-
1
-
-
0030904096
-
Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
-
Swain, S. M.; Whaley, F. S.; Gerber, M. C.; Weisberg, S.; York, M.; Spicer, D.; Jones, S. E., Wadler, S.; Desai, A.; Vogel, C.; Speyer, J.; Mittelman, A.; Reddy, S.; Pendergrass, K.; Velez-Garcia, E.; Ewer, M. S.; Bianchine, J. R.; Gams, R. A. Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J. Clin. Oncol. 1997, 15, 1318-1332.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 1318-1332
-
-
Swain, S.M.1
Whaley, F.S.2
Gerber, M.C.3
Weisberg, S.4
York, M.5
Spicer, D.6
Jones, S.E.7
Wadler, S.8
Desai, A.9
Vogel, C.10
Speyer, J.11
Mittelman, A.12
Reddy, S.13
Pendergrass, K.14
Velez-Garcia, E.15
Ewer, M.S.16
Bianchine, J.R.17
Gams, R.A.18
-
2
-
-
0030991044
-
Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy
-
Swain, S. M.; Whaley, F.; Gerber, M. C.; Ewer, M. S.; Bianchine, J. R.; Gams, R. A. Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy. J. Clin. Oncol. 1997, 15, 1333-1340.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 1333-1340
-
-
Swain, S.M.1
Whaley, F.2
Gerber, M.C.3
Ewer, M.S.4
Bianchine, J.R.5
Gams, R.A.6
-
3
-
-
9044233260
-
Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin
-
Wexler, L. H.; Andrich, M. P.; Venzon, D.; Berg, S. L.; Weaver-McClure, L.; Chen, C. C.; Dilsizian, V.; Avila, N.; Jarosinski, P.; Balis, F. M.; Poplack, D. G.; Horowitz, M. E. Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin. J. Clin. Oncol. 1996, 14, 362-372.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 362-372
-
-
Wexler, L.H.1
Andrich, M.P.2
Venzon, D.3
Berg, S.L.4
Weaver-McClure, L.5
Chen, C.C.6
Dilsizian, V.7
Avila, N.8
Jarosinski, P.9
Balis, F.M.10
Poplack, D.G.11
Horowitz, M.E.12
-
4
-
-
0002246510
-
The biochemical basis of anthracycline toxicity and anti-tumor activity
-
Gianni, L.; Corden, B. J.; Myers, C. E. The biochemical basis of anthracycline toxicity and anti-tumor activity. Rev. Biochem. Toxicol. 1983, 5, 1-82.
-
(1983)
Rev. Biochem. Toxicol.
, vol.5
, pp. 1-82
-
-
Gianni, L.1
Corden, B.J.2
Myers, C.E.3
-
5
-
-
0026714331
-
The anthracyclines: Will we ever find a better doxorubicin?
-
Weiss, R. B. The anthracyclines: will we ever find a better doxorubicin? Semin. Oncol. 1992, 19, 670-686.
-
(1992)
Semin. Oncol.
, vol.19
, pp. 670-686
-
-
Weiss, R.B.1
-
6
-
-
0021221088
-
Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron(III) complex
-
Gutteridge, J. M. C. Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron(III) complex. Biochem. Pharmacol. 1984, 33, 1725-1728.
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 1725-1728
-
-
Gutteridge, J.M.C.1
-
7
-
-
0019992950
-
Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex
-
Myers, C. E.; Gianni, L.; Simone, C. B.; Klecker, R.; Greene, R. Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex. Biochemistry 1982, 21, 1707-1713.
-
(1982)
Biochemistry
, vol.21
, pp. 1707-1713
-
-
Myers, C.E.1
Gianni, L.2
Simone, C.B.3
Klecker, R.4
Greene, R.5
-
8
-
-
0022263591
-
Characterization of the cycle of iron-mediated electron transfer from adriamycin to molecular oxygen
-
Gianni, L.; Zweier, J. L.; Levy, A.; Myers, C. E. Characterization of the cycle of iron-mediated electron transfer from adriamycin to molecular oxygen. J. Biol. Chem. 1985, 260, 6820-6826.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 6820-6826
-
-
Gianni, L.1
Zweier, J.L.2
Levy, A.3
Myers, C.E.4
-
9
-
-
0020632124
-
Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex
-
Demant, E. J. F.; Jensen, P. K. Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex. Eur. J. Biochem. 1983, 132, 551-556.
-
(1983)
Eur. J. Biochem.
, vol.132
, pp. 551-556
-
-
Demant, E.J.F.1
Jensen, P.K.2
-
10
-
-
0029114832
-
Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system
-
Malisza, K. L.; Hasinoff, B. B. Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system. Arch. Biochem. Biophys. 1995, 321, 51-60.
-
(1995)
Arch. Biochem. Biophys.
, vol.321
, pp. 51-60
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
12
-
-
0001793368
-
Metal ion binding to daunomycin and quinizann
-
Kiraly, R.; Martin, R. B. Metal ion binding to daunomycin and quinizann Inorg. Chim. Acta 1982, 67, 13-18.
-
(1982)
Inorg. Chim. Acta
, vol.67
, pp. 13-18
-
-
Kiraly, R.1
Martin, R.B.2
-
13
-
-
0023784504
-
Reappraisal of the association between adriamycin and iron
-
Gelvan, D.; Samuni, A. Reappraisal of the association between adriamycin and iron. Cancer Res. 1988, 48, 5645-5649.
-
(1988)
Cancer Res.
, vol.48
, pp. 5645-5649
-
-
Gelvan, D.1
Samuni, A.2
-
14
-
-
0000466594
-
Speciation studies of adriamycin, quelamycin, and their metal ion complexes
-
May, P. M.; Williams, G. K.; Williams, D. R. Speciation studies of adriamycin, quelamycin, and their metal ion complexes. Inorg. Chim. Acta 1980, 46, 221-228.
-
(1980)
Inorg. Chim. Acta
, vol.46
, pp. 221-228
-
-
May, P.M.1
Williams, G.K.2
Williams, D.R.3
-
15
-
-
0021288259
-
2 by iron-adriamycin
-
2 by iron-adriamycin. J. Biol. Chem. 1984, 253, 6056-6058.
-
(1984)
J. Biol. Chem.
, vol.253
, pp. 6056-6058
-
-
Zweier, J.L.1
-
16
-
-
0022849760
-
2 reduction by the iron complexes of adriamycin and daunomycin: The importance of the sidechain hydroxyl group
-
2 reduction by the iron complexes of adriamycin and daunomycin: the importance of the sidechain hydroxyl group. Biochim. Biophys. Acta 1986, 884, 326-336.
-
(1986)
Biochim. Biophys. Acta
, vol.884
, pp. 326-336
-
-
Zweier, J.L.1
Gianni, L.2
Muindi, J.3
Meyers, C.E.4
-
17
-
-
0023693636
-
Role of daunosamine and hydroxyacetyl side chain in reaction with iron and lipid peroxidation by anthracyclines
-
Gianni, L.; Vigano, L.; Lanzi, C.; Niggeler, M.; Malatesta, V. Role of daunosamine and hydroxyacetyl side chain in reaction with iron and lipid peroxidation by anthracyclines. J. Natl. Cancer Inst. 1988, 80, 1104-1111.
-
(1988)
J. Natl. Cancer Inst.
, vol.80
, pp. 1104-1111
-
-
Gianni, L.1
Vigano, L.2
Lanzi, C.3
Niggeler, M.4
Malatesta, V.5
-
18
-
-
0025274465
-
Time-dependent modifications of fernc-adriamycin
-
Gelvan, D.; Berg, E.; Saltman, P.; Samuni, A. Time-dependent modifications of fernc-adriamycin. Biochem. Pharmacol. 1990, 39, 1289-1295.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 1289-1295
-
-
Gelvan, D.1
Berg, E.2
Saltman, P.3
Samuni, A.4
-
19
-
-
0027315895
-
Interactions of iron-anthracycline complexes with living cells: A microspectrofluorometric study
-
Fiallo, M.; Laigle, A.; Garnier-Suillerot, A.; Amirand, C.; Ballini, J.-P.; Chinsky, L.; Duquesne, M.; Jolies, B.; Sureau, F.; Turpin, P.-Y.; Vigny, P. Interactions of iron-anthracycline complexes with living cells: a microspectrofluorometric study. Biochim. Biophys. Acta. 1993, 1177, 236-244.
-
(1993)
Biochim. Biophys. Acta.
, vol.1177
, pp. 236-244
-
-
Fiallo, M.1
Laigle, A.2
Garnier-Suillerot, A.3
Amirand, C.4
Ballini, J.-P.5
Chinsky, L.6
Duquesne, M.7
Jolies, B.8
Sureau, F.9
Turpin, P.-Y.10
Vigny, P.11
-
20
-
-
0003563914
-
-
Minisci. F., Ed.; Kluwer Academic Publishers: Dordrecht
-
Malatesta, V. In Free Radicals in Synthesis and Biology, Minisci. F., Ed.; Kluwer Academic Publishers: Dordrecht. 1989; pp. 437-460.
-
(1989)
Free Radicals in Synthesis and Biology
, pp. 437-460
-
-
Malatesta, V.1
-
21
-
-
0024829159
-
Self-reduction of the iron(III)-doxorubicin complex
-
Hasinoff, B. B. Self-reduction of the iron(III)-doxorubicin complex. Free Rad. Biol. Med. 1989, 7, 583-593.
-
(1989)
Free Rad. Biol. Med.
, vol.7
, pp. 583-593
-
-
Hasinoff, B.B.1
-
22
-
-
0025572476
-
3+-doxorubicin complex undergoing self-reduction by its α-ketol group
-
3+-doxorubicin complex undergoing self-reduction by its α-ketol group. Biochem. Cell. Biol. 1990, 68, 1331-1336.
-
(1990)
Biochem. Cell. Biol.
, vol.68
, pp. 1331-1336
-
-
Hasinoff, B.B.1
-
23
-
-
0018716636
-
Risk factors for doxorubicin-induced congestive heart failure
-
Von Hoff, D. D.; Lazard, M. W.; Basa, P.; Davis, H. L.; Von Hoff, A. L.; Rozencweig, M.; Muggia, F. Risk factors for doxorubicin-induced congestive heart failure. Ann. Intern. Med. 1979, 91, 710-717.
-
(1979)
Ann. Intern. Med.
, vol.91
, pp. 710-717
-
-
Von Hoff, D.D.1
Lazard, M.W.2
Basa, P.3
Davis, H.L.4
Von Hoff, A.L.5
Rozencweig, M.6
Muggia, F.7
-
24
-
-
0017354816
-
Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases
-
Von Hoff, D. D.; Rozencweig, M.; Layard, M.; Slavik, M.; Muggia, F. M. Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases. Am. J. Med. 1977, 62, 200-210.
-
(1977)
Am. J. Med.
, vol.62
, pp. 200-210
-
-
Von Hoff, D.D.1
Rozencweig, M.2
Layard, M.3
Slavik, M.4
Muggia, F.M.5
-
25
-
-
0025060816
-
Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin
-
Hasinoff, B. B. Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin. Biochem. J. 1990, 265, 865-870.
-
(1990)
Biochem. J.
, vol.265
, pp. 865-870
-
-
Hasinoff, B.B.1
-
26
-
-
0023729643
-
Adriamycin and its iron(III) and copper(II) complexes; glutathione-induced dissociation; cytochrome c oxidase inactivation and protection; binding to cardiolipin
-
Hasinoff, B. B.; Davey, J. P. Adriamycin and its iron(III) and copper(II) complexes; glutathione-induced dissociation; cytochrome c oxidase inactivation and protection; binding to cardiolipin. Biochem. Pharmacol. 1988, 37, 3663-3669.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 3663-3669
-
-
Hasinoff, B.B.1
Davey, J.P.2
-
27
-
-
0018741206
-
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals
-
Bachur, N. R.; Gordon, S. L.; Gee, M. V.; Kon, H. NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc. Natl. Acad. Sci. USA 1979, 76, 954-557.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 954-1557
-
-
Bachur, N.R.1
Gordon, S.L.2
Gee, M.V.3
Kon, H.4
-
28
-
-
0020398870
-
Metal binding by pharmaceuticals Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumor agent ICRF-159 and its inactive homologue ICRF-192
-
Huang, Z.-X.; May, P. M.; Quinlan, K. M.; Williams, D. R.; Creighton, A. M. Metal binding by pharmaceuticals Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumor agent ICRF-159 and its inactive homologue ICRF-192. Agents Actions 1982, 72, 536-542.
-
(1982)
Agents Actions
, vol.72
, pp. 536-542
-
-
Huang, Z.-X.1
May, P.M.2
Quinlan, K.M.3
Williams, D.R.4
Creighton, A.M.5
-
29
-
-
0027489682
-
The role of iron and iron chelators in anthracycline cardiotoxicity
-
Hershko, C.; Link, G.; Tzahor, M.; Pinson, A. The role of iron and iron chelators in anthracycline cardiotoxicity. Leuk. Lymphoma 1933, 11, 207-214.
-
(1933)
Leuk. Lymphoma
, vol.11
, pp. 207-214
-
-
Hershko, C.1
Link, G.2
Tzahor, M.3
Pinson, A.4
-
30
-
-
3543023934
-
-
Muggia, F. M., Ed.; Kluwer Academic Publishers: Dordrecht
-
Green, M. D.; Alderton, P.; Sobol, M. M.; Gross, J ; Muggia, F. M.; Speyer, J. L. In New Drugs, Concepts and Results in Cancer Chemotherapy, Muggia, F. M., Ed.; Kluwer Academic Publishers: Dordrecht, 1992; pp. 101-117.
-
(1992)
New Drugs, Concepts and Results in Cancer Chemotherapy
, pp. 101-117
-
-
Green, M.D.1
Alderton, P.2
Sobol, M.M.3
Gross, J.4
Muggia, F.M.5
Speyer, J.L.6
-
31
-
-
0025681528
-
-
Jucker, E., Ed., Birkhauser Verlag: Basel
-
Witiak, D T.; Wei, Y. In Progress in Drug Research; Jucker, E., Ed., Birkhauser Verlag: Basel, 1991; Vol. 35, pp 249-363.
-
(1991)
Progress in Drug Research
, vol.35
, pp. 249-363
-
-
Witiak, D.T.1
Wei, Y.2
-
32
-
-
0020334850
-
Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds
-
Herman, E. H.; Witiak, D. T.; Hellmann, K.; Waravdekar, V. S. Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds. Adv. Pharmacol. Chemother. 1982, 19, 249-290.
-
(1982)
Adv. Pharmacol. Chemother.
, vol.19
, pp. 249-290
-
-
Herman, E.H.1
Witiak, D.T.2
Hellmann, K.3
Waravdekar, V.S.4
-
33
-
-
6844224209
-
The evolution of a cardioprotective antimetastatic and antitumor drug: An international adventure
-
Nair, R. V.; Witiak, D T. The evolution of a cardioprotective antimetastatic and antitumor drug: An international adventure. J. Chem. Edu 1988, 65, 534-538.
-
(1988)
J. Chem. Edu
, vol.65
, pp. 534-538
-
-
Nair, R.V.1
Witiak, D.T.2
-
34
-
-
0028108109
-
Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity
-
Seifert, C. F.; Nesser, M. E., Thompson, D. F. Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity. Ann. Pharmacother. 1994, 28, 1063-1072.
-
(1994)
Ann. Pharmacother.
, vol.28
, pp. 1063-1072
-
-
Seifert, C.F.1
Nesser, M.E.2
Thompson, D.F.3
-
35
-
-
0344709328
-
-
Priebe, W., Ed.; American Chemical Society: Washington
-
Witiak, D. T.; Herman, E. H. In Anthracycline Antiobiotics, New Analogues, Methods of Delivery, and Mechanisms of Action; Priebe, W., Ed.; American Chemical Society: Washington, 1995; pp. 268-299.
-
(1995)
Anthracycline Antiobiotics, New Analogues, Methods of Delivery, and Mechanisms of Action
, pp. 268-299
-
-
Witiak, D.T.1
Herman, E.H.2
-
36
-
-
0025028092
-
Modulation of the effect of anthracycline efficacy and toxicity by ICRF-187
-
Blum, R. H ; Walsh, C.; Green, M. D.; Speyer, J. L. Modulation of the effect of anthracycline efficacy and toxicity by ICRF-187. Cancer Invest. 1990, 8, 267-268.
-
(1990)
Cancer Invest.
, vol.8
, pp. 267-268
-
-
Blum, R.H.1
Walsh, C.2
Green, M.D.3
Speyer, J.L.4
-
37
-
-
0024788594
-
ICRF-187
-
Hellmann, K. ICRF-187. J. Chemother. 1989, 1, 355-358.
-
(1989)
J. Chemother.
, vol.1
, pp. 355-358
-
-
Hellmann, K.1
-
38
-
-
0025942977
-
Cardioxane-ICRF-187, towards anticancer drug specificity through selective toxicity reduction
-
Koning, J.; Palmer, P.; Franks, C. R.; Mulder, D. E.; Speyer, J. L.; Green, M. D.; Hellmann, K. Cardioxane-ICRF-187, towards anticancer drug specificity through selective toxicity reduction. Cancer Treat Rev. 1991, 18, 1-19.
-
(1991)
Cancer Treat Rev.
, vol.18
, pp. 1-19
-
-
Koning, J.1
Palmer, P.2
Franks, C.R.3
Mulder, D.E.4
Speyer, J.L.5
Green, M.D.6
Hellmann, K.7
-
39
-
-
0023617176
-
ICRF-187
-
Eastland, G. ICRF-187. Drugs Future 1987, 12, 1017-1020.
-
(1987)
Drugs Future
, vol.12
, pp. 1017-1020
-
-
Eastland, G.1
-
40
-
-
0017098531
-
ICRF-159, (±) 1,2-di(3,5-dioxopiperazin-1-yl)propane NSC-129,943; Razoxane
-
Bakowski, M. T. ICRF-159, (±) 1,2-di(3,5-dioxopiperazin-1-yl)propane NSC-129,943; Razoxane. Cancer Treat. Rev. 1976, 3, 95-107.
-
(1976)
Cancer Treat. Rev.
, vol.3
, pp. 95-107
-
-
Bakowski, M.T.1
-
41
-
-
0017674044
-
ICRF-159: Current status and clinical prospects
-
Bellet, R. E.; Rozencweig, M.; Von Hoff, D. D.; Penta, J. S.; Wasserman, T. H ; Muggia, F. M. ICRF-159: Current status and clinical prospects. Eur. J. Cancer 1977, 13, 1293-1298.
-
(1977)
Eur. J. Cancer
, vol.13
, pp. 1293-1298
-
-
Bellet, R.E.1
Rozencweig, M.2
Von Hoff, D.D.3
Penta, J.S.4
Wasserman, T.H.5
Muggia, F.M.6
-
42
-
-
0017232021
-
Utilization of an enantiomer as a solution to a pharmaceutical problem: Application to solubilization of 1,2-di(4-piperazine-2,6-dione)propane
-
Repta, A. J.; Baltezor, M. J.; Bansal, P. C. Utilization of an enantiomer as a solution to a pharmaceutical problem: application to solubilization of 1,2-di(4-piperazine-2,6-dione)propane. J. Pharm. Sci. 1976, 65, 238-242.
-
(1976)
J. Pharm. Sci.
, vol.65
, pp. 238-242
-
-
Repta, A.J.1
Baltezor, M.J.2
Bansal, P.C.3
-
43
-
-
6844229308
-
-
U. K. Patent 1,234,935, 1971
-
Creighton, A. M. U. K. Patent 1,234,935, 1971.
-
-
-
Creighton, A.M.1
-
44
-
-
6844224207
-
-
U. K. Patent 1,374,979, 1974
-
Creighton, A M. U. K. Patent 1,374,979, 1974.
-
-
-
Creighton, A.M.1
-
45
-
-
6844219757
-
-
U. S. Patent 3,941,790, 1976
-
Creighton, A. M. U. S. Patent 3,941,790, 1976.
-
-
-
Creighton, A.M.1
-
46
-
-
6844232516
-
-
U. K. Patent 961,065, 1964
-
Geigy, J. R. U. K. Patent 961,065, 1964.
-
-
-
Geigy, J.R.1
-
47
-
-
0029900745
-
Inhibition of topoisomerase Ii by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration
-
Snapka, R. M.; Woo, S. H.; Blokhin, A. V.; Witiak, D. T. Inhibition of topoisomerase Ii by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem. Pharmacol. 1996, 52, 543-549.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 543-549
-
-
Snapka, R.M.1
Woo, S.H.2
Blokhin, A.V.3
Witiak, D.T.4
-
48
-
-
0000429183
-
Synthesis and 1H NMR conformational analysis of Diastereomeric 4,4′-(4,5-dihydroxy-1,2-cyclohexanediyl)bis(2,6-piperazinedione)s and a synthetically related tricyclic octahydro-2,2-dimehtyl-6-oxo-1,3-dioxolo[4,5-g]quinoline-5,8-diacetic acid ester
-
Witiak, D. T.; Wei, Y. Synthesis and 1H NMR conformational analysis of Diastereomeric 4,4′-(4,5-dihydroxy-1,2-cyclohexanediyl)bis(2,6-piperazinedione)s and a synthetically related tricyclic octahydro-2,2-dimehtyl-6-oxo-1,3-dioxolo[4,5-g]quinoline-5,8-diacetic acid ester. J. Org. Chem. 1991, 56, 5408-5417.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 5408-5417
-
-
Witiak, D.T.1
Wei, Y.2
-
49
-
-
0022183608
-
Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the lewis lung carcinoma model
-
Witiak, D. T.; Nair, R. V.; Schmid, F. A. Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the lewis lung carcinoma model. J. Med. Chem. 1985, 28, 1228-1234.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1228-1234
-
-
Witiak, D.T.1
Nair, R.V.2
Schmid, F.A.3
-
50
-
-
0019781091
-
Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazine) analogues in a B16 melanoma model
-
Witiak, D. T.; Trivedi, B. K.; Campolito, L. B ; Zwilling, B. S.; Reiches, N. A. Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazine) analogues in a B16 melanoma model. J. Med. Chem. 1981, 24, 1329-1332.
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1329-1332
-
-
Witiak, D.T.1
Trivedi, B.K.2
Campolito, L.B.3
Zwilling, B.S.4
Reiches, N.A.5
-
51
-
-
0018238035
-
Stereoselective effects of cis- and trans-cyclopropylbis(dioxopiperazines) related to ICRF-159 on metastases of a hamster lung adenocarcinoma
-
Witiak, D. T.; Lee, H. J.; Goldman, H. D.; Zwilling, B. S. Stereoselective effects of cis- and trans-cyclopropylbis(dioxopiperazines) related to ICRF-159 on metastases of a hamster lung adenocarcinoma. J. Med. Chem. 1978, 27, 1194-1197.
-
(1978)
J. Med. Chem.
, vol.27
, pp. 1194-1197
-
-
Witiak, D.T.1
Lee, H.J.2
Goldman, H.D.3
Zwilling, B.S.4
-
52
-
-
0017638439
-
Study of trans-cyclopropylbis(diketopiperazine) and chelating agents related to ICRF 159. Cytotoxtcity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis
-
Witiak, D. T.; Lee, H. J ; Hart, R. W.; Gibson, R. E. Study of trans-cyclopropylbis(diketopiperazine) and chelating agents related to ICRF 159. Cytotoxtcity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis. J. Med. Chem. 1977, 20, 630-635.
-
(1977)
J. Med. Chem.
, vol.20
, pp. 630-635
-
-
Witiak, D.T.1
Lee, H.J.2
Hart, R.W.3
Gibson, R.E.4
-
53
-
-
6844220809
-
-
Ph.D. Dissertation, Council for National Academic Awards, London
-
Jeffery, W. A. Ph.D. Dissertation, Council for National Academic Awards, London, 1987.
-
(1987)
-
-
Jeffery, W.A.1
-
54
-
-
0026425619
-
Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives
-
Tanabe, K.; Ikegami, Y.; Ishida, R.; Andoh, T. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives. Cancer Res. 1991, 51, 4903-4908.
-
(1991)
Cancer Res.
, vol.51
, pp. 4903-4908
-
-
Tanabe, K.1
Ikegami, Y.2
Ishida, R.3
Andoh, T.4
-
55
-
-
0026425654
-
Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors
-
Ishida, R.; Miki, T.; Narita, T.; Yul, R.; Sato, M.; Utsumi, K. R.; Tanabe, K.; Andoh, T. Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res. 1991, 51, 4909-4916.
-
(1991)
Cancer Res.
, vol.51
, pp. 4909-4916
-
-
Ishida, R.1
Miki, T.2
Narita, T.3
Yul, R.4
Sato, M.5
Utsumi, K.R.6
Tanabe, K.7
Andoh, T.8
-
56
-
-
0030458381
-
A structure-function analysis of DNA topoisomerase II inhibitors
-
Insaf, S. S.; Danks, M. K.; Witiak, D. T. A structure-function analysis of DNA topoisomerase II inhibitors. Curr Med. Chem. 1996, 3, 437-466.
-
(1996)
Curr Med. Chem.
, vol.3
, pp. 437-466
-
-
Insaf, S.S.1
Danks, M.K.2
Witiak, D.T.3
-
57
-
-
0019942448
-
Stereochemistry of the antitumor agent 4,4′-(1,2-propanediyl)bis(4-piperazine-2,6-dione): Crystal and molecular structures of the racemate (ICRF-159) and a soluble enantiomer (ICRF-187)
-
Hempel, A.; Camerman, N.; Camerman, A. Stereochemistry of the antitumor agent 4,4′-(1,2-propanediyl)bis(4-piperazine-2,6-dione): Crystal and molecular structures of the racemate (ICRF-159) and a soluble enantiomer (ICRF-187). J. Am. Chem. Soc. 1982, 105, 3453-3456.
-
(1982)
J. Am. Chem. Soc.
, vol.105
, pp. 3453-3456
-
-
Hempel, A.1
Camerman, N.2
Camerman, A.3
-
58
-
-
0020504692
-
Stereochemistry of the conformationally restricted analogues of the antitumor agent ICRF-159. 2. Structures of the antimetastatically active and inactive isomers of a tricyclic analogue
-
Hempel, A.; Camerman, N.; Camerman, A. Stereochemistry of the conformationally restricted analogues of the antitumor agent ICRF-159. 2. Structures of the antimetastatically active and inactive isomers of a tricyclic analogue. J. Am. Chem. Soc. 1983, 105, 2350-2354.
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 2350-2354
-
-
Hempel, A.1
Camerman, N.2
Camerman, A.3
-
59
-
-
0021205374
-
Bimolane: Structure determination indicates anticancer activity is attributable to ICRF-154
-
Camerman, N.; Hempel, A.; Camerman, A. Bimolane: Structure determination indicates anticancer activity is attributable to ICRF-154. Science 1984, 225, 1165-1166.
-
(1984)
Science
, vol.225
, pp. 1165-1166
-
-
Camerman, N.1
Hempel, A.2
Camerman, A.3
-
60
-
-
0038920876
-
N,N′-methylethylenebis(N-methylcarbamylglycinato)copper(II) dihydrate and N,N′-ethylethylenebis(N-methylcarbamylglycinato)copper(II) dihydrate
-
Prout, C. K., Sanderson, D. S.; Couldwell, M. C. N,N′-methylethylenebis(N-methylcarbamylglycinato)copper(II) dihydrate and N,N′-ethylethylenebis(N-methylcarbamylglycinato)copper(II) dihydrate. Cryst. Struct. Comm. 1979, 8, 181-188.
-
(1979)
Cryst. Struct. Comm.
, vol.8
, pp. 181-188
-
-
Prout, C.K.1
Sanderson, D.S.2
Couldwell, M.C.3
-
61
-
-
0028810791
-
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
-
Hasinoff, B. B.; Kuschak, T. I.; Yalowich, J. C.; Creighton, A. M. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochem. Pharmacol. 1995, 50, 953-958.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 953-958
-
-
Hasinoff, B.B.1
Kuschak, T.I.2
Yalowich, J.C.3
Creighton, A.M.4
-
62
-
-
8544244972
-
-
Simkins, M. A., Ed.; Research Studies Press: Forest Grove, Oregon
-
Creighton, A. M.; Jeffery, W. A ; Long, J. In Medicinal Chemistry I. Proceedings of the 6th international symposium on medicinal chemistry, Simkins, M. A., Ed.; Research Studies Press: Forest Grove, Oregon, 1979; pp. 281-288.
-
(1979)
Medicinal Chemistry I. Proceedings of the 6th International Symposium on Medicinal Chemistry
, pp. 281-288
-
-
Creighton, A.M.1
Jeffery, W.A.2
Long, J.3
-
63
-
-
0025324554
-
The hydrolysis-activation of the doxorubicin cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane)
-
Hasinoff, B. B. The hydrolysis-activation of the doxorubicin cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane). Drug Matab. Dispos. 1990, 18, 344-349.
-
(1990)
Drug Matab. Dispos.
, vol.18
, pp. 344-349
-
-
Hasinoff, B.B.1
-
64
-
-
0031054503
-
High performance liquid chromatographic analysis of the cardioprotective agent dexrazoxane in human plasma and urine
-
Rosing, H.; Vangijn, R.; Huinink, W. W T ; Beijenen, J. H. High performance liquid chromatographic analysis of the cardioprotective agent dexrazoxane in human plasma and urine. J. Liq. Chrom. Ret. Technol. 1997, 20, 583-601.
-
(1997)
J. Liq. Chrom. Ret. Technol.
, vol.20
, pp. 583-601
-
-
Rosing, H.1
Vangijn, R.2
Huinink, W.W.T.3
Beijenen, J.H.4
-
65
-
-
0027943694
-
The pharmacokinetics of high-dose epirubicin and of the cardioprotector ADR 529 given together with cyclophosphamide, 5-fluorouracil, and tamoxifen in metastatic breast-cancer patients
-
Jakobsen, P.; Sorensen, B.; Bastholt, L ; Mirza, M. R.; Gjedde, S. B.; Moundsen, H. T.; Rose, C. The pharmacokinetics of high-dose epirubicin and of the cardioprotector ADR 529 given together with cyclophosphamide, 5-fluorouracil, and tamoxifen in metastatic breast-cancer patients. Cancer Chemother. Pharmacol. 1994, 35, 45-52.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.35
, pp. 45-52
-
-
Jakobsen, P.1
Sorensen, B.2
Bastholt, L.3
Mirza, M.R.4
Gjedde, S.B.5
Moundsen, H.T.6
Rose, C.7
-
66
-
-
0028069095
-
Comparative study of the pharmacokinetics and toxicity of high-dose epirubicin with or without dexrazoxane in patients with advanced malignancy
-
Basser, R. L.; Sobol, M. M., Duggan, G.; Cebon, J.; Rosenthal, M. A.; Mihaly, G.; Green, M. D. Comparative study of the pharmacokinetics and toxicity of high-dose epirubicin with or without dexrazoxane in patients with advanced malignancy. J. Clin. Oncol. 1994, 12, 1659-1666.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 1659-1666
-
-
Basser, R.L.1
Sobol, M.M.2
Duggan, G.3
Cebon, J.4
Rosenthal, M.A.5
Mihaly, G.6
Green, M.D.7
-
67
-
-
0026496068
-
Pharmacokinetics of the cardioprotector ADR-529 (ICRF-187) in escalating doses combined with fixed-dose doxorubicin
-
Hochster, H.; Liebes, L.; Wadler, S.; Oratz, R.; Wernz, J. C.; Meyers, M.; Green, M.; Slum, R. H.; Speyer, J. L. Pharmacokinetics of the cardioprotector ADR-529 (ICRF-187) in escalating doses combined with fixed-dose doxorubicin. J. Natl. Cancer Inst 1992, 84, 1725-1730.
-
(1992)
J. Natl. Cancer Inst
, vol.84
, pp. 1725-1730
-
-
Hochster, H.1
Liebes, L.2
Wadler, S.3
Oratz, R.4
Wernz, J.C.5
Meyers, M.6
Green, M.7
Slum, R.H.8
Speyer, J.L.9
-
68
-
-
0023077799
-
Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors
-
Vogel, C. L.; Gorowski, E.; Davila, E.; Eisenberger, M.; Kosinski, J.; Agarwal, R. P., Savaraj, N. Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors. Invest. New Drugs 1987, 5, 187-198.
-
(1987)
Invest. New Drugs
, vol.5
, pp. 187-198
-
-
Vogel, C.L.1
Gorowski, E.2
Davila, E.3
Eisenberger, M.4
Kosinski, J.5
Agarwal, R.P.6
Savaraj, N.7
-
69
-
-
0020418637
-
Pharmacokinetics of (+)-1,2-di(3,5-dioxopiperazin-1-yl)propane intravenous infusions in adult cancer patients
-
Earhart, R. H.; Tutsch, K. D.; Koeller, J. M.; Rodriguez, R ; Robins, H. I.; Vogel, C. L.; Davis, H. L.; Tormey, D. C. Pharmacokinetics of (+)-1,2-di(3,5-dioxopiperazin-1-yl)propane intravenous infusions in adult cancer patients. Cancer Res. 1982, 42, 5255-5261.
-
(1982)
Cancer Res.
, vol.42
, pp. 5255-5261
-
-
Earhart, R.H.1
Tutsch, K.D.2
Koeller, J.M.3
Rodriguez, R.4
Robins, H.I.5
Vogel, C.L.6
Davis, H.L.7
Tormey, D.C.8
-
70
-
-
0020583846
-
Determination of razoxane by high-pressure liquid chromatography
-
Collins, M.; Fu, X.-C.; Greig, N.; Hellmann, K. Determination of razoxane by high-pressure liquid chromatography. J. Chromatogr. 1983, 274, 434-440.
-
(1983)
J. Chromatogr.
, vol.274
, pp. 434-440
-
-
Collins, M.1
Fu, X.-C.2
Greig, N.3
Hellmann, K.4
-
71
-
-
0026596069
-
A sensitive and specific procedure for quantitation of ADR-529 in biological fluids by high-performance liquid chromatography (HPLC) with column switching and amperometric detection
-
Lewis, R. C.; Phillips, B. A.; Baldwin, J. R.; Rossi, D. T.; Narang, P. K. A sensitive and specific procedure for quantitation of ADR-529 in biological fluids by high-performance liquid chromatography (HPLC) with column switching and amperometric detection. Pharm. Res. 1992, 9, 101-108.
-
(1992)
Pharm. Res.
, vol.9
, pp. 101-108
-
-
Lewis, R.C.1
Phillips, B.A.2
Baldwin, J.R.3
Rossi, D.T.4
Narang, P.K.5
-
72
-
-
0025758931
-
Characterization of the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187) by liquid chromatographic and mass spectral analysis
-
Burke, T. G.; Lee, T. D.; van-Balgooy, J.; Doroshow, J. H. Characterization of the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187) by liquid chromatographic and mass spectral analysis. J. Pharm. Sci. 1991, 80, 338-340.
-
(1991)
J. Pharm. Sci.
, vol.80
, pp. 338-340
-
-
Burke, T.G.1
Lee, T.D.2
Van-Balgooy, J.3
Doroshow, J.H.4
-
73
-
-
0028217545
-
An HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates
-
Hasinoff, B. B. An HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates. Int J. Pharm. 1994, 107, 67-76.
-
(1994)
Int J. Pharm.
, vol.107
, pp. 67-76
-
-
Hasinoff, B.B.1
-
74
-
-
0028093440
-
Pharmacodynamics of the hydrolysis-activation of the cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane
-
Hasinoff, B. B. Pharmacodynamics of the hydrolysis-activation of the cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane. J. Pharm. Sci. 1994, 83, 64-67.
-
(1994)
J. Pharm. Sci.
, vol.83
, pp. 64-67
-
-
Hasinoff, B.B.1
-
75
-
-
0016775708
-
Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells
-
Dawson, K. M. Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells. Biochem. Pharmacol. 1975, 24, 2249-2253.
-
(1975)
Biochem. Pharmacol.
, vol.24
, pp. 2249-2253
-
-
Dawson, K.M.1
-
76
-
-
6844243745
-
-
Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress in Research and Clinical Applications, Proceedings of the VIIth International Congress of Chemotherapy Prague, 1971; Semonsky, M.; Hejzlar, M.; Masak, S., Eds.; University Park Press: Baltimore
-
Livingston, D. C.; Creighton, A. M.; Fisher, S. W. In Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress in Research and Clinical Applications, Proceedings of the VIIth International Congress of Chemotherapy Prague, 1971; Semonsky, M.; Hejzlar, M.; Masak, S., Eds.; University Park Press: Baltimore, 1972; Vol. II: Antineoplastic Chemotherapy and Radioprotectives, pp. 109-110.
-
(1972)
Vol. II: Antineoplastic Chemotherapy and Radioprotectives
, vol.2
, pp. 109-110
-
-
Livingston, D.C.1
Creighton, A.M.2
Fisher, S.W.3
-
77
-
-
0014761980
-
Effect of ICRF 159 on the mammalian cell cycle: Significance for its use in cancer chemotherapy
-
Hellmann, K.; Field, E. O. Effect of ICRF 159 on the mammalian cell cycle: Significance for its use in cancer chemotherapy. J. Natl. Cancer Inst. 1970, 44, 539-543.
-
(1970)
J. Natl. Cancer Inst.
, vol.44
, pp. 539-543
-
-
Hellmann, K.1
Field, E.O.2
-
78
-
-
0026779312
-
Is ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] unusually reactive for an imide?
-
Sisco, J. M.; Stella, V. J. Is ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] unusually reactive for an imide? Pharm. Res. 1992, 9, 1076-1082.
-
(1992)
Pharm. Res.
, vol.9
, pp. 1076-1082
-
-
Sisco, J.M.1
Stella, V.J.2
-
79
-
-
0026784388
-
An unexpected hydrolysis pH-rate profile, at pH values less than 7, of the labile imide, ICRF-187: (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane
-
Sisco, J. M.; Stella, V. J. An unexpected hydrolysis pH-rate profile, at pH values less than 7, of the labile imide, ICRF-187: (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. Pharm. Res. 1992, 9, 1209-1214.
-
(1992)
Pharm. Res.
, vol.9
, pp. 1209-1214
-
-
Sisco, J.M.1
Stella, V.J.2
-
80
-
-
0027169571
-
Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids
-
Beijnen, J. H.; van Gijn, R. Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids. J. Parenter. Sci. Technol. 1993, 47, 166-171.
-
(1993)
J. Parenter. Sci. Technol.
, vol.47
, pp. 166-171
-
-
Beijnen, J.H.1
Van Gijn, R.2
-
81
-
-
0030744361
-
Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron(III) displacement reactions of ICRF-187 and other bisdiketopiperazines
-
Herman, E. H.; Zhang, J.; Hasinoff, B. B.; Chadwick, D.; Clark, J. R. J.; Ferrans, V. J. Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron(III) displacement reactions of ICRF-187 and other bisdiketopiperazines. Cancer Chemother. Pharmacol. 1997, 40, 400-408.
-
(1997)
Cancer Chemother. Pharmacol.
, vol.40
, pp. 400-408
-
-
Herman, E.H.1
Zhang, J.2
Hasinoff, B.B.3
Chadwick, D.4
Clark, J.R.J.5
Ferrans, V.J.6
-
82
-
-
0024573486
-
The interaction of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane), its hydrolysis product ICRF-198, and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin
-
Hasinoff, B. B. The interaction of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane), its hydrolysis product ICRF-198, and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin. Agents Actions 1989, 26, 378-385.
-
(1989)
Agents Actions
, vol.26
, pp. 378-385
-
-
Hasinoff, B.B.1
-
83
-
-
0025237857
-
The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane)
-
Hasinoff, B. B. The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane). Agents Actions 1990, 29, 374-381.
-
(1990)
Agents Actions
, vol.29
, pp. 374-381
-
-
Hasinoff, B.B.1
-
84
-
-
0027740137
-
The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes
-
Buss, J. L.; Hasinoff, B. B. The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes. Agents Actons 1993, 40, 86-95.
-
(1993)
Agents Actons
, vol.40
, pp. 86-95
-
-
Buss, J.L.1
Hasinoff, B.B.2
-
85
-
-
0028959660
-
Ferrous ion strongly promotes the ring opening of the hydrolysis intermediates of the antioxidant doxorubicin cardioprotective agent ICRF-187 (dexrazoxane)
-
Buss, J. L.; Hasinoff, B. B. Ferrous ion strongly promotes the ring opening of the hydrolysis intermediates of the antioxidant doxorubicin cardioprotective agent ICRF-187 (dexrazoxane). Arch. Biochem. Biophys. 1995, 317, 121-127.
-
(1995)
Arch. Biochem. Biophys.
, vol.317
, pp. 121-127
-
-
Buss, J.L.1
Hasinoff, B.B.2
-
86
-
-
6844247662
-
Metal ion-promoted hydrolysis of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and its one-ring open hydrolysis products to its metal-chelating active form
-
Buss, J. L.; Hasinoff, B. B. Metal ion-promoted hydrolysis of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and its one-ring open hydrolysis products to its metal-chelating active form. J. Inorg. Biochem. 1997, 65, 251-256.
-
(1997)
J. Inorg. Biochem.
, vol.65
, pp. 251-256
-
-
Buss, J.L.1
Hasinoff, B.B.2
-
87
-
-
37049099916
-
Synthesis of bis(imides) and bis(half amides) of N, N′-ethylenebis(iminodiacetic acid)
-
Houghton, R. P ; Williams, E. Synthesis of bis(imides) and bis(half amides) of N, N′-ethylenebis(iminodiacetic acid). J. Chem. Soc. Perkin Trans. / 1982, 2693-2696.
-
(1982)
J. Chem. Soc. Perkin Trans.
, pp. 2693-2696
-
-
Houghton, R.P.1
Williams, E.2
-
88
-
-
4243635728
-
Chelating agents as antitumour drugs: Formation of chelating agents from the antitumour pro-drug razoxane
-
Nolan, K. B ; Murphy, T.; Hermanns, R. D.; Rahoo, H. Chelating agents as antitumour drugs: Formation of chelating agents from the antitumour pro-drug razoxane. Inorg. Chim. Acta 1990, 168, 283-288.
-
(1990)
Inorg. Chim. Acta
, vol.168
, pp. 283-288
-
-
Nolan, K.B.1
Murphy, T.2
Hermanns, R.D.3
Rahoo, H.4
-
89
-
-
37049090065
-
Copper(II) complexes of hydrolysis products of the anticancer bis(3,5-dioxopiperazin-1-yl)alkanes. Displacement of co-ordinated carboxylate ligands by deprotonated amide groups in basic solution
-
Daeid, N. N.; Nolan, K. B.; Ryan, L. P. Copper(II) complexes of hydrolysis products of the anticancer bis(3,5-dioxopiperazin-1-yl)alkanes. Displacement of co-ordinated carboxylate ligands by deprotonated amide groups in basic solution. J. Chem. Soc. Dalton Trans. 1991, 2301-2304.
-
(1991)
J. Chem. Soc. Dalton Trans.
, pp. 2301-2304
-
-
Daeid, N.N.1
Nolan, K.B.2
Ryan, L.P.3
-
90
-
-
0000301953
-
-
Priebe, W., Ed.; American Chemical Society: Washington
-
Doroshow, J. H. In Anthracycline Antiobiotics, New Analogues, Methods of Delivery, and Mechanisms of Action; Priebe, W., Ed.; American Chemical Society: Washington, 1995; pp. 259-267.
-
(1995)
Anthracycline Antiobiotics, New Analogues, Methods of Delivery, and Mechanisms of Action
, pp. 259-267
-
-
Doroshow, J.H.1
-
91
-
-
0025981636
-
The enzymatic hydrolysis-activation of the adriamycin cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane
-
Hasinoff, B. B ; Reinders, F. X.; Clark, V. The enzymatic hydrolysis-activation of the adriamycin cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane. Drug Metab. Dispos. 1991, 19, 74-80.
-
(1991)
Drug Metab. Dispos.
, vol.19
, pp. 74-80
-
-
Hasinoff, B.B.1
Reinders, F.X.2
Clark, V.3
-
92
-
-
0027486375
-
Enzymatic ring-opening reactions of the chiral cardioprotective agent (+) (S)- ICRF-187 and its (-) (R)-enantiomer ICRF-186 by dihydropyrimidine amidohydrolase
-
Hasinoff, B. B. Enzymatic ring-opening reactions of the chiral cardioprotective agent (+) (S)- ICRF-187 and its (-) (R)-enantiomer ICRF-186 by dihydropyrimidine amidohydrolase. Drug Metab. Dispos. 1993, 21, 883-888.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 883-888
-
-
Hasinoff, B.B.1
-
93
-
-
0028356250
-
Stereoselective hydrolysis of ICRF-187 (dexrazoxane) and ICRF-186 by dihydropyrimidine amidohydrolase
-
Hasinoff, B. B. Stereoselective hydrolysis of ICRF-187 (dexrazoxane) and ICRF-186 by dihydropyrimidine amidohydrolase. Chirality 1994, 6, 213-215.
-
(1994)
Chirality
, vol.6
, pp. 213-215
-
-
Hasinoff, B.B.1
-
94
-
-
0027970530
-
Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte
-
Hasinoff, B. B.; Venkataram, S.; Singh, M.; Kuschak, T. I. Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte. Xenobiotica 1994, 24, 977-987.
-
(1994)
Xenobiotica
, vol.24
, pp. 977-987
-
-
Hasinoff, B.B.1
Venkataram, S.2
Singh, M.3
Kuschak, T.I.4
-
95
-
-
0021719997
-
Metal binding by pharmaceuticals. Part 5. Interaction of Cd(II), Ni(II) and Pb(II) with the intracellular hydrolysis products of the anti-tumor agent ICRF 159 and its inactive homologue ICRF 192
-
May, P. M.; Willes, M. J.; Williams, D. R.; Creighton, A. M. Metal binding by pharmaceuticals. Part 5. Interaction of Cd(II), Ni(II) and Pb(II) with the intracellular hydrolysis products of the anti-tumor agent ICRF 159 and its inactive homologue ICRF 192. Agents Actions 1984, 15, 449-453.
-
(1984)
Agents Actions
, vol.15
, pp. 449-453
-
-
May, P.M.1
Willes, M.J.2
Williams, D.R.3
Creighton, A.M.4
-
96
-
-
6844242708
-
Metal binding properties of two homologues of razoxane, a bisdioxopiperazine antitumour drug
-
Huang, Z. X.; Creighton, A. M.; Williams, D. R. Metal binding properties of two homologues of razoxane, a bisdioxopiperazine antitumour drug. Inorg. Chim. Acta 1985, 107, L29-L32.
-
(1985)
Inorg. Chim. Acta
, vol.107
-
-
Huang, Z.X.1
Creighton, A.M.2
Williams, D.R.3
-
97
-
-
0026551924
-
In vitro evidence for direct complexation of ADR- 529/ICRF-187 [(+)-1,2-bis-(3,5-dioxo-piperazin-1-yl)propane] onto an existing ferric-anthracycline complex
-
Sobol, M. M.; Amiet, R. G.; Green, M. D. In vitro evidence for direct complexation of ADR- 529/ICRF-187 [(+)-1,2-bis-(3,5-dioxo-piperazin-1-yl)propane] onto an existing ferric-anthracycline complex. Mol. Pharmacol. 1992, 41, 8-17.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 8-17
-
-
Sobol, M.M.1
Amiet, R.G.2
Green, M.D.3
-
98
-
-
0027517827
-
The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its hydrolysis product ADR-925
-
Hasinoff, B. B.; Kala, S. V. The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its hydrolysis product ADR-925. Agents Actions 1993, 39, 72-81.
-
(1993)
Agents Actions
, vol.39
, pp. 72-81
-
-
Hasinoff, B.B.1
Kala, S.V.2
-
99
-
-
0020798741
-
The mechanism of Fe-EDTA catalyzed superoxide dismutation
-
Bull, C.; McClune, G. J.; Fee, J. A. The mechanism of Fe-EDTA catalyzed superoxide dismutation. J. Am. Chem. Soc. 1983, 105, 5290-5300.
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 5290-5300
-
-
Bull, C.1
McClune, G.J.2
Fee, J.A.3
-
100
-
-
0028989055
-
NADPH-cytochrome-P450 reductase promotes hydroxyl radical production by the iron complex of ADR-925, the hydrolysis product of ICRF-187 (dexrazoxane)
-
Hasinoff, B. B. NADPH-cytochrome-P450 reductase promotes hydroxyl radical production by the iron complex of ADR-925, the hydrolysis product of ICRF-187 (dexrazoxane). Free Rad. Res. 1995, 22, 319-325.
-
(1995)
Free Rad. Res.
, vol.22
, pp. 319-325
-
-
Hasinoff, B.B.1
-
101
-
-
0028945064
-
Doxorubicin reduces the iron(III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals
-
Malisza, K. L.; Hasinoff, B. B. Doxorubicin reduces the iron(III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals. Arch. Biochem. Biophys. 1995, 316, 680-588.
-
(1995)
Arch. Biochem. Biophys.
, vol.316
, pp. 680-1588
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
102
-
-
0038596403
-
Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane)
-
Malisza, K. L.; Hasinoff, B. B. Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane). Redox Rep. 1996, 2, 69-73.
-
(1996)
Redox Rep.
, vol.2
, pp. 69-73
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
103
-
-
0027258675
-
The hydrolysis product of ICRF-187 promotes iron-catalysed hydroxyl radical production via the Fenton reaction
-
Thomas, C.; Vile, G. F.; Winterbourn, C. C. The hydrolysis product of ICRF-187 promotes iron-catalysed hydroxyl radical production via the Fenton reaction. Biochem. Pharmacol. 1993, 45, 1967-1972.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1967-1972
-
-
Thomas, C.1
Vile, G.F.2
Winterbourn, C.C.3
-
104
-
-
0021337104
-
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site
-
Graf, E.; Mahoney, J. R.; Bryant, R. G.; Eaton, J. W. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J. Biol. Chem. 1984, 259, 3620-3624.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 3620-3624
-
-
Graf, E.1
Mahoney, J.R.2
Bryant, R.G.3
Eaton, J.W.4
-
105
-
-
0025050763
-
Effects of (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (ADR-529) on iron-catalyzed lipid peroxidation
-
Ryan, T. P.; Samokyszyn, V. M.; Dellis, S., Aust, S. D. Effects of (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (ADR-529) on iron-catalyzed lipid peroxidation. Chem. Res. Toxicol. 1990, 3, 384-390.
-
(1990)
Chem. Res. Toxicol.
, vol.3
, pp. 384-390
-
-
Ryan, T.P.1
Samokyszyn, V.M.2
Dellis, S.3
Aust, S.D.4
-
106
-
-
0025212158
-
3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adriamycin
-
3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adriamycin. Cancer Res. 1990, 50, 2307-2310.
-
(1990)
Cancer Res.
, vol.50
, pp. 2307-2310
-
-
Vile, G.F.1
Winterbourn, C.C.2
-
107
-
-
0029892535
-
Inhibition of anthracycline semiquinone formation by ICRF-187 (dexrazoxane) in cells
-
Malisza, K. L.; Hasinoff, B. B. Inhibition of anthracycline semiquinone formation by ICRF-187 (dexrazoxane) in cells. Free Rad. Biol Med. 1996, 20, 905-914.
-
(1996)
Free Rad. Biol Med.
, vol.20
, pp. 905-914
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
108
-
-
0026074238
-
Scavenging of probimane on semiquinone free radical formation by doxorubicin in rat heart
-
Zhang, Y.; Zhang, T.-M.; Zhao, B.-L.; Han, J.-K.; Chen, W.-C.; Xin, W.-J. Scavenging of probimane on semiquinone free radical formation by doxorubicin in rat heart. Acta Pharmacol. Sin. 1991, 12, 20-23.
-
(1991)
Acta Pharmacol. Sin.
, vol.12
, pp. 20-23
-
-
Zhang, Y.1
Zhang, T.-M.2
Zhao, B.-L.3
Han, J.-K.4
Chen, W.-C.5
Xin, W.-J.6
-
109
-
-
0024430425
-
Free-radical formation by mitomycin C and its novel analogs in cardiac microsomes and the perfused rat heart
-
Politi, P. M.; Rajagopalan, S.; Sinha, B. K. Free-radical formation by mitomycin C and its novel analogs in cardiac microsomes and the perfused rat heart. Biochim. Biophys. Acta 1989, 992, 341-348.
-
(1989)
Biochim. Biophys. Acta
, vol.992
, pp. 341-348
-
-
Politi, P.M.1
Rajagopalan, S.2
Sinha, B.K.3
-
110
-
-
0027461274
-
Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells
-
Shipp, N. G.; Dorr, R. T.; Alberts, D. S.; Dawson, B. V.; Hendrix, M. Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells. Cancer Res. 1993, 53, 550-556.
-
(1993)
Cancer Res.
, vol.53
, pp. 550-556
-
-
Shipp, N.G.1
Dorr, R.T.2
Alberts, D.S.3
Dawson, B.V.4
Hendrix, M.5
-
111
-
-
0026048208
-
Biochemical effects and toxicity of mitoxantrone in cultured heart cells
-
Shipp, N. G.; Dorr, R. T. Biochemical effects and toxicity of mitoxantrone in cultured heart cells. Adv. Exp. Med. Biol. 1991, 283, 821-825.
-
(1991)
Adv. Exp. Med. Biol.
, vol.283
, pp. 821-825
-
-
Shipp, N.G.1
Dorr, R.T.2
-
112
-
-
0027214092
-
Antagonistic effect of the cardioprotector (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) on DNA breaks and cytotoxicity induced by the topoisomerase II directed drugs daunorubicin and etoposide (VP-16)
-
Sehested, M.; Jensen, P. B.; Sorensen, B. S.; Holm, B.; Friche, E.; Demant, E. J. F. Antagonistic effect of the cardioprotector (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) on DNA breaks and cytotoxicity induced by the topoisomerase II directed drugs daunorubicin and etoposide (VP-16). Biochem. Pharmacol. 1993, 46, 389-393.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 389-393
-
-
Sehested, M.1
Jensen, P.B.2
Sorensen, B.S.3
Holm, B.4
Friche, E.5
Demant, E.J.F.6
-
113
-
-
0021151237
-
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
-
Tewey, K. M.; Rowe, T. C.; Yang, L.; Halligan, B. D.; Liu, L. F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984, 226, 466-468.
-
(1984)
Science
, vol.226
, pp. 466-468
-
-
Tewey, K.M.1
Rowe, T.C.2
Yang, L.3
Halligan, B.D.4
Liu, L.F.5
-
114
-
-
0024468481
-
DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA
-
Bodley, A.; Liu, L. F.; Israel, M.; Seshadri, R.; Koseki, Y.; Giuliani, F. C.; Kirschenbaum, S.; Silber, R.; Potmesil, M. DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. Cancer Res. 1989, 49, 5969-5978.
-
(1989)
Cancer Res.
, vol.49
, pp. 5969-5978
-
-
Bodley, A.1
Liu, L.F.2
Israel, M.3
Seshadri, R.4
Koseki, Y.5
Giuliani, F.C.6
Kirschenbaum, S.7
Silber, R.8
Potmesil, M.9
-
115
-
-
0027381810
-
When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs
-
Corbett, A. H.; Osheroff, N. When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs. Chem. Res. Toxicol. 1993, 6, 585-597.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 585-597
-
-
Corbett, A.H.1
Osheroff, N.2
-
116
-
-
0024853052
-
Topoisomerase-targeting antitumor drugs
-
D'Arpa, P.; Liu, L. F. Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 1989, 989, 163-177.
-
(1989)
Biochim. Biophys. Acta
, vol.989
, pp. 163-177
-
-
D'Arpa, P.1
Liu, L.F.2
-
117
-
-
0023237732
-
DNA topoisomerase II- a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy
-
Glisson, B. S.; Ross, W. E. DNA topoisomerase II- a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy. Pharmacol. Ther. 1987, 32, 89-106.
-
(1987)
Pharmacol. Ther.
, vol.32
, pp. 89-106
-
-
Glisson, B.S.1
Ross, W.E.2
-
118
-
-
0028786985
-
Dexrazoxane for cardiac protection against doxorubicin
-
Anon. Dexrazoxane for cardiac protection against doxorubicin. Med. Lett. Drugs Ther. 1995, 37, 109-111.
-
(1995)
Med. Lett. Drugs Ther.
, vol.37
, pp. 109-111
-
-
-
119
-
-
0029796045
-
The effect of dexrazoxane (ICRF-187) on doxorubicin and daunorubicin-mediated growth inhibition of Chinese hamster ovary (CHO) cells
-
Hasinoff, B. B.; Yalowich, J. C.; Ling, Y.; Buss, J. L. The effect of dexrazoxane (ICRF-187) on doxorubicin and daunorubicin-mediated growth inhibition of Chinese hamster ovary (CHO) cells. Anticancer Drugs 1996, 7, 558-567.
-
(1996)
Anticancer Drugs
, vol.7
, pp. 558-567
-
-
Hasinoff, B.B.1
Yalowich, J.C.2
Ling, Y.3
Buss, J.L.4
-
120
-
-
0021238328
-
Influence of ICRF-159 or ICRF-186 on cytotoxicity of daunorubicin and doxorubicin
-
Supino, R. Influence of ICRF-159 or ICRF-186 on cytotoxicity of daunorubicin and doxorubicin. Tumori 1984, 70, 121-126.
-
(1984)
Tumori
, vol.70
, pp. 121-126
-
-
Supino, R.1
-
121
-
-
0026769687
-
The effects of ICRF-154 in combination with other anticancer agents in vitro
-
Kano, Y.; Narita, T.; Suzuki, K.; Akutsu, M.; Suda, K.; Sakamoto, S ; Miura, Y. The effects of ICRF-154 in combination with other anticancer agents In vitro. Br. J. Cancer 1992, 66, 281-286.
-
(1992)
Br. J. Cancer
, vol.66
, pp. 281-286
-
-
Kano, Y.1
Narita, T.2
Suzuki, K.3
Akutsu, M.4
Suda, K.5
Sakamoto, S.6
Miura, Y.7
-
122
-
-
0022549482
-
Synergistic activity of doxorubicin and bisdioxopiperazine (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) against the murine sarcoma S180 cell line
-
Wadler, S.; Green, M. D ; Muggia, F. M. Synergistic activity of doxorubicin and bisdioxopiperazine (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) against the murine sarcoma S180 cell line. Cancer Res. 1986, 46, 1176-1181.
-
(1986)
Cancer Res.
, vol.46
, pp. 1176-1181
-
-
Wadler, S.1
Green, M.D.2
Muggia, F.M.3
-
123
-
-
0023175218
-
Lethal and sublethal effects of the combination of doxorubicin and the bisdioxopiperazine, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane ICRF-187, on murine sarcoma S180 in vitro
-
Wadler, S.; Green, M. D.; Basch, R.; Muggia, F. M Lethal and sublethal effects of the combination of doxorubicin and the bisdioxopiperazine, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane ICRF-187, on murine sarcoma S180 In vitro. Biochem. Pharmacol. 1987, 36, 1495-1501.
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 1495-1501
-
-
Wadler, S.1
Green, M.D.2
Basch, R.3
Muggia, F.M.4
-
124
-
-
0028939657
-
Bisdioxopiperazine, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane, (ICRF-187), enhances the antiproliferative effect of cisplatin on human ovarian cancer cells
-
Scambia, G.; Bitta, R. D.; Panici, P. B.; De Vincenzo, R.; Contu, G.; Ercoli, A.; Bonanno, G.; Pierelli, L.; Mancuso, S. Bisdioxopiperazine, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane, (ICRF-187), enhances the antiproliferative effect of cisplatin on human ovarian cancer cells. Gynecol. Oncol. 1995, 57, 16-22.
-
(1995)
Gynecol. Oncol.
, vol.57
, pp. 16-22
-
-
Scambia, G.1
Bitta, R.D.2
Panici, P.B.3
De Vincenzo, R.4
Contu, G.5
Ercoli, A.6
Bonanno, G.7
Pierelli, L.8
Mancuso, S.9
-
125
-
-
0028345406
-
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
-
Roca, J.; Ishida, R.; Berger, J. M.; Andoh, T.; Wang, J. C. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc. Natl. Acad. Sci. USA 1994, 91, 1781-1785.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1781-1785
-
-
Roca, J.1
Ishida, R.2
Berger, J.M.3
Andoh, T.4
Wang, J.C.5
-
126
-
-
0029909081
-
The combination of different types of antitumor topoisomerase II inhibitors, ICRF-193 and VP-16, has synergistic and antagonistic effects on cell survival, depending on treatment schedule
-
Ishida, R.; Iwai, M.; Hara, A.; Andoh, T. The combination of different types of antitumor topoisomerase II inhibitors, ICRF-193 and VP-16, has synergistic and antagonistic effects on cell survival, depending on treatment schedule. Anticancer Res. 1996, 16, 2735-2740.
-
(1996)
Anticancer Res.
, vol.16
, pp. 2735-2740
-
-
Ishida, R.1
Iwai, M.2
Hara, A.3
Andoh, T.4
-
127
-
-
0030739460
-
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II
-
Hasinoff, B. B.; Kuschak, T. I.; Creighton, A. M.; Fattman, C. L.; Allan, W. P.; Thampatty, P.; Yalowich, J. C. Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II. Biochem. Pharmacol. 1997, 53, 1843-1853.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1843-1853
-
-
Hasinoff, B.B.1
Kuschak, T.I.2
Creighton, A.M.3
Fattman, C.L.4
Allan, W.P.5
Thampatty, P.6
Yalowich, J.C.7
-
128
-
-
6844234368
-
Modulation of transferrin receptor expression by dexrazoxane (ICRF-187) via activation of iron regulatory protein
-
Weiss, G.; Kastner, S.; Brock, J.; Thaler, J.; Grunewald, K. Modulation of transferrin receptor expression by dexrazoxane (ICRF-187) via activation of iron regulatory protein. Mol. Pharmacol. 1997, 15, 1419-1424.
-
(1997)
Mol. Pharmacol.
, vol.15
, pp. 1419-1424
-
-
Weiss, G.1
Kastner, S.2
Brock, J.3
Thaler, J.4
Grunewald, K.5
-
129
-
-
0014066067
-
Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease
-
Tan, C.; Tasaka, H.; Yu, K. P.; Murphy, M. L.; Karnofsky, D. A. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Cancer 1967, 20, 333-353.
-
(1967)
Cancer
, vol.20
, pp. 333-353
-
-
Tan, C.1
Tasaka, H.2
Yu, K.P.3
Murphy, M.L.4
Karnofsky, D.A.5
-
130
-
-
0015849162
-
A clinicopathologic analysis of adriamycin cardiotoxicity
-
Lefrak, E. A.; Pitha, J.; Rosenheim, S.; Gottlieb, J. A. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 1973, 32, 302-314.
-
(1973)
Cancer
, vol.32
, pp. 302-314
-
-
Lefrak, E.A.1
Pitha, J.2
Rosenheim, S.3
Gottlieb, J.A.4
-
131
-
-
0015337898
-
Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart
-
Herman, E. H.; Mhatre, R. M., Lee, I. P.; Waravdekar, V. S. Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart. Proc. Soc. Exp. Biol. Med. 1972, 140, 234-239.
-
(1972)
Proc. Soc. Exp. Biol. Med.
, vol.140
, pp. 234-239
-
-
Herman, E.H.1
Mhatre, R.M.2
Lee, I.P.3
Waravdekar, V.S.4
-
132
-
-
0015976278
-
Modification of some of the toxic effects of daunomycin (NSC- 82, 151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129, 943)
-
Herman, E. H.; Mhatre, R. M. Modification of some of the toxic effects of daunomycin (NSC- 82, 151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129, 943). Toxicol. Appl. Pharmacol. 1974, 27, 517-526.
-
(1974)
Toxicol. Appl. Pharmacol.
, vol.27
, pp. 517-526
-
-
Herman, E.H.1
Mhatre, R.M.2
-
133
-
-
0018403626
-
Reduction in daunorubicin lethality and myocardial alteration by pretreatment with ICRF-187 in Syrian Golden Hamster
-
Herman, E. H.; Ardalan, B.; Bier, C.; Waravdekar, V. S.; Krop, S. Reduction in daunorubicin lethality and myocardial alteration by pretreatment with ICRF-187 in Syrian Golden Hamster. Cancer. Treat Rep. 1979, 63, 89-92.
-
(1979)
Cancer. Treat Rep.
, vol.63
, pp. 89-92
-
-
Herman, E.H.1
Ardalan, B.2
Bier, C.3
Waravdekar, V.S.4
Krop, S.5
-
134
-
-
0019958081
-
Mitigating effects of ICRF-159 (Razoxane) on a daunomycin-induced cardiomyopathy in mice
-
Fischer, V. W.; LaRose, L. S.; Wang, G. M. Mitigating effects of ICRF-159 (Razoxane) on a daunomycin-induced cardiomyopathy in mice. Drug Chem. Toxicol. 1982, 5, 155-164.
-
(1982)
Drug Chem. Toxicol.
, vol.5
, pp. 155-164
-
-
Fischer, V.W.1
LaRose, L.S.2
Wang, G.M.3
-
135
-
-
0022485754
-
Mitigation of an anthracycline-induced cardiomyopathy by pretreatment with razoxane: A quantitative morphological assessment
-
Fischer, V. W.; Wang, G. M.; Hobart, N. H. Mitigation of an anthracycline-induced cardiomyopathy by pretreatment with razoxane: a quantitative morphological assessment. Virchows Arch. B, Cell Pathol. Incl. Mol. Patriot. 1986, 51, 353-361.
-
(1986)
Virchows Arch. B, Cell Pathol. Incl. Mol. Patriot.
, vol.51
, pp. 353-361
-
-
Fischer, V.W.1
Wang, G.M.2
Hobart, N.H.3
-
136
-
-
0019499956
-
Reduction of daunomycin toxicity by razoxane
-
Wang, G.; Finch, M.; Trevan, D.; Hellman, K. Reduction of daunomycin toxicity by razoxane. Br. J. Cancer 1981, 43, 871-877.
-
(1981)
Br. J. Cancer
, vol.43
, pp. 871-877
-
-
Wang, G.1
Finch, M.2
Trevan, D.3
Hellman, K.4
-
137
-
-
0020615079
-
Reduction by ICRF-187 of acute daunorubicin toxicity in Syrian golden hamsters
-
Herman, E. H.; El-Hage, A. N.; Ferrans, V. J.; Witiak, D. T. Reduction by ICRF-187 of acute daunorubicin toxicity in Syrian golden hamsters. Res. Commun. Chem. Pathol. Pharmacol. 1983, 40, 217-231.
-
(1983)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.40
, pp. 217-231
-
-
Herman, E.H.1
El-Hage, A.N.2
Ferrans, V.J.3
Witiak, D.T.4
-
138
-
-
0019352522
-
Reducton of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits
-
Herman, E. H.; Ferrans, V. J.; Jordan, W.; Ardalan, B. Reducton of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits. Res. Commun. Chem. Pathol. Pharmacol. 1981, 31, 85-97.
-
(1981)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.31
, pp. 85-97
-
-
Herman, E.H.1
Ferrans, V.J.2
Jordan, W.3
Ardalan, B.4
-
139
-
-
0019518585
-
Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187)
-
Herman, E. H.; Ferrans, V. J. Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187). Cancer Res. 1981, 41, 3436-3440.
-
(1981)
Cancer Res.
, vol.41
, pp. 3436-3440
-
-
Herman, E.H.1
Ferrans, V.J.2
-
140
-
-
0020568774
-
Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine
-
Herman, E. H.; Ferrans, V. J. Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine. Lab. Invest. 1983, 49, 69-77.
-
(1983)
Lab. Invest.
, vol.49
, pp. 69-77
-
-
Herman, E.H.1
Ferrans, V.J.2
-
141
-
-
0021812284
-
Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters
-
Herman, E. H.; El-Hage, A. N.; Creighton, A. M.; Witiak, D. T.; Ferrans, V. J. Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters. Res. Commun. Chem. Pathol. Pharmacol. 1985, 48, 39-55.
-
(1985)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.48
, pp. 39-55
-
-
Herman, E.H.1
El-Hage, A.N.2
Creighton, A.M.3
Witiak, D.T.4
Ferrans, V.J.5
-
142
-
-
0020470584
-
Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig
-
Perkins, W. E.; Schroeder, R. L.; Carrano, R. A.; Imondi, A. R. Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig. Br. J. Cancer 1982, 46, 662-667.
-
(1982)
Br. J. Cancer
, vol.46
, pp. 662-667
-
-
Perkins, W.E.1
Schroeder, R.L.2
Carrano, R.A.3
Imondi, A.R.4
-
143
-
-
0025193832
-
Rote of (±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) in modulating free radical scavenging enzymes in doxorubicin-induced cardiomyopathy
-
Alderton, P.; Gross, J.; Green, M. D. Rote of (±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) in modulating free radical scavenging enzymes in doxorubicin-induced cardiomyopathy. Cancer Res. 1990, 50, 5136-5142.
-
(1990)
Cancer Res.
, vol.50
, pp. 5136-5142
-
-
Alderton, P.1
Gross, J.2
Green, M.D.3
-
144
-
-
0029887798
-
Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. A new model to test potential protectors
-
van Acker, S. A.; Kramer, K.; Voest, E. E.; Grimbergen, J. A.; Zhang, J.; van der Vijgh, W. J.; Bast, A. Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. A new model to test potential protectors. Cancer Chemother. Pharmacol. 1996, 38, 95-101.
-
(1996)
Cancer Chemother. Pharmacol.
, vol.38
, pp. 95-101
-
-
Van Acker, S.A.1
Kramer, K.2
Voest, E.E.3
Grimbergen, J.A.4
Zhang, J.5
Van Der Vijgh, W.J.6
Bast, A.7
-
145
-
-
0020664867
-
Inhibition of cardiotoxic, nephrotoxic and neurotoxic effects of doxorubicin by ICRF-159
-
Hu, S. T.; Brandle, E.; Zhinden, G. Inhibition of cardiotoxic, nephrotoxic and neurotoxic effects of doxorubicin by ICRF-159. Pharmacology 1983, 26, 210-220.
-
(1983)
Pharmacology
, vol.26
, pp. 210-220
-
-
Hu, S.T.1
Brandle, E.2
Zhinden, G.3
-
146
-
-
6844235405
-
ICRF-187 prevents ECG alterations induced by doxorubicin treatment in the rat
-
Bernardini, N.; Danesi, R.; Macchiarini, P.; Del Tacca, M. ICRF-187 prevents ECG alterations induced by doxorubicin treatment in the rat. Proc. Am. Assoc. Cancer Res. 1990, 37, 443.
-
(1990)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 443
-
-
Bernardini, N.1
Danesi, R.2
Macchiarini, P.3
Del Tacca, M.4
-
147
-
-
0021814289
-
Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats
-
Herman, E. H.; el-Hage, A. N.; Ardalan, B. Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats. Toxicol. Appl Pharmacol. 1985, 78, 202-214.
-
(1985)
Toxicol. Appl Pharmacol.
, vol.78
, pp. 202-214
-
-
Herman, E.H.1
El-Hage, A.N.2
Ardalan, B.3
-
148
-
-
0023873326
-
Protective effect of ICRF-187 on doxorubicin- induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats
-
Herman, E. H.; El-Hage, A.; Ferrans, V. J. Protective effect of ICRF-187 on doxorubicin- induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Toxicol. Appl. Pharmacol. 1988, 92, 42-53.
-
(1988)
Toxicol. Appl. Pharmacol.
, vol.92
, pp. 42-53
-
-
Herman, E.H.1
El-Hage, A.2
Ferrans, V.J.3
-
149
-
-
0027751913
-
Dendritic cells in the hearts of spontaneously hypertensive rats treated with doxorubicin with or without ICRF-187
-
Zhang, J.; Herman, E. H.; Ferrans, V. J. Dendritic cells in the hearts of spontaneously hypertensive rats treated with doxorubicin with or without ICRF-187. Am. J. Pathol. 1993, 142, 1916-1926.
-
(1993)
Am. J. Pathol.
, vol.142
, pp. 1916-1926
-
-
Zhang, J.1
Herman, E.H.2
Ferrans, V.J.3
-
150
-
-
0022620588
-
Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits
-
Herman, E. H.; Ferrans, V. J. Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits. Cancer Chemother. Pharmacol. 1986, 16, 102-106.
-
(1986)
Cancer Chemother. Pharmacol.
, vol.16
, pp. 102-106
-
-
Herman, E.H.1
Ferrans, V.J.2
-
151
-
-
0025174962
-
Effect of ICRF-187 pretreatment against doxorubicin-induced delayed cardiotoxicity in the rat
-
Villani, F.; Galimberti, M.; Monti, E.; Cova, D.; Lanza, E.; Rozza-Dionigi, A.; Favalli, L.; Poggi, P. Effect of ICRF-187 pretreatment against doxorubicin-induced delayed cardiotoxicity in the rat Toxicol. Appl. Pharmacol. 1990, 102, 292-299.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.102
, pp. 292-299
-
-
Villani, F.1
Galimberti, M.2
Monti, E.3
Cova, D.4
Lanza, E.5
Rozza-Dionigi, A.6
Favalli, L.7
Poggi, P.8
-
152
-
-
0026559463
-
The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat
-
Yeung, T. K.; Jaenke, R. S.; Wilding, D.; Creighton, A. M.; Hopewell, J. W. The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat. Cancer Chemother. Pharmacol 1992, 30, 58-64.
-
(1992)
Cancer Chemother. Pharmacol
, vol.30
, pp. 58-64
-
-
Yeung, T.K.1
Jaenke, R.S.2
Wilding, D.3
Creighton, A.M.4
Hopewell, J.W.5
-
153
-
-
0029790879
-
Long-lasting effects of dexrazoxane against anthracacyline cardiotoxicity in rats
-
Torre, P. D.; Popesta, A.; Pinciroli, G. Long-lasting effects of dexrazoxane against anthracacyline cardiotoxicity in rats. Toxicol. Pathol, 1996, 24, 398-402.
-
(1996)
Toxicol. Pathol
, vol.24
, pp. 398-402
-
-
Torre, P.D.1
Popesta, A.2
Pinciroli, G.3
-
154
-
-
0027181374
-
Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity
-
Herman, E. H.; Ferrans, V. J. Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity. Cancer Chemother. Pharmacol. 1993, 32, 445-449.
-
(1993)
Cancer Chemother. Pharmacol.
, vol.32
, pp. 445-449
-
-
Herman, E.H.1
Ferrans, V.J.2
-
155
-
-
0026545346
-
Reducing doxorubicin toxocity in rat using deferred treatment with ADR-529
-
Agen, C.; Bernardini, N.; Danesi, R.; Torre, P. D.; Costa, M.; Tacca, M. D. Reducing doxorubicin toxocity in rat using deferred treatment with ADR-529. Cancer Chemother. Pharmacol. 1992, 30, 95-99.
-
(1992)
Cancer Chemother. Pharmacol.
, vol.30
, pp. 95-99
-
-
Agen, C.1
Bernardini, N.2
Danesi, R.3
Torre, P.D.4
Costa, M.5
Tacca, M.D.6
-
156
-
-
0023771921
-
Examination of minoxidil-induced acute cardiotoxicity in miniature swine
-
Herman, E. H.; Ferrans, V. J.; Young, R. S.; Balazs, T. Examination of minoxidil-induced acute cardiotoxicity in miniature swine. Toxicol. 1988, 48, 41-51.
-
(1988)
Toxicol.
, vol.48
, pp. 41-51
-
-
Herman, E.H.1
Ferrans, V.J.2
Young, R.S.3
Balazs, T.4
-
157
-
-
0024519069
-
Effects of ICRF-187 on the cardiac and renal toxicity of epirubicin in spontaneously hypertensive rats
-
Dardir, M.; Herman, E. H.; Ferrans, V. J. Effects of ICRF-187 on the cardiac and renal toxicity of epirubicin in spontaneously hypertensive rats. Cancer Chemother. Pharmacol. 1989, 23, 269-275.
-
(1989)
Cancer Chemother. Pharmacol.
, vol.23
, pp. 269-275
-
-
Dardir, M.1
Herman, E.H.2
Ferrans, V.J.3
-
158
-
-
0344277294
-
Cardioprotective activity of ADR-529 for daunorubicin and idarubicin
-
Verhoef, V.; Colborn, D.; Bell, V.; Filppi, J. Cardioprotective activity of ADR-529 for daunorubicin and idarubicin. Proc. Am. Assoc. Cancer Res. 1990, 31, 404.
-
(1990)
Proc. Am. Assoc. Cancer Res.
, vol.31
, pp. 404
-
-
Verhoef, V.1
Colborn, D.2
Bell, V.3
Filppi, J.4
-
159
-
-
0026575694
-
Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model
-
Alderton, P. M.; Gross, J.; Green, M. D. Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model. Cancer Res. 1992, 52, 194-201.
-
(1992)
Cancer Res.
, vol.52
, pp. 194-201
-
-
Alderton, P.M.1
Gross, J.2
Green, M.D.3
-
160
-
-
0026465662
-
Prevention of doxorubicin-induced nyocardial and haematological toxicities in rats by the iron chelator desferrioxamine
-
Al-Harbi, M. M.; Al-Gharably, N. M.; Al-Shabanah, O. A.; Al-Bekairi, A. M.; Osman, A. M. M.; Tawfik, H. N. Prevention of doxorubicin-induced nyocardial and haematological toxicities in rats by the iron chelator desferrioxamine. Cancer Chemother. Pharmacol. 1992, 31, 200-204.
-
(1992)
Cancer Chemother. Pharmacol.
, vol.31
, pp. 200-204
-
-
Al-Harbi, M.M.1
Al-Gharably, N.M.2
Al-Shabanah, O.A.3
Al-Bekairi, A.M.4
Osman, A.M.M.5
Tawfik, H.N.6
-
161
-
-
0028025390
-
Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity
-
Voest, E. E.; van Acker, A. B. E.; van Vijgh, W. J. F.; van Asbeck, B. S.; Bast, A. Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity. J. Mol. Cell Cardiol. 1994, 26, 1179-1185.
-
(1994)
J. Mol. Cell Cardiol.
, vol.26
, pp. 1179-1185
-
-
Voest, E.E.1
Van Acker, A.B.E.2
Van Vijgh, W.J.F.3
Van Asbeck, B.S.4
Bast, A.5
-
162
-
-
0028080144
-
Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats
-
Herman, E. H.; Zhang, J.; Ferrans, V. J. Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats. Cancer Chemother. Pharmacol. 1994, 35, 93-100.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.35
, pp. 93-100
-
-
Herman, E.H.1
Zhang, J.2
Ferrans, V.J.3
-
163
-
-
84912885593
-
ICRF-197
-
Yeung, T. K.; Jeffery, W. A.; Long, J.; Wilding, D.; Hopewell, J. W.; Creighton, A. M. ICRF-197: Ann. Oncol. 1992, 3 (Supp. 1), 114
-
(1992)
Ann. Oncol.
, vol.3
, Issue.1 SUPPL.
, pp. 114
-
-
Yeung, T.K.1
Jeffery, W.A.2
Long, J.3
Wilding, D.4
Hopewell, J.W.5
Creighton, A.M.6
-
164
-
-
0027991980
-
Effects of ICRF-186 [(L)1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] on the toxicity of doxorubicin in spontaneously hypertensive rats
-
Zhang, J.; Herman, E.H.; Ferrans, V. Effects of ICRF-186 [(L)1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] on the toxicity of doxorubicin in spontaneously hypertensive rats. Toxicol. 1994, 92, 179-192.
-
(1994)
Toxicol.
, vol.92
, pp. 179-192
-
-
Zhang, J.1
Herman, E.H.2
Ferrans, V.3
-
165
-
-
0000137504
-
-
Muggia, F. M.; Green, M. D.; Speyer, J. L., Eds.; John Hopkins University Press: Baltimore
-
Herman, E. H.; Ferrans, V. J.; Sanchez, J. A. In Cancer Treatment and the
-
(1992)
Cancer Treatment and the Heart
, pp. 114-170
-
-
Herman, E.H.1
Ferrans, V.J.2
Sanchez, J.A.3
-
166
-
-
0025082723
-
Role of oxygen radicals in adriamycin-induced nephrosis
-
Wu, S. H.; Yang, Y. C.; Wang, Z. M. Role of oxygen radicals in adriamycin-induced nephrosis. Chin. Med. J. (Engl) 1990, 103, 283-289.
-
(1990)
Chin. Med. J. (Engl)
, vol.103
, pp. 283-289
-
-
Wu, S.H.1
Yang, Y.C.2
Wang, Z.M.3
-
167
-
-
0023812739
-
Cell death by apoptosis following X-irradiation of the foetal and neonatal rat Kidney
-
Gobe, G. C.; Axelsen, R. A.; Harmon, B. V.; Allan, D. J. Cell death by apoptosis following X-irradiation of the foetal and neonatal rat Kidney. Int. J. Rad. Biol. 1996, 54, 567-576.
-
(1996)
Int. J. Rad. Biol.
, vol.54
, pp. 567-576
-
-
Gobe, G.C.1
Axelsen, R.A.2
Harmon, B.V.3
Allan, D.J.4
-
168
-
-
0030248675
-
Doxorubicin-induced apoptosis in spontaneously hypertensive rats: Differential effects in heart, kidney and intestine, and inhibition by ICRF-187
-
Zhang, J.; Clark, J. R.; Herman, E. H.; Ferrans, V. J. Doxorubicin-induced apoptosis in spontaneously hypertensive rats: Differential effects in heart, kidney and intestine, and inhibition by ICRF-187. J. Mol. Cell Cardiol. 1996, 28, 1931-1943.
-
(1996)
J. Mol. Cell Cardiol.
, vol.28
, pp. 1931-1943
-
-
Zhang, J.1
Clark, J.R.2
Herman, E.H.3
Ferrans, V.J.4
-
169
-
-
0344741819
-
Effect of the cardioprotective agent ADR-529 (ICRF-187) on the antitumor activity of doxorubicin
-
Verhoef, V.; Bell, V.; Filippi, J. Effect of the cardioprotective agent ADR-529 (ICRF-187) on the antitumor activity of doxorubicin. Proc. Am. Assoc. Cancer Res. 1988, 29, 273.
-
(1988)
Proc. Am. Assoc. Cancer Res.
, vol.29
, pp. 273
-
-
Verhoef, V.1
Bell, V.2
Filippi, J.3
-
170
-
-
0019427078
-
Reduction in the diabetogenic effect of alloxan in mice by treatment with the antineopiastic agent ICRF-187
-
El-Hage, A.; Herman, E. H.; Ferrans, V. J. Reduction in the diabetogenic effect of alloxan in mice by treatment with the antineopiastic agent ICRF-187. Res. Commun. Chem. Pathol. Pharmacol. 1981, 33, 509-523
-
(1981)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.33
, pp. 509-523
-
-
El-Hage, A.1
Herman, E.H.2
Ferrans, V.J.3
-
171
-
-
0021084131
-
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters
-
El-Hage, A. N.; Herman, E. H.; Ferrans, V. J. Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters. Toxicol. 1983, 28, 295-303.
-
(1983)
Toxicol.
, vol.28
, pp. 295-303
-
-
El-Hage, A.N.1
Herman, E.H.2
Ferrans, V.J.3
-
172
-
-
0026701351
-
Effect of ICRF-187 on the pulmonary damage induced by hyperoxia in the rat
-
Fukuda, Y.; Herman, E. H.; Ferrans, V. J. Effect of ICRF-187 on the pulmonary damage induced by hyperoxia in the rat. Toxicol. 1992, 74, 185-202.
-
(1992)
Toxicol.
, vol.74
, pp. 185-202
-
-
Fukuda, Y.1
Herman, E.H.2
Ferrans, V.J.3
-
173
-
-
0029891617
-
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high dose topoisomerase II poisons to CNS tumors
-
Holm, B.; Jensen, P. B.; Sehested, M. ICRF-187 rescue in etoposide treatment In vivo. A model targeting high dose topoisomerase II poisons to CNS tumors. Cancer Chemother. Pharmacol. 1996, 38, 203-209.
-
(1996)
Cancer Chemother. Pharmacol.
, vol.38
, pp. 203-209
-
-
Holm, B.1
Jensen, P.B.2
Sehested, M.3
-
174
-
-
0014683558
-
Control of malignant metastases by ICRF I59
-
Hellmann, K.; Burrage, K. Control of malignant metastases by ICRF I59. Nature 1969, 224, 273-275.
-
(1969)
Nature
, vol.224
, pp. 273-275
-
-
Hellmann, K.1
Burrage, K.2
-
175
-
-
0018139256
-
Effect of chelating agents and metal ions on the degradation of DNA by bleomycin
-
Sausville, E. A.; Peisach, J.; Horwitz, S. B. Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. Biochemistry 1978, 17, 2740-2746.
-
(1978)
Biochemistry
, vol.17
, pp. 2740-2746
-
-
Sausville, E.A.1
Peisach, J.2
Horwitz, S.B.3
-
176
-
-
0024455931
-
ICRF 187 and polyhydroxyphenyl derivatives fail to protect bleomycin induced lung injury
-
Tryka, A. F. ICRF 187 and polyhydroxyphenyl derivatives fail to protect bleomycin induced lung injury. Toxicol 1989, 59, 127-138.
-
(1989)
Toxicol
, vol.59
, pp. 127-138
-
-
Tryka, A.F.1
-
177
-
-
0028915312
-
Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity
-
Herman, E. H.; Hasinoff, B. B.; Zhang, J.; Raley, L. G.; Zhang, T.-M.; Fukada, Y.; Ferrans, V. J. Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity. Toxicol. 1995, 98, 163-175.
-
(1995)
Toxicol.
, vol.98
, pp. 163-175
-
-
Herman, E.H.1
Hasinoff, B.B.2
Zhang, J.3
Raley, L.G.4
Zhang, T.-M.5
Fukada, Y.6
Ferrans, V.J.7
-
178
-
-
0016051485
-
Histological analysis of the antimetastatic effect of (±)-1,2-bis(3,5-dioxopiperazin-1-yl)propane
-
Salsbury, A. J.; Burrage, K.; Hellmann, K. Histological analysis of the antimetastatic effect of (±)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. Cancer Res. 1974, 34, 843-849.
-
(1974)
Cancer Res.
, vol.34
, pp. 843-849
-
-
Salsbury, A.J.1
Burrage, K.2
Hellmann, K.3
-
179
-
-
0015493534
-
Metastases and the normalization of tumour blood vessels by ICRF 159: A new type of drug action
-
Le Serve, A. W.; Hellmann, K. Metastases and the normalization of tumour blood vessels by ICRF 159: a new type of drug action. Br. Med J. 1972, 1, 597-601
-
(1972)
Br. Med J.
, vol.1
, pp. 597-601
-
-
Le Serve, A.W.1
Hellmann, K.2
-
180
-
-
0016826758
-
A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour
-
Peters, L. J. A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour. Br. J. Cancer 1975, 32, 355-365.
-
(1975)
Br. J. Cancer
, vol.32
, pp. 355-365
-
-
Peters, L.J.1
-
181
-
-
6844230387
-
-
Pollard, M ; Burleson, G. R.; Lucker, T. P. The Prostrate 1976, 2, 1.
-
(1976)
The Prostrate
, vol.2
, pp. 1
-
-
Pollard, M.1
Burleson, G.R.2
Lucker, T.P.3
-
182
-
-
0016517272
-
The effect of (±) 1,2-bis(3,5-dioxopiperazin-1-yl) propane (ICRF 159) on liver metastases from a hamster lymphoma
-
Atherton, A. The effect of (±) 1,2-bis(3,5-dioxopiperazin-1-yl) propane (ICRF 159) on liver metastases from a hamster lymphoma. Eur. J. Cancer 1975, 11, 383-388.
-
(1975)
Eur. J. Cancer
, vol.11
, pp. 383-388
-
-
Atherton, A.1
-
183
-
-
0016442471
-
Influence of ICRF 159 and trition WR 1339 on metastases of a rat epithelioma
-
Pimm, M. V.; Baldwin, R. W. Influence of ICRF 159 and trition WR 1339 on metastases of a rat epithelioma. Br. J. Cancer 1975, 31, 62-67.
-
(1975)
Br. J. Cancer
, vol.31
, pp. 62-67
-
-
Pimm, M.V.1
Baldwin, R.W.2
-
184
-
-
0016272055
-
Synergism of ICRF 159 and radiotherapy in experimental tumours
-
Hellmann, K.; Murkin, G. E. Synergism of ICRF 159 and radiotherapy in experimental tumours. Cancer 1974, 34, 1033-1039.
-
(1974)
Cancer
, vol.34
, pp. 1033-1039
-
-
Hellmann, K.1
Murkin, G.E.2
-
185
-
-
0018761370
-
ICRF-159 enhancement of radiation response in combined modality therapies. I. Time/dose relationships for tumour response
-
Kovacs, C. J.; Evans, M. J.; Schenken, L. L.; Burholt, D. R. ICRF-159 enhancement of radiation response in combined modality therapies. I. Time/dose relationships for tumour response. Br. J. Cancer 1979, 39, 516-523.
-
(1979)
Br. J. Cancer
, vol.39
, pp. 516-523
-
-
Kovacs, C.J.1
Evans, M.J.2
Schenken, L.L.3
Burholt, D.R.4
-
186
-
-
0018626233
-
Therapeutic potentiation of combined cis-dichlorodiammineplatinum(II) and irradiation by ICRF-159
-
Kovacs, C. J.; Schenken, L. L.; Burholt, D. R. Therapeutic potentiation of combined cis-dichlorodiammineplatinum(II) and irradiation by ICRF-159. Int. J. Radiat. Oncol. Biol. Phys. 1979, 5, 1361-1364.
-
(1979)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.5
, pp. 1361-1364
-
-
Kovacs, C.J.1
Schenken, L.L.2
Burholt, D.R.3
-
187
-
-
0017389485
-
Changes in sensitivity to radiation and ICRF-159 during the life of monolayer cultures of EMT6 tumour line
-
Taylor, I. W ; Bleehen, N. M. Changes in sensitivity to radiation and ICRF-159 during the life of monolayer cultures of EMT6 tumour line. Br. J. Cancer 1977, 35, 587-594.
-
(1977)
Br. J. Cancer
, vol.35
, pp. 587-594
-
-
Taylor, I.W.1
Bleehen, N.M.2
-
188
-
-
0019951483
-
Interaction of razoxane and radiation on cultured Chinese hamster cells
-
Kimler, B. Interaction of razoxane and radiation on cultured Chinese hamster cells. J. Radiat. Oncol. Biol. Phys. 1982, 8, 1333-1338.
-
(1982)
J. Radiat. Oncol. Biol. Phys.
, vol.8
, pp. 1333-1338
-
-
Kimler, B.1
-
189
-
-
0022457791
-
A comparative study of Ro 03-8799: Racemic mixture and enantiomers
-
Newman, H. F.; Dunphy, E. P.; Bleehen, N. M.; Dische, S.; Saunders, M. I.; Des Rochers, C.; Workman, P.; Lenox-Smith, I.; Smithen, C. E. A comparative study of Ro 03-8799: racemic mixture and enantiomers. Br. J. Radiol. 1986, 59, 997-999.
-
(1986)
Br. J. Radiol.
, vol.59
, pp. 997-999
-
-
Newman, H.F.1
Dunphy, E.P.2
Bleehen, N.M.3
Dische, S.4
Saunders, M.I.5
Des Rochers, C.6
Workman, P.7
Lenox-Smith, I.8
Smithen, C.E.9
-
190
-
-
0027086809
-
Radiotherapeutic enhancement by razoxane
-
Hellmann, K.; Rhomberg, W. Radiotherapeutic enhancement by razoxane. Cancer Treat. Rev. 1991, 18, 225-240.
-
(1991)
Cancer Treat. Rev.
, vol.18
, pp. 225-240
-
-
Hellmann, K.1
Rhomberg, W.2
-
191
-
-
0015189396
-
Blood Cleaner of ICRF-159
-
Field, E. O.; Mauro, F.; Hellmann, K. Blood Cleaner of ICRF-159. Cancer Chemother. Rep. 1971, 55, 527-530.
-
(1971)
Cancer Chemother. Rep.
, vol.55
, pp. 527-530
-
-
Field, E.O.1
Mauro, F.2
Hellmann, K.3
-
192
-
-
0016512729
-
Determination of (±)-1,2-bis(3,5-dioxopiperazinyl)propane plasma levels in rats, rabbits, and humans by glc and mass fragmentography
-
Sadée, W.; Staroscik, J.; Finn, C.; Cohen, J. Determination of (±)-1,2-bis(3,5-dioxopiperazinyl)propane plasma levels in rats, rabbits, and humans by glc and mass fragmentography. J. Pharm. Sci. 1975, 64, 998-1001.
-
(1975)
J. Pharm. Sci.
, vol.64
, pp. 998-1001
-
-
Sadée, W.1
Staroscik, J.2
Finn, C.3
Cohen, J.4
-
193
-
-
6844256457
-
Absorption, distribution and pharmacokinetics of ICRF-187 in dogs
-
Mhatre, R. M.; Tew, K. D.; van Hennik, M. B.; Waravdekar, V. S.; Schein, P. S. Absorption, distribution and pharmacokinetics of ICRF-187 in dogs. Proc. Am. Assoc. Cancer Res. 1983, 24, 290.
-
(1983)
Proc. Am. Assoc. Cancer Res.
, vol.24
, pp. 290
-
-
Mhatre, R.M.1
Tew, K.D.2
Van Hennik, M.B.3
Waravdekar, V.S.4
Schein, P.S.5
-
194
-
-
6844256458
-
Preclinical Pharmacokinetics, disposition and metabolism of ICRF-187
-
McPherson, E.; Archila, R.; Schein, P. S.; Tew, K. D.; Mhatre, R. M. Preclinical Pharmacokinetics, disposition and metabolism of ICRF-187. Proc. Am. Assoc. Cancer Res 1984, 25, 1436.
-
(1984)
Proc. Am. Assoc. Cancer Res
, vol.25
, pp. 1436
-
-
McPherson, E.1
Archila, R.2
Schein, P.S.3
Tew, K.D.4
Mhatre, R.M.5
-
195
-
-
6844244852
-
ADR-529: Disposition of a cardioprotective agent in mice
-
Narang, P. K.; Baldwin, J. R.; Benjamin, E. J.; Bianchine, J. R. ADR-529: disposition of a cardioprotective agent in mice. Pharm. Res. 1988, 5, S189.
-
(1988)
Pharm. Res.
, vol.5
-
-
Narang, P.K.1
Baldwin, J.R.2
Benjamin, E.J.3
Bianchine, J.R.4
-
196
-
-
84916257752
-
Disposition of cardioprotective agent ICRF-187 in rats
-
Baldwin, J. R.; Uhrig, B. A.; Imondi, A.; Narang, P. K. Disposition of cardioprotective agent ICRF-187 in rats. Pharm. Res 1988, 5, 5186.
-
(1988)
Pharm. Res
, vol.5
, pp. 5186
-
-
Baldwin, J.R.1
Uhrig, B.A.2
Imondi, A.3
Narang, P.K.4
-
197
-
-
0026655755
-
Influence of the cardioprotective agent dexrazoxane on doxorubicin pharmacokinetics in the dog
-
Baldwin, J R.; Phillips, B. A.; Overmyer, S. K.; Hatfield, N. Z.; Narang, P. K. Influence of the cardioprotective agent dexrazoxane on doxorubicin pharmacokinetics in the dog. Cancer Chemother. Pharmacol. 1992, 30, 433-438.
-
(1992)
Cancer Chemother. Pharmacol.
, vol.30
, pp. 433-438
-
-
Baldwin, J.R.1
Phillips, B.A.2
Overmyer, S.K.3
Hatfield, N.Z.4
Narang, P.K.5
-
198
-
-
0016737232
-
Enhancement of the effectiveness of daunorubicin (NSC-82151) or Adriamycin (NSC-123127) against early mouse L1210 leukemia with ICRF-159 (NSC-129943)
-
Woodman, R. J.; Cysyk, R. L.; Kline, J.; Gang, M.; Venditti, J. M. Enhancement of the effectiveness of daunorubicin (NSC-82151) or Adriamycin (NSC-123127) against early mouse L1210 leukemia with ICRF-159 (NSC-129943). Cancer Chemother. Rep. 1975, Part 1, 59, 689-695.
-
(1975)
Cancer Chemother. Rep.
, vol.59
, Issue.1 PART
, pp. 689-695
-
-
Woodman, R.J.1
Cysyk, R.L.2
Kline, J.3
Gang, M.4
Venditti, J.M.5
-
199
-
-
0019499901
-
Studies in mice treated with ICRF-159 combined with daunorubicin and doxorubicin
-
Giuliani, F ; Cesazze, A. M.; Dimarco, A.; Savi, G. Studies in mice treated with ICRF-159 combined with daunorubicin and doxorubicin. Cancer. Treat. Rep. 1981, 65, 267-276.
-
(1981)
Cancer. Treat. Rep.
, vol.65
, pp. 267-276
-
-
Giuliani, F.1
Cesazze, A.M.2
Dimarco, A.3
Savi, G.4
-
200
-
-
0025186121
-
Potentiation of doxorubicin cytotoxicity by (+)-1,2-bis-(3,5- Dioxopiperazin-1-yl) propane (ICRF-187) in human leukemic HL-60 cells
-
Monti, E.; Sinha, B. K. Potentiation of doxorubicin cytotoxicity by (+)-1,2-bis-(3,5- dioxopiperazin-1-yl) propane (ICRF-187) in human leukemic HL-60 cells. Cancer Commun. 1990, 2, 145-149.
-
(1990)
Cancer Commun.
, vol.2
, pp. 145-149
-
-
Monti, E.1
Sinha, B.K.2
-
201
-
-
0016168516
-
Preclinical toxicology studies with ICRF-159
-
Gralla, E. J.; Coleman, G. R.; Jonas, A. M. Preclinical toxicology studies with ICRF-159. Cancer Chemother. Rep. 1974, 5, 1-7.
-
(1974)
Cancer Chemother. Rep.
, vol.5
, pp. 1-7
-
-
Gralla, E.J.1
Coleman, G.R.2
Jonas, A.M.3
-
202
-
-
0019298576
-
Preclinical toxicologic evaluation of ICRF-187 in dogs
-
Levine, B. S.; Henry, M. C.; Port, C. D.; Rosen, E. Preclinical toxicologic evaluation of ICRF-187 in dogs. Cancer. Treat Rep. 1980, 64, 1211-1215.
-
(1980)
Cancer. Treat Rep.
, vol.64
, pp. 1211-1215
-
-
Levine, B.S.1
Henry, M.C.2
Port, C.D.3
Rosen, E.4
-
203
-
-
0026585672
-
ICRF-187 permits longer treatment with doxorubicin in women with breast cancer
-
Speyer, J. L.; Green, M. D.; Zeleniuch-Jacquotte, A.; Wernz, J. C.; Rey, M.; Sanger, J.; Kramer, E.; Ferrans, V.; Hochster, H.; Meyers, M.; Blum, R. H.; Feit, F.; Attubato, M.; Burrows, W.; Muggia, F. M. ICRF-187 permits longer treatment with doxorubicin in women with breast cancer. J. Clin. Oncol. 1992, 10, 117-127.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 117-127
-
-
Speyer, J.L.1
Green, M.D.2
Zeleniuch-Jacquotte, A.3
Wernz, J.C.4
Rey, M.5
Sanger, J.6
Kramer, E.7
Ferrans, V.8
Hochster, H.9
Meyers, M.10
Blum, R.H.11
Feit, F.12
Attubato, M.13
Burrows, W.14
Muggia, F.M.15
-
204
-
-
0015070693
-
Use of first generation transplants of a slow growing solid tumor for the evaluation of new cancer chemotherapeutic agents
-
Sandberg, J.; Goldin, A. Use of first generation transplants of a slow growing solid tumor for the evaluation of new cancer chemotherapeutic agents. Cancer Chemother. Rep. 1971, 55, 233-238.
-
(1971)
Cancer Chemother. Rep.
, vol.55
, pp. 233-238
-
-
Sandberg, J.1
Goldin, A.2
-
205
-
-
0017664859
-
Phase II study of dianhydrogalactitol and ICRF-159 in patients with advanced breast cancer previously exposed to cytotoxic chemotherapy
-
Ahmann, D. L.; O'Connell, M. J.; Bisel, H. F.; Edmonson, J. H.; Hahn, R. G.; Frytak, S. Phase II study of dianhydrogalactitol and ICRF-159 in patients with advanced breast cancer previously exposed to cytotoxic chemotherapy. Cancer. Treat Rep. 1977, 61, 81-82.
-
(1977)
Cancer. Treat Rep.
, vol.61
, pp. 81-82
-
-
Ahmann, D.L.1
O'Connell, M.J.2
Bisel, H.F.3
Edmonson, J.H.4
Hahn, R.G.5
Frytak, S.6
-
206
-
-
0018230079
-
Adjuvant treatment with razoxane (ICRF 159) following resection of cancer of the stomach
-
Gilbert, J. M.; Cassell, P.; Ellis, H.; Wastell, C.; Hermon-Taylor, J.; Hellmann, K. Adjuvant treatment with razoxane (ICRF 159) following resection of cancer of the stomach. Recent Results Cancer Res. 1979, 68, 217-221.
-
(1979)
Recent Results Cancer Res.
, vol.68
, pp. 217-221
-
-
Gilbert, J.M.1
Cassell, P.2
Ellis, H.3
Wastell, C.4
Hermon-Taylor, J.5
Hellmann, K.6
-
207
-
-
0017084561
-
ICRF 159 versus polychemotherapy in non-small cell lung cancer
-
Eagan, B. T.; Carr, D. T.; Coles, D. T.; Rubin, J.; Frytak, S. ICRF 159 versus polychemotherapy in non-small cell lung cancer. Cancer. Treat. Rep. 1979, 60, 947-948.
-
(1979)
Cancer. Treat. Rep.
, vol.60
, pp. 947-948
-
-
Eagan, B.T.1
Carr, D.T.2
Coles, D.T.3
Rubin, J.4
Frytak, S.5
-
208
-
-
0022592160
-
Randomized trial of oral adjuvant razoxane (ICRF 159) in resectable colorectal cancer five-year follow-up
-
Gilbert, J. M.; Hellmann, K.; Evans, M.; Cassell, P. G.; Taylor, R. H.; Stoodley, B.; Ellis, H.; Wastell, C. Randomized trial of oral adjuvant razoxane (ICRF 159) in resectable colorectal cancer five-year follow-up. Brit J. Surg. 1986, 73, 446-450.
-
(1986)
Brit J. Surg.
, vol.73
, pp. 446-450
-
-
Gilbert, J.M.1
Hellmann, K.2
Evans, M.3
Cassell, P.G.4
Taylor, R.H.5
Stoodley, B.6
Ellis, H.7
Wastell, C.8
-
209
-
-
0023142734
-
Effect of razoxane on metastases from colorectal cancer
-
Hellmann, K.; Gilbert, J.; Evans, M., Cassell, P.; Taylor, R. Effect of razoxane on metastases from colorectal cancer. Clin. Exp. Metastasis 1987, 5, 3-8.
-
(1987)
Clin. Exp. Metastasis
, vol.5
, pp. 3-8
-
-
Hellmann, K.1
Gilbert, J.2
Evans, M.3
Cassell, P.4
Taylor, R.5
-
210
-
-
84920313493
-
Ultra high dose anthracycline combination therapy with peripheral blood stem cell (PBSC), G-CSF and ADR-529 support
-
Abst 948
-
Langleben, A.; Ahlgren, P.; Burdette-Radoux, S.; et al. Ultra high dose anthracycline combination therapy with peripheral blood stem cell (PBSC), G-CSF and ADR-529 support. Proc. Am. Soe. Clin. Oncol. 1995, 14, Abst 948.
-
(1995)
Proc. Am. Soe. Clin. Oncol.
, vol.14
-
-
Langleben, A.1
Ahlgren, P.2
Burdette-Radoux, S.3
-
211
-
-
0025850827
-
Cardiac toxicity 4 to 20 years after completing anthracycline therapy
-
Steinherz, L. J.; Steinherz, P. G.; Tan, C. T. C.; Heller, G.; Murphy, M. L. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 1991, 266, 1672-1677.
-
(1991)
JAMA
, vol.266
, pp. 1672-1677
-
-
Steinherz, L.J.1
Steinherz, P.G.2
Tan, C.T.C.3
Heller, G.4
Murphy, M.L.5
-
212
-
-
0027169157
-
Cardioprotection by ICRF 187 against high dose anthracycline toxicity in children with malignant disese
-
Bu'Lock, F. A.; Gabriel, H. M.; Oakhill, A.; Mott, M. G.; Martin, R. P. Cardioprotection by ICRF 187 against high dose anthracycline toxicity in children with malignant disese. Br. Heart J. 1993, 70, 185-188.
-
(1993)
Br. Heart J.
, vol.70
, pp. 185-188
-
-
Bu'Lock, F.A.1
Gabriel, H.M.2
Oakhill, A.3
Mott, M.G.4
Martin, R.P.5
-
213
-
-
0030998937
-
Use of ICRF-187 for prevention of anthracycline cardiotoxicity in children: Preliminary results
-
Schiavetti, A.; Castello, M. A.; Versacci, P.; Varrasso, G.; Padula, A.; Ventriglia, F.; Wemer, B.; Colloridi, V. Use of ICRF-187 for prevention of anthracycline cardiotoxicity in children: preliminary results. Pediatr. Hematol. Oncol. 1997, 14, 213-222.
-
(1997)
Pediatr. Hematol. Oncol.
, vol.14
, pp. 213-222
-
-
Schiavetti, A.1
Castello, M.A.2
Versacci, P.3
Varrasso, G.4
Padula, A.5
Ventriglia, F.6
Wemer, B.7
Colloridi, V.8
-
214
-
-
0023605019
-
Mitozantrone therapeutic index improvement by gangliosides
-
Hellmann, K.; Hutchinson, G.; Henry, K. Mitozantrone therapeutic index improvement by gangliosides. Cancer Treat. Rev. 1987, 14, 373-378.
-
(1987)
Cancer Treat. Rev.
, vol.14
, pp. 373-378
-
-
Hellmann, K.1
Hutchinson, G.2
Henry, K.3
-
215
-
-
0029061898
-
Cardiotoxicty and cardioprotection during chemotherapy
-
Hochster, H.; Wasserheit, C.; Speyer, J. Cardiotoxicty and cardioprotection during chemotherapy. Curr. Opin. Oncol. 1995, 7, 304-309.
-
(1995)
Curr. Opin. Oncol.
, vol.7
, pp. 304-309
-
-
Hochster, H.1
Wasserheit, C.2
Speyer, J.3
-
216
-
-
0021075186
-
Razoxane: A review of 6 years' therapy in psoriasis
-
Horton, J. J.; Wells, R. S. Razoxane: a review of 6 years' therapy in psoriasis. Br. J. Dermatol. 1983, 109, 669-673.
-
(1983)
Br. J. Dermatol.
, vol.109
, pp. 669-673
-
-
Horton, J.J.1
Wells, R.S.2
-
217
-
-
0017180464
-
Razoxane (ICRF 159) in psoriasis
-
Atherton, D. J.; Wells, R. S.; Hellmann, K. Razoxane (ICRF 159) in psoriasis [letter]. Lancet 1976, 2, 1296.
-
(1976)
Lancet
, vol.2
, pp. 1296
-
-
Atherton, D.J.1
Wells, R.S.2
Hellmann, K.3
-
218
-
-
0015493534
-
Metastases and the normalization of tumour blood vessels by ICRF 159: A new type of drug action
-
Le Serve, A. W.; Hellmann, K. Metastases and the normalization of tumour blood vessels by ICRF 159: A new type of drug action. Br. Med. J. 1972, 1, 597-601.
-
(1972)
Br. Med. J.
, vol.1
, pp. 597-601
-
-
Le Serve, A.W.1
Hellmann, K.2
-
219
-
-
0027096639
-
Razoxane for Crohn's colitis and non-specific proctitis
-
Kingston, R. D.; Hellmann, K. Razoxane for Crohn's colitis and non-specific proctitis. Br. J. Clin. Pract. 1992, 46, 252-255.
-
(1992)
Br. J. Clin. Pract.
, vol.46
, pp. 252-255
-
-
Kingston, R.D.1
Hellmann, K.2
-
220
-
-
0017761107
-
The effect of certain chelating compounds on the urinary excretion of copper by the rat: Observations on their clinical significance
-
Gibbs, K.; Walshe, J. M. The effect of certain chelating compounds on the urinary excretion of copper by the rat: observations on their clinical significance. Clin. Sci. Mol. Med. 1977, 53, 317-320.
-
(1977)
Clin. Sci. Mol. Med.
, vol.53
, pp. 317-320
-
-
Gibbs, K.1
Walshe, J.M.2
-
221
-
-
0026523567
-
Responses of liver metastases to radiotherapy and razoxane
-
Hellmann, K.; Goold, M; Higgins, N., Phillips, R. H. Responses of liver metastases to radiotherapy and razoxane. J. R. Soc. Med. 1992, 85, 136-138.
-
(1992)
J. R. Soc. Med.
, vol.85
, pp. 136-138
-
-
Hellmann, K.1
Goold, M.2
Higgins, N.3
Phillips, R.H.4
-
222
-
-
0014938009
-
Mode of action of the cytostatic agent 'ICRF 159'
-
Sharpe, H. B. A.; Field, E. O.; Hellmann, K. Mode of action of the cytostatic agent 'ICRF 159'. Nature 1970, 226, 524-526.
-
(1970)
Nature
, vol.226
, pp. 524-526
-
-
Sharpe, H.B.A.1
Field, E.O.2
Hellmann, K.3
|