-
1
-
-
0031567095
-
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
-
Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim. Biophys. Acta 1331, 1-40 (1997).
-
(1997)
Biochim. Biophys. Acta
, vol.1331
, pp. 1-40
-
-
Richardson, D.R.1
Ponka, P.2
-
2
-
-
0033599057
-
Disorders of iron metabolism
-
Andrews NC. Disorders of iron metabolism. N. Engl. J. Med. 341, 1986-1995 (1999).
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 1986-1995
-
-
Andrews, N.C.1
-
3
-
-
0035804416
-
The roles of iron in health and disease
-
Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Mol. Aspects Med. 22, 1-87 (2001).
-
(2001)
Mol. Aspects Med.
, vol.22
, pp. 1-87
-
-
Lieu, P.T.1
Heiskala, M.2
Peterson, P.A.3
Yang, Y.4
-
4
-
-
0041308109
-
Therapeutic potential of iron chelators in cancer therapy
-
Richardson DR. Therapeutic potential of iron chelators in cancer therapy. Adv. Exp. Med. Biol. 509, 231-249 (2002).
-
(2002)
Adv. Exp. Med. Biol.
, vol.509
, pp. 231-249
-
-
Richardson, D.R.1
-
5
-
-
2042546096
-
Balancing acts: Molecular control of mammalian iron metabolism
-
Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 117, 285-297 (2004).
-
(2004)
Cell
, vol.117
, pp. 285-297
-
-
Hentze, M.W.1
Muckenthaler, M.U.2
Andrews, N.C.3
-
7
-
-
29844457587
-
The evolution of iron chelators for the treatment of iron overload disease and cancer
-
Kalinowski DS, Richardson DR. The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev. 57, 547-583 (2005).
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 547-583
-
-
Kalinowski, D.S.1
Richardson, D.R.2
-
8
-
-
0038324398
-
The role of iron chelation in cancer therapy
-
Buss JL, Torti FM, Torti SV. The role of iron chelation in cancer therapy. Curr. Med. Chem. 10, 1021-1034 (2003).
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1021-1034
-
-
Buss, J.L.1
Torti, F.M.2
Torti, S.V.3
-
9
-
-
10644257442
-
Iron chelators in cancer chemotherapy
-
Buss JL, Greene BT, Turner J, Torti FM, Torti SV. Iron chelators in cancer chemotherapy. Curr. Top. Med. Chem. 4, 1623-1635 (2004).
-
(2004)
Curr. Top. Med. Chem.
, vol.4
, pp. 1623-1635
-
-
Buss, J.L.1
Greene, B.T.2
Turner, J.3
Torti, F.M.4
Torti, S.V.5
-
10
-
-
39749110624
-
Oxidative stress and iron homeostasis: Mechanistic and health aspects
-
Galaris D, Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit. Rev. Clin. Lab. Sci. 45, 1-23 (2008).
-
(2008)
Crit. Rev. Clin. Lab. Sci.
, vol.45
, pp. 1-23
-
-
Galaris, D.1
Pantopoulos, K.2
-
11
-
-
0021351203
-
Oxygen toxicity, oxygen radicals, transition metals and disease
-
Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219, 1-14 (1984).
-
(1984)
Biochem. J.
, vol.219
, pp. 1-14
-
-
Halliwell, B.1
Gutteridge, J.M.2
-
12
-
-
0025126555
-
Role of free radicals and catalytic metal ions in human disease: An overview
-
Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 186, 1-85 (1990).
-
(1990)
Methods Enzymol
, vol.186
, pp. 1-85
-
-
Halliwell, B.1
Gutteridge, J.M.2
-
13
-
-
47649126246
-
Forging a field: The golden age of iron biology
-
Andrews NC. Forging a field: the golden age of iron biology. Blood 112, 219-230 (2008).
-
(2008)
Blood
, vol.112
, pp. 219-230
-
-
Andrews, N.C.1
-
15
-
-
0034677467
-
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
-
Donovan A, Brownlie A, Zhou Y et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403, 776-781 (2000).
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
-
16
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
Donovan A, Lima CA, Pinkus JL et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1, 191-200 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 191-200
-
-
Donovan, A.1
Lima, C.A.2
Pinkus, J.L.3
-
17
-
-
26944441309
-
Cellular iron: Ferroportin is the only way out
-
Ganz T. Cellular iron: ferroportin is the only way out. Cell Metab. 1, 155-157 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 155-157
-
-
Ganz, T.1
-
18
-
-
0032909207
-
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the SLA mouse
-
Vulpe CD, Kuo YM, Murphy TL et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the SLA mouse. Nat. Genet. 21, 195-199 (1999).
-
(1999)
Nat. Genet.
, vol.21
, pp. 195-199
-
-
Vulpe, C.D.1
Kuo, Y.M.2
Murphy, T.L.3
-
19
-
-
27644455133
-
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
-
Ohgami RS, Campagna DR, Greer EL et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet. 37, 1264-1269 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 1264-1269
-
-
Ohgami, R.S.1
Campagna, D.R.2
Greer, E.L.3
-
20
-
-
0032477866
-
Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
-
Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl Acad. Sci. USA 95, 1148-1153 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 1148-1153
-
-
Fleming, M.D.1
Romano, M.A.2
Su, M.A.3
Garrick, L.M.4
Garrick, M.D.5
Andrews, N.C.6
-
21
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
Fleming MD, Trenor CC 3rd, Su MA et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16, 383-386 (1997).
-
(1997)
Nat. Genet.
, vol.16
, pp. 383-386
-
-
Fleming, M.D.1
Trenor III, C.C.2
Su, M.A.3
-
22
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin H, Mackenzie B, Berger UV et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488 (1997).
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
MacKenzie, B.2
Berger, U.V.3
-
23
-
-
0035525741
-
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells
-
Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood 98, 2714-2719 (2001).
-
(2001)
Blood
, vol.98
, pp. 2714-2719
-
-
Kawabata, H.1
Nakamaki, T.2
Ikonomi, P.3
Smith, R.D.4
Germain, R.S.5
Koeffler, H.P.6
-
24
-
-
8844236171
-
Analyses for binding of the transferrin family of proteins to the transferrin receptor 2
-
Kawabata H, Tong X, Kawanami T et al. Analyses for binding of the transferrin family of proteins to the transferrin receptor 2. Br. J. Haematol. 127, 464-473 (2004).
-
(2004)
Br. J. Haematol.
, vol.127
, pp. 464-473
-
-
Kawabata, H.1
Tong, X.2
Kawanami, T.3
-
25
-
-
34047214190
-
Optimal management strategies for chronic iron overload
-
Barton JC. Optimal management strategies for chronic iron overload. Drugs 67, 685-700 (2007).
-
(2007)
Drugs
, vol.67
, pp. 685-700
-
-
Barton, J.C.1
-
26
-
-
29744468975
-
The design of orally active iron chelators
-
Hider RC, Zhou T. The design of orally active iron chelators. Ann. NY Acad. Sci. 1054, 141-154 (2005).
-
(2005)
Ann. NY Acad. Sci.
, vol.1054
, pp. 141-154
-
-
Hider, R.C.1
Zhou, T.2
-
27
-
-
65449120792
-
Iron behaving badly: Inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
-
Kell DB. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med. Genomics 2, 2 (2009).
-
(2009)
BMC Med. Genomics
, vol.2
, pp. 2
-
-
Kell, D.B.1
-
28
-
-
63449115492
-
Ferritin for the clinician
-
Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 23, 95-104 (2009).
-
(2009)
Blood Rev
, vol.23
, pp. 95-104
-
-
Knovich, M.A.1
Storey, J.A.2
Coffman, L.G.3
Torti, S.V.4
Torti, F.M.5
-
29
-
-
41149177025
-
Pharmacological and clinical aspects of heme oxygenase
-
Abraham NG, Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol. Rev. 60, 79-127 (2008).
-
(2008)
Pharmacol. Rev.
, vol.60
, pp. 79-127
-
-
Abraham, N.G.1
Kappas, A.2
-
30
-
-
33645945014
-
Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
-
Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86, 583-650 (2006).
-
(2006)
Physiol. Rev.
, vol.86
, pp. 583-650
-
-
Ryter, S.W.1
Alam, J.2
Choi, A.M.3
-
31
-
-
33845613215
-
The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases
-
Vitek L, Schwertner HA. The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv. Clin. Chem. 43, 1-57 (2007).
-
(2007)
Adv. Clin. Chem.
, vol.43
, pp. 1-57
-
-
Vitek, L.1
Schwertner, H.A.2
-
32
-
-
34250865977
-
The molecular mechanism of hepcidinmediated ferroportin down-regulation
-
De Domenico I, Ward DM, Langelier C et al. The molecular mechanism of hepcidinmediated ferroportin down-regulation. Mol. Biol. Cell 18, 2569-2578 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 2569-2578
-
-
De Domenico, I.1
Ward, D.M.2
Langelier, C.3
-
33
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093 (2004).
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
-
35
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang RH, Li C, Xu X et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2, 399-409 (2005).
-
(2005)
Cell Metab
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
-
36
-
-
33845985236
-
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
-
Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109, 353-358 (2007).
-
(2007)
Blood
, vol.109
, pp. 353-358
-
-
Verga Falzacappa, M.V.1
Vujic Spasic, M.2
Kessler, R.3
Stolte, J.4
Hentze, M.W.5
Muckenthaler, M.U.6
-
37
-
-
33751175421
-
Interleukin-6 induces hepcidin expression through STAT3
-
Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 108, 3204-3209 (2006).
-
(2006)
Blood
, vol.108
, pp. 3204-3209
-
-
Wrighting, D.M.1
Andrews, N.C.2
-
38
-
-
33947095427
-
ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPa and STAT-3
-
Choi SO, Cho YS, Kim HL, Park JW. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPa and STAT-3. Biochem. Biophys. Res. Commun. 356, 312-317 (2007).
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.356
, pp. 312-317
-
-
Choi, S.O.1
Cho, Y.S.2
Kim, H.L.3
Park, J.W.4
-
39
-
-
0037093202
-
Regulation of ferritin genes and protein
-
Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 99, 3505-3516 (2002).
-
(2002)
Blood
, vol.99
, pp. 3505-3516
-
-
Torti, F.M.1
Torti, S.V.2
-
40
-
-
0030608152
-
The ferritins: Molecular properties, iron storage function and cellular regulation
-
Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta. 1275, 161-203 (1996).
-
(1996)
Biochim. Biophys. Acta.
, vol.1275
, pp. 161-203
-
-
Harrison, P.M.1
Arosio, P.2
-
41
-
-
0017644189
-
Characterization of serum ferritin in iron overload: Possible identity to natural apoferritin
-
Arosio P, Yokota M, Drysdale JW. Characterization of serum ferritin in iron overload: possible identity to natural apoferritin. Br. J. Haematol. 36, 199-207 (1977).
-
(1977)
Br. J. Haematol.
, vol.36
, pp. 199-207
-
-
Arosio, P.1
Yokota, M.2
Drysdale, J.W.3
-
42
-
-
58849163970
-
Regulatory effects of ferritin on angiogenesis
-
Coffman LG, Parsonage D, D'Agostino R Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc. Natl Acad. Sci. USA 106, 570-575 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 570-575
-
-
Coffman, L.G.1
Parsonage, D.2
D'Agostino Jr., R.3
Torti, F.M.4
Torti, S.V.5
-
43
-
-
38349111676
-
Role of the hypoxia inducible factors HIF in iron metabolism
-
Peyssonnaux C, Nizet V, Johnson RS. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 7, 28-32 (2008).
-
(2008)
Cell Cycle
, vol.7
, pp. 28-32
-
-
Peyssonnaux, C.1
Nizet, V.2
Johnson, R.S.3
-
44
-
-
0029858079
-
Identification of hypoxically inducible mRNAs in HeLa cells using differentialdisplay PCR. Role of hypoxia-inducible factor-1
-
O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ. Identification of hypoxically inducible mRNAs in HeLa cells using differentialdisplay PCR. Role of hypoxia-inducible factor-1. Eur. J. Biochem. 241, 403-410 (1996).
-
(1996)
Eur. J. Biochem.
, vol.241
, pp. 403-410
-
-
O'Rourke, J.F.1
Pugh, C.W.2
Bartlett, S.M.3
Ratcliffe, P.J.4
-
45
-
-
33947113793
-
The flavonoid quercetin induces hypoxia-inducible factor-1a (HIF-1a) and inhibits cell proliferation by depleting intracellular iron
-
Triantafyllou A, Liakos P, Tsakalof A et al. The flavonoid quercetin induces hypoxia-inducible factor-1a (HIF-1a) and inhibits cell proliferation by depleting intracellular iron. Free Radic. Res. 41, 342-356 (2007).
-
(2007)
Free Radic. Res.
, vol.41
, pp. 342-356
-
-
Triantafyllou, A.1
Liakos, P.2
Tsakalof, A.3
-
46
-
-
34347334632
-
Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: A structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase
-
Jeon H, Kim H, Choi D et al. Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase. Mol. Pharmacol. 71, 1676-1684 (2007).
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 1676-1684
-
-
Jeon, H.1
Kim, H.2
Choi, D.3
-
47
-
-
0036136401
-
Design of clinically useful iron(III)-selective chelators
-
Liu ZD, Hider RC. Design of clinically useful iron(III)-selective chelators. Med. Res. Rev. 22, 26-64 (2002).
-
(2002)
Med. Res. Rev.
, vol.22
, pp. 26-64
-
-
Liu, Z.D.1
Hider, R.C.2
-
48
-
-
0030051137
-
Evaluation of new iron chelators for clinical use
-
Porter JB. Evaluation of new iron chelators for clinical use. Acta. Haematol. 95, 13-25 (1996).
-
(1996)
Acta. Haematol.
, vol.95
, pp. 13-25
-
-
Porter, J.B.1
-
49
-
-
2442530651
-
Competing pathways of iron chelation: Angiogenesis or anti-tumor activity: Targeting different molecules to induce specific effects
-
Le NT, Richardson DR. Competing pathways of iron chelation: angiogenesis or anti-tumor activity: targeting different molecules to induce specific effects. Int. J. Cancer 110, 468-469 (2004).
-
(2004)
Int. J. Cancer
, vol.110
, pp. 468-469
-
-
Le, N.T.1
Richardson, D.R.2
-
50
-
-
33845753448
-
Chelators at the cancer coalface: Desferrioxamine to Triapine and beyond
-
Yu Y, Wong J, Lovejoy DB, Kalinowski DS, Richardson DR. Chelators at the cancer coalface: desferrioxamine to Triapine and beyond. Clin. Cancer Res. 12, 6876-6883 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6876-6883
-
-
Yu, Y.1
Wong, J.2
Lovejoy, D.B.3
Kalinowski, D.S.4
Richardson, D.R.5
-
51
-
-
39749112684
-
Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques in patients with asymptomatic carotid stenosis undergoing coronary artery bypass grafting: An ultrasmall superparamagnetic iron oxide enhanced magnetic resonance study
-
Tang TY, Howarth SP, Miller SR et al. Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques in patients with asymptomatic carotid stenosis undergoing coronary artery bypass grafting: an ultrasmall superparamagnetic iron oxide enhanced magnetic resonance study. Eur. J. Vasc. Endovasc. Surg. 35, 392-398 (2008).
-
(2008)
Eur. J. Vasc. Endovasc. Surg.
, vol.35
, pp. 392-398
-
-
Tang, T.Y.1
Howarth, S.P.2
Miller, S.R.3
-
52
-
-
40849097485
-
Iron and the liver: Update 2008
-
Deugnier Y, Brissot P, Loreal O. Iron and the liver: update 2008. J. Hepatol. 48(Suppl. 1), S113-S123 (2008).
-
(2008)
J. Hepatol.
, vol.48
, Issue.SUPPL. 1
-
-
Deugnier, Y.1
Brissot, P.2
Loreal, O.3
-
53
-
-
57049181320
-
Iron acquisition: A novel perspective on mucormycosis pathogenesis and treatment
-
Ibrahim AS, Spellberg B, Edwards J Jr. Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. Curr. Opin. Infect. Dis. 21, 620-625 (2008).
-
(2008)
Curr. Opin. Infect. Dis.
, vol.21
, pp. 620-625
-
-
Ibrahim, A.S.1
Spellberg, B.2
Edwards Jr., J.3
-
54
-
-
59149085899
-
Iron chelation as a potential therapy for neurodegenerative disease
-
Hider RC, Ma Y, Molina-Holgado F, Gaeta A, Roy S. Iron chelation as a potential therapy for neurodegenerative disease. Biochem. Soc. Trans. 36, 1304-1308 (2008).
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 1304-1308
-
-
Hider, R.C.1
Ma, Y.2
Molina-Holgado, F.3
Gaeta, A.4
Roy, S.5
-
55
-
-
34447132110
-
The role of iron in diabetes and its complications
-
Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes Care 30, 1926-1933 (2007).
-
(2007)
Diabetes Care
, vol.30
, pp. 1926-1933
-
-
Swaminathan, S.1
Fonseca, V.A.2
Alam, M.G.3
Shah, S.V.4
-
56
-
-
65549090148
-
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: Inhibition by desferrioxamine
-
Li L, Frei B. Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine. Arterioscler. Thromb. Vasc. Biol. 29, 732-738 (2009).
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 732-738
-
-
Li, L.1
Frei, B.2
-
57
-
-
67349180293
-
Iron in arterial plaque: A modifiable risk factor for atherosclerosis
-
Sullivan JL. Iron in arterial plaque: a modifiable risk factor for atherosclerosis. Biochim. Biophys. Acta 1790(7), 718-723 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1790
, Issue.7
, pp. 718-723
-
-
Sullivan, J.L.1
-
59
-
-
0029928156
-
Molecular biology of iron acquisition in Saccharomyces cerevisiae
-
Askwith CC, de Silva D, Kaplan J. Molecular biology of iron acquisition in Saccharomyces cerevisiae. Mol. Microbiol. 20, 27-34 (1996).
-
(1996)
Mol. Microbiol.
, vol.20
, pp. 27-34
-
-
Askwith, C.C.1
De Silva, D.2
Kaplan, J.3
-
60
-
-
40049109580
-
What is new in iron overload? Eur
-
Vermylen C. What is new in iron overload? Eur. J. Pediatr. 167, 377-381 (2008).
-
(2008)
J. Pediatr.
, vol.167
, pp. 377-381
-
-
Vermylen, C.1
-
61
-
-
34548132409
-
Iron chelation, quo vadis?
-
Nick H. Iron chelation, quo vadis? Curr. Opin. Chem. Biol. 11, 419-423 (2007).
-
(2007)
Curr. Opin. Chem. Biol.
, vol.11
, pp. 419-423
-
-
Nick, H.1
-
62
-
-
34547185474
-
Iron storage disease: Facts, fiction and progress
-
Beutler E. Iron storage disease: facts, fiction and progress. Blood Cells Mol. Dis. 39, 140-147 (2007).
-
(2007)
Blood Cells Mol. Dis.
, vol.39
, pp. 140-147
-
-
Beutler, E.1
-
63
-
-
38149109843
-
Iron chelators can protect against oxidative stress through ferryl heme reduction
-
Reeder BJ, Hider RC, Wilson MT. Iron chelators can protect against oxidative stress through ferryl heme reduction. Free Radic. Biol. Med. 44, 264-273 (2008).
-
(2008)
Free Radic. Biol. Med.
, vol.44
, pp. 264-273
-
-
Reeder, B.J.1
Hider, R.C.2
Wilson, M.T.3
-
64
-
-
0025651113
-
Free radicals, myocytes and reperfusion injury
-
Turner JJ, Rice-Evans CA, Davies MJ, Newman ES. Free radicals, myocytes and reperfusion injury. Biochem. Soc. Trans. 18, 1056-1059 (1990).
-
(1990)
Biochem. Soc. Trans.
, vol.18
, pp. 1056-1059
-
-
Turner, J.J.1
Rice-Evans, C.A.2
Davies, M.J.3
Newman, E.S.4
-
65
-
-
0030023384
-
Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation
-
Miller YI, Felikman Y, Shaklai N. Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Arch. Biochem. Biophys. 326, 252-260 (1996).
-
(1996)
Arch. Biochem. Biophys.
, vol.326
, pp. 252-260
-
-
Miller, Y.I.1
Felikman, Y.2
Shaklai, N.3
-
66
-
-
21144432892
-
Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: A mechanism to protect against oxidative stress without iron chelation
-
Reeder BJ, Wilson MT. Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: a mechanism to protect against oxidative stress without iron chelation. Chem. Res. Toxicol. 18, 1004-1011 (2005).
-
(2005)
Chem. Res. Toxicol.
, vol.18
, pp. 1004-1011
-
-
Reeder, B.J.1
Wilson, M.T.2
-
67
-
-
34447316694
-
Light and shadows in the iron chelation treatment of haematological diseases
-
Maggio A. Light and shadows in the iron chelation treatment of haematological diseases. Br. J. Haematol. 138, 407-421 (2007).
-
(2007)
Br. J. Haematol.
, vol.138
, pp. 407-421
-
-
Maggio, A.1
-
68
-
-
34548708556
-
Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: A literature review
-
Delea TE, Edelsberg J, Sofrygin O et al. Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion 47, 1919-1929 (2007).
-
(2007)
Transfusion
, vol.47
, pp. 1919-1929
-
-
Delea, T.E.1
Edelsberg, J.2
Sofrygin, O.3
-
69
-
-
7944230624
-
Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance
-
Anderson LJ, Westwood MA, Holden S et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br. J. Haematol. 127, 348-355 (2004).
-
(2004)
Br. J. Haematol.
, vol.127
, pp. 348-355
-
-
Anderson, L.J.1
Westwood, M.A.2
Holden, S.3
-
70
-
-
33646407268
-
Cardiac morbidity and mortality in deferoxamine-or deferipronetreated patients with thalassemia major
-
Borgna-Pignatti C, Cappellini MD, De Stefano P et al. Cardiac morbidity and mortality in deferoxamine-or deferipronetreated patients with thalassemia major. Blood 107, 3733-3737 (2006).
-
(2006)
Blood
, vol.107
, pp. 3733-3737
-
-
Borgna-Pignatti, C.1
Cappellini, M.D.2
De Stefano, P.3
-
71
-
-
3042746877
-
Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
-
Davis BA, O'Sullivan C, Jarritt PH, Porter JB. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 104, 263-269 (2004).
-
(2004)
Blood
, vol.104
, pp. 263-269
-
-
Davis, B.A.1
O'Sullivan, C.2
Jarritt, P.H.3
Porter, J.B.4
-
72
-
-
36849089638
-
Concepts and goals in the management of transfusional iron overload
-
Porter JB. Concepts and goals in the management of transfusional iron overload. Am. J. Hematol. 82, 1136-1139 (2007).
-
(2007)
Am. J. Hematol.
, vol.82
, pp. 1136-1139
-
-
Porter, J.B.1
-
73
-
-
0023613154
-
Transfusion and exchange transfusion in sickle cell anaemias, with particular erence to iron metabolism
-
Porter JB, Huehns ER. Transfusion and exchange transfusion in sickle cell anaemias, with particular erence to iron metabolism. Acta Haematol. 78, 198-205 (1987).
-
(1987)
Acta Haematol.
, vol.78
, pp. 198-205
-
-
Porter, J.B.1
Huehns, E.R.2
-
74
-
-
36248970160
-
Improving clinical outcome in patients with myelodysplastic syndrome and iron overload using iron chelation therapy
-
Leitch HA. Improving clinical outcome in patients with myelodysplastic syndrome and iron overload using iron chelation therapy. Leuk. Res. 31(Suppl. 3), S7-S9 (2007).
-
(2007)
Leuk. Res.
, vol.31
, Issue.SUPPL. 3
-
-
Leitch, H.A.1
-
75
-
-
13444269356
-
Myelodysplastic syndromes -Coping with ineffective hematopoiesis
-
Cazzola M, Malcovati L. Myelodysplastic syndromes -coping with ineffective hematopoiesis. N. Engl. J. Med. 352, 536-538 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 536-538
-
-
Cazzola, M.1
Malcovati, L.2
-
76
-
-
33646363066
-
Transfusion independence in patients with myelodysplastic syndromes: Impact on outcomes and quality of life
-
Balducci L. Transfusion independence in patients with myelodysplastic syndromes: impact on outcomes and quality of life. Cancer 106, 2087-2094 (2006).
-
(2006)
Cancer
, vol.106
, pp. 2087-2094
-
-
Balducci, L.1
-
77
-
-
36248933231
-
Guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload
-
Gattermann N. Guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload. Leuk. Res. 31(Suppl. 3), S10-S15 (2007).
-
(2007)
Leuk. Res.
, vol.31
, Issue.SUPPL. 3
-
-
Gattermann, N.1
-
78
-
-
33845991537
-
Oxidants in chronic kidney disease
-
Shah SV, Baliga R, Rajapurkar M, Fonseca VA. Oxidants in chronic kidney disease. J. Am. Soc. Nephrol. 18, 16-28 (2007).
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 16-28
-
-
Shah, S.V.1
Baliga, R.2
Rajapurkar, M.3
Fonseca, V.A.4
-
79
-
-
43549087627
-
Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
-
Aigner E, Theurl I, Theurl M et al. Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. Am. J. Clin. Nutr. 87, 1374-1383 (2008).
-
(2008)
Am. J. Clin. Nutr.
, vol.87
, pp. 1374-1383
-
-
Aigner, E.1
Theurl, I.2
Theurl, M.3
-
80
-
-
28444454447
-
Hepatotoxicity of iron overload: Mechanisms of iron-induced hepatic fibrogenesis
-
Ramm GA, Ruddell RG. Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin. Liver Dis. 25, 433-449 (2005).
-
(2005)
Semin. Liver Dis.
, vol.25
, pp. 433-449
-
-
Ramm, G.A.1
Ruddell, R.G.2
-
81
-
-
44449173627
-
Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis
-
Swaminathan S, High WA, Ranville J et al. Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis. Kidney Int. 73, 1413-1418 (2008).
-
(2008)
Kidney Int
, vol.73
, pp. 1413-1418
-
-
Swaminathan, S.1
High, W.A.2
Ranville, J.3
-
82
-
-
1642371463
-
Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury
-
de Vries B, Walter SJ, von Bonsdorff L et al. Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury. Transplantation 77, 669-675 (2004).
-
(2004)
Transplantation
, vol.77
, pp. 669-675
-
-
De Vries, B.1
Walter, S.J.2
Von Bonsdorff, L.3
-
83
-
-
54849163400
-
Iron involvement in multiple signaling pathways of atherosclerosis: A revisited hypothesis
-
Yuan XM, Li W. Iron involvement in multiple signaling pathways of atherosclerosis: a revisited hypothesis. Curr. Med. Chem. 15, 2157-2172 (2008).
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 2157-2172
-
-
Yuan, X.M.1
Li, W.2
-
84
-
-
33745233825
-
Zinc supplementation decreases the development of atherosclerosis in rabbits
-
Ren M, Rajendran R, Ning P et al. Zinc supplementation decreases the development of atherosclerosis in rabbits. Free Radic. Biol. Med. 41, 222-225 (2006).
-
(2006)
Free Radic. Biol. Med.
, vol.41
, pp. 222-225
-
-
Ren, M.1
Rajendran, R.2
Ning, P.3
-
85
-
-
27644585384
-
Iron chelation and vascular function: In search of the mechanisms
-
Ferrara DE, Taylor WR. Iron chelation and vascular function: in search of the mechanisms. Arterioscler. Thromb. Vasc. Biol. 25, 2235-2237 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 2235-2237
-
-
Ferrara, D.E.1
Taylor, W.R.2
-
86
-
-
27644535717
-
Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats
-
Ishizaka N, Saito K, Mori I, Matsuzaki G, Ohno M, Nagai R. Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats. Arterioscler. Thromb. Vasc. Biol. 25, 2282-2288 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 2282-2288
-
-
Ishizaka, N.1
Saito, K.2
Mori, I.3
Matsuzaki, G.4
Ohno, M.5
Nagai, R.6
-
87
-
-
0024469459
-
Deferoxamine therapy in high-ferritin diabetes
-
Cutler P. Deferoxamine therapy in high-ferritin diabetes. Diabetes 38, 1207-1210 (1989).
-
(1989)
Diabetes
, vol.38
, pp. 1207-1210
-
-
Cutler, P.1
-
88
-
-
0036317939
-
Coronary microvascular adaptation to myocardial metabolic demand can be restored by inhibition of iron-catalyzed formation of oxygen free radicals in type 2 diabetic patients
-
Nitenberg A, Ledoux S, Valensi P, Sachs R, Antony I. Coronary microvascular adaptation to myocardial metabolic demand can be restored by inhibition of iron-catalyzed formation of oxygen free radicals in type 2 diabetic patients. Diabetes 51, 813-818 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 813-818
-
-
Nitenberg, A.1
Ledoux, S.2
Valensi, P.3
Sachs, R.4
Antony, I.5
-
89
-
-
40449120460
-
Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver
-
Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am. J. Pathol. 172, 738-747 (2008).
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 738-747
-
-
Dongiovanni, P.1
Valenti, L.2
Ludovica Fracanzani, A.3
Gatti, S.4
Cairo, G.5
Fargion, S.6
-
90
-
-
12544253460
-
Glucose metabolism disorders improvement in patients with thalassaemia major after 24-36 months of intensive chelation therapy
-
Platis O, Anagnostopoulos G, Farmaki K, Posantzis M, Gotsis E, Tolis G. Glucose metabolism disorders improvement in patients with thalassaemia major after 24-36 months of intensive chelation therapy. Pediatr. Endocrinol. Rev. 2(Suppl. 2), 279-281 (2004).
-
(2004)
Pediatr. Endocrinol. Rev.
, vol.2
, Issue.SUPPL. 2
, pp. 279-281
-
-
Platis, O.1
Anagnostopoulos, G.2
Farmaki, K.3
Posantzis, M.4
Gotsis, E.5
Tolis, G.6
-
91
-
-
39349103963
-
The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: Therapeutic effects by chelators
-
Zheng Y, Li XK, Wang Y, Cai L. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin 32, 135-145 (2008).
-
(2008)
Hemoglobin
, vol.32
, pp. 135-145
-
-
Zheng, Y.1
Li, X.K.2
Wang, Y.3
Cai, L.4
-
92
-
-
33748742706
-
Combined chelation therapy improves glucose metabolism in patients with b-thalassaemia major
-
Christoforidis A, Perifanis V, Athanassiou-Metaxa M. Combined chelation therapy improves glucose metabolism in patients with b-thalassaemia major. Br. J. Haematol. 135, 271-272 (2006).
-
(2006)
Br. J. Haematol.
, vol.135
, pp. 271-272
-
-
Christoforidis, A.1
Perifanis, V.2
Athanassiou-Metaxa, M.3
-
93
-
-
33846897786
-
Evolution of OGTT in patients with b-thalassaemia major in relation to chelation therapy
-
Christoforidis A, Perifanis V, Tsatra I, Vlachaki E, Athanassiou-Metaxa M. Evolution of OGTT in patients with b-thalassaemia major in relation to chelation therapy. Diabetes Res. Clin. Pract. 76, 6-11 (2007).
-
(2007)
Diabetes Res. Clin. Pract.
, vol.76
, pp. 6-11
-
-
Christoforidis, A.1
Perifanis, V.2
Tsatra, I.3
Vlachaki, E.4
Athanassiou-Metaxa, M.5
-
94
-
-
33746049146
-
Effect of enhanced iron chelation therapy on glucose metabolism in patients with b-thalassaemia major
-
Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos G, Tolis G. Effect of enhanced iron chelation therapy on glucose metabolism in patients with b-thalassaemia major. Br. J. Haematol. 134, 438-444 (2006).
-
(2006)
Br. J. Haematol.
, vol.134
, pp. 438-444
-
-
Farmaki, K.1
Angelopoulos, N.2
Anagnostopoulos, G.3
Gotsis, E.4
Rombopoulos, G.5
Tolis, G.6
-
95
-
-
30044449567
-
Cell permeable iron chelators as potential cancer chemotherapeutic agents
-
Pahl PM, Horwitz LD. Cell permeable iron chelators as potential cancer chemotherapeutic agents. Cancer Invest. 23, 683-691 (2005).
-
(2005)
Cancer Invest
, vol.23
, pp. 683-691
-
-
Pahl, P.M.1
Horwitz, L.D.2
-
96
-
-
29144521885
-
Iron chelators deferoxamine and diethylenetriamine pentaacetic acid induce apoptosis in ovarian carcinoma
-
Brard L, Granai CO, Swamy N. Iron chelators deferoxamine and diethylenetriamine pentaacetic acid induce apoptosis in ovarian carcinoma. Gynecol. Oncol. 100, 116-127 (2006).
-
(2006)
Gynecol. Oncol.
, vol.100
, pp. 116-127
-
-
Brard, L.1
Granai, C.O.2
Swamy, N.3
-
97
-
-
21344437787
-
Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
-
Hoke EM, Maylock CA, Shacter E. Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin. Free Radic. Biol. Med. 39, 403-411 (2005).
-
(2005)
Free Radic. Biol. Med.
, vol.39
, pp. 403-411
-
-
Hoke, E.M.1
Maylock, C.A.2
Shacter, E.3
-
98
-
-
47249110726
-
Iron chelator differentially activates macrophage inflammatory protein-3a/CCL20 in immortalized and malignant human oral keratinocytes
-
Lee SK, Lee J, Min SK et al. Iron chelator differentially activates macrophage inflammatory protein-3a/CCL20 in immortalized and malignant human oral keratinocytes. Arch. Oral Biol. 53, 801-809 (2008).
-
(2008)
Arch. Oral Biol.
, vol.53
, pp. 801-809
-
-
Lee, S.K.1
Lee, J.2
Min, S.K.3
-
99
-
-
67349137868
-
Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
-
Richardson DR, Kalinowski DS, Lau S, Jansson PJ, Lovejoy DB. Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochim. Biophys. Acta 1790(7), 702-717 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1790
, Issue.7
, pp. 702-717
-
-
Richardson, D.R.1
Kalinowski, D.S.2
Lau, S.3
Jansson, P.J.4
Lovejoy, D.B.5
-
100
-
-
0025835284
-
Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators
-
Bergeron RJ, Wiegand J, Dionis JB et al. Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators. J. Med. Chem. 34, 2072-2078 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2072-2078
-
-
Bergeron, R.J.1
Wiegand, J.2
Dionis, J.B.3
-
101
-
-
0035437385
-
The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents
-
Kicic A, Chua AC, Baker E. The desferrithiocin (DFT) class of iron chelators: potential as antineoplastic agents. Anticancer Drug Des. 16, 195-207 (2001).
-
(2001)
Anticancer Drug des
, vol.16
, pp. 195-207
-
-
Kicic, A.1
Chua, A.C.2
Baker, E.3
-
102
-
-
0036214907
-
Desferrithiocin is a more potent antineoplastic agent than desferrioxamine
-
Kicic A, Chua AC, Baker E. Desferrithiocin is a more potent antineoplastic agent than desferrioxamine. Br. J. Pharmacol. 135, 1393-1402 (2002).
-
(2002)
Br. J. Pharmacol.
, vol.135
, pp. 1393-1402
-
-
Kicic, A.1
Chua, A.C.2
Baker, E.3
-
103
-
-
0027401142
-
A comparative study of the iron-clearing properties of desferrithiocin analogues with desferrioxamine B in a Cebus monkey model
-
Bergeron RJ, Streiff RR, Creary EA et al. A comparative study of the iron-clearing properties of desferrithiocin analogues with desferrioxamine B in a Cebus monkey model. Blood 81, 2166-2173 (1993).
-
(1993)
Blood
, vol.81
, pp. 2166-2173
-
-
Bergeron, R.J.1
Streiff, R.R.2
Creary, E.A.3
-
104
-
-
30344471110
-
Iron chelation treatment with combined therapy with deferiprone and deferioxamine: A 12-month trial
-
Kattamis A, Ladis V, Berdousi H et al. Iron chelation treatment with combined therapy with deferiprone and deferioxamine: a 12-month trial. Blood Cells Mol. Dis. 36, 21-25 (2006).
-
(2006)
Blood Cells Mol. Dis.
, vol.36
, pp. 21-25
-
-
Kattamis, A.1
Ladis, V.2
Berdousi, H.3
-
105
-
-
66949116353
-
Oral iron chelation therapy with deferiprone in patients with Thalassemia Major
-
Sajid R, Ghani F, Adil S, Khurshid M. Oral iron chelation therapy with deferiprone in patients with Thalassemia Major. J. Pak. Med. Assoc. 59, 388-390 (2009).
-
(2009)
J. Pak. Med. Assoc.
, vol.59
, pp. 388-390
-
-
Sajid, R.1
Ghani, F.2
Adil, S.3
Khurshid, M.4
-
106
-
-
44649108912
-
Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells
-
Molina-Holgado F, Gaeta A, Francis PT, Williams RJ, Hider RC. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. J. Neurochem. 105(6), 2466-2476 (2008).
-
(2008)
J. Neurochem
, vol.105
, Issue.6
, pp. 2466-2476
-
-
Molina-Holgado, F.1
Gaeta, A.2
Francis, P.T.3
Williams, R.J.4
Hider, R.C.5
-
107
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39, 889-909 (2003).
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
108
-
-
0041731997
-
Neuroprotective strategies in Parkinson's disease: An update on progress
-
Mandel S, Grunblatt E, Riederer P, Gerlach M, Levites Y, Youdim MB. Neuroprotective strategies in Parkinson's disease: an update on progress. CNS Drugs 17, 729-762 (2003).
-
(2003)
CNS Drugs
, vol.17
, pp. 729-762
-
-
Mandel, S.1
Grunblatt, E.2
Riederer, P.3
Gerlach, M.4
Levites, Y.5
Youdim, M.B.6
-
109
-
-
33750716051
-
Iron: A new target for pharmacological intervention in neurodegenerative diseases
-
Whitnall M, Richardson DR. Iron: a new target for pharmacological intervention in neurodegenerative diseases. Semin. Pediatr. Neurol. 13, 186-197 (2006).
-
(2006)
Semin. Pediatr. Neurol.
, vol.13
, pp. 186-197
-
-
Whitnall, M.1
Richardson, D.R.2
-
110
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits b-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny RA, Atwood CS, Xilinas ME et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits b-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665-676 (2001).
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
111
-
-
0242684415
-
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
-
Kaur D, Yantiri F, Rajagopalan S et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron 37, 899-909 (2003).
-
(2003)
Neuron
, vol.37
, pp. 899-909
-
-
Kaur, D.1
Yantiri, F.2
Rajagopalan, S.3
-
112
-
-
33748202940
-
Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
-
Liu G, Men P, Harris PL, Rolston RK, Perry G, Smith MA. Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neurosci. Lett. 406, 189-193 (2006).
-
(2006)
Neurosci. Lett.
, vol.406
, pp. 189-193
-
-
Liu, G.1
Men, P.2
Harris, P.L.3
Rolston, R.K.4
Perry, G.5
Smith, M.A.6
-
113
-
-
0033032774
-
Synthesis and cytotoxicity evaluation of some 8-hydroxyquinoline derivatives
-
Shen AY, Wu SN, Chiu CT. Synthesis and cytotoxicity evaluation of some 8-hydroxyquinoline derivatives. J. Pharm. Pharmacol. 51, 543-548 (1999).
-
(1999)
J. Pharm. Pharmacol.
, vol.51
, pp. 543-548
-
-
Shen, A.Y.1
Wu, S.N.2
Chiu, C.T.3
-
114
-
-
33750613624
-
Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox
-
Gaboriau F, Laupen-Chassay C, Pasdeloup N, Pierre JL, Brissot P, Lescoat G. Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox. Biometals 19, 623-632 (2006).
-
(2006)
Biometals
, vol.19
, pp. 623-632
-
-
Gaboriau, F.1
Laupen-Chassay, C.2
Pasdeloup, N.3
Pierre, J.L.4
Brissot, P.5
Lescoat, G.6
-
115
-
-
0034069521
-
Antiproliferative and apoptotic effects of O-trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines
-
Rakba N, Loyer P, Gilot D et al. Antiproliferative and apoptotic effects of O-trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines. Carcinogenesis 21, 943-951 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 943-951
-
-
Rakba, N.1
Loyer, P.2
Gilot, D.3
-
116
-
-
0028350236
-
Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation
-
Ballardini G, Groff P, Zoli M et al. Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation. J. Hepatol. 20, 218-222 (1994).
-
(1994)
J. Hepatol.
, vol.20
, pp. 218-222
-
-
Ballardini, G.1
Groff, P.2
Zoli, M.3
-
117
-
-
0026634766
-
Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis
-
Tarao K, Shimizu A, Ohkawa S et al. Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology 103, 595-600 (1992).
-
(1992)
Gastroenterology
, vol.103
, pp. 595-600
-
-
Tarao, K.1
Shimizu, A.2
Ohkawa, S.3
-
118
-
-
33646414765
-
A Phase III study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with b-thalassemia
-
Cappellini MD, Cohen A, Piga A et al. A Phase III study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with b-thalassemia. Blood 107, 3455-3462 (2006).
-
(2006)
Blood
, vol.107
, pp. 3455-3462
-
-
Cappellini, M.D.1
Cohen, A.2
Piga, A.3
-
119
-
-
33745774771
-
Randomized Phase II trial of deferasirox (Exjade, ICL670), a once-daily, orallyadministered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
-
Piga A, Galanello R, Forni GL et al. Randomized Phase II trial of deferasirox (Exjade, ICL670), a once-daily, orallyadministered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica 91, 873-880 (2006).
-
(2006)
Haematologica
, vol.91
, pp. 873-880
-
-
Piga, A.1
Galanello, R.2
Forni, G.L.3
-
120
-
-
42949148046
-
Clinical application of deferasirox: Practical patient management
-
Vichinsky E. Clinical application of deferasirox: practical patient management. Am. J. Hematol. 83, 398-402 (2008).
-
(2008)
Am. J. Hematol.
, vol.83
, pp. 398-402
-
-
Vichinsky, E.1
-
121
-
-
35048901389
-
Deferasirox: A review of its use in the management of transfusional chronic iron overload
-
Yang LP, Keam SJ, Keating GM. Deferasirox: a review of its use in the management of transfusional chronic iron overload. Drugs 67, 2211-2230 (2007).
-
(2007)
Drugs
, vol.67
, pp. 2211-2230
-
-
Yang, L.P.1
Keam, S.J.2
Keating, G.M.3
-
122
-
-
38049151217
-
Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): A 1-yr prospective study
-
Porter J, Galanello R, Saglio G et al. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur. J. Haematol. 80, 168-176 (2008).
-
(2008)
Eur. J. Haematol.
, vol.80
, pp. 168-176
-
-
Porter, J.1
Galanello, R.2
Saglio, G.3
-
123
-
-
0032529333
-
Tumor cell cytotoxicity of a novel metal chelator
-
Torti SV, Torti FM, Whitman SP, Brechbiel MW, Park G, Planalp RP. Tumor cell cytotoxicity of a novel metal chelator. Blood 92, 1384-1389 (1998).
-
(1998)
Blood
, vol.92
, pp. 1384-1389
-
-
Torti, S.V.1
Torti, F.M.2
Whitman, S.P.3
Brechbiel, M.W.4
Park, G.5
Planalp, R.P.6
-
124
-
-
1842785914
-
Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator
-
Zhao R, Planalp RP, Ma R et al. Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator. Biochem. Pharmacol. 67, 1677-1688 (2004).
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 1677-1688
-
-
Zhao, R.1
Planalp, R.P.2
Ma, R.3
-
125
-
-
4744345552
-
Synthesis and potent antitumor activities of novel 1,3,5-cis, cistriaminocyclohexane N-pyridyl derivatives
-
Chong HS, Torti SV, Ma R, Torti FM, Brechbiel MW. Synthesis and potent antitumor activities of novel 1,3,5-cis,cistriaminocyclohexane N-pyridyl derivatives. J. Med. Chem. 47, 5230-5234 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5230-5234
-
-
Chong, H.S.1
Torti, S.V.2
Ma, R.3
Torti, F.M.4
Brechbiel, M.W.5
-
126
-
-
27644552326
-
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
-
Turner J, Koumenis C, Kute TE et al. Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood 106, 3191-3199 (2005).
-
(2005)
Blood
, vol.106
, pp. 3191-3199
-
-
Turner, J.1
Koumenis, C.2
Kute, T.E.3
-
127
-
-
37049031427
-
Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators
-
Childers ML, Cho J, Regino CA et al. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. J. Inorg. Biochem. 102, 150-156 (2008).
-
(2008)
J. Inorg. Biochem.
, vol.102
, pp. 150-156
-
-
Childers, M.L.1
Cho, J.2
Regino, C.A.3
-
128
-
-
34548299563
-
Dexrazoxane: How it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
-
Hasinoff BB, Herman EH. Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug? Cardiovasc. Toxicol. 7, 140-144 (2007).
-
(2007)
Cardiovasc. Toxicol.
, vol.7
, pp. 140-144
-
-
Hasinoff, B.B.1
Herman, E.H.2
-
129
-
-
0025687514
-
Examination of the potential long-lasting protective effect of ICRF-187 against anthracycline-induced chronic cardiomyopathy
-
Herman EH, Ferrans VJ. Examination of the potential long-lasting protective effect of ICRF-187 against anthracycline-induced chronic cardiomyopathy. Cancer Treat. Rev. 17, 155-160 (1990).
-
(1990)
Cancer Treat. Rev.
, vol.17
, pp. 155-160
-
-
Herman, E.H.1
Ferrans, V.J.2
-
130
-
-
0742269397
-
The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: Expert panel review
-
Swain SM, Vici P. The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review. J. Cancer Res. Clin. Oncol. 130, 1-7 (2004).
-
(2004)
J. Cancer Res. Clin. Oncol.
, vol.130
, pp. 1-7
-
-
Swain, S.M.1
Vici, P.2
-
131
-
-
0031906718
-
Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
-
Hasinoff BB, Hellmann K, Herman EH, Ferrans VJ. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Curr. Med. Chem. 5, 1-28 (1998).
-
(1998)
Curr. Med. Chem.
, vol.5
, pp. 1-28
-
-
Hasinoff, B.B.1
Hellmann, K.2
Herman, E.H.3
Ferrans, V.J.4
-
132
-
-
0041854306
-
The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
-
Hasinoff BB, Schroeder PE, Patel D. The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity. Mol. Pharmacol. 64, 670-678 (2003).
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 670-678
-
-
Hasinoff, B.B.1
Schroeder, P.E.2
Patel, D.3
-
133
-
-
0036363028
-
Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxiareoxygenation damage
-
Hasinoff BB. Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxiareoxygenation damage. Cardiovasc. Toxicol. 2, 111-118 (2002).
-
(2002)
Cardiovasc. Toxicol.
, vol.2
, pp. 111-118
-
-
Hasinoff, B.B.1
-
134
-
-
2442698003
-
Phase i and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion
-
Wadler S, Makower D, Clairmont C, Lambert P, Fehn K, Sznol M. Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion. J. Clin. Oncol. 22, 1553-1563 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1553-1563
-
-
Wadler, S.1
Makower, D.2
Clairmont, C.3
Lambert, P.4
Fehn, K.5
Sznol, M.6
-
135
-
-
1642453838
-
In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
-
Shao J, Zhou B, Zhu L et al. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Res. 64, 1-6 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 1-6
-
-
Shao, J.1
Zhou, B.2
Zhu, L.3
-
136
-
-
33646734458
-
In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehydethiosemicarbazone)
-
Barker CA, Burgan WE, Carter DJ et al. In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehydethiosemicarbazone). Clin. Cancer Res. 12, 2912-2918 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 2912-2918
-
-
Barker, C.A.1
Burgan, W.E.2
Carter, D.J.3
-
137
-
-
4644288941
-
A Phase i trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer
-
Yen Y, Margolin K, Doroshow J et al. A Phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer. Cancer Chemother. Pharmacol. 54, 331-342 (2004).
-
(2004)
Cancer Chemother. Pharmacol.
, vol.54
, pp. 331-342
-
-
Yen, Y.1
Margolin, K.2
Doroshow, J.3
-
138
-
-
33744526999
-
Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome
-
Yee KW, Cortes J, Ferrajoli A et al. Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome. Leuk. Res. 30, 813-822 (2006).
-
(2006)
Leuk. Res.
, vol.30
, pp. 813-822
-
-
Yee, K.W.1
Cortes, J.2
Ferrajoli, A.3
-
139
-
-
0037986658
-
Iron chelators as anti-neoplastic agents: Current developments and promise of the PIH class of chelators
-
Lovejoy DB, Richardson DR. Iron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators. Curr. Med. Chem. 10, 1035-1049 (2003).
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1035-1049
-
-
Lovejoy, D.B.1
Richardson, D.R.2
-
140
-
-
12344319022
-
Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits
-
Simunek T, Klimtova I, Kaplanova J et al. Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits. Pharmacol. Res. 51, 223-231 (2005).
-
(2005)
Pharmacol. Res.
, vol.51
, pp. 223-231
-
-
Simunek, T.1
Klimtova, I.2
Kaplanova, J.3
-
141
-
-
0033566305
-
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III. the effect of the ligands on molecular targets involved in proliferation
-
Darnell G, Richardson DR. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III. The effect of the ligands on molecular targets involved in proliferation. Blood 94, 781-792 (1999).
-
(1999)
Blood
, vol.94
, pp. 781-792
-
-
Darnell, G.1
Richardson, D.R.2
-
142
-
-
34848927142
-
Iron chelators ICL670 and 311 inhibit HIV-1 transcription
-
Debebe Z, Ammosova T, Jerebtsova M et al. Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Virology 367, 324-333 (2007).
-
(2007)
Virology
, vol.367
, pp. 324-333
-
-
Debebe, Z.1
Ammosova, T.2
Jerebtsova, M.3
-
143
-
-
0037351292
-
Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents
-
Becker EM, Lovejoy DB, Greer JM, Watts R, Richardson DR. Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents. Br. J. Pharmacol. 138, 819-830 (2003).
-
(2003)
Br. J. Pharmacol.
, vol.138
, pp. 819-830
-
-
Becker, E.M.1
Lovejoy, D.B.2
Greer, J.M.3
Watts, R.4
Richardson, D.R.5
-
144
-
-
8444235919
-
Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation
-
Chaston TB, Watts RN, Yuan J, Richardson DR. Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation. Clin. Cancer Res. 10, 7365-7374 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7365-7374
-
-
Chaston, T.B.1
Watts, R.N.2
Yuan, J.3
Richardson, D.R.4
-
145
-
-
36649015540
-
Tuning the antiproliferative activity of biologically active iron chelators: Characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands
-
Bernhardt PV, Wilson GJ, Sharpe PC, Kalinowski DS, Richardson DR. Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands. J. Biol. Inorg. Chem. 13, 107-119 (2008).
-
(2008)
J. Biol. Inorg. Chem.
, vol.13
, pp. 107-119
-
-
Bernhardt, P.V.1
Wilson, G.J.2
Sharpe, P.C.3
Kalinowski, D.S.4
Richardson, D.R.5
-
146
-
-
4444248453
-
Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment
-
Yuan J, Lovejoy DB, Richardson DR. Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood 104, 1450-1458 (2004).
-
(2004)
Blood
, vol.104
, pp. 1450-1458
-
-
Yuan, J.1
Lovejoy, D.B.2
Richardson, D.R.3
-
147
-
-
62949221047
-
Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells
-
Noulsri E, Richardson DR, Lerdwana S et al. Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells. Am. J. Hematol. 84, 170-176 (2009).
-
(2009)
Am. J. Hematol.
, vol.84
, pp. 170-176
-
-
Noulsri, E.1
Richardson, D.R.2
Lerdwana, S.3
-
148
-
-
59149089078
-
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIa in breast cancer cells
-
Rao VA, Klein SR, Agama KK et al. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIa in breast cancer cells. Cancer Res. 69, 948-957 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 948-957
-
-
Rao, V.A.1
Klein, S.R.2
Agama, K.K.3
-
149
-
-
33749515083
-
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
-
Whitnall M, Howard J, Ponka P, Richardson DR. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc. Natl Acad. Sci. USA 103, 14901-14906 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 14901-14906
-
-
Whitnall, M.1
Howard, J.2
Ponka, P.3
Richardson, D.R.4
-
150
-
-
44749093175
-
Curcumin: From ancient medicine to current clinical trials
-
Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol. Life Sci. 65, 1631-1652 (2008).
-
(2008)
Cell Mol. Life Sci.
, vol.65
, pp. 1631-1652
-
-
Hatcher, H.1
Planalp, R.2
Cho, J.3
Torti, F.M.4
Torti, S.V.5
-
152
-
-
0027492737
-
Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
-
Morel I, Lescoat G, Cogrel P et al. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmacol. 45, 13-19 (1993).
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 13-19
-
-
Morel, I.1
Lescoat, G.2
Cogrel, P.3
-
153
-
-
0037462639
-
Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae
-
Guo M, Harvey I, Yang W et al. Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae. J. Biol. Chem. 278, 2490-2502 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2490-2502
-
-
Guo, M.1
Harvey, I.2
Yang, W.3
-
154
-
-
0037388042
-
Dealing with iron: Common structural principles in proteins that transport iron and heme
-
Baker HM, Anderson BF, Baker EN. Dealing with iron: common structural principles in proteins that transport iron and heme. Proc. Natl Acad. Sci. USA 100, 3579-3583 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 3579-3583
-
-
Baker, H.M.1
Anderson, B.F.2
Baker, E.N.3
-
156
-
-
33746211331
-
Short oxo-titanium(IV) bond in bacterial transferrin: A protein target for metalloantibiotics
-
Guo M, Harvey I, Campopiano DJ, Sadler PJ. Short oxo-titanium(IV) bond in bacterial transferrin: a protein target for metalloantibiotics. Angew. Chem. Int. Ed. Engl. 45, 2758-2761 (2006).
-
(2006)
Angew. Chem. Int. Ed. Engl.
, vol.45
, pp. 2758-2761
-
-
Guo, M.1
Harvey, I.2
Campopiano, D.J.3
Sadler, P.J.4
-
158
-
-
0345688126
-
Oxo-iron clusters in a bacterial iron-trafficking protein: New roles for a conserved motif
-
Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ. Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif. Biochem. J. 376, 35-41 (2003).
-
(2003)
Biochem. J.
, vol.376
, pp. 35-41
-
-
Zhu, H.1
Alexeev, D.2
Hunter, D.J.3
Campopiano, D.J.4
Sadler, P.J.5
-
159
-
-
0036774226
-
Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships
-
Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 13, 572-584 (2002).
-
(2002)
J. Nutr. Biochem.
, vol.13
, pp. 572-584
-
-
Heim, K.E.1
Tagliaferro, A.R.2
Bobilya, D.J.3
-
160
-
-
34547117120
-
Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: A comparative study
-
Rao YK, Geethangili M, Fang SH, Tzeng YM. Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem. Toxicol. 45, 1770-1776 (2007).
-
(2007)
Food Chem. Toxicol.
, vol.45
, pp. 1770-1776
-
-
Rao, Y.K.1
Geethangili, M.2
Fang, S.H.3
Tzeng, Y.M.4
-
161
-
-
0028908824
-
Structure-activity relationship of flavonoids with superoxide scavenging activity
-
Hu JP, Calomme M, Lasure A et al. Structure-activity relationship of flavonoids with superoxide scavenging activity. Biol. Trace Elem. Res. 47, 327-331 (1995).
-
(1995)
Biol. Trace Elem. Res.
, vol.47
, pp. 327-331
-
-
Hu, J.P.1
Calomme, M.2
Lasure, A.3
-
162
-
-
13844281685
-
Bioavailability and bioefficacy of polyphenols in humans.I. Review of 97 bioavailability studies
-
Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81, 230S-242S (2005).
-
(2005)
Am. J. Clin. Nutr.
, vol.81
-
-
Manach, C.1
Williamson, G.2
Morand, C.3
Scalbert, A.4
Remesy, C.5
-
163
-
-
13844271387
-
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
-
Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr. 81, 243S-255S (2005).
-
(2005)
Am. J. Clin. Nutr.
, vol.81
-
-
Williamson, G.1
Manach, C.2
-
164
-
-
0035543628
-
Tannins: Classification and definition
-
Khanbabaee K, van Ree T. Tannins: classification and definition. Nat. Prod. Rep. 18, 641-649 (2001).
-
(2001)
Nat. Prod. Rep.
, vol.18
, pp. 641-649
-
-
Khanbabaee, K.1
Van Ree, T.2
-
165
-
-
38949131470
-
Flavan-3-ols: Nature, occurrence and biological activity
-
Aron PM, Kennedy JA. Flavan-3-ols: nature, occurrence and biological activity. Mol. Nutr. Food Res. 52, 79-104 (2008).
-
(2008)
Mol. Nutr. Food Res.
, vol.52
, pp. 79-104
-
-
Aron, P.M.1
Kennedy, J.A.2
-
166
-
-
2342597191
-
Proanthocyanidins in health care: Current and new trends
-
Cos P, De Bruyne T, Hermans N, Apers S, Berghe DV, Vlietinck AJ. Proanthocyanidins in health care: current and new trends. Curr. Med. Chem. 11, 1345-1359 (2004).
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 1345-1359
-
-
Cos, P.1
De Bruyne, T.2
Hermans, N.3
Apers, S.4
Berghe, D.V.5
Vlietinck, A.J.6
-
167
-
-
0036849077
-
The biochemistry and medical significance of the flavonoids
-
Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96, 67-202 (2002).
-
(2002)
Pharmacol. Ther.
, vol.96
, pp. 67-202
-
-
Havsteen, B.H.1
-
168
-
-
33750708260
-
An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels
-
Messina M, Kucuk O, Lampe JW. An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J. AOAC Int. 89, 1121-1134 (2006).
-
(2006)
J. AOAC Int.
, vol.89
, pp. 1121-1134
-
-
Messina, M.1
Kucuk, O.2
Lampe, J.W.3
-
169
-
-
1942502249
-
The toxicology and safety of apple polyphenol extract
-
Shoji T, Akazome Y, Kanda T, Ikeda M. The toxicology and safety of apple polyphenol extract. Food Chem. Toxicol. 42, 959-967 (2004).
-
(2004)
Food Chem. Toxicol.
, vol.42
, pp. 959-967
-
-
Shoji, T.1
Akazome, Y.2
Kanda, T.3
Ikeda, M.4
-
170
-
-
58849102674
-
Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
-
Jiao Y, Wilkinson Jt, Di X et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 113, 462-469 (2009).
-
(2009)
Blood
, vol.113
, pp. 462-469
-
-
Jiao, Y.1
Wilkinson Jt Di, X.2
-
171
-
-
1842842944
-
Spectrophotometric and electrochemical determination of the formation constants of the complexes Curcumin-Fe(III)-water and Curcumin-Fe(II)-water
-
Bernabe-Pineda M, Ramirez-Silva MT, Romero-Romo MA, Gonzalez-Vergara E, Rojas-Hernandez A. Spectrophotometric and electrochemical determination of the formation constants of the complexes Curcumin-Fe(III)-water and Curcumin-Fe(II)-water. Spectrochim. Acta A Mol. Biomol. Spectrosc. 60, 1105-1113 (2004).
-
(2004)
Spectrochim. Acta A Mol. Biomol. Spectrosc.
, vol.60
, pp. 1105-1113
-
-
Bernabe-Pineda, M.1
Ramirez-Silva, M.T.2
Romero-Romo, M.A.3
Gonzalez-Vergara, E.4
Rojas-Hernandez, A.5
-
172
-
-
33644988713
-
Iron chelation in the biological activity of curcumin
-
Jiao Y, Wilkinson Jt, Christine Pietsch E et al. Iron chelation in the biological activity of curcumin. Free Radic. Biol. Med. 40, 1152-1160 (2006).
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 1152-1160
-
-
Jiao, Y.1
Jt, W.2
Christine Pietsch, E.3
-
173
-
-
70349142708
-
Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice
-
Thephinlap C, Phisalaphong C, Fucharoen S, Porter JB, Srichairatanakool S. Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice. Med. Chem. 5(5), 474-482 (2009).
-
(2009)
Med. Chem.
, vol.5
, Issue.5
, pp. 474-482
-
-
Thephinlap, C.1
Phisalaphong, C.2
Fucharoen, S.3
Porter, J.B.4
Srichairatanakool, S.5
-
174
-
-
38549134407
-
Antiparkinson drug -mucuna pruriens shows antioxidant and metal chelating activity
-
Dhanasekaran M, Tharakan B, Manyam BV. Antiparkinson drug -mucuna pruriens shows antioxidant and metal chelating activity. Phytother. Res. 22, 6-11 (2008).
-
(2008)
Phytother. Res.
, vol.22
, pp. 6-11
-
-
Dhanasekaran, M.1
Tharakan, B.2
Manyam, B.V.3
-
175
-
-
20944444111
-
Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
-
Mandel SA, Avramovich-Tirosh Y, Reznichenko L et al. Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway. Neurosignals 14, 46-60 (2005).
-
(2005)
Neurosignals
, vol.14
, pp. 46-60
-
-
Mandel, S.A.1
Avramovich-Tirosh, Y.2
Reznichenko, L.3
-
176
-
-
48349145010
-
Curcuma oil: Reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain
-
Rathore P, Dohare P, Varma S et al. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem. Res. 33, 1672-1682 (2008).
-
(2008)
Neurochem. Res.
, vol.33
, pp. 1672-1682
-
-
Rathore, P.1
Dohare, P.2
Varma, S.3
-
177
-
-
35649015344
-
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
-
Kahles T, Luedike P, Endres M et al. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke 38, 3000-3006 (2007).
-
(2007)
Stroke
, vol.38
, pp. 3000-3006
-
-
Kahles, T.1
Luedike, P.2
Endres, M.3
-
178
-
-
34547858520
-
Apocynin attenuates cerebral infarction after transient focal ischaemia in rats
-
Tang LL, Ye K, Yang XF, Zheng JS. Apocynin attenuates cerebral infarction after transient focal ischaemia in rats. J. Int. Med. Res. 35, 517-522 (2007).
-
(2007)
J. Int. Med. Res.
, vol.35
, pp. 517-522
-
-
Tang, L.L.1
Ye, K.2
Yang, X.F.3
Zheng, J.S.4
-
179
-
-
33744509306
-
Apocynin protects against global cerebral ischemia-reperfusioninduced oxidative stress and injury in the gerbil hippocampus
-
Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. Apocynin protects against global cerebral ischemia-reperfusioninduced oxidative stress and injury in the gerbil hippocampus. Brain Res. 1090, 182-189 (2006).
-
(2006)
Brain Res
, vol.1090
, pp. 182-189
-
-
Wang, Q.1
Tompkins, K.D.2
Simonyi, A.3
Korthuis, R.J.4
Sun, A.Y.5
Sun, G.Y.6
-
180
-
-
65249178920
-
Botanical phenolics and brain health
-
Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecular. Med. 10, 259-274 (2008).
-
(2008)
Neuromolecular. Med.
, vol.10
, pp. 259-274
-
-
Sun, A.Y.1
Wang, Q.2
Simonyi, A.3
Sun, G.Y.4
-
181
-
-
22644436005
-
Anti-oxidant mechanisms of kolaviron: Studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
-
Farombi EO, Nwaokeafor IA. Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats. Clin. Exp. Pharmacol. Physiol. 32, 667-674 (2005).
-
(2005)
Clin. Exp. Pharmacol. Physiol.
, vol.32
, pp. 667-674
-
-
Farombi, E.O.1
Nwaokeafor, I.A.2
-
182
-
-
34248655403
-
Physicochemical study of floranol, its copper(II) and iron(III) complexes, and their inhibitory effect on LDL oxidation
-
Botelho FV, Alvarez-Leite JI, Lemos VS et al. Physicochemical study of floranol, its copper(II) and iron(III) complexes, and their inhibitory effect on LDL oxidation. J. Inorg. Biochem. 101, 935-943 (2007).
-
(2007)
J. Inorg. Biochem.
, vol.101
, pp. 935-943
-
-
Botelho, F.V.1
Alvarez-Leite, J.I.2
Lemos, V.S.3
-
183
-
-
0032839592
-
Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol
-
Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic. Biol. Med. 27, 704-724 (1999).
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 704-724
-
-
Packer, L.1
Rimbach, G.2
Virgili, F.3
-
184
-
-
0344188829
-
Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: Antioxidant intervention and/or iron and copper sequestering ability
-
Maffei Facino R, Carini M, Aldini G et al. Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Planta. Med. 62, 495-502 (1996).
-
(1996)
Planta. Med.
, vol.62
, pp. 495-502
-
-
Maffei Facino, R.1
Carini, M.2
Aldini, G.3
-
185
-
-
0032031283
-
Interaction of iron with polyphenolic compounds: Application to antioxidant characterization
-
Yoshino M, Murakami K. Interaction of iron with polyphenolic compounds: application to antioxidant characterization. Anal. Biochem. 257, 40-44 (1998).
-
(1998)
Anal. Biochem.
, vol.257
, pp. 40-44
-
-
Yoshino, M.1
Murakami, K.2
-
186
-
-
59649124184
-
Iron-binding and anti-Fenton properties of baicalein and baicalin
-
Perez CA, Wei Y, Guo M. Iron-binding and anti-Fenton properties of baicalein and baicalin. J. Inorg. Biochem. 103, 326-332 (2009).
-
(2009)
J. Inorg. Biochem.
, vol.103
, pp. 326-332
-
-
Perez, C.A.1
Wei, Y.2
Guo, M.3
-
187
-
-
17444390875
-
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells
-
Lee HZ, Leung HW, Lai MY, Wu CH. Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res. 25, 959-964 (2005).
-
(2005)
Anticancer Res
, vol.25
, pp. 959-964
-
-
Lee, H.Z.1
Leung, H.W.2
Lai, M.Y.3
Wu, C.H.4
-
188
-
-
45949094793
-
The role of Ca2+ in baicalein-induced apoptosis in human breast
-
Lee JH, Li YC, Ip SW et al. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria-and caspase-3-dependent pathway. Anticancer Res. 28, 1701-1711 (2008).
-
(2008)
Anticancer Res
, vol.28
, pp. 1701-1711
-
-
Lee, J.H.1
Li, Y.C.2
Ip, S.W.3
-
189
-
-
33645381909
-
Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury
-
Zhang Y, Li H, Zhao Y, Gao Z. Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury. Eur. J. Pharmacol. 535, 263-269 (2006).
-
(2006)
Eur. J. Pharmacol.
, vol.535
, pp. 263-269
-
-
Zhang, Y.1
Li, H.2
Zhao, Y.3
Gao, Z.4
-
190
-
-
14044278644
-
Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury
-
Zhao Y, Li H, Gao Z, Xu H. Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury. Eur. J. Pharmacol. 509, 195-200 (2005).
-
(2005)
Eur. J. Pharmacol.
, vol.509
, pp. 195-200
-
-
Zhao, Y.1
Li, H.2
Gao, Z.3
Xu, H.4
-
191
-
-
35548981681
-
Iron-binding properties of plant phenolics and cranberry's bio-effects
-
Guo M, Perez C, Wei Y et al. Iron-binding properties of plant phenolics and cranberry's bio-effects. Dalton Trans. 21(43), 4951-4961 (2007).
-
(2007)
Dalton Trans
, vol.21
, Issue.43
, pp. 4951-4961
-
-
Guo, M.1
Perez, C.2
Wei, Y.3
-
192
-
-
0037466465
-
Iron-induced oxidative damage and apoptosis in cerebellar granule cells: Attenuation by tetramethylpyrazine and ferulic acid
-
Zhang Z, Wei T, Hou J, Li G, Yu S, Xin W. Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid. Eur. J. Pharmacol. 467, 41-47 (2003).
-
(2003)
Eur. J. Pharmacol.
, vol.467
, pp. 41-47
-
-
Zhang, Z.1
Wei, T.2
Hou, J.3
Li, G.4
Yu, S.5
Xin, W.6
-
193
-
-
77953387513
-
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury
-
Feng L, Ke N, Cheng F et al. The protective mechanism of ligustrazine against renal ischemia/reperfusion injury. J. Surg. Res. (2009).
-
(2009)
J. Surg. Res.
-
-
Feng, L.1
Ke, N.2
Cheng, F.3
-
194
-
-
7044260531
-
Effect of ligustrazine on ischemiareperfusion injury in murine kidney
-
Feng L, Xiong Y, Cheng F, Zhang L, Li S, Li Y. Effect of ligustrazine on ischemiareperfusion injury in murine kidney. Transplant Proc. 36, 1949-1951 (2004).
-
(2004)
Transplant Proc
, vol.36
, pp. 1949-1951
-
-
Feng, L.1
Xiong, Y.2
Cheng, F.3
Zhang, L.4
Li, S.5
Li, Y.6
-
195
-
-
0037438947
-
Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers
-
Moridani MY, Pourahmad J, Bui H, Siraki A, O'Brien PJ. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic. Biol. Med. 34, 243-253 (2003).
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 243-253
-
-
Moridani, M.Y.1
Pourahmad, J.2
Bui, H.3
Siraki, A.4
O'Brien, P.J.5
-
196
-
-
1042290475
-
Cellular uptake and metabolism of flavonoids and their metabolites: Implications for their bioactivity
-
Spencer JP, Abd-el-Mohsen MM, Rice-Evans C. Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Arch. Biochem. Biophys. 423, 148-161 (2004).
-
(2004)
Arch. Biochem. Biophys.
, vol.423
, pp. 148-161
-
-
Spencer, J.P.1
Abd-El-Mohsen, M.M.2
Rice-Evans, C.3
-
197
-
-
0037048738
-
Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon)
-
Yan X, Murphy BT, Hammond GB, Vinson JA, Neto CC. Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). J. Agric. Food Chem. 50, 5844-5849 (2002).
-
(2002)
J. Agric. Food Chem.
, vol.50
, pp. 5844-5849
-
-
Yan, X.1
Murphy, B.T.2
Hammond, G.B.3
Vinson, J.A.4
Neto, C.C.5
-
198
-
-
0034784008
-
Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu2+-induced oxidation
-
Porter ML, Krueger CG, Wiebe DA, Cunningham DG, Reed JD. Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu2+-induced oxidation. J. Sci. Food Agric. 81, 1306-1313 (2001).
-
(2001)
J. Sci. Food Agric.
, vol.81
, pp. 1306-1313
-
-
Porter, M.L.1
Krueger, C.G.2
Wiebe, D.A.3
Cunningham, D.G.4
Reed, J.D.5
-
199
-
-
29244464806
-
Cranberry phenolics: Effects on oxidative processes, neuron cell death and tumor cell growth
-
Columbus, OH, USA
-
Neto CC, Sweeney-Nixon MI, Lamoureaux TL, Solomon F, Kondo M, MacKinnon SL. Cranberry Phenolics: Effects on Oxidative Processes, Neuron Cell Death and Tumor Cell Growth. ACS Books, Columbus, OH, USA 271-282 (2005).
-
(2005)
ACS Books
, pp. 271-282
-
-
Neto, C.C.1
Sweeney-Nixon, M.I.2
Lamoureaux, T.L.3
Solomon, F.4
Kondo, M.5
MacKinnon, S.L.6
-
200
-
-
0036265622
-
Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults (small star, filled)
-
Youdim KA, McDonald J, Kalt W, Joseph JA. Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults (small star, filled). J. Nutr. Biochem. 13, 282-288 (2002).
-
(2002)
J. Nutr. Biochem.
, vol.13
, pp. 282-288
-
-
Youdim, K.A.1
McDonald, J.2
Kalt, W.3
Joseph, J.A.4
-
201
-
-
2342515521
-
Total cranberry extract versus its phytochemical constituents: Antiproliferative and synergistic effects against human tumor cell lines
-
Seeram NP, Adams LS, Hardy ML, Heber D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 52, 2512-2517 (2004).
-
(2004)
J. Agric. Food Chem.
, vol.52
, pp. 2512-2517
-
-
Seeram, N.P.1
Adams, L.S.2
Hardy, M.L.3
Heber, D.4
-
202
-
-
14644446143
-
Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract
-
Bagchi D, Sen CK, Ray SD et al. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat. Res. 523-524, 87-97 (2003).
-
(2003)
Mutat. Res.
, vol.523-524
, pp. 87-97
-
-
Bagchi, D.1
Sen, C.K.2
Ray, S.D.3
-
203
-
-
34447511565
-
Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits
-
Frederiksen H, Mortensen A, Schroder M et al. Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Mol. Nutr. Food Res. 51, 564-571 (2007).
-
(2007)
Mol. Nutr. Food Res.
, vol.51
, pp. 564-571
-
-
Frederiksen, H.1
Mortensen, A.2
Schroder, M.3
-
204
-
-
51049099169
-
Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers
-
Kim EY, Ham SK, Shigenaga MK, Han O. Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers. J. Nutr. 138, 1647-1651 (2008).
-
(2008)
J. Nutr.
, vol.138
, pp. 1647-1651
-
-
Kim, E.Y.1
Ham, S.K.2
Shigenaga, M.K.3
Han, O.4
-
205
-
-
0033152913
-
Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury
-
Sato M, Maulik G, Ray PS, Bagchi D, Das DK. Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury. J. Mol. Cell Cardiol. 31, 1289-1297 (1999).
-
(1999)
J. Mol. Cell Cardiol.
, vol.31
, pp. 1289-1297
-
-
Sato, M.1
Maulik, G.2
Ray, P.S.3
Bagchi, D.4
Das, D.K.5
-
206
-
-
33645294934
-
Reduction of iron-regulated amyloid precursor protein and b-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: Implications for iron chelation in Alzheimer's disease
-
Reznichenko L, Amit T, Zheng H et al. Reduction of iron-regulated amyloid precursor protein and b-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease. J. Neurochem. 97, 527-536 (2006).
-
(2006)
J. Neurochem.
, vol.97
, pp. 527-536
-
-
Reznichenko, L.1
Amit, T.2
Zheng, H.3
-
207
-
-
34247185925
-
Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1
-
Cai F, Li CR, Wu JL et al. Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm. 2006, 30490 (2006).
-
(2006)
Mediators Inflamm
, vol.2006
, pp. 30490
-
-
Cai, F.1
Li, C.R.2
Wu, J.L.3
-
208
-
-
0030582664
-
Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes
-
Guo Q, Zhao B, Li M, Shen S, Xin W. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim. Biophys. Acta 1304, 210-222 (1996).
-
(1996)
Biochim. Biophys. Acta
, vol.1304
, pp. 210-222
-
-
Guo, Q.1
Zhao, B.2
Li, M.3
Shen, S.4
Xin, W.5
-
209
-
-
0035221140
-
Effects of pH and metal ions on antioxidative activities of catechins
-
Kumamoto M, Sonda T, Nagayama K, Tabata M. Effects of pH and metal ions on antioxidative activities of catechins. Biosci. Biotechnol. Biochem. 65, 126-132 (2001).
-
(2001)
Biosci. Biotechnol. Biochem.
, vol.65
, pp. 126-132
-
-
Kumamoto, M.1
Sonda, T.2
Nagayama, K.3
Tabata, M.4
-
210
-
-
0030679601
-
Protective effects of tea polyphenols against oxidative damage to red blood cells
-
Grinberg LN, Newmark H, Kitrossky N, Rahamim E, Chevion M, Rachmilewitz EA. Protective effects of tea polyphenols against oxidative damage to red blood cells. Biochem. Pharmacol. 54, 973-978 (1997).
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 973-978
-
-
Grinberg, L.N.1
Newmark, H.2
Kitrossky, N.3
Rahamim, E.4
Chevion, M.5
Rachmilewitz, E.A.6
-
211
-
-
34047226088
-
Structure-activity relationships of tea compounds against human cancer cells
-
Friedman M, Mackey BE, Kim HJ et al. Structure-activity relationships of tea compounds against human cancer cells. J. Agric. Food Chem. 55, 243-253 (2007).
-
(2007)
J. Agric. Food Chem.
, vol.55
, pp. 243-253
-
-
Friedman, M.1
MacKey, B.E.2
Kim, H.J.3
-
212
-
-
44149090471
-
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
-
Lahiry L, Saha B, Chakraborty J et al. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis 13, 771-781 (2008).
-
(2008)
Apoptosis
, vol.13
, pp. 771-781
-
-
Lahiry, L.1
Saha, B.2
Chakraborty, J.3
-
213
-
-
56949101468
-
PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate
-
Lu J, Gosslau A, Liu AY, Chen KY. PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. Eur. J. Pharmacol. 601, 66-72 (2008).
-
(2008)
Eur. J. Pharmacol.
, vol.601
, pp. 66-72
-
-
Lu, J.1
Gosslau, A.2
Liu, A.Y.3
Chen, K.Y.4
-
214
-
-
33745561778
-
Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells
-
Cao X, Qin J, Xie Y et al. Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells. Oncogene 25, 3719-3734 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 3719-3734
-
-
Cao, X.1
Qin, J.2
Xie, Y.3
-
215
-
-
33744459471
-
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis
-
Kelly P, Moeller BJ, Juneja J et al. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc. Natl Acad. Sci. USA 103, 8173-8178 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 8173-8178
-
-
Kelly, P.1
Moeller, B.J.2
Juneja, J.3
-
216
-
-
34249308188
-
Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts
-
Kaur S, Greaves P, Cooke DN et al. Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts. J. Agric. Food Chem. 55, 3378-3385 (2007).
-
(2007)
J. Agric. Food Chem.
, vol.55
, pp. 3378-3385
-
-
Kaur, S.1
Greaves, P.2
Cooke, D.N.3
-
217
-
-
0031903419
-
Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a] anthracene in rats fed control or high fat diets
-
Rogers AE, Hafer LJ, Iskander YS, Yang S. Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets. Carcinogenesis 19, 1269-1273 (1998).
-
(1998)
Carcinogenesis
, vol.19
, pp. 1269-1273
-
-
Rogers, A.E.1
Hafer, L.J.2
Iskander, Y.S.3
Yang, S.4
-
218
-
-
0030942890
-
Tea, or tea and milk, inhibit mammary gland and colon carcinogenesis in rats
-
Weisburger JH, Rivenson A, Garr K, Aliaga C. Tea, or tea and milk, inhibit mammary gland and colon carcinogenesis in rats. Cancer Lett. 114, 323-327 (1997).
-
(1997)
Cancer Lett
, vol.114
, pp. 323-327
-
-
Weisburger, J.H.1
Rivenson, A.2
Garr, K.3
Aliaga, C.4
-
219
-
-
0345687985
-
Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice
-
Zhou JR, Yu L, Mai Z, Blackburn GL. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int. J. Cancer 108, 8-14 (2004).
-
(2004)
Int. J. Cancer
, vol.108
, pp. 8-14
-
-
Zhou, J.R.1
Yu, L.2
Mai, Z.3
Blackburn, G.L.4
-
220
-
-
33947542075
-
Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression
-
Banerjee S, Manna S, Mukherjee S, Pal D, Panda CK, Das S. Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. Asian Pac. J. Cancer Prev. 7, 661-666 (2006).
-
(2006)
Asian Pac. J. Cancer Prev.
, vol.7
, pp. 661-666
-
-
Banerjee, S.1
Manna, S.2
Mukherjee, S.3
Pal, D.4
Panda, C.K.5
Das, S.6
-
221
-
-
34248562294
-
Green tea catechins as brain-permeable non toxic iron chelators to "iron out iron" from the brain
-
Mandel S, Weinreb O, Reznichenko L, Kalfon L, Amit T. Green tea catechins as brain-permeable, non toxic iron chelators to "iron out iron" from the brain. J. Neural Transm. Suppl. 71, 249-257 (2006).
-
(2006)
J. Neural Transm. Suppl.
, vol.71
, pp. 249-257
-
-
Mandel, S.1
Weinreb, O.2
Reznichenko, L.3
Kalfon, L.4
Amit, T.5
-
222
-
-
49449090948
-
Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins
-
Mandel SA, Amit T, Kalfon L, Reznichenko L, Youdim MB. Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. J. Nutr. 138, 1578S-1583S (2008).
-
(2008)
J. Nutr.
, vol.138
-
-
Mandel, S.A.1
Amit, T.2
Kalfon, L.3
Reznichenko, L.4
Youdim, M.B.5
-
223
-
-
0034733810
-
Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
-
Lee S, Suh S, Kim S. Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci. Lett. 287, 191-194 (2000).
-
(2000)
Neurosci. Lett.
, vol.287
, pp. 191-194
-
-
Lee, S.1
Suh, S.2
Kim, S.3
-
224
-
-
13244255652
-
Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: Novel mechanisms of action
-
Sutherland BA, Shaw OM, Clarkson AN, Jackson DN, Sammut IA, Appleton I. Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: novel mechanisms of action. FASEB. J. 19, 258-260 (2005).
-
(2005)
FASEB. J.
, vol.19
, pp. 258-260
-
-
Sutherland, B.A.1
Shaw, O.M.2
Clarkson, A.N.3
Jackson, D.N.4
Sammut, I.A.5
Appleton, I.6
-
225
-
-
6344274849
-
Green tea epigallocatechin-3-gallate mediates T cellular NF-k B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
-
Aktas O, Prozorovski T, Smorodchenko A et al. Green tea epigallocatechin-3-gallate mediates T cellular NF-k B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J. Immunol. 173, 5794-5800 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 5794-5800
-
-
Aktas, O.1
Prozorovski, T.2
Smorodchenko, A.3
-
226
-
-
33645519220
-
Long-term administration of green tea catechins improves spatial cognition learning ability in rats
-
Haque AM, Hashimoto M, Katakura M, Tanabe Y, Hara Y, Shido O. Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J. Nutr. 136, 1043-1047 (2006).
-
(2006)
J. Nutr.
, vol.136
, pp. 1043-1047
-
-
Haque, A.M.1
Hashimoto, M.2
Katakura, M.3
Tanabe, Y.4
Hara, Y.5
Shido, O.6
-
227
-
-
25444500410
-
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
-
Rezai-Zadeh K, Shytle D, Sun N et al. Green tea epigallocatechin-3- gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J. Neurosci. 25, 8807-8814 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 8807-8814
-
-
Rezai-Zadeh, K.1
Shytle, D.2
Sun, N.3
-
228
-
-
34447322278
-
A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate
-
Weinreb O, Amit T, Youdim MB. A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate. Free Radic. Biol. Med. 43, 546-556 (2007).
-
(2007)
Free Radic. Biol. Med.
, vol.43
, pp. 546-556
-
-
Weinreb, O.1
Amit, T.2
Youdim, M.B.3
-
229
-
-
0033610239
-
A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins
-
Crouse JR 3rd, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch. Intern. Med. 159, 2070-2076 (1999).
-
(1999)
Arch. Intern. Med.
, vol.159
, pp. 2070-2076
-
-
Crouse III, J.R.1
Morgan, T.2
Terry, J.G.3
Ellis, J.4
Vitolins, M.5
Burke, G.L.6
-
230
-
-
33750631885
-
Effects of soy isoflavones and phytate on homocysteine. C-reactive protein, and iron status in postmenopausal women
-
Hanson LN, Engelman HM, Alekel DL, Schalinske KL, Kohut ML, Reddy MB. Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am. J. Clin. Nutr. 84, 774-780 (2006).
-
(2006)
Am. J. Clin. Nutr.
, vol.84
, pp. 774-780
-
-
Hanson, L.N.1
Engelman, H.M.2
Alekel, D.L.3
Schalinske, K.L.4
Kohut, M.L.5
Reddy, M.B.6
-
231
-
-
0034919419
-
Soy protein isoflavones, lipids and arterial disease
-
Vitolins MZ, Anthony M, Burke GL. Soy protein isoflavones, lipids and arterial disease. Curr. Opin. Lipidol. 12, 433-437 (2001).
-
(2001)
Curr. Opin. Lipidol.
, vol.12
, pp. 433-437
-
-
Vitolins, M.Z.1
Anthony, M.2
Burke, G.L.3
-
232
-
-
0019434645
-
Iron and the sex difference in heart disease risk
-
Sullivan JL. Iron and the sex difference in heart disease risk. Lancet 1, 1293-1294 (1981).
-
(1981)
Lancet
, vol.1
, pp. 1293-1294
-
-
Sullivan, J.L.1
-
233
-
-
0026800629
-
Soy protein, phytate, and iron absorption in humans
-
Hurrell RF, Juillerat MA, Reddy MB, Lynch SR, Dassenko SA, Cook JD. Soy protein, phytate, and iron absorption in humans. Am. J. Clin. Nutr. 56, 573-578 (1992).
-
(1992)
Am. J. Clin. Nutr.
, vol.56
, pp. 573-578
-
-
Hurrell, R.F.1
Juillerat, M.A.2
Reddy, M.B.3
Lynch, S.R.4
Dassenko, S.A.5
Cook, J.D.6
-
234
-
-
0030027776
-
The influence of different protein sources on phytate inhibition of nonhemeiron absorption in humans
-
Reddy MB, Hurrell RF, Juillerat MA, Cook JD. The influence of different protein sources on phytate inhibition of nonhemeiron absorption in humans. Am. J. Clin. Nutr. 63, 203-207 (1996).
-
(1996)
Am. J. Clin. Nutr.
, vol.63
, pp. 203-207
-
-
Reddy, M.B.1
Hurrell, R.F.2
Juillerat, M.A.3
Cook, J.D.4
-
235
-
-
0036297356
-
Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women
-
Swain JH, Alekel DL, Dent SB, Peterson CT, Reddy MB. Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women. Am. J. Clin. Nutr. 76, 165-171 (2002).
-
(2002)
Am. J. Clin. Nutr.
, vol.76
, pp. 165-171
-
-
Swain, J.H.1
Alekel, D.L.2
Dent, S.B.3
Peterson, C.T.4
Reddy, M.B.5
-
236
-
-
34247620808
-
Inhibition of lipoxygenase by soy isoflavones: Evidence of isoflavones as redox inhibitors
-
Mahesha HG, Singh SA, Rao AG. Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors. Arch. Biochem. Biophys. 461, 176-185 (2007).
-
(2007)
Arch. Biochem. Biophys.
, vol.461
, pp. 176-185
-
-
Mahesha, H.G.1
Singh, S.A.2
Rao, A.G.3
-
237
-
-
34447289163
-
Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
-
Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol. Genomics 30, 8-16 (2007).
-
(2007)
Physiol. Genomics
, vol.30
, pp. 8-16
-
-
Su, Y.1
Simmen, F.A.2
Xiao, R.3
Simmen, R.C.4
-
238
-
-
34247339685
-
Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat
-
Davis J, Higginbotham A, O'Connor T et al. Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat. Ann. Nutr. Metab. 51, 42-52 (2007).
-
(2007)
Ann. Nutr. Metab.
, vol.51
, pp. 42-52
-
-
Davis, J.1
Higginbotham, A.2
O'Connor, T.3
-
239
-
-
21244465140
-
Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats
-
Davis J, Iqbal MJ, Steinle J et al. Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats. Horm. Metab. Res. 37, 316-325 (2005).
-
(2005)
Horm. Metab. Res.
, vol.37
, pp. 316-325
-
-
Davis, J.1
Iqbal, M.J.2
Steinle, J.3
-
240
-
-
21244480954
-
Soy protein influences insulin sensitivity and cardiovascular risk in male lean SHHF rats
-
Davis J, Steinle J, Higginbotham DA, Oitker J, Peterson RG, Banz WJ. Soy protein influences insulin sensitivity and cardiovascular risk in male lean SHHF rats. Horm. Metab. Res. 37, 309-315 (2005).
-
(2005)
Horm. Metab. Res.
, vol.37
, pp. 309-315
-
-
Davis, J.1
Steinle, J.2
Higginbotham, D.A.3
Oitker, J.4
Peterson, R.G.5
Banz, W.J.6
-
241
-
-
0037657668
-
Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
-
Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J. Nutr. 133, 1238-1243 (2003).
-
(2003)
J. Nutr.
, vol.133
, pp. 1238-1243
-
-
Mezei, O.1
Banz, W.J.2
Steger, R.W.3
Peluso, M.R.4
Winters, T.A.5
Shay, N.6
-
242
-
-
0033850693
-
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats
-
Peluso MR, Winters TA, Shanahan MF, Banz WJ. A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. J. Nutr. 130, 2333-2342 (2000).
-
(2000)
J. Nutr.
, vol.130
, pp. 2333-2342
-
-
Peluso, M.R.1
Winters, T.A.2
Shanahan, M.F.3
Banz, W.J.4
-
244
-
-
38749092971
-
Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy
-
Devanur LD, Evans RW, Evans PJ, Hider RC. Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy. Biochem. J. 409, 439-447 (2008).
-
(2008)
Biochem. J.
, vol.409
, pp. 439-447
-
-
Devanur, L.D.1
Evans, R.W.2
Evans, P.J.3
Hider, R.C.4
-
245
-
-
33846078725
-
Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)
-
Fabio G, Minonzio F, Delbini P, Bianchi A, Cappellini MD. Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH). Blood 109, 362-364 (2007).
-
(2007)
Blood
, vol.109
, pp. 362-364
-
-
Fabio, G.1
Minonzio, F.2
Delbini, P.3
Bianchi, A.4
Cappellini, M.D.5
-
246
-
-
0038472463
-
Safety monitoring of cardiac and hepatic systems in b-thalassemia patients with chelating treatment in Taiwan
-
Peng CT, Chow KC, Chen JH, Chiang YP, Lin TY, Tsai CH. Safety monitoring of cardiac and hepatic systems in b-thalassemia patients with chelating treatment in Taiwan. Eur. J. Haematol. 70, 392-397 (2003).
-
(2003)
Eur. J. Haematol.
, vol.70
, pp. 392-397
-
-
Peng, C.T.1
Chow, K.C.2
Chen, J.H.3
Chiang, Y.P.4
Lin, T.Y.5
Tsai, C.H.6
-
247
-
-
33845580481
-
Dietary polyphenols: Good, bad, or indifferent for your health?
-
Halliwell B. Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc. Res. 73, 341-347 (2007).
-
(2007)
Cardiovasc. Res.
, vol.73
, pp. 341-347
-
-
Halliwell, B.1
|