Analyses for binding of the transferrin family of proteins to the transferrin receptor 2

British Journal of Haematology

Volumn 127, Issue 4, 2004, Pages 464-473

  Kawabata, Hiroshi ^a,b   Tong, Xiangjun ^a,c   Kawanami, Takafumi ^b   Wano, Yuji ^b   Hirose, Yuko ^b   Sugai, Susumu ^b   Koeffler, H Phillip ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c PEKING UNIVERSITY   (China)

Author keywords

Functional studies; Iron; Iron metabolism; Iron overload

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CD71 ANTIGEN; LACTOFERRIN; LIGAND; MELANOTRANSFERRIN; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; FLOW CYTOMETRY; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC TRANSFECTION; HEMOCHROMATOSIS; HUMAN; IN VITRO STUDY; IRON METABOLISM; IRON TRANSPORT; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

BIOTINYLATION; BLOTTING, WESTERN; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; MUTATION; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 8844236171     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.05224.x     Document Type: Article

References (49)

1. Bennett, M.-J., Lebrón, J.-A. & Bjorkman, P.-J. (2000) Crystal structure of the hereditary haemachromatosis protein HFE complexed with transferrin receptor. Nature, 403, 46-53.
2. Bridle, K.-R., Frazer, D.-M., Wilkins, S.-J., Dixon, J.-L., Purdie, D.-M., Crawford, D.-H., Subramaniam, V.-N., Powell, L.-W., Anderson, G.-J. & Ram, G.-A. (2003) Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet, 361, 669-673.
3. Camaschella, C., Roetto, A., Cali, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A. & Gasparini, P. (2000) The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nature Genetics, 25, 14-15.
4. Curiel, D.T., Agarwal, S., Wagner, E. & Cotten, M. (1991) Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proceedings of the National Academy of Sciences of the United States of America, 88, 8850-8854.
5. Deaglio, S., Capobianco, A., Cali, A., Bellora, F., Alberti, F., Righi, L., Sapino, A., Camaschella, C. & Malavasi, F. (2002) Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood, 100, 3782-3789.
6. Dubljevic, V., Sali, A. & Goding, J.-W. (1999) A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin. The Biochemical Journal, 341, 11-14.
7. Feder, J.-N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.-A., Basava, A., Dormishian, F., Domingo, R.-J., Ellis, M.-C., Fullan, A., Hinton, L.-M., Jones, N.-L, Kimmel, B.-E., Kronmal, G.-S., Lauer, P., Lee, V.-K., Loeb, D.-B., Mapa, F.-A., McClelland, E., Meyer, N.-C., Mintier, G.-A., Moeller, N., Moore, T., Morikang, E., Prass, C.-E., Quintana, L., Starnes, S.-M., Schatzman, R.-C., Brunke, K.-J., Drayna, D.-T., Risch, N.-J., Bacon, B.-R. & Wolff, R.-K. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genetics, 13, 399-408.
8. Fleming, R.-E., Migas, M.-C., Holden, C.-C., Waheed, A., Britton, R.-S., Tomatsu, S., Bacon, B.-R. & Sly, W.-S. (2000) Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America, 97, 2214-2219.
9. Fleming, R.-E., Ahmann, J.-R., Migas, M.-C., Waheed, A., Koeffler, H.-P., Kawabata, H., Britton, R.-S., Bacon, B.-R. & Sly, W.-S. (2002) Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America, 99, 10653-10658.
10. Food, M.-R. & Des Richardson, R. (2002) Iron uptake by melanoma cells from the soluble form of the transferrin homologue, melanotransferrin. Redox Report, 7, 279-282.
11. Food, M.-R., Sekyere, E.-O. & Richardson, D.-R. (2002) The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein. European Journal of Biochemistry, 269, 4435-4445.
12. Frazer, D.-M. & Anderson, G.-J. (2003) The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells, Molecules and Diseases, 30, 288-297.
13. Frazer, D.-M., Wilkins, S.-J., Becker, E.-M., Vulpe, C-D., McKie, A.-T., Trinder, D. & Anderson, G.-J. (2002) Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology, 123, 835-844.
14. Ganz, T. (2003) Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 27, 27.
15. Gehrke, S.-G., Kulaksiz, H., Herrmann, T., Riedel, H.-D., Bents, K., Veltkamp, C. & Stremmel, W. (2003) Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to serum transferrin saturation and non-transferrin-bound iron. Blood, 13, 13.
16. Griffiths, W.-J. & Cox, T.-M. (2003) Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. The Journal of Histochemistry Cytochemistry, 51, 613-624.
17. Hattori, A., Wakusawa, S., Hayashi, H., Harashima, A., Sanae, F., Kawanaka, M., Yamada, G., Yano, M. & Yoshioka, K. (2003) AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis. Hepatology Research, 26, 154-156.
18. Kawabata, H., Yang, R., Hirama, T., Vuong, P.-T., Kawano, S., Gombart, A.-F. & Koeffler, H.-P. (1999) Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family. The Journal of Biological Chemistry, 274, 20826-20832.
19. Kawabata, H., Germain, R.-S., Vuong, P.-T., Nakamaki, T., Said, J.-W. & Koeffler, H.-P. (2000) Transferrin receptor 2α supports cell growth both in iron-chelated cultured cells and in vivo. The Journal of Biological Chemistry, 275, 16618-16625.
20. Kawabata, H., Nakamaki, T., Ikonomi, P., Smith, R.-D., Germain, R.-S. & Koeffler, H.-P. (2001) Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood, 98, 2714-2719.
21. Kawabata, H., Fleming, R.-E., Gui, D., Moon, S.-Y., Saitoh, T., O'Kelly, J., Umehara, Y., Wano, Y., Said, J.-W. & Koeffler, H.-P. (2004) Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood, in press.
22. Lawrence, C.-M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D.-W. & Harrison, S.-C. (1999) Crystal structure of the ectodomain of human transferrin receptor. Science, 286, 779-782.
23. Lonnerdal, B. & Iyer, S. (1995) Lactoferrin: molecular structure and biological function. Annual Review of Nutrition, 15, 93-110.
24. Mattman, A., Huntsman, D., Lockitch, G., Langlois, S., Buskard, N., Ralston, D., Butterfield, Y., Rodrigues, P., Jones, S., Porto, G., Marra, M., De Sousa, M. & Vatcher, G. (2002) Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. Blood, 100, 1075-1077.
25. McGraw, T.-E., Greenfield, L. & Maxfield, F.-R. (1987) Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor. The Journal of Cell Biology, 105, 207-214.
26. Morabito, M.-A. & Moczydlowski, E. (1995) Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin. Proceedings of the National Academy of Sciences of the United States of America, 92, 6651.
27. Muckenthaler, M., Roy, C.N., Custodio, A.-O., Minana, B., DeGraaf, J., Montross, L.-K., Andrews, N.-C. & Hentze, M.-W. (2003) Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrdl expression in mouse hemochromatosis. Nature Genetics, 34, 102-107.
28. Nemeth, E., Valore, E.-V., Territo, M., Schiller, G., Lichtenstein, A. & Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 101, 2461-2463.
29. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A. & Vaulont, S. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 98, 8780-8785.
30. Nicolas, G., Chauvet, C., Viatte, L., Danan, J.-L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. & Vaulont, S. (2002a) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. The Journal Clinical Investigation, 110, 1037-1044.
31. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A. & Vaulont, S. (2002b) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proceedings of the National Academy of Sciences of the United States of America, 99, 4596-4601.
32. Nicolas, G., Viatte, L., Lou, D.Q., Bennoun, M., Beaumont, C., Kahn, A., Andrews, N.-C. & Vaulont, S. (2003) Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nature Genetics, 34, 97-101.
33. Papanikolaou, G., Samuels, M.-E., Ludwig, E.-H., MacDonald, M.-L., Franchini, P.-L., Dube, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J.-K., Zaborowska, C., Babakaiff, R., Radomski, C.-C., Pape, T.-D., Davidas, O., Christakis, J., Brissot, P., Lockitch, G., Ganz, T., Hayden, M.-R. & Goldberg, Y.-P. (2003) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nature Genetics, 30, 30.
34. Park, C.-H., Valore, E.-V., Waring, A.-J. & Ganz, T. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. The Journal of Biological Chemistry, 276, 7806-7810.
35. Qian, Z.-M., Li, H., Sun, H. & Ho, K. (2002) Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacological Reviews, 54, 561-587.
36. Richardson, D.-R. (2000) The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell. European Journal of Biochemistry, 267, 1290-1298.
37. Roetto, A., Totaro, A., Piperno, A., Piga, A., Longo, F., Garozzo, G., Cali, A., De Gobbi, M., Gasparini, P. & Camaschella, C. (2001) New mutations inactivating transferrin receptor 2 in hemochromatosis type. Blood, 97, 2555-2560.
38. Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D. & Camaschella, C. (2003) Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nature Genetics, 33, 21-22.
39. Rose, T.-M., Plowman, G.-D., Teplow, D.-B., Dreyer, W.-J., Hellström, K.-E. & Brown, J.-P. (1986) Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. Proceedings of the National Academy of Sciences of the United States of America, 83, 1261-1265.
40. Sala, R., Jefferies, W.A., Walker, B., Yang, J., Tiong, J., Law, S.-K., Carlevaro, M-F., Di Marco, E., Vacca, A., Cancedda, R., Cancedda, F.-D. & Ribatti, D. (2002) The human melanoma associated protein melanotransferrin promotes endothelial cell migration and angiogenesis in vivo. European Journal of Cell Biology, 81, 599-607.
41. Suzuki, Y.-A., Shin, K. & Lonnerdal, B. (2001) Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry, 40, 15771-15779.
42. Tong, X., Kawabata, H. & Koeffler, H.-P. (2002) Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level. British Journal of Haematology, 116, 458-464.
43. Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D.-T. & Birnstiel, M.-L. (1992) Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proceedings of the National Academy of Sciences of the United States of America, 89, 6099-6103.
44. Weinstein, D.-A., Roy, C-N., Fleming, M.-D., Loda, M.-F., Wolfsdorf, J.I. & Andrews, N.C. (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood, 100, 3776-3781.
45. West, Jr, A.-P., Bennett, M.-J., Sellers, V.-M., Andrews, N.-C., Enns, C.-A. & Bjorkman, P.-J. (2000) Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. The Journal of Biological Chemistry, 275, 38135-38138.
46. West, Jr A.-P., Giannetti, A.-M., Herr, A.-B., Bennett, M.-J., Nangiana, J.-S., Pierce, J.-R., Weiner, L.-P., Snow, P.-M. & Bjorkman, P.-J. (2001) Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. Journal of Molecular Biology, 313, 385-397.
47. Wuebbens, M.-W., Roush, E.-D., Decastro, C.-M. & Fierke, C.-A. (1997) Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: A novel member of the transferrin family. Biochemistry, 36, 4327-4336.
48. Yang, R., Morosetti, R. & Koeffler, H.-P. (1997) Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Research, 57, 913-920.
49. Young, S.-P. & Garner, C. (1990) Delivery of iron to human cells by bovine transferrin. Implications for the growth of human cells in vitro. The Biochemical Journal, 265, 587-591.