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Iron chelators as therapeutic iron depletion agents
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This report describes clinically used iron chelators including desferrioxamine, deferasirox, deferiprone (iron overload), dexrazoxane (protection from cardiotoxicity), ciclopirox (antifungal), and iron chelators in the preclinical stage of development, as well as the patent status of these compounds.
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Birch N., Wang X., and Chong H.-S. Iron chelators as therapeutic iron depletion agents. Expert Opin Ther Patents 16 (2006) 1533-1556. This report describes clinically used iron chelators including desferrioxamine, deferasirox, deferiprone (iron overload), dexrazoxane (protection from cardiotoxicity), ciclopirox (antifungal), and iron chelators in the preclinical stage of development, as well as the patent status of these compounds.
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Nisbet-Brown E., Olivieri N.F., Giardina P.J., Grady R.W., Neufeld E.J., Sechaud R., Krebs-Brown A.J., Anderson J.R., Alberti D., Sizer K.C., and Nathan D.G. Randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 361 (2003) 1597-1602. This article is a clinical trial with deferasirox to assess net iron excretion (iron balance study) at doses of 10, 20, and 40 mg/kg.
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Reed C., Ibrahim A., Edwards Jr. J.E., Walot I., and Spellberg B. Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis. Antimicrob Agents Chemother 50 (2006) 3968-3969. This article is a case report describing the astounding recovery of a patient from a deadly fungal infection after short-term administration of deferasirox.
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