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Volumn 57, Issue 4, 2005, Pages 547-583

The evolution of iron chelators for the treatment of iron overload disease and cancer

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFERRIFERRITHIOCIN; HEME; IRON CHELATING AGENT; IRON REGULATORY FACTOR; PYRIDINE DERIVATIVE; SIDEROPHORE; THIOSEMICARBAZONE DERIVATIVE;

EID: 29844457587     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.57.4.2     Document Type: Review
Times cited : (647)

References (258)
  • 1
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S and Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275:19906-19912.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 3
    • 0018201230 scopus 로고
    • The chemistry and biological activity of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones
    • Agrawal KC and Sartorelli AC (1978) The chemistry and biological activity of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones. Prog Med Chem 15:321-356.
    • (1978) Prog Med Chem , vol.15 , pp. 321-356
    • Agrawal, K.C.1    Sartorelli, A.C.2
  • 5
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, and Pennell DJ (2002) Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia. Lancet 360:516-520.
    • (2002) Lancet , vol.360 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennell, D.J.6
  • 6
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341:1986-1995.
    • (1999) N Engl J Med , vol.341 , pp. 1986-1995
    • Andrews, N.C.1
  • 7
    • 0017357778 scopus 로고
    • Studies of the reaction of 2-formylpyridine thiosemicarbazone and its iron and copper complexes with biological systems
    • Antholine W, Knight J, Whelan H, and Petering DH (1977) Studies of the reaction of 2-formylpyridine thiosemicarbazone and its iron and copper complexes with biological systems. Mol Pharmacol 13:89-98.
    • (1977) Mol Pharmacol , vol.13 , pp. 89-98
    • Antholine, W.1    Knight, J.2    Whelan, H.3    Petering, D.H.4
  • 9
    • 0037356211 scopus 로고    scopus 로고
    • Structural variations and formation constants of first-row transition metal complexes of biologically active aroylhydrazones
    • Armstrong CM, Bernhardt PV, Chin P, and Richardson DR (2003) Structural variations and formation constants of first-row transition metal complexes of biologically active aroylhydrazones. Eur J Inorg Chem 1145-1156.
    • (2003) Eur J Inorg Chem , pp. 1145-1156
    • Armstrong, C.M.1    Bernhardt, P.V.2    Chin, P.3    Richardson, D.R.4
  • 10
    • 84985163711 scopus 로고
    • The synthesis, crystal and molecular structure and oxidation state of iron complex from pyridoxal isonicotinoyl hydrazone and ferrous sulfate
    • Avramovici-Grisaru S, Sarel S, Cohen S, and Bauminger RE (1985) The synthesis, crystal and molecular structure and oxidation state of iron complex from pyridoxal isonicotinoyl hydrazone and ferrous sulfate. Israel J Chem 25:288-292.
    • (1985) Israel J Chem , vol.25 , pp. 288-292
    • Avramovici-Grisaru, S.1    Sarel, S.2    Cohen, S.3    Bauminger, R.E.4
  • 11
    • 0026575576 scopus 로고
    • Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture
    • Baker E, Richardson DR, Gross S, and Ponka P (1992b) Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture. Hepatology 15:492-501.
    • (1992) Hepatology , vol.15 , pp. 492-501
    • Baker, E.1    Richardson, D.R.2    Gross, S.3    Ponka, P.4
  • 12
    • 0022386084 scopus 로고
    • Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture
    • Baker E, Vitolo ML, and Webb J (1985) Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture. Biochem Pharmacol 34:3011-3017.
    • (1985) Biochem Pharmacol , vol.34 , pp. 3011-3017
    • Baker, E.1    Vitolo, M.L.2    Webb, J.3
  • 13
    • 0026725057 scopus 로고
    • Desferrithiocin is an effective iron chelator in vivo and in vitro but ferrithiocin is toxic
    • Baker E, Wong A, Peter H, and Jacobs A (1992a) Desferrithiocin is an effective iron chelator in vivo and in vitro but ferrithiocin is toxic. Br J Haematol 81:424-431.
    • (1992) Br J Haematol , vol.81 , pp. 424-431
    • Baker, E.1    Wong, A.2    Peter, H.3    Jacobs, A.4
  • 14
    • 0032887235 scopus 로고    scopus 로고
    • Deferiprone: A review of its clinical potential in iron overload in β-thalassemia major and other transfusion-dependent disease
    • Balfour JAB and Foster RH (1999) Deferiprone: a review of its clinical potential in iron overload in β-thalassemia major and other transfusion-dependent disease. Drugs 58:553-578.
    • (1999) Drugs , vol.58 , pp. 553-578
    • Balfour, J.A.B.1    Foster, R.H.2
  • 15
    • 0034491797 scopus 로고    scopus 로고
    • Combined oral and parenteral iron chelation in beta thalassaemia major
    • Balveer K, Pyar K, and Wonke B (2000) Combined oral and parenteral iron chelation in beta thalassaemia major. Med J Malaysia 55:493-497.
    • (2000) Med J Malaysia , vol.55 , pp. 493-497
    • Balveer, K.1    Pyar, K.2    Wonke, B.3
  • 18
    • 0033230124 scopus 로고    scopus 로고
    • Development of novel aroylhydrazone ligands for iron chelation therapy: 2-Pyridylcarboxaldehyde isonicotinoyl hydrazone analogs
    • Becker E and Richardson DR (1999) Development of novel aroylhydrazone ligands for iron chelation therapy: 2-Pyridylcarboxaldehyde isonicotinoyl hydrazone analogs. J Lab Clin Med 134:510-521.
    • (1999) J Lab Clin Med , vol.134 , pp. 510-521
    • Becker, E.1    Richardson, D.R.2
  • 19
    • 0035122450 scopus 로고    scopus 로고
    • Frataxin: Its role in iron metabolism and the pathogenesis of Friedreich's ataxia
    • Becker E and Richardson DR (2001) Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia. Int J Biochem Cell Biol 33:1-10.
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 1-10
    • Becker, E.1    Richardson, D.R.2
  • 20
    • 0037093206 scopus 로고    scopus 로고
    • Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: Characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization
    • Becker EM, Greer JM, Ponka P, and Richardson DR (2002) Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization. Blood 99:3813-3822.
    • (2002) Blood , vol.99 , pp. 3813-3822
    • Becker, E.M.1    Greer, J.M.2    Ponka, P.3    Richardson, D.R.4
  • 21
    • 0037351292 scopus 로고    scopus 로고
    • Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents
    • Becker EM, Lovejoy DB, Greer JM, Watts RN, and Richardson DR (2003) Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents. Br J Pharmacol 138:819-830.
    • (2003) Br J Pharmacol , vol.138 , pp. 819-830
    • Becker, E.M.1    Lovejoy, D.B.2    Greer, J.M.3    Watts, R.N.4    Richardson, D.R.5
  • 26
    • 0026520355 scopus 로고
    • A comparison of the iron-clearing properties of 1,2-dimethyl-3- hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one and deferoxamine
    • Bergeron RJ, Streiff RR, Wiegand J, Luchetta G, Creary EA, and Peter HH (1992) A comparison of the iron-clearing properties of 1,2-dimethyl-3- hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one and deferoxamine. Blood 79:1882-1890.
    • (1992) Blood , vol.79 , pp. 1882-1890
    • Bergeron, R.J.1    Streiff, R.R.2    Wiegand, J.3    Luchetta, G.4    Creary, E.A.5    Peter, H.H.6
  • 29
    • 0033168448 scopus 로고    scopus 로고
    • Effects of C-4 stereochemistry and C-4′ hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues
    • Bergeron RJ, Wiegand J, McManis JS, McCosar BH, Weimar WR, Brittenham GM, and Smith RE (1999a) Effects of C-4 stereochemistry and C-4′ hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues. J Med Chem 42:2432-2440.
    • (1999) J Med Chem , vol.42 , pp. 2432-2440
    • Bergeron, R.J.1    Wiegand, J.2    McManis, J.S.3    McCosar, B.H.4    Weimar, W.R.5    Brittenham, G.M.6    Smith, R.E.7
  • 34
    • 0345714575 scopus 로고    scopus 로고
    • Cytotoxic iron chelators: Characterisation of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues
    • Bernhardt PV, Caldwell LM, Chaston TB, Chin P, and Richardson DR (2003) Cytotoxic iron chelators: characterisation of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues. J Biol Inorg Chem 8:866-880.
    • (2003) J Biol Inorg Chem , vol.8 , pp. 866-880
    • Bernhardt, P.V.1    Caldwell, L.M.2    Chaston, T.B.3    Chin, P.4    Richardson, D.R.5
  • 35
    • 0035161372 scopus 로고    scopus 로고
    • Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): Serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy
    • Bernhardt PV, Chin P, and Richardson DR (2001) Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy. J Biol Inorg Chem 6:801-809.
    • (2001) J Biol Inorg Chem , vol.6 , pp. 801-809
    • Bernhardt, P.V.1    Chin, P.2    Richardson, D.R.3
  • 36
    • 9244262434 scopus 로고    scopus 로고
    • Iron catalysed assembly of an asymmetric mixed-ligand triple helicate
    • Bernhardt PV, Chin P, and Richardson DR (2004) Iron catalysed assembly of an asymmetric mixed-ligand triple helicate. Dalton Trans 3342-3346.
    • (2004) Dalton Trans , pp. 3342-3346
    • Bernhardt, P.V.1    Chin, P.2    Richardson, D.R.3
  • 38
    • 2642709214 scopus 로고    scopus 로고
    • Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone
    • Blaha K, Cikrt M, Nerudova J, Fornuskova H, and Ponka P (1998) Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone. Blood 11:4368-4372.
    • (1998) Blood , vol.11 , pp. 4368-4372
    • Blaha, K.1    Cikrt, M.2    Nerudova, J.3    Fornuskova, H.4    Ponka, P.5
  • 39
    • 0023092624 scopus 로고
    • Antineuroblastoma activity of desferoxamine in human cell lines
    • Blatt J and Stitely S (1987) Antineuroblastoma activity of desferoxamine in human cell lines. Cancer Res 47:1749-1750.
    • (1987) Cancer Res , vol.47 , pp. 1749-1750
    • Blatt, J.1    Stitely, S.2
  • 40
    • 0023689207 scopus 로고
    • Mechanism of antineuroblastoma activity of deferoxamine in vitro
    • Blatt J, Taylor SR, and Stitely S (1988) Mechanism of antineuroblastoma activity of deferoxamine in vitro. J Lab Clin Med 112:433-436.
    • (1988) J Lab Clin Med , vol.112 , pp. 433-436
    • Blatt, J.1    Taylor, S.R.2    Stitely, S.3
  • 41
    • 0025194404 scopus 로고
    • Pyridoxal isonicotinoyl hydrazone: An effective iron-chelator after oral administration
    • Brittenham GM (1990) Pyridoxal isonicotinoyl hydrazone: an effective iron-chelator after oral administration. Semin Hematol 27:112-116.
    • (1990) Semin Hematol , vol.27 , pp. 112-116
    • Brittenham, G.M.1
  • 42
    • 0042384674 scopus 로고    scopus 로고
    • Iron chelators and iron toxicity
    • Brittenham GM (2003) Iron chelators and iron toxicity. Alcohol 30:151-158.
    • (2003) Alcohol , vol.30 , pp. 151-158
    • Brittenham, G.M.1
  • 43
    • 0023234092 scopus 로고
    • Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator
    • Brock JH and Stevenson J (1987) Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator. Immunol Lett 15:23-25.
    • (1987) Immunol Lett , vol.15 , pp. 23-25
    • Brock, J.H.1    Stevenson, J.2
  • 44
    • 0037114461 scopus 로고    scopus 로고
    • Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes
    • Buss JL, Arduini E, and Ponka P (2002a) Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes. Biochem Pharmacol 64:1689-1701.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1689-1701
    • Buss, J.L.1    Arduini, E.2    Ponka, P.3
  • 45
    • 0037300716 scopus 로고    scopus 로고
    • Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells
    • Buss JL, Arduini E, Shephard KC, and Ponka P (2003a) Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells. Biochem Pharmacol 65:349-360.
    • (2003) Biochem Pharmacol , vol.65 , pp. 349-360
    • Buss, J.L.1    Arduini, E.2    Shephard, K.C.3    Ponka, P.4
  • 47
    • 0041808760 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone and its analogues
    • Buss JL, Hermes-Lima M, and Ponka P (2002b) Pyridoxal isonicotinoyl hydrazone and its analogues. Adv Exp Med Biol 509:205-229.
    • (2002) Adv Exp Med Biol , vol.509 , pp. 205-229
    • Buss, J.L.1    Hermes-Lima, M.2    Ponka, P.3
  • 48
    • 0037437796 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their ironchelating properties
    • Buss JL, Neuzil J, Gellert N, Weber C, and Ponka P (2003b) Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their ironchelating properties. Biochem Pharmacol 65:161-172.
    • (2003) Biochem Pharmacol , vol.65 , pp. 161-172
    • Buss, J.L.1    Neuzil, J.2    Gellert, N.3    Weber, C.4    Ponka, P.5
  • 49
    • 0036672087 scopus 로고    scopus 로고
    • The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues
    • Buss JL, Neuzil J, and Ponka P (2002c) The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues. Biochem Soc Trans 30:755-757.
    • (2002) Biochem Soc Trans , vol.30 , pp. 755-757
    • Buss, J.L.1    Neuzil, J.2    Ponka, P.3
  • 50
    • 0347479372 scopus 로고    scopus 로고
    • Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs
    • Buss JL, Neuzil J, and Ponka P (2004b) Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs. Arch Biochem Biophys 421:1-9.
    • (2004) Arch Biochem Biophys , vol.421 , pp. 1-9
    • Buss, J.L.1    Neuzil, J.2    Ponka, P.3
  • 51
    • 0038324398 scopus 로고    scopus 로고
    • The role of iron chelation in cancer therapy
    • Buss JL, Torti FM, and Torti SV (2003c) The role of iron chelation in cancer therapy. Curr Med Chem 10:1021-1034.
    • (2003) Curr Med Chem , vol.10 , pp. 1021-1034
    • Buss, J.L.1    Torti, F.M.2    Torti, S.V.3
  • 53
    • 0029419451 scopus 로고
    • Molecular basis of β-thalassemia
    • Cao A (1995) Molecular basis of β-thalassemia. Bull Mol Biol Med 20:102-112.
    • (1995) Bull Mol Biol Med , vol.20 , pp. 102-112
    • Cao, A.1
  • 54
    • 0037237032 scopus 로고    scopus 로고
    • Examination of the antiproliferative activity of iron chelators: Multiple cellular targets and the different mechanism of action of Triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311
    • Chaston TB, Lovejoy DB, Watts RN, and Richardson DR (2003) Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of Triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311. Clin Cancer Res 9:402-414.
    • (2003) Clin Cancer Res , vol.9 , pp. 402-414
    • Chaston, T.B.1    Lovejoy, D.B.2    Watts, R.N.3    Richardson, D.R.4
  • 55
    • 0037631496 scopus 로고    scopus 로고
    • Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity and toxicity
    • Chaston TB and Richardson DR (2003a) Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity and toxicity. Am J Hematol 73:200-210.
    • (2003) Am J Hematol , vol.73 , pp. 200-210
    • Chaston, T.B.1    Richardson, D.R.2
  • 56
    • 0038814301 scopus 로고    scopus 로고
    • Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: Implications for toxicity in the treatment of iron overload disease
    • Chaston TB and Richardson DR (2003b) Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease. J Biol Inorg Chem 8:427-438.
    • (2003) J Biol Inorg Chem , vol.8 , pp. 427-438
    • Chaston, T.B.1    Richardson, D.R.2
  • 57
    • 8444235919 scopus 로고    scopus 로고
    • Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves Fenton-derived free radical generation
    • Chaston TB, Watts RN, Yuan J, and Richardson DR (2004) Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves Fenton-derived free radical generation. Clin Cancer Res 10:7365-7374.
    • (2004) Clin Cancer Res , vol.10 , pp. 7365-7374
    • Chaston, T.B.1    Watts, R.N.2    Yuan, J.3    Richardson, D.R.4
  • 58
    • 4244102846 scopus 로고    scopus 로고
    • Triapine, a ribonucleotide reductase inhibitor, enhances incorporation of gemcitabine into DNA and cytotoxicity to KB cells
    • Chen CH, King I, and Belcourt M (2002) Triapine, a ribonucleotide reductase inhibitor, enhances incorporation of gemcitabine into DNA and cytotoxicity to KB cells. Eur J Cancer 38:S26.
    • (2002) Eur J Cancer , vol.38
    • Chen, C.1    King, I.2    Belcourt, M.3
  • 60
    • 1342264310 scopus 로고    scopus 로고
    • Structure of the human transferrin receptor-transferrin complex
    • Cheng Y, Zak O, Aisen P, Harrison SC, and Walz T (2004) Structure of the human transferrin receptor-transferrin complex. Cell 116:565-576.
    • (2004) Cell , vol.116 , pp. 565-576
    • Cheng, Y.1    Zak, O.2    Aisen, P.3    Harrison, S.C.4    Walz, T.5
  • 61
    • 4744345552 scopus 로고    scopus 로고
    • Synthesis and potent antitumor activities of novel 1,3,5-cis,cis- triaminocyclohexane N-pyridyl derivatives
    • Chong HS, Torti SV, Ma R, Torti FM, and Brechbiel MW (2004) Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives. J Med Chem 47:5230-5234.
    • (2004) J Med Chem , vol.47 , pp. 5230-5234
    • Chong, H.S.1    Torti, S.V.2    Ma, R.3    Torti, F.M.4    Brechbiel, M.W.5
  • 62
    • 0030933588 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of 1-(2′-trimethylacetoxyethyl)-2- ethyl-3-hydroxypyridin-4-one (CP117) in the rat
    • Choudhury R, Epemolu RO, Rai BL, Hider RC, and Singh S (1997) Metabolism and pharmacokinetics of 1-(2′-trimethylacetoxyethyl)-2-ethyl-3- hydroxypyridin-4-one (CP117) in the rat. Drug Metab Dispos 25:332-339.
    • (1997) Drug Metab Dispos , vol.25 , pp. 332-339
    • Choudhury, R.1    Epemolu, R.O.2    Rai, B.L.3    Hider, R.C.4    Singh, S.5
  • 63
    • 0018831805 scopus 로고
    • Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone
    • Cikrt M, Ponka P, Necas E, and Neuwirt J (1980) Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone. Br J Haematol 45:275-283.
    • (1980) Br J Haematol , vol.45 , pp. 275-283
    • Cikrt, M.1    Ponka, P.2    Necas, E.3    Neuwirt, J.4
  • 64
    • 0034683482 scopus 로고    scopus 로고
    • Mixed hydroxypyridinonate ligands as iron chelators
    • Cohen SM, O'Sullivan B, and Raymond KN (2000) Mixed hydroxypyridinonate ligands as iron chelators. Inorg Chem 39:4339-4346.
    • (2000) Inorg Chem , vol.39 , pp. 4339-4346
    • Cohen, S.M.1    O'Sullivan, B.2    Raymond, K.N.3
  • 66
    • 0029833706 scopus 로고    scopus 로고
    • The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase
    • Cooper CE, Lynagh GR, Hoyes KP, Hider RC, Cammack R, and Porter JB (1996) The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J Biol Chem 271:20291-20299.
    • (1996) J Biol Chem , vol.271 , pp. 20291-20299
    • Cooper, C.E.1    Lynagh, G.R.2    Hoyes, K.P.3    Hider, R.C.4    Cammack, R.5    Porter, J.B.6
  • 68
    • 0027934897 scopus 로고
    • Inhibitors of ribonucleotide reductase: Comparative effects of amino- and hydroxysubstituted pyridine-2-carboxaldehyde thiosemicarbazones
    • Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, and Sartorelli AC (1994) Inhibitors of ribonucleotide reductase: comparative effects of amino- and hydroxysubstituted pyridine-2-carboxaldehyde thiosemicarbazones. Biochem Pharmacol 48:335-344.
    • (1994) Biochem Pharmacol , vol.48 , pp. 335-344
    • Cory, J.G.1    Cory, A.H.2    Rappa, G.3    Lorico, A.4    Liu, M.C.5    Lin, T.S.6    Sartorelli, A.C.7
  • 69
    • 0032528402 scopus 로고    scopus 로고
    • The iron chelator L1 potentiates oxidative DNA damage in iron-loaded liver cells
    • Cragg L, Hebbel RP, Miller W, Solovey A, Selby S, and Enright H (1998) The iron chelator L1 potentiates oxidative DNA damage in iron-loaded liver cells. Blood 92:632-638.
    • (1998) Blood , vol.92 , pp. 632-638
    • Cragg, L.1    Hebbel, R.P.2    Miller, W.3    Solovey, A.4    Selby, S.5    Enright, H.6
  • 70
    • 0015303832 scopus 로고
    • Anti-neoplastic activity and metabolism of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice
    • Creasey WA, Agrawal KC, Capizzi RL, Stinson KK, and Sartorelli AC (1972) Antineoplastic activity and metabolism of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice. Cancer Res 32:565-572.
    • (1972) Cancer Res , vol.32 , pp. 565-572
    • Creasey, W.A.1    Agrawal, K.C.2    Capizzi, R.L.3    Stinson, K.K.4    Sartorelli, A.C.5
  • 71
    • 0033566305 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: The effect of the ligands on molecular targets involved in proliferation
    • Darnell G and Richardson DR (1999) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation. Blood 94:781-792.
    • (1999) Blood , vol.94 , pp. 781-792
    • Darnell, G.1    Richardson, D.R.2
  • 72
    • 0026530821 scopus 로고
    • Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines
    • Davidoff AM, Pence JC, Shorter NA, Iglehart JD, and Marks JR (1992) Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. Oncogene 7:127-133.
    • (1992) Oncogene , vol.7 , pp. 127-133
    • Davidoff, A.M.1    Pence, J.C.2    Shorter, N.A.3    Iglehart, J.D.4    Marks, J.R.5
  • 73
    • 2942724321 scopus 로고    scopus 로고
    • Desferoxamine (DFO)-mediated iron chelation: Rationale for a novel approach to therapy for brain cancer
    • Dayani PN, Bishop MC, Black K, and Zeltzer PM (2004) Desferoxamine (DFO)-mediated iron chelation: rationale for a novel approach to therapy for brain cancer. J Neurooncol 67:367-377.
    • (2004) J Neurooncol , vol.67 , pp. 367-377
    • Dayani, P.N.1    Bishop, M.C.2    Black, K.3    Zeltzer, P.M.4
  • 78
    • 0040914893 scopus 로고
    • Kinetic and thermodynamic study of complex formation between iron(II) and pyridoxal isonicotinoylhydrazone and other synthetic chelating agents
    • Dubois JE, Fakhrayan H, Doucet JP, and El Hage Chahine JM (1992) Kinetic and thermodynamic study of complex formation between iron(II) and pyridoxal isonicotinoylhydrazone and other synthetic chelating agents. Inorg Chem 31:853-859.
    • (1992) Inorg Chem , vol.31 , pp. 853-859
    • Dubois, J.E.1    Fakhrayan, H.2    Doucet, J.P.3    El Hage Chahine, J.M.4
  • 79
    • 0001738986 scopus 로고
    • Synthesis of new acylhydrazones as iron-chelating compounds
    • Edward JT, Gauthier M, Chubb FL, and Ponka P (1988) Synthesis of new acylhydrazones as iron-chelating compounds. J Chem Eng Data 33:538-540.
    • (1988) J Chem Eng Data , vol.33 , pp. 538-540
    • Edward, J.T.1    Gauthier, M.2    Chubb, F.L.3    Ponka, P.4
  • 82
    • 0033975268 scopus 로고    scopus 로고
    • Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity
    • Finch RA, Liu MC, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng YC, and Sartorelli AC (2000) Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): a potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Biochem Pharmacol 59:983-991.
    • (2000) Biochem Pharmacol , vol.59 , pp. 983-991
    • Finch, R.A.1    Liu, M.C.2    Grill, S.P.3    Rose, W.C.4    Loomis, R.5    Vasquez, K.M.6    Cheng, Y.C.7    Sartorelli, A.C.8
  • 84
    • 0022903110 scopus 로고
    • Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: Effects of suramin and a lipophilic iron chelator (PIH)
    • Forsbeck K, Bjelkenkrantz K, and Nilsson K (1986) Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH). Scand J Haematol 37:429-437.
    • (1986) Scand J Haematol , vol.37 , pp. 429-437
    • Forsbeck, K.1    Bjelkenkrantz, K.2    Nilsson, K.3
  • 85
    • 0034192162 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous bolus injection deferoxamine in adult patients with iron overload
    • Franchini M, Gandini G, de Gironcoli M, Vassanelli A, Borgna-Pignatti C, and Aprili G (2000) Safety and efficacy of subcutaneous bolus injection deferoxamine in adult patients with iron overload. Blood 95:2776-2779.
    • (2000) Blood , vol.95 , pp. 2776-2779
    • Franchini, M.1    Gandini, G.2    De Gironcoli, M.3    Vassanelli, A.4    Borgna-Pignatti, C.5    Aprili, G.6
  • 86
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T (2003) Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102:783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 87
    • 0035437183 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression
    • Gao J and Richardson DR (2001) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progression. Blood 98:842-850.
    • (2001) Blood , vol.98 , pp. 842-850
    • Gao, J.1    Richardson, D.R.2
  • 90
    • 0029913805 scopus 로고    scopus 로고
    • Exochelins of Mycobacterium tuberculosis remove iron for human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall
    • Gobin J and Horwitz MA (1996) Exochelins of Mycobacterium tuberculosis remove iron for human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall. J Exp Med 183:1527-1532.
    • (1996) J Exp Med , vol.183 , pp. 1527-1532
    • Gobin, J.1    Horwitz, M.A.2
  • 91
    • 0035181433 scopus 로고    scopus 로고
    • Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: Effect on the R2 subunit of ribonucleotide reductase
    • Green DA, Antholine WE, Wong SJ, Richardson DR, and Chitambar CR (2001) Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase. Clin Cancer Res 11:2574-2579.
    • (2001) Clin Cancer Res , vol.11 , pp. 2574-2579
    • Green, D.A.1    Antholine, W.E.2    Wong, S.J.3    Richardson, D.R.4    Chitambar, C.R.5
  • 92
    • 0024564712 scopus 로고
    • Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis: Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy
    • Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bomford A, and Sadler PJ (1989) Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis: characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. J Biol Chem 264:4417-4422.
    • (1989) J Biol Chem , vol.264 , pp. 4417-4422
    • Grootveld, M.1    Bell, J.D.2    Halliwell, B.3    Aruoma, O.I.4    Bomford, A.5    Sadler, P.J.6
  • 94
    • 0021910539 scopus 로고
    • Low-molecularweight iron complexes and oxygen radical reactions in idiopathic haemochromatosis
    • Gutteridge JMC, Rowley DA, Griffiths E, and Halliwell B (1985) Low-molecularweight iron complexes and oxygen radical reactions in idiopathic haemochromatosis. Clin Sci 68:463-467.
    • (1985) Clin Sci , vol.68 , pp. 463-467
    • Gutteridge, J.M.C.1    Rowley, D.A.2    Griffiths, E.3    Halliwell, B.4
  • 95
    • 0022529172 scopus 로고
    • Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
    • Halliwell B and Gutteridge JMC (1986) Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 246:501-514.
    • (1986) Arch Biochem Biophys , vol.246 , pp. 501-514
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 97
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, and Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 99
    • 0030608152 scopus 로고    scopus 로고
    • The ferritins: Molecular properties, iron storage function and cellular regulation
    • Harrison PM and Arosio P (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1275:161-203.
    • (1996) Biochim Biophys Acta , vol.1275 , pp. 161-203
    • Harrison, P.M.1    Arosio, P.2
  • 101
    • 0033520468 scopus 로고    scopus 로고
    • 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]-benzoic acid: A novel efficient and selective iron(III) complexing agent
    • Heinz U, Hegetschweiler H, Acklin P, Faller B, Lattmann R, and Schnebli HP (1999) 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]-benzoic acid: a novel efficient and selective iron(III) complexing agent. Angew Chem Int Ed 38:2568-2570.
    • (1999) Angew Chem Int Ed , vol.38 , pp. 2568-2570
    • Heinz, U.1    Hegetschweiler, H.2    Acklin, P.3    Faller, B.4    Lattmann, R.5    Schnebli, H.P.6
  • 102
    • 0029758487 scopus 로고    scopus 로고
    • Molecular control of vertebrate iron metabolism: MRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress
    • Hentze MW and Kühn LC (1996) Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress. Proc Natl Acad Sci USA 93:8175-8182.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8175-8182
    • Hentze, M.W.1    Kühn, L.C.2
  • 103
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, and Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 106
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassemia: An abnormal serum iron fraction of potential toxicity
    • Hershko C, Graham G, Bates GW, and Rachmilewitz EA (1978) Non-specific serum iron in thalassemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol 40:255-263.
    • (1978) Br J Haematol , vol.40 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3    Rachmilewitz, E.A.4
  • 107
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: A new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-laded rat heart cells in culture
    • Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, and Link G (2001) ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-laded rat heart cells in culture. Blood 97:1115-1122.
    • (2001) Blood , vol.97 , pp. 1115-1122
    • Hershko, C.1    Konijn, A.M.2    Nick, H.P.3    Breuer, W.4    Cabantchik, Z.I.5    Link, G.6
  • 108
    • 0029615532 scopus 로고
    • Potential protection from toxicity by oral iron chelators
    • Hider RC (1995) Potential protection from toxicity by oral iron chelators. Toxicol Lett 82-83:961-967.
    • (1995) Toxicol Lett , vol.82-83 , pp. 961-967
    • Hider, R.C.1
  • 109
    • 17944388628 scopus 로고    scopus 로고
    • Nature of nontransferrin-bound iron
    • Hider RC (2002a) Nature of nontransferrin-bound iron. Eur J Clin Investig 32:50-54.
    • (2002) Eur J Clin Investig , vol.32 , pp. 50-54
    • Hider, R.C.1
  • 110
    • 0036669925 scopus 로고    scopus 로고
    • Design of therapeutic chelating agents
    • Hider RC (2002b) Design of therapeutic chelating agents. Biochem Soc Trans 30:751-754.
    • (2002) Biochem Soc Trans , vol.30 , pp. 751-754
    • Hider, R.C.1
  • 113
    • 0001751906 scopus 로고    scopus 로고
    • 3, M = Ga, In) of N,N′,N″ -tris(2-pyridylmethyl)-cis-1,3,5-triaminocyclohexane: Preparation and structure
    • 3, M = Ga, In) of N,N′,N″ -tris(2-pyridylmethyl)-cis-1,3,5-triaminocyclohexane: Preparation and structure. Inorg Chem 36:4600-4603.
    • (1997) Inorg Chem , vol.36 , pp. 4600-4603
    • Hilfiker, K.A.1    Brechbiel, M.W.2    Rogers, R.D.3    Planalp, R.P.4
  • 114
    • 1242295296 scopus 로고    scopus 로고
    • Effect on ribonucleotide reductase of novel lipophilic iron chelators: The desferri-exochelins
    • Hodges YK, Antholine WE, and Horwitz LD (2004) Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins. Biochem Biophys Res Commun 315:595-598.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 595-598
    • Hodges, Y.K.1    Antholine, W.E.2    Horwitz, L.D.3
  • 115
    • 0018567483 scopus 로고
    • Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone
    • Hoy T, Humphrys J, Jacobs A, Williams A, and Ponka P (1979) Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone. Br J Haematol 43:443-449.
    • (1979) Br J Haematol , vol.43 , pp. 443-449
    • Hoy, T.1    Humphrys, J.2    Jacobs, A.3    Williams, A.4    Ponka, P.5
  • 116
    • 0033639239 scopus 로고    scopus 로고
    • Synthesis and solution properties of deferoxamine amides
    • Ihnat PM, Vennerstrom JL, and Robinson DH (2000) Synthesis and solution properties of deferoxamine amides. J Pharm Sci 89:1525-1536.
    • (2000) J Pharm Sci , vol.89 , pp. 1525-1536
    • Ihnat, P.M.1    Vennerstrom, J.L.2    Robinson, D.H.3
  • 117
    • 0017700831 scopus 로고
    • Low molecular weight intracellular iron transport compounds
    • Jacobs A (1977) Low molecular weight intracellular iron transport compounds. Blood 50:433-439.
    • (1977) Blood , vol.50 , pp. 433-439
    • Jacobs, A.1
  • 118
    • 0001525013 scopus 로고
    • Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone
    • Johnson DK, Murphy TB, Rose NJ, Goodwin WH, and Pickart L (1982) Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone. Inorg Chim Acta 67:159-165.
    • (1982) Inorg Chim Acta , vol.67 , pp. 159-165
    • Johnson, D.K.1    Murphy, T.B.2    Rose, N.J.3    Goodwin, W.H.4    Pickart, L.5
  • 119
    • 0025774978 scopus 로고
    • Regulation of the transferrin-independent iron transport system in cultured cells
    • Kaplan J, Jordan I, and Sturrock A (1991) Regulation of the transferrin-independent iron transport system in cultured cells. J Biol Chem 266:2997-3004.
    • (1991) J Biol Chem , vol.266 , pp. 2997-3004
    • Kaplan, J.1    Jordan, I.2    Sturrock, A.3
  • 120
    • 0347363715 scopus 로고    scopus 로고
    • Combined therapy with desferrioxamine and deferiprone in thalassemic patients: Effect on urinary iron excretion
    • Kattamis A, Kassou C, Berdousi H, Ladis V, Papassotiriou I, and Kattamis C (2003) Combined therapy with desferrioxamine and deferiprone in thalassemic patients: effect on urinary iron excretion. Haematologica 88:1423-1425.
    • (2003) Haematologica , vol.88 , pp. 1423-1425
    • Kattamis, A.1    Kassou, C.2    Berdousi, H.3    Ladis, V.4    Papassotiriou, I.5    Kattamis, C.6
  • 121
    • 0030580112 scopus 로고    scopus 로고
    • The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2
    • Kauppi B, Nielsen BB, Ramaswamy S, Larsen IK, Thelander M, Thelander L, and Eklund H (1996) The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. J Mol Biol 262:706-720.
    • (1996) J Mol Biol , vol.262 , pp. 706-720
    • Kauppi, B.1    Nielsen, B.B.2    Ramaswamy, S.3    Larsen, I.K.4    Thelander, M.5    Thelander, L.6    Eklund, H.7
  • 122
    • 0034595856 scopus 로고    scopus 로고
    • Transferrin receptor 2-α supports cell growth in both iron-chelated cultured cells and in vivo
    • Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, and Koeffler HP (2000) Transferrin receptor 2-α supports cell growth in both iron-chelated cultured cells and in vivo. J Biol Chem 275:16618-16625.
    • (2000) J Biol Chem , vol.275 , pp. 16618-16625
    • Kawabata, H.1    Germain, R.S.2    Vuong, P.T.3    Nakamaki, T.4    Said, J.W.5    Koeffler, H.P.6
  • 124
    • 0035892992 scopus 로고    scopus 로고
    • Effect of iron chelators on proliferation and iron uptake in hepatoma cells
    • Kicic A, Chua AC, and Baker E (2001a) Effect of iron chelators on proliferation and iron uptake in hepatoma cells. Cancer 92:3093-3110.
    • (2001) Cancer , vol.92 , pp. 3093-3110
    • Kicic, A.1    Chua, A.C.2    Baker, E.3
  • 125
    • 0035437385 scopus 로고    scopus 로고
    • The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents
    • Kicic A, Chua AC, and Baker E (2001b) The desferrithiocin (DFT) class of iron chelators: potential as antineoplastic agents. Anticancer Drug Des 16:195-207.
    • (2001) Anticancer Drug Des , vol.16 , pp. 195-207
    • Kicic, A.1    Chua, A.C.2    Baker, E.3
  • 126
    • 0036214907 scopus 로고    scopus 로고
    • Desferrithiocin is a more potent antineoplastic agent than desferrioxamine
    • Kicic A, Chua AC, and Baker E (2002) Desferrithiocin is a more potent antineoplastic agent than desferrioxamine. Br J Pharmacol 135:1393-1402.
    • (2002) Br J Pharmacol , vol.135 , pp. 1393-1402
    • Kicic, A.1    Chua, A.C.2    Baker, E.3
  • 128
    • 1642337304 scopus 로고    scopus 로고
    • A study of potential toxic effects after repeated 10-week administration of a new iron chelator - Salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits
    • Klimtova I, Simunek T, Mazurova Y, Kaplanova J, Sterba M, Hrdina R, Gersl V, Adamcova M, and Ponka P (2003) A study of potential toxic effects after repeated 10-week administration of a new iron chelator-salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits. Acta Medica (Hradec Kralove) 46:163-170.
    • (2003) Acta Medica (Hradec Kralove) , vol.46 , pp. 163-170
    • Klimtova, I.1    Simunek, T.2    Mazurova, Y.3    Kaplanova, J.4    Sterba, M.5    Hrdina, R.6    Gersl, V.7    Adamcova, M.8    Ponka, P.9
  • 131
    • 0038649860 scopus 로고    scopus 로고
    • Benefits and risks of deferiprone in iron overload in thalassaemia and other conditions: Comparison of epidemiological and therapeutic aspects with deferoxamine
    • Kontoghiorghes GJ, Neocleous K, and Kolnagou A (2003) Benefits and risks of deferiprone in iron overload in thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf 26:553-584.
    • (2003) Drug Saf , vol.26 , pp. 553-584
    • Kontoghiorghes, G.J.1    Neocleous, K.2    Kolnagou, A.3
  • 132
    • 3242753676 scopus 로고    scopus 로고
    • The design and development of deferiprone (L1) and other iron chelators for clinical use: Targeting methods and application prospects
    • Kontoghiorghes GJ, Pattichis K, Neocleous K, and Kolnagou A (2004) The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects. Curr Med Chem 11:2161-2183.
    • (2004) Curr Med Chem , vol.11 , pp. 2161-2183
    • Kontoghiorghes, G.J.1    Pattichis, K.2    Neocleous, K.3    Kolnagou, A.4
  • 133
    • 0016236741 scopus 로고
    • Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC-107392), with special reference to its iron-chelating properties
    • Krakoff IH, Etcubanas E, Tan C, Mayer K, Betehune V, and Burchenal JH (1974) Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC-107392), with special reference to its iron-chelating properties. Cancer Chemother Rep 53:207-212.
    • (1974) Cancer Chemother Rep , vol.53 , pp. 207-212
    • Krakoff, I.H.1    Etcubanas, E.2    Tan, C.3    Mayer, K.4    Betehune, V.5    Burchenal, J.H.6
  • 134
    • 0036118607 scopus 로고    scopus 로고
    • The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
    • Kwok J and Richardson DR (2002) The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol 42:65-78.
    • (2002) Crit Rev Oncol Hematol , vol.42 , pp. 65-78
    • Kwok, J.1    Richardson, D.R.2
  • 135
    • 0001787556 scopus 로고
    • Cardiac iron deposits in Friedreich's ataxia
    • Lectenberg R ed, Marcel Dekker, New York
    • Lamarche JB, Shapcott D, Cote M, and Lemieux B (1993) Cardiac iron deposits in Friedreich's ataxia, in Handbook of Cerebellar Diseases (Lectenberg R ed) pp 453-457, Marcel Dekker, New York.
    • (1993) Handbook of Cerebellar Diseases , pp. 453-457
    • Lamarche, J.B.1    Shapcott, D.2    Cote, M.3    Lemieux, B.4
  • 136
    • 0037009846 scopus 로고    scopus 로고
    • The role of iron in cell cycle progression and the proliferation of neoplastic cells
    • Le NT and Richardson DR (2002) The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 1603:31-46.
    • (2002) Biochim Biophys Acta , vol.1603 , pp. 31-46
    • Le, N.T.1    Richardson, D.R.2
  • 137
    • 0038687772 scopus 로고    scopus 로고
    • CIP1/WAF1, but paradoxically inhibit its translation: A potential mechanism of cell cycle dysregulation
    • CIP1/WAF1, but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation. Carcinogenesis 24:1045-1058.
    • (2003) Carcinogenesis , vol.24 , pp. 1045-1058
    • Le, N.T.1    Richardson, D.R.2
  • 138
    • 7244239197 scopus 로고    scopus 로고
    • Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation
    • Le NT and Richardson DR (2004) Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation. Blood 104:2967-2975.
    • (2004) Blood , vol.104 , pp. 2967-2975
    • Le, N.T.1    Richardson, D.R.2
  • 140
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 141
    • 0142154312 scopus 로고    scopus 로고
    • The effect of potent iron chelators on the regulation of p53: Examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1
    • Liang S and Richardson DR (2003) The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1. Carcinogenesis 24:1601-1614.
    • (2003) Carcinogenesis , vol.24 , pp. 1601-1614
    • Liang, S.1    Richardson, D.R.2
  • 143
    • 0038603210 scopus 로고    scopus 로고
    • Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells
    • Link G, Ponka P, Konijn AM, Breuer W, Cabantchik I, and Hershko C (2003) Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells. Blood 101:4172-4179.
    • (2003) Blood , vol.101 , pp. 4172-4179
    • Link, G.1    Ponka, P.2    Konijn, A.M.3    Breuer, W.4    Cabantchik, I.5    Hershko, C.6
  • 144
    • 0026666125 scopus 로고
    • Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone
    • Liu MC, Lin TS, and Sartorelli AC (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J Med Chem 35:3672-3677.
    • (1992) J Med Chem , vol.35 , pp. 3672-3677
    • Liu, M.C.1    Lin, T.S.2    Sartorelli, A.C.3
  • 145
    • 0036784079 scopus 로고    scopus 로고
    • Design of iron chelators with therapeutic application
    • Liu ZD and Hider RC (2002a) Design of iron chelators with therapeutic application. Coord Chem Rev 232:151-171.
    • (2002) Coord Chem Rev , vol.232 , pp. 151-171
    • Liu, Z.D.1    Hider, R.C.2
  • 146
    • 0036136401 scopus 로고    scopus 로고
    • Design of clinically useful iron(III)-selective chelators
    • Liu ZD and Hider RC (2002b) Design of clinically useful iron(III)-selective chelators. Med Res Rev 22:26-64.
    • (2002) Med Res Rev , vol.22 , pp. 26-64
    • Liu, Z.D.1    Hider, R.C.2
  • 149
    • 0034034680 scopus 로고    scopus 로고
    • Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia
    • Lovejoy DB and Richardson DR (2000) Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia. Exp Opin Investig Drugs 9:1257-1270.
    • (2000) Exp Opin Investig Drugs , vol.9 , pp. 1257-1270
    • Lovejoy, D.B.1    Richardson, D.R.2
  • 150
    • 0037100453 scopus 로고    scopus 로고
    • Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells
    • Lovejoy DB and Richardson DR (2002) Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells. Blood 100:666-676.
    • (2002) Blood , vol.100 , pp. 666-676
    • Lovejoy, D.B.1    Richardson, D.R.2
  • 151
    • 0037986658 scopus 로고    scopus 로고
    • Iron chelators as anti-neoplastic agents: Current developments and promise of the PIH class of chelators
    • Lovejoy DB and Richardson DR (2003) Iron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators. Cur Med Chem 10:1035-1049.
    • (2003) Cur Med Chem , vol.10 , pp. 1035-1049
    • Lovejoy, D.B.1    Richardson, D.R.2
  • 152
    • 0036153601 scopus 로고    scopus 로고
    • Novel chelating agents for potential clinical applications of copper
    • Ma D, Lu F, Overstreet T, Milenic DE, and Brechbiel MW (2002) Novel chelating agents for potential clinical applications of copper. Nucl Med Biol 29:91-105.
    • (2002) Nucl Med Biol , vol.29 , pp. 91-105
    • Ma, D.1    Lu, F.2    Overstreet, T.3    Milenic, D.E.4    Brechbiel, M.W.5
  • 157
    • 0019860059 scopus 로고
    • Transferrin biochemistry, physiology and clinical significance
    • Morgan EH (1981) Transferrin biochemistry, physiology and clinical significance. Mol Aspects Med 4:1-123.
    • (1981) Mol Aspects Med , vol.4 , pp. 1-123
    • Morgan, E.H.1
  • 158
    • 0002614944 scopus 로고
    • Stabilities of the iron(III) chelates of 1,2-dimethyl-3-hydroxy-4- pyridinone and related ligands
    • Motekaitis RJ and Martell AE (1991) Stabilities of the iron(III) chelates of 1,2-dimethyl-3-hydroxy-4-pyridinone and related ligands. Inorg Chim Acta 183:71-80.
    • (1991) Inorg Chim Acta , vol.183 , pp. 71-80
    • Motekaitis, R.J.1    Martell, A.E.2
  • 159
    • 0037101845 scopus 로고    scopus 로고
    • The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins
    • Muhlenhoff U, Richhardt N, Ristow M, Kispal G, and Lill R (2002) The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet 11:2025-2036.
    • (2002) Hum Mol Genet , vol.11 , pp. 2025-2036
    • Muhlenhoff, U.1    Richhardt, N.2    Ristow, M.3    Kispal, G.4    Lill, R.5
  • 160
    • 0141455148 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors
    • Murren J, Modiano M, Clairmont C, Lambert P, Savaraj N, Doyle T, and Sznol M (2003) Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors. Clin Cancer Res 15:4092-4100.
    • (2003) Clin Cancer Res , vol.15 , pp. 4092-4100
    • Murren, J.1    Modiano, M.2    Clairmont, C.3    Lambert, P.4    Savaraj, N.5    Doyle, T.6    Sznol, M.7
  • 161
    • 0034738967 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene is a transcriptional target of p53 and p73
    • Nakano K, Balint E, Ashcroft M, and Vousdes KH (2000) A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 19:4283-4289.
    • (2000) Oncogene , vol.19 , pp. 4283-4289
    • Nakano, K.1    Balint, E.2    Ashcroft, M.3    Vousdes, K.H.4
  • 162
    • 14944387002 scopus 로고    scopus 로고
    • Iron trafficking in the mitochondrion: Novel pathways revealed by disease
    • Napier I, Ponka P, and Richardson DR (2005) Iron trafficking in the mitochondrion: novel pathways revealed by disease. Blood 105: 1867-1874.
    • (2005) Blood , vol.105 , pp. 1867-1874
    • Napier, I.1    Ponka, P.2    Richardson, D.R.3
  • 163
    • 0028850367 scopus 로고
    • Siderophores: Structure and function of microbial iron transport compounds
    • Neilands JB (1995) Siderophores: structure and function of microbial iron transport compounds. J Biol Chem 270:26723-26726.
    • (1995) J Biol Chem , vol.270 , pp. 26723-26726
    • Neilands, J.B.1
  • 166
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, and Vaulont S (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98:8780-8785.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 168
    • 0027521831 scopus 로고
    • Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators
    • Nyholm S, Mann GJ, Johansson AG, Bergeron RJ, Graeslund A, and Thelander L (1993) Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J Biol Chem 268:26200-26205.
    • (1993) J Biol Chem , vol.268 , pp. 26200-26205
    • Nyholm, S.1    Mann, G.J.2    Johansson, A.G.3    Bergeron, R.J.4    Graeslund, A.5    Thelander, L.6
  • 169
    • 0031001278 scopus 로고    scopus 로고
    • Iron-chelating therapy and the treatment of thalassemia
    • Olivieri NF and Brittenham GM (1997) Iron-chelating therapy and the treatment of thalassemia. Blood 89:739-761.
    • (1997) Blood , vol.89 , pp. 739-761
    • Olivieri, N.F.1    Brittenham, G.M.2
  • 171
    • 0027378891 scopus 로고
    • Redox, transferrin-independent and receptor-mediated endocytosis iron uptake systems in cultured human fibroblasts
    • Oshiro S, Nakajima H, Markello T, Krasnewich D, Bernardini I, and Gahl WA (1993) Redox, transferrin-independent and receptor-mediated endocytosis iron uptake systems in cultured human fibroblasts. J Biol Chem 268:21586-21591.
    • (1993) J Biol Chem , vol.268 , pp. 21586-21591
    • Oshiro, S.1    Nakajima, H.2    Markello, T.3    Krasnewich, D.4    Bernardini, I.5    Gahl, W.A.6
  • 172
    • 0015593512 scopus 로고
    • Effects of iron on copper metabolism and copper on iron metabolism in rats
    • Owen CA Jr (1973) Effects of iron on copper metabolism and copper on iron metabolism in rats. Am J Physiol 224:514-518.
    • (1973) Am J Physiol , vol.224 , pp. 514-518
    • Owen Jr., C.A.1
  • 173
    • 0035171325 scopus 로고    scopus 로고
    • Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells
    • Pahl PMB, Horwitz MA, Horwitz KB, and Horwitz LD (2001) Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res Treat 69:69-79.
    • (2001) Breast Cancer Res Treat , vol.69 , pp. 69-79
    • Pahl, P.M.B.1    Horwitz, M.A.2    Horwitz, K.B.3    Horwitz, L.D.4
  • 174
    • 0034625399 scopus 로고    scopus 로고
    • An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro
    • Pahl PMB, Yan XD, Hodges YK, Rosenthal EA, Horwitz MA, and Horwitz LD (2000) An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro. J Biol Chem 275:17821-17826.
    • (2000) J Biol Chem , vol.275 , pp. 17821-17826
    • Pahl, P.M.B.1    Yan, X.D.2    Hodges, Y.K.3    Rosenthal, E.A.4    Horwitz, M.A.5    Horwitz, L.D.6
  • 175
    • 0642287902 scopus 로고    scopus 로고
    • Iron metabolism and mitochondrial abnormalities in Friedreich ataxia
    • Pandolfo M (2002) Iron metabolism and mitochondrial abnormalities in Friedreich ataxia. Blood Cells Mol Dis 29:536-547.
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 536-547
    • Pandolfo, M.1
  • 176
  • 177
    • 0031755277 scopus 로고    scopus 로고
    • Novel iron complexed and chelators based on cis,cis-1,3,5- triaminocyclohexane: Iron-mediated ligand oxidation and biochemical properties
    • Park G, Lu FH, Ye N, Brechbiel MW, Torti SV, Torti FM, and Planalp RP (1998) Novel iron complexed and chelators based on cis,cis-1,3,5- triaminocyclohexane: iron-mediated ligand oxidation and biochemical properties. J Biol Inorg Chem 3:449-457.
    • (1998) J Biol Inorg Chem , vol.3 , pp. 449-457
    • Park, G.1    Lu, F.H.2    Ye, N.3    Brechbiel, M.W.4    Torti, S.V.5    Torti, F.M.6    Planalp, R.P.7
  • 180
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, and Loreal O (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 182
    • 0031028178 scopus 로고    scopus 로고
    • Tissue-specific regulation of iron metabolism and heme synthesis: Distinct control mechanisms in erythroid cells
    • Ponka P (1997) Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood 89:1-25.
    • (1997) Blood , vol.89 , pp. 1-25
    • Ponka, P.1
  • 183
    • 0018394556 scopus 로고
    • Mobilization of iron from reticulocytes: Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent
    • Ponka P, Borova J, Neuwirt J, and Fuchs O (1979a) Mobilization of iron from reticulocytes: identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Lett 97:317-321.
    • (1979) FEBS Lett , vol.97 , pp. 317-321
    • Ponka, P.1    Borova, J.2    Neuwirt, J.3    Fuchs, O.4
  • 184
    • 0018798539 scopus 로고
    • A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents
    • Ponka P, Borova J, Neuwirt J, Fuchs O, and Necas E (1979b) A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochim Biophys Acta 586:278-297.
    • (1979) Biochim Biophys Acta , vol.586 , pp. 278-297
    • Ponka, P.1    Borova, J.2    Neuwirt, J.3    Fuchs, O.4    Necas, E.5
  • 185
    • 0023780401 scopus 로고
    • Effect of pyridoxal isonicotinoyl hydrazone (PIH) and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes
    • Ponka P, Richardson D, Baker E, Schulman HM, and Edward JT (1988) Effect of pyridoxal isonicotinoyl hydrazone (PIH) and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes. Biochim Biophys Acta 967:122-129.
    • (1988) Biochim Biophys Acta , vol.967 , pp. 122-129
    • Ponka, P.1    Richardson, D.2    Baker, E.3    Schulman, H.M.4    Edward, J.T.5
  • 186
    • 0022406630 scopus 로고
    • Acquisition of iron from transferrin regulates reticulocytes heme synthesis
    • Ponka P and Schulman HM (1985) Acquisition of iron from transferrin regulates reticulocytes heme synthesis. J Biol Chem 260:14717-14721.
    • (1985) J Biol Chem , vol.260 , pp. 14717-14721
    • Ponka, P.1    Schulman, H.M.2
  • 187
    • 0020412905 scopus 로고
    • Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes
    • Ponka P, Schulman HM, and Wilczynska A (1982) Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes. Biochim Biophys Acta 718:151-156.
    • (1982) Biochim Biophys Acta , vol.718 , pp. 151-156
    • Ponka, P.1    Schulman, H.M.2    Wilczynska, A.3
  • 188
    • 1842611080 scopus 로고    scopus 로고
    • Hydroxamate-based iron chelators: Combinatorial syntheses of desferrioxamine B analogues and evaluation of binding affinities
    • Poreddy AR, Schall OF, Osiek TA, Wheatley JR, Beusen DD, Marshall GR, and Slomczynska U (2004) Hydroxamate-based iron chelators: combinatorial syntheses of desferrioxamine B analogues and evaluation of binding affinities. J Comb Chem 6:239-254.
    • (2004) J Comb Chem , vol.6 , pp. 239-254
    • Poreddy, A.R.1    Schall, O.F.2    Osiek, T.A.3    Wheatley, J.R.4    Beusen, D.D.5    Marshall, G.R.6    Slomczynska, U.7
  • 189
    • 0025201168 scopus 로고
    • Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice
    • Porter JB, Morgan J, Hoyes KP, Burke LC, Huehns ER, and Hider RC (1990) Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice. Blood 76:2389-2396.
    • (1990) Blood , vol.76 , pp. 2389-2396
    • Porter, J.B.1    Morgan, J.2    Hoyes, K.P.3    Burke, L.C.4    Huehns, E.R.5    Hider, R.C.6
  • 190
    • 0028046672 scopus 로고
    • Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds
    • Porter JB, Singh S, Hoyes KP, Epemolu O, Abeysinghe RD, and Hider RC (1994) Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds. Adv Exp Med Biol 356:361-370.
    • (1994) Adv Exp Med Biol , vol.356 , pp. 361-370
    • Porter, J.B.1    Singh, S.2    Hoyes, K.P.3    Epemolu, O.4    Abeysinghe, R.D.5    Hider, R.C.6
  • 192
    • 0342700237 scopus 로고    scopus 로고
    • Recent advances in the molecular pathogenesis of Friedreich ataxia
    • Puccio H and Koenig M (2000) Recent advances in the molecular pathogenesis of Friedreich ataxia. Hum Mol Genet 9:887-892.
    • (2000) Hum Mol Genet , vol.9 , pp. 887-892
    • Puccio, H.1    Koenig, M.2
  • 193
    • 0035138072 scopus 로고    scopus 로고
    • Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
    • Puccio H, Simon D, Cossee M, Criqui-Filipe P, Tiziano F, Melki J, Hindelang C, Matyas R, Rustin P, and Koenig M (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27:181-186.
    • (2001) Nat Genet , vol.27 , pp. 181-186
    • Puccio, H.1    Simon, D.2    Cossee, M.3    Criqui-Filipe, P.4    Tiziano, F.5    Melki, J.6    Hindelang, C.7    Matyas, R.8    Rustin, P.9    Koenig, M.10
  • 195
    • 0027906707 scopus 로고
    • A siderophore from a marine bacterium with an exceptional ferric ion affinity constant
    • Reid RT, Live DH, Faulkner DJ, and Butler A (1993) A siderophore from a marine bacterium with an exceptional ferric ion affinity constant. Nature (Lond) 366:455-458.
    • (1993) Nature (Lond) , vol.366 , pp. 455-458
    • Reid, R.T.1    Live, D.H.2    Faulkner, D.J.3    Butler, A.4
  • 196
    • 0031436976 scopus 로고    scopus 로고
    • Iron chelators as effective anti-proliferative agents
    • Richardson DR (1997) Iron chelators as effective anti-proliferative agents. Can J Physiol Pharmacol 75:164-1180.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 164-1180
    • Richardson, D.R.1
  • 197
    • 0033231215 scopus 로고    scopus 로고
    • The role of ceruloplasmin and ascorbate in cellular iron release
    • Richardson DR (1999) The role of ceruloplasmin and ascorbate in cellular iron release. J Lab Clin Med 134:454-465.
    • (1999) J Lab Clin Med , vol.134 , pp. 454-465
    • Richardson, D.R.1
  • 198
    • 0035336822 scopus 로고    scopus 로고
    • The controversial role of deferiprone in the treatment of thalassemia
    • Richardson DR (2001) The controversial role of deferiprone in the treatment of thalassemia. J Lab Clin Med 137:324-329.
    • (2001) J Lab Clin Med , vol.137 , pp. 324-329
    • Richardson, D.R.1
  • 199
    • 0036269005 scopus 로고    scopus 로고
    • Iron chelators as therapeutic agents for the treatment of cancer
    • Richardson DR (2002) Iron chelators as therapeutic agents for the treatment of cancer. Crit Rev Oncol Hematol 42:267-281.
    • (2002) Crit Rev Oncol Hematol , vol.42 , pp. 267-281
    • Richardson, D.R.1
  • 200
    • 0037317490 scopus 로고    scopus 로고
    • Friedreich's ataxia: Iron chelators that target the mitochondrion as a therapeutic strategy?
    • Richardson DR (2003) Friedreich's ataxia: iron chelators that target the mitochondrion as a therapeutic strategy? Expert Opin Investig Drugs 12:235-245.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 235-245
    • Richardson, D.R.1
  • 201
    • 1342264314 scopus 로고    scopus 로고
    • Mysteries of the transferrin-transferrin receptor 1 interaction uncovered
    • Richardson DR (2004) Mysteries of the transferrin-transferrin receptor 1 interaction uncovered. Cell 116:483-489.
    • (2004) Cell , vol.116 , pp. 483-489
    • Richardson, D.R.1
  • 202
    • 27744528421 scopus 로고    scopus 로고
    • Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer and other diseases
    • in press
    • Richardson DR (2005) Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer and other diseases. Curr Med Chem, in press.
    • (2005) Curr Med Chem
    • Richardson, D.R.1
  • 203
    • 0025341256 scopus 로고
    • The uptake of iron and transferrin by the human malignant melanoma cell
    • Richardson DR and Baker E (1990) The uptake of iron and transferrin by the human malignant melanoma cell. Biochim Biophys Acta 1053:1-12.
    • (1990) Biochim Biophys Acta , vol.1053 , pp. 1-12
    • Richardson, D.R.1    Baker, E.2
  • 204
    • 0025793961 scopus 로고
    • The uptake of inorganic iron complexes by human melanoma cells
    • Richardson DR and Baker E (1991) The uptake of inorganic iron complexes by human melanoma cells. Biochim Biophys Acta 1093:20-28.
    • (1991) Biochim Biophys Acta , vol.1093 , pp. 20-28
    • Richardson, D.R.1    Baker, E.2
  • 205
    • 0026690909 scopus 로고
    • Two mechanisms of iron uptake from transferrin by melanoma cells: The effect of desferrioxamine and ferric ammonium citrate
    • Richardson DR and Baker E (1992) Two mechanisms of iron uptake from transferrin by melanoma cells: the effect of desferrioxamine and ferric ammonium citrate. J Biol Chem 267:13972-13979.
    • (1992) J Biol Chem , vol.267 , pp. 13972-13979
    • Richardson, D.R.1    Baker, E.2
  • 206
    • 0000827572 scopus 로고    scopus 로고
    • The biologically active iron chelators 2-pyridylcarboxaldehyde isonicotinoylhydrazone, 2-pyridylcarboxaldehyde benzoylhydrazone monohydrate and 2-furaldehyde isonicotinoylhydrazone
    • Richardson DR, Becker E, and Bernhardt PV (1999) The biologically active iron chelators 2-pyridylcarboxaldehyde isonicotinoylhydrazone, 2-pyridylcarboxaldehyde benzoylhydrazone monohydrate and 2-furaldehyde isonicotinoylhydrazone. Acta Crystallogr C 55:2102-2105.
    • (1999) Acta Crystallogr C , vol.55 , pp. 2102-2105
    • Richardson, D.R.1    Becker, E.2    Bernhardt, P.V.3
  • 207
    • 0032771646 scopus 로고    scopus 로고
    • Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: An iron chelator with anti-tumour activity
    • Richardson DR and Bernhardt PV (1999) Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity. J Biol Inorg Chem 4:266-273.
    • (1999) J Biol Inorg Chem , vol.4 , pp. 266-273
    • Richardson, D.R.1    Bernhardt, P.V.2
  • 208
    • 0024920255 scopus 로고
    • Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium( II), magnesium(II) and zinc(II)
    • Richardson DR, Hefter GT, May PM, Webb J, and Baker E (1989) Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium( II), magnesium(II) and zinc(II). Biol Met 3:161-167.
    • (1989) Biol Met , vol.3 , pp. 161-167
    • Richardson, D.R.1    Hefter, G.T.2    May, P.M.3    Webb, J.4    Baker, E.5
  • 209
    • 0030894798 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1- naphthylaldehyde benzoyl hydrazone
    • Richardson DR and Milnes K (1997) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood 89:3025-3038.
    • (1997) Blood , vol.89 , pp. 3025-3038
    • Richardson, D.R.1    Milnes, K.2
  • 210
    • 0035978474 scopus 로고    scopus 로고
    • Development of potential iron chelators for the treatment of Friedreich's ataxia: Ligands that mobilize mitochondrial iron
    • Richardson DR, Mouralian C, Ponka P, and Becker E (2001) Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron. Biochim Biophys Acta 1536:133-140.
    • (2001) Biochim Biophys Acta , vol.1536 , pp. 133-140
    • Richardson, D.R.1    Mouralian, C.2    Ponka, P.3    Becker, E.4
  • 211
    • 0028535112 scopus 로고
    • The iron metabolism of the human neuroblastoma cell: Lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis
    • Richardson DR and Ponka P (1994) The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. J Lab Clin Med 124:660-671.
    • (1994) J Lab Clin Med , vol.124 , pp. 660-671
    • Richardson, D.R.1    Ponka, P.2
  • 212
    • 0028875152 scopus 로고
    • Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction
    • Richardson DR and Ponka P (1995) Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction. Biochim Biophys Acta 1269:105-114.
    • (1995) Biochim Biophys Acta , vol.1269 , pp. 105-114
    • Richardson, D.R.1    Ponka, P.2
  • 213
    • 0031567095 scopus 로고    scopus 로고
    • The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
    • Richardson DR and Ponka P (1997) The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta 1331:1-40.
    • (1997) Biochim Biophys Acta , vol.1331 , pp. 1-40
    • Richardson, D.R.1    Ponka, P.2
  • 214
    • 0032055861 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease
    • Richardson DR and Ponka P (1998) Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med 131:306-315.
    • (1998) J Lab Clin Med , vol.131 , pp. 306-315
    • Richardson, D.R.1    Ponka, P.2
  • 215
    • 0029865751 scopus 로고    scopus 로고
    • Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: Examination of the intermediates involved in iron metabolism
    • Richardson DR, Ponka P, and Vyoral D (1996) Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism. Blood 87:3477-3488.
    • (1996) Blood , vol.87 , pp. 3477-3488
    • Richardson, D.R.1    Ponka, P.2    Vyoral, D.3
  • 216
    • 0028891974 scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents
    • Richardson DR, Tran EH, and Ponka P (1995) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents. Blood 86:4295-4306.
    • (1995) Blood , vol.86 , pp. 4295-4306
    • Richardson, D.R.1    Tran, E.H.2    Ponka, P.3
  • 217
    • 0000166947 scopus 로고
    • Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part I. Ionisation characteristics of the ligands and their relevance to biological properties
    • Richardson DR, Vitolo LMW, Hefter GT, Mat PM, Clare BW, Webb J, and Wilairat P (1990) Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part I. Ionisation characteristics of the ligands and their relevance to biological properties. Inorg Chim Acta 170:165-170.
    • (1990) Inorg Chim Acta , vol.170 , pp. 165-170
    • Richardson, D.R.1    Vitolo, L.M.W.2    Hefter, G.T.3    Mat, P.M.4    Clare, B.W.5    Webb, J.6    Wilairat, P.7
  • 219
    • 0028062981 scopus 로고
    • Molecular effects of 2′,2′-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells
    • Ross DD and Cuddy DP (1994) Molecular effects of 2′,2′- difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells. Biochem Pharmacol 48:1619-1630.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1619-1630
    • Ross, D.D.1    Cuddy, D.P.2
  • 222
    • 0017031971 scopus 로고
    • Pathology of the heart in Friedreich's ataxia
    • Sachez-Casis G, Cote M, and Barbeau A (1976) Pathology of the heart in Friedreich's ataxia. Can J Neurol Sci 3:349-354.
    • (1976) Can J Neurol Sci , vol.3 , pp. 349-354
    • Sachez-Casis, G.1    Cote, M.2    Barbeau, A.3
  • 224
    • 0015153126 scopus 로고
    • Mechanism of inhibition of ribonucleoside diphosphate reductase by α-(N)-heterocyclic aldehyde thiosemicarbazones
    • Sartorelli AC, Agrawal KC, and Moore EC (1971) Mechanism of inhibition of ribonucleoside diphosphate reductase by α-(N)-heterocyclic aldehyde thiosemicarbazones. Biochem Pharmacol 20:3119-3123.
    • (1971) Biochem Pharmacol , vol.20 , pp. 3119-3123
    • Sartorelli, A.C.1    Agrawal, K.C.2    Moore, E.C.3
  • 225
    • 0014123472 scopus 로고
    • Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis(thiosemicarbazone)
    • Sartorelli AC and Booth BA (1967) Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis(thiosemicarbazone). Cancer Res 27:1614-1619.
    • (1967) Cancer Res , vol.27 , pp. 1614-1619
    • Sartorelli, A.C.1    Booth, B.A.2
  • 226
    • 0347028551 scopus 로고    scopus 로고
    • The role of oxidant injury in the pathophysiology of human thalassemias
    • Schrier SL, Centis F, Verneris M, Ma L, and Angelucci E (2003) The role of oxidant injury in the pathophysiology of human thalassemias. Redox Rep 8:241-245.
    • (2003) Redox Rep , vol.8 , pp. 241-245
    • Schrier, S.L.1    Centis, F.2    Verneris, M.3    Ma, L.4    Angelucci, E.5
  • 227
    • 0033761055 scopus 로고    scopus 로고
    • Chelator-induced iron excretion in iron-overloaded marmosets
    • Sergejew T, Forgiarini P, and Schnebli HP (2000) Chelator-induced iron excretion in iron-overloaded marmosets. Br J Haematol 110:985-992.
    • (2000) Br J Haematol , vol.110 , pp. 985-992
    • Sergejew, T.1    Forgiarini, P.2    Schnebli, H.P.3
  • 228
    • 1642453838 scopus 로고    scopus 로고
    • In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
    • Shao J, Zhou B, Zhu L, Qui W, Yuan YC, Xi B, and Yen Y (2004) In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Res 64:1-6.
    • (2004) Cancer Res , vol.64 , pp. 1-6
    • Shao, J.1    Zhou, B.2    Zhu, L.3    Qui, W.4    Yuan, Y.C.5    Xi, B.6    Yen, Y.7
  • 229
    • 0025060810 scopus 로고
    • Oxidative denaturation of red blood cells in thalassemia
    • Shinar E and Rachmilewitz EA (1990) Oxidative denaturation of red blood cells in thalassemia. Semin Hematol 27:70-82.
    • (1990) Semin Hematol , vol.27 , pp. 70-82
    • Shinar, E.1    Rachmilewitz, E.A.2
  • 231
    • 0025291804 scopus 로고
    • Novel 3-hydroxy-2(1H)-pyridinones: Synthesis, iron(III)-chelating properties and biological activity
    • Streater M, Taylor PD, Hider RC, and Porter J (1990) Novel 3-hydroxy-2(1H)-pyridinones: synthesis, iron(III)-chelating properties and biological activity. J Med Chem 33:1749-1755.
    • (1990) J Med Chem , vol.33 , pp. 1749-1755
    • Streater, M.1    Taylor, P.D.2    Hider, R.C.3    Porter, J.4
  • 232
    • 0025231790 scopus 로고
    • Characterization of a transferrin-independent uptake system for iron in HeLa cells
    • Sturrock A, Alexander J, Lamb J, Craven CM, and Kaplan J (1990) Characterization of a transferrin-independent uptake system for iron in HeLa cells. J Biol Chem 265:3139-3145.
    • (1990) J Biol Chem , vol.265 , pp. 3139-3145
    • Sturrock, A.1    Alexander, J.2    Lamb, J.3    Craven, C.M.4    Kaplan, J.5
  • 235
    • 0020567471 scopus 로고
    • Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone
    • Thelander L and Gräslund A (1983) Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. J Biol Chem 258:4063-4066.
    • (1983) J Biol Chem , vol.258 , pp. 4063-4066
    • Thelander, L.1    Gräslund, A.2
  • 236
    • 0021099095 scopus 로고
    • Continual presence of oxygen and iron is required for mammalian ribonucleotide reduction: Possible regulation mechanism
    • Thelander L, Gräslund A, and Thelander M (1983) Continual presence of oxygen and iron is required for mammalian ribonucleotide reduction: possible regulation mechanism. Biochem Biophys Res Commun 110:859-865.
    • (1983) Biochem Biophys Res Commun , vol.110 , pp. 859-865
    • Thelander, L.1    Gräslund, A.2    Thelander, M.3
  • 237
    • 0018337084 scopus 로고
    • The reduction of ribonucleotides
    • Thelander L and Reichard P (1979) The reduction of ribonucleotides. Annu Rev Biochem 48:133-158.
    • (1979) Annu Rev Biochem , vol.48 , pp. 133-158
    • Thelander, L.1    Reichard, P.2
  • 239
    • 0029953577 scopus 로고    scopus 로고
    • Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression
    • Trinder D, Zak O, and Aisen P (1996) Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology 23:1512-1520.
    • (1996) Hepatology , vol.23 , pp. 1512-1520
    • Trinder, D.1    Zak, O.2    Aisen, P.3
  • 240
    • 9244234407 scopus 로고    scopus 로고
    • Heme transport exhibits polarity in Caco-2 cells: Evidence for an active and membrane protein-mediated process
    • Uc A, Stokes JB, and Britigan BE (2004) Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process. Am J Physiol 287:G1150-G1157.
    • (2004) Am J Physiol , vol.287
    • Uc, A.1    Stokes, J.B.2    Britigan, B.E.3
  • 242
    • 0000424901 scopus 로고
    • Iron chelators of the pyridoxal isonictinoyl hydrazone class. Part II. Formation constants with iron(III) and iron( II)
    • Vitolo LMW, Hefter GT, Clare BW, and Webb J (1990) Iron chelators of the pyridoxal isonictinoyl hydrazone class. Part II. Formation constants with iron(III) and iron( II). Inorg Chim Acta 170:171-176.
    • (1990) Inorg Chim Acta , vol.170 , pp. 171-176
    • Vitolo, L.M.W.1    Hefter, G.T.2    Clare, B.W.3    Webb, J.4
  • 244
    • 0026775830 scopus 로고
    • Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis
    • Vyoral D, Hradilek A, and Neuwirt J (1992) Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis. Biochim Biophys Acta 137:148-154.
    • (1992) Biochim Biophys Acta , vol.137 , pp. 148-154
    • Vyoral, D.1    Hradilek, A.2    Neuwirt, J.3
  • 245
    • 2442698003 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion
    • Wadler S, Makower D, Clairmont C, Lambert P, Fehn K, and Sznol M (2004) Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion. J Clin Oncol 22:1553-1563.
    • (2004) J Clin Oncol , vol.22 , pp. 1553-1563
    • Wadler, S.1    Makower, D.2    Clairmont, C.3    Lambert, P.4    Fehn, K.5    Sznol, M.6
  • 246
    • 0036721452 scopus 로고    scopus 로고
    • Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent betathalassemia
    • Wanless IR, Sweeney G, Dhillon AP, Guido M, Piga A, Galanello R, Gamberini MR, Schwartz E, and Cohen AR (2002) Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent betathalassemia. Blood 100:1566-1569.
    • (2002) Blood , vol.100 , pp. 1566-1569
    • Wanless, I.R.1    Sweeney, G.2    Dhillon, A.P.3    Guido, M.4    Piga, A.5    Galanello, R.6    Gamberini, M.R.7    Schwartz, E.8    Cohen, A.R.9
  • 247
    • 0037328284 scopus 로고    scopus 로고
    • Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: Mirror-image effector molecules that target iron
    • Watts RN, Ponka P, and Richardson DR (2003) Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron. Biochem J 369:429-440.
    • (2003) Biochem J , vol.369 , pp. 429-440
    • Watts, R.N.1    Ponka, P.2    Richardson, D.R.3
  • 248
    • 0033054177 scopus 로고    scopus 로고
    • The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis
    • Wong A, Yang J, Cavadini P, Gellera C, Lonnerdal B, Taroni F, and Cortopassi G (1999) The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. Hum Mol Genet 8:425-430.
    • (1999) Hum Mol Genet , vol.8 , pp. 425-430
    • Wong, A.1    Yang, J.2    Cavadini, P.3    Gellera, C.4    Lonnerdal, B.5    Taroni, F.6    Cortopassi, G.7
  • 249
    • 0037411115 scopus 로고    scopus 로고
    • β-Thalassaemia: Emergence of new and improved iron chelators for treatment
    • Wong C and Richardson DR (2003) β-Thalassaemia: emergence of new and improved iron chelators for treatment. Int J Biochem Cell Biol 35:1144-1149.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1144-1149
    • Wong, C.1    Richardson, D.R.2
  • 250
    • 10644295737 scopus 로고    scopus 로고
    • PCTH: A novel orally active chelator of the aroylhydrazone class that induces iron excretion from mice
    • Wong CSM, Kwok JC, and Richardson DR (2004) PCTH: a novel orally active chelator of the aroylhydrazone class that induces iron excretion from mice. Biochim Biophys Acta 1739:70-80.
    • (2004) Biochim Biophys Acta , vol.1739 , pp. 70-80
    • Wong, C.S.M.1    Kwok, J.C.2    Richardson, D.R.3
  • 251
    • 0037121863 scopus 로고    scopus 로고
    • Hexadentate hydroxypyridonate iron chelators based on TREN-Me-3,2-HOPO: Variation of cap size
    • Xu J, O'Sullivan B, and Raymond KN (2002) Hexadentate hydroxypyridonate iron chelators based on TREN-Me-3,2-HOPO: variation of cap size. Inorg Chem 41:6731-6742.
    • (2002) Inorg Chem , vol.41 , pp. 6731-6742
    • Xu, J.1    O'Sullivan, B.2    Raymond, K.N.3
  • 252
    • 4644288941 scopus 로고    scopus 로고
    • A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer
    • Yen Y, Margolin K, Doroshow J, Fishman M, Johnson B, Clairmont C, Sullivan D, and Sznol M (2004) A phase I trial of 3-aminopyridine-2- carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer. Cancer Chemother Pharmacol 54:331-342.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 331-342
    • Yen, Y.1    Margolin, K.2    Doroshow, J.3    Fishman, M.4    Johnson, B.5    Clairmont, C.6    Sullivan, D.7    Sznol, M.8
  • 253
    • 0033820935 scopus 로고    scopus 로고
    • The hexadentate hydroxypyridinoate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue
    • Yokel RA, Fredenburg AM, Durbin PW, Xu J, Rayens MK, and Raymond KN (2000) The hexadentate hydroxypyridinoate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue. J Pharm Sci 89:545-555.
    • (2000) J Pharm Sci , vol.89 , pp. 545-555
    • Yokel, R.A.1    Fredenburg, A.M.2    Durbin, P.W.3    Xu, J.4    Rayens, M.K.5    Raymond, K.N.6
  • 254
    • 4444248453 scopus 로고    scopus 로고
    • Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment
    • Yuan J, Lovejoy DB, and Richardson DR (2004) Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood 104:1450-1458.
    • (2004) Blood , vol.104 , pp. 1450-1458
    • Yuan, J.1    Lovejoy, D.B.2    Richardson, D.R.3
  • 256
    • 0029670422 scopus 로고    scopus 로고
    • Regulation of p21 WAF1/CIP1 expression by p53-independent pathways
    • Zeng YX and El-Deiry WS (1996) Regulation of p21 WAF1/CIP1 expression by p53-independent pathways. Oncogene 12:1557-1564.
    • (1996) Oncogene , vol.12 , pp. 1557-1564
    • Zeng, Y.X.1    El-Deiry, W.S.2
  • 257
    • 11144226961 scopus 로고    scopus 로고
    • Intracellular kinetics of iron in reticulocytes: Evidence for endosome involvement in iron targeting to mitochondria
    • Zhang AS, Sheftel AD, and Ponka P (2005) Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria. Blood 105:368-375.
    • (2005) Blood , vol.105 , pp. 368-375
    • Zhang, A.S.1    Sheftel, A.D.2    Ponka, P.3


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