메뉴 건너뛰기




Volumn 21, Issue 5, 2000, Pages 943-951

Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; IRON; IRON CHELATING AGENT; TRENSOX; UNCLASSIFIED DRUG; ZINC;

EID: 0034069521     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.5.943     Document Type: Article
Times cited : (77)

References (31)
  • 4
    • 0023681960 scopus 로고
    • Iron nutrition and tumor growth: Decreased tumor growth in iron deficient mice
    • Hann, H.W.L., Stahlhut, M.W. and Blumberg, B.S. (1988) Iron nutrition and tumor growth: decreased tumor growth in iron deficient mice. Cancer Res., 48, 4168-4170.
    • (1988) Cancer Res. , vol.48 , pp. 4168-4170
    • Hann, H.W.L.1    Stahlhut, M.W.2    Blumberg, B.S.3
  • 5
    • 0025979409 scopus 로고
    • Effect of dietary iron deficiency or excess on the induction of mammary carcinogenenis by 1-methyl-1-nitrosourea
    • Thompson, H.J., Kennedy, K., Witt, M. and Juzefyk, J. (1991) Effect of dietary iron deficiency or excess on the induction of mammary carcinogenenis by 1-methyl-1-nitrosourea. Carcinogenesis, 12, 111-114.
    • (1991) Carcinogenesis , vol.12 , pp. 111-114
    • Thompson, H.J.1    Kennedy, K.2    Witt, M.3    Juzefyk, J.4
  • 6
    • 0026634766 scopus 로고
    • Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis
    • Tarao, K., Shimizu, A., Ohkawa, S., Harada, M., Ito, Y., Tamai, S. and Kuni, Y. (1992) Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology, 103, 595-600.
    • (1992) Gastroenterology , vol.103 , pp. 595-600
    • Tarao, K.1    Shimizu, A.2    Ohkawa, S.3    Harada, M.4    Ito, Y.5    Tamai, S.6    Kuni, Y.7
  • 8
    • 0021652124 scopus 로고
    • The effect of desferrioxamine on the proliferative response of rat lymphocytes stimulated with various mitogens in vitro
    • Soyano, A., Chinea, M. and Romano, E.L. (1984) The effect of desferrioxamine on the proliferative response of rat lymphocytes stimulated with various mitogens in vitro. Immunopharmacology, 8, 163-169.
    • (1984) Immunopharmacology , vol.8 , pp. 163-169
    • Soyano, A.1    Chinea, M.2    Romano, E.L.3
  • 10
    • 0030894798 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone
    • Richardson, D.R. and Milnes, K. (1997) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood, 89, 3025-3038.
    • (1997) Blood , vol.89 , pp. 3025-3038
    • Richardson, D.R.1    Milnes, K.2
  • 13
    • 0022371544 scopus 로고
    • Cell cycle effects of iron depletion on T-47D human breast cancer cells
    • Reddel, R.R., Hedley, D.W. and Sutherland, R.L. (1985) Cell cycle effects of iron depletion on T-47D human breast cancer cells. Exp. Cell Res., 161, 277-284.
    • (1985) Exp. Cell Res. , vol.161 , pp. 277-284
    • Reddel, R.R.1    Hedley, D.W.2    Sutherland, R.L.3
  • 14
    • 0026782447 scopus 로고
    • Cell cycle synchronisation and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines
    • Hoyes, K.P., Hider, R.C. and Porter, J.B. (1992) Cell cycle synchronisation and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines. Cancer Res., 52, 4591-4599.
    • (1992) Cancer Res. , vol.52 , pp. 4591-4599
    • Hoyes, K.P.1    Hider, R.C.2    Porter, J.B.3
  • 15
    • 0030601987 scopus 로고    scopus 로고
    • Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells
    • Kulp, K.S., Green, S.L. and Vulliet, P.R. (1996) Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells. Exp. Cell Res., 229, 60-68.
    • (1996) Exp. Cell Res. , vol.229 , pp. 60-68
    • Kulp, K.S.1    Green, S.L.2    Vulliet, P.R.3
  • 16
    • 0028931345 scopus 로고
    • Iron chelators induce apoptosis in proliferating cells
    • Hileti, D., Panayiotidis, P. and Hoffbrand, A.V. (1995) Iron chelators induce apoptosis in proliferating cells. Br. J. Haematol., 89, 181-187.
    • (1995) Br. J. Haematol. , vol.89 , pp. 181-187
    • Hileti, D.1    Panayiotidis, P.2    Hoffbrand, A.V.3
  • 20
    • 0029562526 scopus 로고
    • Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent
    • Caris, C., Baret, P., Béguin, C., Serratrice, G., Pierre, J.L. and Laulhère, J.P. (1995) Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent. Biochem. J., 312, 879-885.
    • (1995) Biochem. J. , vol.312 , pp. 879-885
    • Caris, C.1    Baret, P.2    Béguin, C.3    Serratrice, G.4    Pierre, J.L.5    Laulhère, J.P.6
  • 21
    • 0019332750 scopus 로고
    • Human hepatocellular carcinoma cell lines secrete the major proteins and hepatitis B antigen
    • Knowles, B.B., Howe, C.C. and Aden, D.P. (1980) Human hepatocellular carcinoma cell lines secrete the major proteins and hepatitis B antigen. Science, 209, 497-499.
    • (1980) Science , vol.209 , pp. 497-499
    • Knowles, B.B.1    Howe, C.C.2    Aden, D.P.3
  • 23
    • 0030881603 scopus 로고    scopus 로고
    • Biochemical characteristics of caspases-3, -6, -7 and -8
    • Stennicke, H.R. and Salvesen, G.S. (1997) Biochemical characteristics of caspases-3, -6, -7 and -8. J. Biol. Chem., 272, 25719-25723.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25719-25723
    • Stennicke, H.R.1    Salvesen, G.S.2
  • 25
    • 0027201502 scopus 로고
    • Neuroblastoma sensitivity to growth inhibition by desferrioxamine: Evidence for a block in G1 phase of the cell cycle
    • Brodie, C., Siriwardana, G., Lucas, J., Schleicher, R., Terada, N., Szepesi, A., Gelfand, E. and Seligman, P. (1993) Neuroblastoma sensitivity to growth inhibition by desferrioxamine: evidence for a block in G1 phase of the cell cycle. Cancer Res., 53, 3968-3975.
    • (1993) Cancer Res. , vol.53 , pp. 3968-3975
    • Brodie, C.1    Siriwardana, G.2    Lucas, J.3    Schleicher, R.4    Terada, N.5    Szepesi, A.6    Gelfand, E.7    Seligman, P.8
  • 26
    • 0029087637 scopus 로고
    • Effects of iron depletion on cell cycle progression in normal human T lymphocytes: Selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase
    • Lucas, J.J., Szepesi, A., Domenico, J., Takase, K., Tordai, A., Terada, N. and Gelfand, E.W. (1995) Effects of iron depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase. Blood, 86, 2268-2280.
    • (1995) Blood , vol.86 , pp. 2268-2280
    • Lucas, J.J.1    Szepesi, A.2    Domenico, J.3    Takase, K.4    Tordai, A.5    Terada, N.6    Gelfand, E.W.7
  • 27
    • 0027521831 scopus 로고
    • Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators
    • Nyholm, S., Mann, G.J., Johansson, A.G., Bergeron, R.J., Graslund, A. and Thelander, L. (1993) Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J. Biol. Chem., 268, 26200-26205.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26200-26205
    • Nyholm, S.1    Mann, G.J.2    Johansson, A.G.3    Bergeron, R.J.4    Graslund, A.5    Thelander, L.6
  • 28
    • 0029833706 scopus 로고    scopus 로고
    • The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase
    • Cooper, C.E., Lynagh, G.R., Hoyes, K.P., Hider, R.C., Cammack, R. and Porter, J.B. (1996) The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J. Biol. Chem., 271, 20291-20299.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20291-20299
    • Cooper, C.E.1    Lynagh, G.R.2    Hoyes, K.P.3    Hider, R.C.4    Cammack, R.5    Porter, J.B.6
  • 29
    • 0027458334 scopus 로고
    • 2,2′-Bipyridyl-6-carbothioamide and its ferrous complex: Their in vitro antitumoral activity related to the inhibition of ribonucleotide reductase R2 subunit
    • Nocentini, G., Federici, F., Franchetti, P. and Barzi, A. (1993) 2,2′-Bipyridyl-6-carbothioamide and its ferrous complex: their in vitro antitumoral activity related to the inhibition of ribonucleotide reductase R2 subunit. Cancer Res., 53, 19-26.
    • (1993) Cancer Res. , vol.53 , pp. 19-26
    • Nocentini, G.1    Federici, F.2    Franchetti, P.3    Barzi, A.4
  • 30
    • 0025827421 scopus 로고
    • Growth, ribonucleotide reductase and metals in murine leukemic lymphocytes
    • Oblender, M. and Carpentieri, U. (1991) Growth, ribonucleotide reductase and metals in murine leukemic lymphocytes. J. Cancer Res. Clin. Oncol., 117, 444-448.
    • (1991) J. Cancer Res. Clin. Oncol. , vol.117 , pp. 444-448
    • Oblender, M.1    Carpentieri, U.2
  • 31
    • 0028922876 scopus 로고
    • The influence of zinc on apoptosis
    • Sunderman, F.W. (1995) The influence of zinc on apoptosis. Ann. Clin. Lab Sci., 25, 134-142.
    • (1995) Ann. Clin. Lab Sci. , vol.25 , pp. 134-142
    • Sunderman, F.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.