. Wenzel. 1996. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97:1288-1296.
4. Pretolani, M., and M. Goldman. 1997. IL-10: a potential therapy for allergic inflammation? Immunol. Today. 18:277-280.
5. Barnes, P.J. 2001. IL-10: a key regulator of allergic disease. Clin. Exp. Allergy. 31:667-669.
6. Zuany-Amorim, C., S. Haile, D. Leduc, C. Dumarey, M. Huerre, B.B. Vargaftig, and M. Pretolani. 1995. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95:2644-2651.
7. Oh, J.W., C.M. Seroogy, E.H. Meyer, O. Akbari, G. Berry, C.G. Fathman, R.H. Dekruyff, and D.T. Umetsu. 2002. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J. Allergy Clin. Immunol. 110:460-468.
8. Stampfli, M.R., M. Cwiartka, B.U. Gajewska, D. Alvarez, S.A. Ritz, M.D. Inman, Z. Xing, and M. Jordana. 1999. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am. J. Respir. Cell Mol. Biol. 21:586-596.
9. Akbari, O., R.H. DeKruyff, and D.T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725-731.
10. Constant, S.L., and K. Bottomly. 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297-322.
11. Sloan-Lancaster, J., B.D. Evavold, and P.M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195-1205.
12. O'Garra, A., L. Steinman, and K. Gijbels. 1997. CD4+ T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9:872-883.
13. Soumelis, V., P.A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma, et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3:673-680.
14. Stuber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med. 183:979-989.
15. Eisenbarth, S.C., D.A. Piggott, and K. Bottomly. 2003. The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Curr. Opin. Immunol. 15:620-626.
16. Ohshima, Y., L.P. Yang, T. Uchiyama, Y. Tanaka, P. Baum, M. Sergerie, P. Hermann, and G. Delespesse. 1998. OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood. 92:3338-3345.
17. Akiba, H., Y. Miyahira, M. Atsuta, K. Takeda, C. Nohara, T. Futagawa, H. Matsuda, T. Aoki, H. Yagita, and K. Okumura. 2000. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 191:375-380.
18. Jember, A.G., R. Zuberi, F.T. Liu, and M. Croft. 2001. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 193:387-392.
19. Murphy, K.M., and S.L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933-944.
20. Rogers, P.R., J. Song, I. Gramaglia, N. Killeen, and M. Croft. 2001. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for longterm survival of CD4 T cells. Immunity. 15:445-455.
21. Watts, T.H. 2005. Tnf/Tnfr family members in costimulation of T cell responses. Annu. Rev. Immunol. 23:23-68.
22. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M.T. Scupoli, M. Aste-Amezaga, I. Frank, and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183:2559-2569.
23. Windhagen, A., D.E. Anderson, A. Carrizosa, R.E. Williams, and D.A. Hafler. 1996. IL-12 induces human T cells secreting IL-10 with IFN-gamma. J. Immunol. 157:1127-1131.
24. + T cells, analyzed at the single-cell level. J. Exp. Med. 184:473-483.
25. Demeure, C.E., C.Y. Wu, U. Shu, P.V. Schneider, C. Heusser, H. Yssel, and G. Delespesse. 1994. In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production. J. Immunol. 152:4775-4782.
26. Peng, X., A. Kasran, and J.L. Ceuppens. 1997. Interleukin 12 and B7/CD28 interaction synergistically upregulate interleukin 10 production by human T cells. Cytokine. 9:499-506.
27. Jankovic, D., M.C. Kullberg, S. Hieny, P. Caspar, C.M. Collazo, and A. Sher. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity. 16:429-439.
28. Chiffoleau, E., T. Kobayashi, M.C. Walsh, C.G. King, P.T. Walsh, W.W. Hancock, Y. Choi, and L.A. Turka. 2003. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J. Immunol. 171:5751-5759.
29. Schnare, M., G.M. Barton, A.C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2:947-950.
30. Martin-Orozco, N., Z. Chen, L. Poirot, E. Hyatt, A. Chen, O. Kanagawa, A. Sharpe, D. Mathis, and C. Benoist. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J. Immunol. 171:6954-6960.
31. Yoshioka, T., A. Nakajima, H. Akiba, T. Ishiwata, G. Asano, S. Yoshino, H. Yagita, and K. Okumura. 2000. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur. J. Immunol. 30:2815-2823.
32. Ndhlovu, L.C., N. Ishii, K. Murata, T. Sato, and K. Sugamura. 2001. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J. Immunol. 167:2991-2999.
33. Totsuka, T., T. Kanai, K. Uraushihara, R. Iiyama, M. Yamazaki, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 284:G595-G603.
34. Weinberg, A.D., A.T. Vella, and M. Croft. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471-480.
35. Lathrop, S.K., C.A. Huddleston, P.A. Dullforce, M.J. Montfort, A.D. Weinberg, and D.C. Parker. 2004. A signal through OX40 (CD134) allows anergic, autoreactive T cells to acquire effector cell functions. J. Immunol. 172:6735-6743.
36. Prell, R.A., D.E. Evans, C. Thalhofer, T. Shi, C. Funatake, and A.D. Weinberg. 2003. OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent. J. Immunol. 171:5997-6005.
37. Moser, M., and K.M. Murphy. 2000. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1:199-205.
38. Kips, J.C. 2001. Cytokines in asthma. Eur. Respir. J. Suppl. 34:24s-33s.
39. Artis, D., N.E. Humphreys, A.J. Bancroft, N.J. Rothwell, C.S. Potten, and R.K. Grencis. 1999. Tumor necrosis factor-α is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during Helminth infection. J. Exp. Med. 190:953-962.
40. Iwasaki, M., K. Saito, M. Takemura, K. Sekikawa, H. Fujii, Y. Yamada, H. Wada, K. Mizuta, M. Seishima, and Y. Ito. 2003. TNF-alpha contributes to the development of allergic rhinitis in mice. J. Allergy Clin. Immunol. 112:134-140.
41. Chen, L., O. Martinez, L. Overbergh, C. Mathieu, B.S. Prabhakar, and L.S. Chan. 2004. Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin. Exp. Immunol. 138:375-387.
42. Stock, P., O. Akbari, G. Berry, G.J. Freeman, R.H. Dekruyff, and D.T. Umetsu. 2004. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat. Immunol. 5:1149-1156.
43. Watanabe, N., S. Hanabuchi, V. Soumelis, W. Yuan, S. Ho, R. de Waal Malefyt, and Y.J. Liu. 2004. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat. Immunol. 5:426-434.