메뉴 건너뛰기




Volumn 11, Issue 4, 2007, Pages 419-423

Iron chelation, quo vadis?

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; CHOLYLHYDROXAMIC ACID; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; DEFERRIFERRITHIOCIN; DIHYDROXYBENZOIC ACID; PYRIDOXAL ISONICOTINOYLHYDRAZONE; UNCLASSIFIED DRUG;

EID: 34548132409     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2007.04.025     Document Type: Review
Times cited : (35)

References (35)
  • 1
    • 33751222525 scopus 로고    scopus 로고
    • Iron chelators as therapeutic iron depletion agents
    • This report describes clinically used iron chelators including desferrioxamine, deferasirox, deferiprone (iron overload), dexrazoxane (protection from cardiotoxicity), ciclopirox (antifungal), and iron chelators in the preclinical stage of development, as well as the patent status of these compounds.
    • Birch N., Wang X., and Chong H.-S. Iron chelators as therapeutic iron depletion agents. Expert Opin Ther Patents 16 (2006) 1533-1556. This report describes clinically used iron chelators including desferrioxamine, deferasirox, deferiprone (iron overload), dexrazoxane (protection from cardiotoxicity), ciclopirox (antifungal), and iron chelators in the preclinical stage of development, as well as the patent status of these compounds.
    • (2006) Expert Opin Ther Patents , vol.16 , pp. 1533-1556
    • Birch, N.1    Wang, X.2    Chong, H.-S.3
  • 2
    • 28444435827 scopus 로고    scopus 로고
    • Iron in nonhemochromatotic liver disorders
    • The authors emphasize the comorbid role of iron in liver diseases such as porphyria cutanea tarda, alcoholic liver disease, nonalcoholic steatohepatitis, and chronic hepatitis C.
    • Alla V., and Bonkovsky H.L. Iron in nonhemochromatotic liver disorders. Semin Liver Dis 25 (2005) 461-472. The authors emphasize the comorbid role of iron in liver diseases such as porphyria cutanea tarda, alcoholic liver disease, nonalcoholic steatohepatitis, and chronic hepatitis C.
    • (2005) Semin Liver Dis , vol.25 , pp. 461-472
    • Alla, V.1    Bonkovsky, H.L.2
  • 3
    • 0021270928 scopus 로고
    • Effect of hematologic treatment on the growth and puberty of children with thalassemia major
    • Pomarede R., Girot R., Constant S., and Rappaport R. Effect of hematologic treatment on the growth and puberty of children with thalassemia major. Arch Fr Pediatr 41 (1984) 255-259
    • (1984) Arch Fr Pediatr , vol.41 , pp. 255-259
    • Pomarede, R.1    Girot, R.2    Constant, S.3    Rappaport, R.4
  • 4
    • 0000390903 scopus 로고
    • Transfusion therapy in Cooley's anemia: growth and health as related to long-range haemoglobin levels. A progress report
    • Wolman I.J. Transfusion therapy in Cooley's anemia: growth and health as related to long-range haemoglobin levels. A progress report. Ann NY Acad Sci 119 (1964) 736-747
    • (1964) Ann NY Acad Sci , vol.119 , pp. 736-747
    • Wolman, I.J.1
  • 6
    • 0017077213 scopus 로고
    • Reassessment of the use of desferrioxamine B in iron overload
    • Propper R.D., Shurin S.B., and Nathan D.G. Reassessment of the use of desferrioxamine B in iron overload. N Engl J Med 294 (1976) 1421-1423
    • (1976) N Engl J Med , vol.294 , pp. 1421-1423
    • Propper, R.D.1    Shurin, S.B.2    Nathan, D.G.3
  • 7
    • 33644701423 scopus 로고    scopus 로고
    • Changes in the epidemiology of thalassemia in North America: a new minority disease
    • Vichinsky E.P., MacKlin E.A., Waye J.S., Lorey F., and Olivieri N.F. Changes in the epidemiology of thalassemia in North America: a new minority disease. Pediatrics 116 (2005) e818-e825
    • (2005) Pediatrics , vol.116
    • Vichinsky, E.P.1    MacKlin, E.A.2    Waye, J.S.3    Lorey, F.4    Olivieri, N.F.5
  • 11
    • 0018567483 scopus 로고
    • Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone
    • Hoy T., Humphrys J., Jacobs A., Williams A., and Ponka P. Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone. Br J Haematol 43 (1979) 443-449
    • (1979) Br J Haematol , vol.43 , pp. 443-449
    • Hoy, T.1    Humphrys, J.2    Jacobs, A.3    Williams, A.4    Ponka, P.5
  • 12
    • 0032055861 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease
    • Richardson D.R., and Ponka P. Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med 131 (1998) 306-315
    • (1998) J Lab Clin Med , vol.131 , pp. 306-315
    • Richardson, D.R.1    Ponka, P.2
  • 14
    • 34548113493 scopus 로고    scopus 로고
    • Hider RC, Kontoghiorghes GJ, Silver J: UK Patent GB-2118176 1982.
  • 15
    • 0023214937 scopus 로고
    • 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload
    • Kontoghiorghes G.J., Aldouri M.A., Sheppard L., and Hoffbrand A.V. 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload. Lancet 1 (1987) 1294-1295
    • (1987) Lancet , vol.1 , pp. 1294-1295
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Sheppard, L.3    Hoffbrand, A.V.4
  • 17
    • 0034061525 scopus 로고    scopus 로고
    • A molecular mechanics approach for the prediction of the geometry of high spin Fe(III) complexes with oxygen and nitrogen as coordinating atoms
    • Acklin P. A molecular mechanics approach for the prediction of the geometry of high spin Fe(III) complexes with oxygen and nitrogen as coordinating atoms. Helv Chim Acta 83 (2000) 677-686
    • (2000) Helv Chim Acta , vol.83 , pp. 677-686
    • Acklin, P.1
  • 19
    • 10744230223 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled, dose-escalation trial
    • This article is a clinical trial with deferasirox to assess net iron excretion (iron balance study) at doses of 10, 20, and 40 mg/kg.
    • Nisbet-Brown E., Olivieri N.F., Giardina P.J., Grady R.W., Neufeld E.J., Sechaud R., Krebs-Brown A.J., Anderson J.R., Alberti D., Sizer K.C., and Nathan D.G. Randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 361 (2003) 1597-1602. This article is a clinical trial with deferasirox to assess net iron excretion (iron balance study) at doses of 10, 20, and 40 mg/kg.
    • (2003) Lancet , vol.361 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3    Grady, R.W.4    Neufeld, E.J.5    Sechaud, R.6    Krebs-Brown, A.J.7    Anderson, J.R.8    Alberti, D.9    Sizer, K.C.10    Nathan, D.G.11
  • 20
    • 33745774771 scopus 로고    scopus 로고
    • Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
    • Piga A., Galanello R., Forni G.L., Cappellini M.D., Origa R., Zappu A., Donato G., Bordone E., Lavagetto A., Zanaboni L., et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica 91 (2006) 873-880
    • (2006) Haematologica , vol.91 , pp. 873-880
    • Piga, A.1    Galanello, R.2    Forni, G.L.3    Cappellini, M.D.4    Origa, R.5    Zappu, A.6    Donato, G.7    Bordone, E.8    Lavagetto, A.9    Zanaboni, L.10
  • 24
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
    • Hershko C., Konijn A.M., Nick H.P., Breuer W., Cabantchik Z.I., and Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97 (2001) 1115-1122
    • (2001) Blood , vol.97 , pp. 1115-1122
    • Hershko, C.1    Konijn, A.M.2    Nick, H.P.3    Breuer, W.4    Cabantchik, Z.I.5    Link, G.6
  • 25
    • 85117739584 scopus 로고    scopus 로고
    • Boddaert N, Le Quan Sang KH, Rotig A, Leroy-Willig A, Gallet S, Brunelle F, Sidi D, Thalabard JC, Munnich A, Cabantchik ZI: Selective iron chelation in Friedreich ataxia. Biological and clinical implications. Blood 2007, March 22 [Epub ahead of print].
  • 26
    • 33746868342 scopus 로고    scopus 로고
    • Hereditary hemochromatosis
    • Pietrangelo A. Hereditary hemochromatosis. Biochim Biophys Acta 1763 (2006) 700-710
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 700-710
    • Pietrangelo, A.1
  • 27
    • 28444466958 scopus 로고    scopus 로고
    • Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
    • This article is a concise review of the hereditary hemochromatosis disorders due to mutations in HFE, hemojuvelin, hepcidin, transferrin receptor 1, and ferroportin, emphasizing the central role of hepcidin for iron homeostasis.
    • Camaschella C. Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood 106 (2005) 3710-3717. This article is a concise review of the hereditary hemochromatosis disorders due to mutations in HFE, hemojuvelin, hepcidin, transferrin receptor 1, and ferroportin, emphasizing the central role of hepcidin for iron homeostasis.
    • (2005) Blood , vol.106 , pp. 3710-3717
    • Camaschella, C.1
  • 28
    • 33748746427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: screening and management
    • Waalen J., and Beutler E. Hereditary hemochromatosis: screening and management. Curr Hematol Rep 5 (2006) 34-40
    • (2006) Curr Hematol Rep , vol.5 , pp. 34-40
    • Waalen, J.1    Beutler, E.2
  • 30
    • 33845753448 scopus 로고    scopus 로고
    • Chelators at the cancer coalface: desferrioxamine to Triapine and beyond
    • Yu Y., Wong J., Lovejoy D.B., Kalinowski D.S., and Richardson D.R. Chelators at the cancer coalface: desferrioxamine to Triapine and beyond. Clin Cancer Res 12 (2006) 6876-6883
    • (2006) Clin Cancer Res , vol.12 , pp. 6876-6883
    • Yu, Y.1    Wong, J.2    Lovejoy, D.B.3    Kalinowski, D.S.4    Richardson, D.R.5
  • 31
    • 0042384674 scopus 로고    scopus 로고
    • Iron chelators and iron toxicity
    • Brittenham G.M. Iron chelators and iron toxicity. Alcohol 30 (2003) 151-158
    • (2003) Alcohol , vol.30 , pp. 151-158
    • Brittenham, G.M.1
  • 32
    • 22244466058 scopus 로고    scopus 로고
    • Novel perspectives on mucormycosis: pathophysiology, presentation, and management
    • Spellberg B., Edwards Jr. J., and Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 18 (2005) 556-569
    • (2005) Clin Microbiol Rev , vol.18 , pp. 556-569
    • Spellberg, B.1    Edwards Jr., J.2    Ibrahim, A.3
  • 33
    • 1842608741 scopus 로고    scopus 로고
    • Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions
    • Richardson D.R. Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions. Ann NY Acad Sci 1012 (2004) 326-341
    • (2004) Ann NY Acad Sci , vol.1012 , pp. 326-341
    • Richardson, D.R.1
  • 34
    • 33750583529 scopus 로고    scopus 로고
    • Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis
    • This article is a case report describing the astounding recovery of a patient from a deadly fungal infection after short-term administration of deferasirox.
    • Reed C., Ibrahim A., Edwards Jr. J.E., Walot I., and Spellberg B. Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis. Antimicrob Agents Chemother 50 (2006) 3968-3969. This article is a case report describing the astounding recovery of a patient from a deadly fungal infection after short-term administration of deferasirox.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3968-3969
    • Reed, C.1    Ibrahim, A.2    Edwards Jr., J.E.3    Walot, I.4    Spellberg, B.5
  • 35
    • 33750716051 scopus 로고    scopus 로고
    • Iron: a new target for pharmacological intervention in neurodegenerative diseases
    • The authors describe the potential role of iron in Huntington disease, Alzheimer's disease, Parkinson's disease, and Friedreich's ataxia.
    • Whitnall M., and Richardson D.R. Iron: a new target for pharmacological intervention in neurodegenerative diseases. Semin Pediatr Neurol 13 (2006) 186-197. The authors describe the potential role of iron in Huntington disease, Alzheimer's disease, Parkinson's disease, and Friedreich's ataxia.
    • (2006) Semin Pediatr Neurol , vol.13 , pp. 186-197
    • Whitnall, M.1    Richardson, D.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.