A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats

Journal of Nutrition

Volumn 130, Issue 9, 2000, Pages 2333-2342

  Peluso, Michael R ^a,b   Winters, Todd A ^a,b   Shanahan, Michael F ^b   Banz, William J ^a,b  

^a SOUTHERN ILLINOIS UNIVERSITY   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatic lipids; Platelets; Rats; Soy isoflavones; Soy protein

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; ISOFLAVONE DERIVATIVE; SOYBEAN PROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; ATHEROGENIC DIET; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FOOD COMPOSITION; LIVER METABOLISM; LIVER WEIGHT; NONHUMAN; PROTEIN INTAKE; RAT;

EID: 0033850693     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.9.2333     Document Type: Article

References (57)

1. Plasma concentrations of phyto-estrogens in Japanese men
2. Enzymatic determination of total serum cholesterol
3. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies
4. Meta-analysis of the effects of soy protein intake on serum lipids
5. Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys
6. Effects of soy isoflavones on atherosclerosis: Potential mechanisms
7. 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
8. Cell membrane lipid composition and distribution: Implications for cell function and lessons learned from photoreceptors and platelets
9. Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin
10. Quantitative determination of serum triglycerides by the use of enzymes
11. Soy consumption and cholesterol reduction: Review of animal and human studies
12. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease
13. A colorimetric method for estimating serum triglycerides
14. A simple method for the isolation and purification of total lipides from animal tissues
15. Altered hepatic metabolism of free fatty acids underlying hypersecretion of very low density lipoproteins in the genetically obese Zucker rat
16. Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys
17. Sensitivity to platelet aggregation appears related to the lipoprotein profile and atherosclerosis risk in humans and across species
18. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: A randomized controlled trial in humans
19. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques
20. Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats
21. Effects of dietary proteins on lipogenic enzymes in rat liver
22. --rats
23. Modulation of liver canalicular transport processes by the tyrosin-kinase inhibitor genistein: Implications of genistein metabolism in the rat
24. Hyperinsulinemia in obesity syndromes: Its metabolic consequences and possible etiology
25. Tyrosine kinase inhibitors potentiate the induction of low density receptor gene expression by hepatocyte growth factor
26. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury
27. Genetic obesity: Is the defect in the sympathetic nervous system? A review through developmental studies in the preobese Zucker rat
28. Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation
29. Lipoprotein metabolism in the fat Zucker rat: Reduced basal expression but normal regulation of hepatic low density lipoprotein receptors
30. Serum cholesterol, lecithin-cholesterol acyltransferase, and hepatic hydroxymethylglutaryl coenzyme A reductase activities of lean and obese Zucker rats
31. Protein measurement with the Folin phenol reagent
32. Cholesterol homeostasis in lean and obese male Zucker rats
33. Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins
34. 2-mediated human platelet responses
35. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women
36. Kinetics of serotonin in platelets in essential hypertension
37. Overview of proposed mechanisms for the hypocholesterolemic effect of soy
38. Soy protein and cardiovascular disease: The impact of bioactive components in soy
39. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
40. The pathogenesis of atherosclerosis
41. The role of endothelial injury and platelet and macrophage interactions in atherosclerosis
42. Liquid-chromatographic determination of serotonin in serum and plasma
43. Intestinal uptake and biliary excretion of the isoflavone genistein in rats
44. Platelet function and platelet lipid composition in the dyslipoproteinemias
45. Platelet hypersensitivity induced by cholesterol incorporation
46. Nonalcoholic steatohepatitis
47. Soybean-protein diet in the treatment of type-II hyperlipoproteinemia
48. Reduction of serum cholesterol by soy proteins: Clinical experience and potential molecular mechanisms
49. Soy and cholesterol reduction: Clinical experience
50. Reduced platelet serotonin content and release in familial hypercholesterolemia
51. Arterial lipid biochemistry in the spontaneously hyperlipidemic Zucker rat and its similarity to early atherogenesis
52. The influence of lipoproteins on blood platelets
53. Expression of hepatic microsomal cholesterol 7α-hydroxylase activity in lean and obese Zucker rats
54. Serum lipids, lipoprotein composition and liver cholesterol in genetically obese Zucker rats fed semipurified diets containing either casein or soy protein
55. Regulation and role of phosphoinositide phosphorylation in human platelets
56. Dietary soy isoflavones inhibit in-vivo constrictor responses of coronary arteries to collagen-induced platelet activation
57. Metabolizable energy of diets low or high in dietary fiber from fruits and vegetables when consumed by humans