The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway

Anticancer Research

Volumn 28, Issue 3 A, 2008, Pages 1701-1711

  Lee, Jau Hong ^a   Li, Yu Ching ^b   Ip, Siu Wan ^c   Hsu, Shu Chun ^c   Chang, Nai Wen ^c   Tang, Nou Ying ^c   Yu, Chun Shu ^c   Chou, Su Tze ^d   Lin, Song Shei ^b   Lin, Chin Chung ^e   Yang, Jai Sing ^c   Chung, Jing Gung ^c,f,g  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b Mid Taiwan Technology University   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d PROVIDENCE UNIVERSITY   (Taiwan)

^e FENG YUAN HOSPITAL   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Baicalein; Calcium; GADD153; Mitochondrial membrane potential

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; BAICALEIN; CALCIUM ION; CASPASE; CASPASE 3; CYTOCHROME C; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROPIDIUM IODIDE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TRYPAN BLUE; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; ACETYL ASPARTYL GLUTAMYL VALYL ASPARTAL; ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL; BAX PROTEIN, HUMAN; CALCIUM; CHAPERONE; DDIT3 PROTEIN, HUMAN; DRUG DERIVATIVE; EGTAZIC ACID; FLAVANONE DERIVATIVE; HEAT SHOCK PROTEIN; MESSENGER RNA; MOLECULAR CHAPERONE GRP78; OLIGOPEPTIDE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRESS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; WESTERN BLOTTING; BIOSYNTHESIS; BREAST TUMOR; CALCIUM SIGNALING; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MITOCHONDRION; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BREAST NEOPLASMS; CALCIUM; CALCIUM SIGNALING; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; EGTAZIC ACID; FLAVANONES; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MOLECULAR CHAPERONES; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSCRIPTION FACTOR CHOP;

EID: 45949094793     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Yunis JJ, Frizzera G, Oken MM, McKenna J, Theologides A and Arnesen M: Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Eng J Med 316: 79-84, 1987.
2. Cory S and Adams JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nature reviews Cancer 2: 647-656, 2002.
3. Johnstone RW, Ruefli AA and Lowe SW: Apoptosis: a link between cancer genetics and chemotherapy. Cell 108: 153-164, 2002.
4. Cory S, Vaux DL, Strasser A, Harris AW and Adams JM: Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res 59(1): 1685-1692, 1999.
5. Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
6. Borner C: The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mo1 Immun 39: 615-647, 2003.
7. Lowe SW and Lin AW: Apoptosis in cancer. Carcinogenesis 21: 485-495, 2000
8. Kim YO, Leem K, Park J, Lee P, Ahn DK, Lee BC, Park HK, Suk K, Kim SY and Kim H: Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J Ethnopharmacol 77: 183-188, 2001.
9. Chen ZY, Su YL, Bi YR, Tsang SY and Huang Y: Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. Eur J Pharmacol 11: 41-47, 1999.
10. Lin CC and Shieh DE: The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. Am J Chin Med 241: 31-36, 1995.
11. Nakahata N, Kutsuwa M, Kyo R, Kubo M, Hayashi K and Ohizumi Y: Analysis of inhibitory effects of Scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells. Am J Chin Med 26: 311-323, 1999.
12. Hamada H, Hiramatsu M, Edamatsu R and Mori A: Free radical scavenging action of baicalein. Arch Biochem Biophys 306: 261-266, 1993.
13. Gao Z, Huang K, Yang X and Xu H: Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1472: 643-650, 1999.
14. Shieh DE, Liu LT and Lin CC: Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 20: 2861-2866, 2000.
15. Gao Z, Huang K and Xu H: Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol Res 43: 173-178,2001.
16. Ishige K, Schubert D and Sagara Y: Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30: 433-446, 2001.
17. Lebeau A, Esclaire F, Rostene W and Pelaprat D: Baicalein protects cortical neurons from beta-amyloid induced toxicity. Neuroreport 12(2): 2199-2202, 2001.
18. Choi J, Conrad CC, Malakowsky CA, Talent JM, Yuan CS and Gracy RW: Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim Biophys Acta 1571: 201-210, 2002.
19. Chang WH, Chen CH, Gau RJ, Lin CC, Tsai CL, Tsai K and Lu FJ: Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction. Planta Med 68: 302-306, 2002.
20. Tong W, Ding X and Adrian T: The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochem Biophys Res Commun 296: 942-948, 2002.
21. Pidgeon GP, Kandouz M, Meram A and Honn KV: Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res 62: 2721-2727, 2002.
22. Wong BC, Wang WP, Cho CH, Fan XM, Lin MC, Kung HF and Lam SK: 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells. Carcinogenesis 22: 1349-1354, 2001.
23. Lin CC, Kao ST, Chen GW, Ho HC and Chung JG: Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 26: 227-242, 2006.
24. Lin JP, Yang JS, Lee JH, Hsieh WT and Chung JG: Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol 12: 21-28, 2006.
25. Tang NY, Yang JS, Chang YH, Lu HF, Hsia TC, Lin WC and Chung JG: Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. In Vivo 20: 527-532, 2006.
26. Hsu MH, Chen CJ, Kuo SC, Chung JG, Lai YY, Teng CM, Pan SL and Huang LJ: 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells. Eur J Pharmacol 559: 14-20, 2007.
27. Miocinovic R, McCabe NP, Keck RW, Jankun J, Hampton JA and Selman SH: In vivo and in vitro effect of baicalein on human prostate cancer cells. Int J Oncol 26: 241-246, 2005.
28. Li QB, You Y, Chen ZC, Lu J, Shao J and Zou P: Role of Baicalein in the regulation of proliferation and apoptosis in human myeloma RPMI8226 cells. Chin Med J 119: 948-952, 2003.
29. Lee HJ, Noh YH, Lee DY, Kim YS, Kim KY, Chung YH, Lee WB and Kim SS: Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Eur J Cell Biol 84: 897-905, 2005.
30. Yu W, Sanders BG and Kline K: RRR-a-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res 63: 2483-2491, 2003.
31. Choi SE, Sohn S, Cho JW, Shin EA, Song PS and Kang Y: 9-Hydroxypheo-phorbide a-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation. J Photochem Photobiol Biol 73: 101-107, 2004.
32. Willis S, Day CL, Hinds MG and Huang DCS: The Bcl-2-regulated apoptotic pathway. J Cell Sci 116: 4053-4056, 2003.
33. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E and Mori M: Targeted disruption of the CHOP gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532, 2002.
34. Tajiri S, Oyadomari S, Yano S, Morioka M, Gotoh T, Hamada JI, Ushio Y and Mori M: Ischaemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ 1: 403-415, 2004.
35. Gotoh T, Oyadomari S, Mori K and Mori M: Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem 2(77): 12343-12350, 2002.
36. Lovat PE, Oliverio S, Corazzari M, Rodolfo C, Ranalli M, Goranov B, Melino G, Redfern CP and Piacentini M: Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells. Cancer Res 63: 7310-7313, 2003.
37. Gotoh T, Terada K, Oyadomari S and Mori M: Hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ 11: 390-402, 2004.
38. Wang J, Yu Y, Hashimoto F, Sakata Y, Fujii M and Hou DX: Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med 14: 627-632, 2004.
39. Lee HZ, Leung HW, Lai MY and Wu CH: Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res 25: 959-964, 2005.