-
1
-
-
33646414765
-
A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
-
Cappellini, M. D., Cohen, A., Piga, A., Bejaoui, M., Perrotta, S., Agaoglu, L., Aydinok, Y., Kattamis, A., Kilinc, Y., Porter, J. et al. (2006) A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood 167, 3455-3462
-
(2006)
Blood
, vol.167
, pp. 3455-3462
-
-
Cappellini, M.D.1
Cohen, A.2
Piga, A.3
Bejaoui, M.4
Perrotta, S.5
Agaoglu, L.6
Aydinok, Y.7
Kattamis, A.8
Kilinc, Y.9
Porter, J.10
-
3
-
-
0038472463
-
Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan
-
Peng, C-T., Chow, K-C., Chen, J-H., Chiang, Y-P., Lin, T-Y. and Tsai, C-H. (2003) Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan. Eur. J. Haematol. 76, 392-397
-
(2003)
Eur. J. Haematol
, vol.76
, pp. 392-397
-
-
Peng, C.-T.1
Chow, K.-C.2
Chen, J.-H.3
Chiang, Y.-P.4
Lin, T.-Y.5
Tsai, C.-H.6
-
4
-
-
34250778335
-
Future of toxicology-iron chelators and differing modes of action and toxicity: The changing face of iron chelation therapy
-
Kalinowski, D. S. and Richardson, D. R. (2007) Future of toxicology-iron chelators and differing modes of action and toxicity: The changing face of iron chelation therapy. Chem. Res. Toxicol. 26, 715-720
-
(2007)
Chem. Res. Toxicol
, vol.26
, pp. 715-720
-
-
Kalinowski, D.S.1
Richardson, D.R.2
-
5
-
-
29044438902
-
The crucial role of metal ions in neurodegeneration: The basis for a promising therapeutic strategy
-
Gaeta, A. and Hider, R. C. (2005) The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br. J. Pharmacol. 146, 1041-1059
-
(2005)
Br. J. Pharmacol
, vol.146
, pp. 1041-1059
-
-
Gaeta, A.1
Hider, R.C.2
-
6
-
-
34347370842
-
Selective iron chelation in Friedreich ataxia: Biological and clinical implications
-
Boddaert, N., Le Quan Sang, K. H., Rotig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J-C., Munnich, A. and Cabantchik., Z. I. (2007) Selective iron chelation in Friedreich ataxia: biological and clinical implications. Blood 110, 401-408
-
(2007)
Blood
, vol.110
, pp. 401-408
-
-
Boddaert, N.1
Le Quan Sang, K.H.2
Rotig, A.3
Leroy-Willig, A.4
Gallet, S.5
Brunelle, F.6
Sidi, D.7
Thalabard, J.-C.8
Munnich, A.9
Cabantchik, Z.I.10
-
7
-
-
38749106471
-
-
Grady, R. W., Bardoukas, V. A and Giardina, P. J. (1998) Iron chelation: combined therapy could be a better approach. Blood 92 (suppl 1), 16b
-
Grady, R. W., Bardoukas, V. A and Giardina, P. J. (1998) Iron chelation: combined therapy could be a better approach. Blood 92 (suppl 1), 16b
-
-
-
-
8
-
-
0018278509
-
Mixed ligand therapy for plutonium and cadmium poisoning
-
Schubert, J. and Derr, S. K. (1978) Mixed ligand therapy for plutonium and cadmium poisoning. Nature 275, 311-313
-
(1978)
Nature
, vol.275
, pp. 311-313
-
-
Schubert, J.1
Derr, S.K.2
-
9
-
-
0027080322
-
The effect of alpha-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo
-
Evans, R. W., Sharma, M., Ogwang, W., Patel, K. J., Bartlett, A. N. and Kontoghiorghes, G. J. (1992) The effect of alpha-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo. Drugs Today 28, (suppl A), 19-23
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 19-23
-
-
Evans, R.W.1
Sharma, M.2
Ogwang, W.3
Patel, K.J.4
Bartlett, A.N.5
Kontoghiorghes, G.J.6
-
10
-
-
0017194077
-
Chelate mediated transfer of iron from transferrin to desferrioxamine
-
Pollack, S., Aisen, P., Lasky, F. D. and Vanderhoff, G. (1976) Chelate mediated transfer of iron from transferrin to desferrioxamine. Br. J. Haematol. 34, 231-235
-
(1976)
Br. J. Haematol
, vol.34
, pp. 231-235
-
-
Pollack, S.1
Aisen, P.2
Lasky, F.D.3
Vanderhoff, G.4
-
11
-
-
0017344129
-
Iron removal from transferrin. An experimental study
-
Pollack, S., Vanderhoff, G. and Lasky, F. (1977) Iron removal from transferrin. An experimental study. Biochim. Biophys. Acta 497, 481-487
-
(1977)
Biochim. Biophys. Acta
, vol.497
, pp. 481-487
-
-
Pollack, S.1
Vanderhoff, G.2
Lasky, F.3
-
12
-
-
0027328530
-
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)- pyridinones: Orally active iron chelators with clinical potential
-
Dobbin, P. S., Hider, R. C., Hall, A. D., Taylor, P. D., Sarpong, P., Porter, J. B., Xiao, G. and van der Helm, D. (1993) Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)- pyridinones: orally active iron chelators with clinical potential. J. Med. Chem. 36, 2448-2458
-
(1993)
J. Med. Chem
, vol.36
, pp. 2448-2458
-
-
Dobbin, P.S.1
Hider, R.C.2
Hall, A.D.3
Taylor, P.D.4
Sarpong, P.5
Porter, J.B.6
Xiao, G.7
van der Helm, D.8
-
13
-
-
0037203975
-
Design, synthesis and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: Structure-activity investigation of metalloenzymes inhibition by iron chelators
-
Liu, Z. D., Kayyali, R., Hider, R. C., Porter, J. B. and Theobald, A. E. (2002) Design, synthesis and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: Structure-activity investigation of metalloenzymes inhibition by iron chelators. J. Med. Chem. 45, 631-639
-
(2002)
J. Med. Chem
, vol.45
, pp. 631-639
-
-
Liu, Z.D.1
Kayyali, R.2
Hider, R.C.3
Porter, J.B.4
Theobald, A.E.5
-
14
-
-
0036136401
-
Design of clinically useful iron(III) selective chelators
-
Liu, Z. D. and Hider, R. C. (2002) Design of clinically useful iron(III) selective chelators. Med. Res. Rev. 22, 26-64
-
(2002)
Med. Res. Rev
, vol.22
, pp. 26-64
-
-
Liu, Z.D.1
Hider, R.C.2
-
16
-
-
0035897095
-
Novel synthetic approach to 2-(1′-hydroxyalkyl)- and 2-amido-3-hydroxypyridin-4-ones
-
Piyamongkol S., Liu Z. D. and Hider, R. C. (2001) Novel synthetic approach to 2-(1′-hydroxyalkyl)- and 2-amido-3-hydroxypyridin-4-ones. Tetrahedron 57, 3479-3486
-
(2001)
Tetrahedron
, vol.57
, pp. 3479-3486
-
-
Piyamongkol, S.1
Liu, Z.D.2
Hider, R.C.3
-
17
-
-
0003836971
-
-
Oxford University, Oxford
-
Dawson, R. M. C., Elliott, D. C., Elliott, W. H. and Jones, K. M. (1986) Data for Biochemical Research, Oxford University, Oxford.
-
(1986)
Data for Biochemical Research
-
-
Dawson, R.M.C.1
Elliott, D.C.2
Elliott, W.H.3
Jones, K.M.4
-
19
-
-
0019198386
-
The electrophoresis of transferrins in urea/polyacrylamide gels
-
Evans, R. W and Williams, J. (1980) The electrophoresis of transferrins in urea/polyacrylamide gels. Biochem. J. 189, 541-546
-
(1980)
Biochem. J
, vol.189
, pp. 541-546
-
-
Evans, R.W.1
Williams, J.2
-
20
-
-
0033435874
-
Hyperguad simulation and speciation (HySS): A utility program for the investigation of equilibria involving soluble and partially soluble species
-
Alderighi, L., Gans, P., Ienco, A., Peters, D., Sabatini, A. and Vacca, A. (1999) Hyperguad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species. Coord. Chem. Rev. 184, 311-318
-
(1999)
Coord. Chem. Rev
, vol.184
, pp. 311-318
-
-
Alderighi, L.1
Gans, P.2
Ienco, A.3
Peters, D.4
Sabatini, A.5
Vacca, A.6
-
22
-
-
0002614944
-
Stabilities of the iron(III) chelates of 1,2-dimethyl-3-hydroxy-4-pyridinone and related ligands
-
Motekaitis, R. J. and Martell, A. E. (1991) Stabilities of the iron(III) chelates of 1,2-dimethyl-3-hydroxy-4-pyridinone and related ligands. Inorg. Chim. Acta. 183, 71-80
-
(1991)
Inorg. Chim. Acta
, vol.183
, pp. 71-80
-
-
Motekaitis, R.J.1
Martell, A.E.2
-
24
-
-
0025007785
-
Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
-
Kontoghiorghes, G. J., Goddard, J. G., Bartlett, A. N. and Sheppard, L. (1990) Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin. Pharmacol. Ther 48, 255-261
-
(1990)
Clin. Pharmacol. Ther
, vol.48
, pp. 255-261
-
-
Kontoghiorghes, G.J.1
Goddard, J.G.2
Bartlett, A.N.3
Sheppard, L.4
-
25
-
-
0035138693
-
Deferoxamine Pharmacokinetics
-
Porter, J. B. (2001) Deferoxamine Pharmacokinetics. Semin. Hematol. 38, (1 Suppl 1), 63-68
-
(2001)
Semin. Hematol
, vol.38
, Issue.1 SUPPL. 1
, pp. 63-68
-
-
Porter, J.B.1
-
26
-
-
0942298725
-
Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children
-
Gomber, S., Saxena, R. and Madan, N. (2004) Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children. Indian Pediatr. 41, 21-27
-
(2004)
Indian Pediatr
, vol.41
, pp. 21-27
-
-
Gomber, S.1
Saxena, R.2
Madan, N.3
-
27
-
-
43249092172
-
-
Devanur, L. D., Neubert, H. and Hider, R. C. (2007) The Fenton activity of iron(III) in the presence of deferiprone, J. Pharm. Sci., doi: 10.1002/jps.21039
-
Devanur, L. D., Neubert, H. and Hider, R. C. (2007) The Fenton activity of iron(III) in the presence of deferiprone, J. Pharm. Sci., doi: 10.1002/jps.21039
-
-
-
-
28
-
-
36649038516
-
-
Evans, R. W., Rafique, R., Zarea, A., Rapisarda, C., Cammack, R., Evans, P. J., Porter, J. B. and Hider, R. C. (2007) Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera, J. Biol. Inorg. Chem., doi: 10.1007/s00775-007-0297-8
-
Evans, R. W., Rafique, R., Zarea, A., Rapisarda, C., Cammack, R., Evans, P. J., Porter, J. B. and Hider, R. C. (2007) Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera, J. Biol. Inorg. Chem., doi: 10.1007/s00775-007-0297-8
-
-
-
-
29
-
-
0029887959
-
The environment of the lipoxygenase iron-binding site explored with novel hydroxypyridinone iron chelators
-
Abeysinghe, R. D., Roberts, P. J., Cooper, C. E., Maclean, K. H., Hider, R. C. and Porter, J. B. (1996) The environment of the lipoxygenase iron-binding site explored with novel hydroxypyridinone iron chelators. J. Biol. Chem. 271, 7965-7972
-
(1996)
J. Biol. Chem
, vol.271
, pp. 7965-7972
-
-
Abeysinghe, R.D.1
Roberts, P.J.2
Cooper, C.E.3
Maclean, K.H.4
Hider, R.C.5
Porter, J.B.6
-
30
-
-
0029833706
-
The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase
-
Cooper, C. E., Lynagh, G. R., Hoyes, K. P., Hider, R. C., Cammack, R. and Porter, J. B. (1996) The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J. Biol. Chem. 271, 20291-20299
-
(1996)
J. Biol. Chem
, vol.271
, pp. 20291-20299
-
-
Cooper, C.E.1
Lynagh, G.R.2
Hoyes, K.P.3
Hider, R.C.4
Cammack, R.5
Porter, J.B.6
-
31
-
-
0027175998
-
Inhibition of catechol-o-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4- one (L1,CP20), in rat brain in vivo
-
Waldmeier, P. C, Buchle, A-M. and Steulet, A-F. (1993) Inhibition of catechol-o-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4- one (L1,CP20), in rat brain in vivo. Biochem. Pharmacol. 45, 2417-2424
-
(1993)
Biochem. Pharmacol
, vol.45
, pp. 2417-2424
-
-
Waldmeier, P.C.1
Buchle, A.-M.2
Steulet, A.-F.3
-
32
-
-
33846078725
-
Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)
-
Fabio, G., Minonzio, F., Delbini, P., Bianchi, A. and Cappellini, M. D. (2007) Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH). Blood 109, 362-364
-
(2007)
Blood
, vol.109
, pp. 362-364
-
-
Fabio, G.1
Minonzio, F.2
Delbini, P.3
Bianchi, A.4
Cappellini, M.D.5
-
33
-
-
0034928342
-
Exploring the "iron shuttle" hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rate heart cells in culture
-
Link, G., Konijn, A. M., Breuer, W., Cabantchik, Z. I. and Hersko, C. (2001) Exploring the "iron shuttle" hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rate heart cells in culture. J. Lab. Clin. Med. 138, 130-138
-
(2001)
J. Lab. Clin. Med
, vol.138
, pp. 130-138
-
-
Link, G.1
Konijn, A.M.2
Breuer, W.3
Cabantchik, Z.I.4
Hersko, C.5
|