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Volumn 12, Issue 9, 2006, Pages 2912-2918

In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; DRUG VEHICLE; IRON CHELATING AGENT;

EID: 33646734458     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-2860     Document Type: Article
Times cited : (38)

References (31)
  • 1
    • 0020541188 scopus 로고
    • Ribonucleotide reductase - A radical enzyme
    • Reichard P, Ehrenberg A. Ribonucleotide reductase - a radical enzyme. Science 1983;221:514-9.
    • (1983) Science , vol.221 , pp. 514-519
    • Reichard, P.1    Ehrenberg, A.2
  • 2
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • Tanaka H, Arakawa H, Yamaguchi T, et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 2000; 404:42-9.
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3
  • 3
    • 0035798630 scopus 로고    scopus 로고
    • Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
    • Guittet O, Hakansson P, Voevodskaya N, et al. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem 2001; 276:40647-51.
    • (2001) J Biol Chem , vol.276 , pp. 40647-40651
    • Guittet, O.1    Hakansson, P.2    Voevodskaya, N.3
  • 4
    • 0642368323 scopus 로고    scopus 로고
    • Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity
    • Kuo ML, Hwang HS, Sosnay PR, Kunugi KA, Kinsella TJ. Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity. Cancer J 2003;9:277-85.
    • (2003) Cancer J , vol.9 , pp. 277-285
    • Kuo, M.L.1    Hwang, H.S.2    Sosnay, P.R.3    Kunugi, K.A.4    Kinsella, T.J.5
  • 5
    • 0026778383 scopus 로고
    • Mechanism of action of hydroxyurea
    • Yarbro JW. Mechanism of action of hydroxyurea. Semin Oncol 1992;19:1-10.
    • (1992) Semin Oncol , vol.19 , pp. 1-10
    • Yarbro, J.W.1
  • 6
    • 0014253355 scopus 로고
    • The Combined Effect of Hydroxyurea at X-rays on Chinese Hamster Cells in vitro
    • Sinclair WK. The Combined Effect of Hydroxyurea at X-rays on Chinese Hamster Cells in vitro. Cancer Res 1968;28:198-206.
    • (1968) Cancer Res , vol.28 , pp. 198-206
    • Sinclair, W.K.1
  • 7
    • 0029025552 scopus 로고
    • The interaction of hydroxyurea and iododeoxyuridine on the radiosensitivity of human bladder cancer cells
    • Kuo ML, Kunugi KA, Lindstrom MJ, Kinsella TJ. The interaction of hydroxyurea and iododeoxyuridine on the radiosensitivity of human bladder cancer cells. Cancer Res 1995;55:2800-5.
    • (1995) Cancer Res , vol.55 , pp. 2800-2805
    • Kuo, M.L.1    Kunugi, K.A.2    Lindstrom, M.J.3    Kinsella, T.J.4
  • 8
    • 0015296927 scopus 로고
    • Effect of hydroxyurea on the radiation response of C3H mouse mammary tumors
    • Piver MS, Howes AE, Suit HD, Marshall N. Effect of hydroxyurea on the radiation response of C3H mouse mammary tumors. Cancer 1972;29:407-12.
    • (1972) Cancer , vol.29 , pp. 407-412
    • Piver, M.S.1    Howes, A.E.2    Suit, H.D.3    Marshall, N.4
  • 9
    • 0034068488 scopus 로고    scopus 로고
    • Hydroxyurea and trimidox enhance the radiation effect in human pancreatic adenocarcinoma cells
    • Leyden D, Ahmed N, Hassan HT. Hydroxyurea and trimidox enhance the radiation effect in human pancreatic adenocarcinoma cells. Anticancer Res 2000;20: 133-8.
    • (2000) Anticancer Res , vol.20 , pp. 133-138
    • Leyden, D.1    Ahmed, N.2    Hassan, H.T.3
  • 10
    • 3242802931 scopus 로고    scopus 로고
    • Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: A systematic review
    • Symonds RP, Collingwood M, Kirwan J, et al. Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review. Cancer Treat Rev 2004;30:405-14.
    • (2004) Cancer Treat Rev , vol.30 , pp. 405-414
    • Symonds, R.P.1    Collingwood, M.2    Kirwan, J.3
  • 11
    • 1642453838 scopus 로고    scopus 로고
    • In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
    • Shao J, Zhou B, Zhu L, et al. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Res 2004;64:1-6.
    • (2004) Cancer Res , vol.64 , pp. 1-6
    • Shao, J.1    Zhou, B.2    Zhu, L.3
  • 12
    • 0037237032 scopus 로고    scopus 로고
    • Examination of the antiproliferative activity of iron chelators: Multiple cellular targets and the different mechanism of action of Triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311
    • Chaston TB, Lovejoy DB, Watts RN, Richardson DR. Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of Triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311. Clin Cancer Res 2003;9: 402-14.
    • (2003) Clin Cancer Res , vol.9 , pp. 402-414
    • Chaston, T.B.1    Lovejoy, D.B.2    Watts, R.N.3    Richardson, D.R.4
  • 13
    • 0032832996 scopus 로고    scopus 로고
    • Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): An inhibitor of ribonucleotide reductase with antineoplastic activity
    • Finch RA, Liu MC, Cory AH, Cory JG, Sartorelli AC. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul 1999;39:3-12.
    • (1999) Adv Enzyme Regul , vol.39 , pp. 3-12
    • Finch, R.A.1    Liu, M.C.2    Cory, A.H.3    Cory, J.G.4    Sartorelli, A.C.5
  • 14
    • 0030996827 scopus 로고    scopus 로고
    • Discrimination of late apoptotic/necrotic cells (type III) by flow cytometry in solid tumors
    • O'Brien MC, Healy SF, Jr., Raney SR, et al. Discrimination of late apoptotic/necrotic cells (type III) by flow cytometry in solid tumors. Cytometry 1997;28:81-9.
    • (1997) Cytometry , vol.28 , pp. 81-89
    • O'Brien, M.C.1    Healy Jr., S.F.2    Raney, S.R.3
  • 16
    • 3042661952 scopus 로고    scopus 로고
    • Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse
    • Mason KA, Hunter NR, Raju U, et al. Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse. Int J Radiat Oncol Biol Phys 2004;59:1181-9.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 1181-1189
    • Mason, K.A.1    Hunter, N.R.2    Raju, U.3
  • 17
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 18
    • 0033975268 scopus 로고    scopus 로고
    • Triapine (3-amino-pyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): A Potent Inhibitor of Ribonucleotide Reductase Activity wit Broad Spectrum Antitumor Activity
    • Finch RA, Liu MC, Grill SP, et al. Triapine (3-amino-pyridine-2- carboxaldehyde thiosemicarbazone; 3-AP): A Potent Inhibitor of Ribonucleotide Reductase Activity wit Broad Spectrum Antitumor Activity. Biochem Pharmacol 2000;59:983-91.
    • (2000) Biochem Pharmacol , vol.59 , pp. 983-991
    • Finch, R.A.1    Liu, M.C.2    Grill, S.P.3
  • 20
    • 0022254166 scopus 로고
    • The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY)
    • Moore EC, Hurlbert RB. The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY). Pharmacol Ther 1985;27:167-96.
    • (1985) Pharmacol Ther , vol.27 , pp. 167-196
    • Moore, E.C.1    Hurlbert, R.B.2
  • 21
    • 0027934897 scopus 로고
    • Inhibitors of ribonucleotide reductase. Comparative effects of amino-and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones
    • Cory JG, Cory AH, Rappa G, et al. Inhibitors of ribonucleotide reductase. Comparative effects of amino-and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones. Biochem Pharmacol 1994;48: 335-44.
    • (1994) Biochem Pharmacol , vol.48 , pp. 335-344
    • Cory, J.G.1    Cory, A.H.2    Rappa, G.3
  • 22
    • 4644288941 scopus 로고    scopus 로고
    • A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer
    • Yen Y, Margolin K, Doroshow J, et al. A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer. Cancer Chemother Pharmacol 2004;54:331-42.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 331-342
    • Yen, Y.1    Margolin, K.2    Doroshow, J.3
  • 23
    • 2442698003 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion
    • Wadler S, Makower D, Clairmont C, Lambert P, Fehn K, Sznol M. Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion. J Clin Oncol 2004;22:1553-63.
    • (2004) J Clin Oncol , vol.22 , pp. 1553-1563
    • Wadler, S.1    Makower, D.2    Clairmont, C.3    Lambert, P.4    Fehn, K.5    Sznol, M.6
  • 24
    • 0141455148 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors
    • Murren J, Modiano M, Clairmont C, et al. Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors. Clin Cancer Res 2003;9:4092-100.
    • (2003) Clin Cancer Res , vol.9 , pp. 4092-4100
    • Murren, J.1    Modiano, M.2    Clairmont, C.3
  • 25
    • 0042563157 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia
    • Giles FJ, Fracasso PM, Kantarjian HM, et al. Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia. Leuk Res 2003;27:1077-83.
    • (2003) Leuk Res , vol.27 , pp. 1077-1083
    • Giles, F.J.1    Fracasso, P.M.2    Kantarjian, H.M.3
  • 26
    • 0036042522 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule
    • Feun L, Modiano M, Lee K, et al. Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule. Cancer Chemother Pharmacol 2002;50:223-9.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 223-229
    • Feun, L.1    Modiano, M.2    Lee, K.3
  • 27
    • 0141566685 scopus 로고    scopus 로고
    • Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models
    • Voskoglou-Nomikos T, Pater JL, Seymour L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin Cancer Res 2003;9:4227-39.
    • (2003) Clin Cancer Res , vol.9 , pp. 4227-4239
    • Voskoglou-Nomikos, T.1    Pater, J.L.2    Seymour, L.3
  • 28
    • 0013853539 scopus 로고
    • Hydroxyurea: Differential lethal effects on cultured mammalian cells during the cell cycle
    • Sinclair WK. Hydroxyurea: differential lethal effects on cultured mammalian cells during the cell cycle. Science 1965;150:1729-31.
    • (1965) Science , vol.150 , pp. 1729-1731
    • Sinclair, W.K.1
  • 29
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125) IdU-induced DNA double-strand breaks with g-H2AX antibody
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125) IdU-induced DNA double-strand breaks with g-H2AX antibody. Radiat Res 2002;158:486-92.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 30
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses
    • U S A
    • Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci U S A 2003; 100:5057-62.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 31
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 2003;23: 5706-15.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.