Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women

American Journal of Clinical Nutrition

Volumn 84, Issue 4, 2006, Pages 774-780

  Hanson, Laura N ^a   Engelman, Heather M ^a   Alekel, D Lee ^a   Schalinske, Kevin L ^a   Kohut, Marian L ^a   Reddy, Manju B ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

C reactive protein; Cardiovascular disease; Homocysteine; Iron; Isoflavones; Phytate; Postmenopausal women; Soy protein

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; HOMOCYSTEINE; IRON; ISOFLAVONE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTATE; SOYBEAN PROTEIN; BIOLOGICAL MARKER; FERRITIN; FOLIC ACID; LIPID; PHYTIC ACID; TRANSFERRIN; VEGETABLE PROTEIN;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOSE RESPONSE; DRUG EFFECT; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IRON BLOOD LEVEL; LIPID BLOOD LEVEL; OXIDATIVE STRESS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; BLOOD; CORONARY ARTERY ATHEROSCLEROSIS; DOUBLE BLIND PROCEDURE; METABOLISM; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTOR;

AGED; BIOLOGICAL MARKERS; BODY MASS INDEX; C-REACTIVE PROTEIN; CORONARY ARTERIOSCLEROSIS; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; FOLIC ACID; HOMOCYSTEINE; HUMANS; IRON; ISOFLAVONES; LIPIDS; MIDDLE AGED; OXIDATIVE STRESS; PHYTIC ACID; POSTMENOPAUSE; REGRESSION ANALYSIS; RISK FACTORS; SOYBEAN PROTEINS; TRANSFERRIN; VEGETABLE PROTEINS; VITAMIN B 12;

EID: 33750631885     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/84.4.774     Document Type: Article

References (52)

1. Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. Health, United States, 2003. Trend tables. Internet: http://www.cdc.gov/nchs/products/pubs/pubd/hus/trendtables. htm (accessed 10 June 2004).
2. Witteman JCM, Grobbee DE, Kok FJ, Hofman A, Valkenburg HA. Increased risk of atherosclerosis in women after menopause. BMJ 1989;298:642-4.
3. Ridker PM, Manson JE, Bruing JE, Shih J, Matias M, Hennekens CH. Homocysteine and risk of cardiovascular disease among postmenopausal women. JAMA 1999;281:1817-21.
4. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 1998;97:2007-11.
5. Sullivan JL. Iron and the sex differences in heart disease risk. Lancet 1981;13:1293-4.
6. Nygård O, Nordrehaug JE, Fefsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.
7. Hak AE, Polderman KH, Westendorp ICD, et al. Increased plasma homocysteine after menopause. Atherosclerosis 2000;149:163-8.
8. Panagiotakos DB, Pitsavos C, Zeimbekis A, Chrysohoou C, Stefanadis C. The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the "ATTICA" Study. Int J Cardiol 2005;98:471-7.
9. Fu WY, Dudman NPB, Perry MA, Wang XL. Homocysteine attenuates hemodynamic responses to nitric oxide in vivo. Atherosclerosis 2002;161:169-76.
10. Heydrick SJ, Weiss N, Thomas SR, et al. L-homocysteine and L-homocysteine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. Free Radic Biol Med 2004;36:632-40.
11. Nestel PJ, Chronopoulos A, Cehun M. Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine. Atherosclerosis 2003;171:83-6.
12. Zeng X, Dai J, Remick DG, Wang X. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res 2003;93:311-20.
13. Sanada M, Tsuda M, Kodama I, Sakashita T, Nakagawa H, Ohama K. Substitution of transdermal estradiol during oral estrogen-progestin therapy in postmenopausal women: effects on hypertriglyceridemia. Menopause 2004;11:331-6.
14. Yilmazer M, Fenkci V, Fenkci S, et al. Hormone replacement therapy, C-reactive protein, and fibrinogen in healthy postmenopausal women. Maturitas 2003;46:245-53.
15. Khreiss T, József L, Potempa LA, Filep JG. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 2004;109:2016-22.
16. Devaraj S, Kumaresan PR, Jialal I. Effect of C-reactive protein on chemokine expression in human aortic endothelial cells. J Mol Cell Cardiol 2004;36:405-10.
17. Venugopal SK, Devaraj S, Jialal I. C-reactive protein decreases prostacyclin release from human aortic endothelial cells. Circulation 2003;108:1676-8.
18. Verma S, Kuliszewski MA, Li SH, et al. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Circulation 2004;109:2058-67.
19. Salonen JT, Nyyssönen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 1992;86:803-11.
20. Kiechl S, Aichner F, Gerstenbrand F, et al. Body iron stores and presence of carotid atherosclerosis. Arterioscler Thromb 1994;14:1625-30.
21. Day SM, Duquaine D, Mundada LV, et al. Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis. Circulation 2003;107:2601-6.
22. Halliwell B, Gutteridge JMC. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986;246:501-14.
23. Berge LN, Bønaa KH, Nordøy A. Serum ferritin, sex hormones, and cardiovascular risk factors in healthy women. Arterioscler Thromb 1994;14:857-61.
24. Food and Drug Administration. 2002. Code of Federal Regulations: 21CFR101.82, pages 144-6. References health claims: soy protein and risk of coronary heart disease. US Government Printing Office. Internet: http://www.cfsan.fda.gov/∼lrd/cf101-82.html (accessed 5 June 2004).
25. Jenkins JA, Kendall CWC, Jackson CJC, et al. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 2002;76:365-72.
26. Tonstad S, Smerud K, Høie L. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am J Clin Nutr 2002;76:78-84.
27. Zhan S, Ho S. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 2005;81:397-408.
28. Jenkins DJA, Kendall CW, Connelly PW, et al. Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism 2002;51:919-24.
29. Hurrell RF, Juillerat MA, Reddy MB, Lynch SR, Dassenko SA, Cook JD. Soy protein, phytate, and iron absorption in humans. Am J Clin Nutr 1992;56:573-8.
30. Reddy MB, Hurrell RF, Juillerat MA, Cook JD. The influence of different protein sources on phytate inhibition of nonheme-iron absorption in humans. Am J Clin Nutr 1996;63:203-7.
31. Porres JM, Stahl CH, Cheng WH, et al. Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake. Proc Soc Exp Biol Med 1999;221:80-6.
32. Rao PS, Liu X, Das DK, Weinstein GS, Tyras DH. Protection of ischemic heart from reperfusion injury by myo-inositol hexaphosphate, a natural antioxidant. Ann Thorac Surg 1991;52:908-12.
33. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-52.
34. Kirk P, Patterson RE, Lampe J. Development of a soy food frequency questionnaire to estimate isoflavone consumption in US adults. J Am Diet Assoc 1999;99:558-63.
35. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52.
36. Ubbink JB, Vermaak WJH, Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 1991;565:441-6.
37. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press, 1998:150, 196.
38. Engelman HM, Alekel DL, Hanson LN, Kanthasamy AG, Reddy MB. Blood lipid and oxidative stress responses to soy isoflavones and phytic acid in postmenopausal women. Am J Clin Nutr 2005;81:590-6.
39. Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K. Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women. J Nutr 2003;133:797-800.
40. Reimann M, Dierkes J, Carlsohn A, et al. Consumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal women. J Nutr 2006;136:100-5.
41. Shoveller A, House J, Brunton J, Pencharz PB, Ball RO. The balance of dietary sulfur amino acids and the route of feeding affect plasma homocysteine concentrations in neonatal piglets. J Nutr 2004;134:609-12.
42. Jacques PF, Bostom AG, Wilson PWF, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001;73:613-21.
43. McKinley MC, McNulty H, McPartlin J, et al. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 2001;73:759-64.
44. Suh JR, Oppenheim EW, Girgis S, Stover PJ. Purification and properties of a folate-catabolizing enzyme. J Biol Chem 2000;275:35646-55.
45. Picard V, Renaudie F, Porcher C, Hentze MW, Grandchamp B, Beaumont C. Overexperession of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Blood 1996;87:2057-64.
46. Girgis S, Suh JR, Jolivet J, Stover PJ. 5-Formyltetrahydrofolate regulates homocysteine remethylation in human neuroblastoma. J Biol Chem 1997;272:4729-34.
47. Oppenheim EW, Adelman C, Liu X, Stover PJ. Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J Biol Chem 2001;276:19855-61.
48. Ganji V, Kafai MR. Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-20002. J Nutr 2006;136:153-8.
49. Ganji V, Kafai MR. Demographic, health, lifestyle and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2003;77:826-33.
50. Lear SA, Chen MM, Birmingham CL, Frohlich JJ. The relationship between simple anthropometric indices and C-reactive protein: ethnic differences. Metabolism 2003;52:1542-6.
51. Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis. A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 2001;285:2481-5.
52. Wolff B, Völzke H, Lüdemann J, et al. Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). Stroke 2004;35:453-7.