-
1
-
-
33847026354
-
Autophagy delays apoptotic death in breast Cancer cells following DNA damage
-
Abedin M.J., Wang D., McDonnell M.A., et al. Autophagy delays apoptotic death in breast Cancer cells following DNA damage. Cell Death. Diff. 2006, 14:500-510.
-
(2006)
Cell Death. Diff.
, vol.14
, pp. 500-510
-
-
Abedin, M.J.1
Wang, D.2
McDonnell, M.A.3
-
2
-
-
33749071359
-
Randomized Phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic Cancer
-
Abou-Alfa G.K., Letourneau R., Harker G., et al. Randomized Phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic Cancer. J. Clin. Oncol.; 2006, 24:4441-4447.
-
(2006)
J. Clin. Oncol.;
, vol.24
, pp. 4441-4447
-
-
Abou-Alfa, G.K.1
Letourneau, R.2
Harker, G.3
-
3
-
-
0242610818
-
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ- III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I
-
Antony S., Jayaraman M., Laco G., et al. Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ- III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I. Cancer Res.; 2003, 63:7428-7435.
-
(2003)
Cancer Res.;
, vol.63
, pp. 7428-7435
-
-
Antony, S.1
Jayaraman, M.2
Laco, G.3
-
4
-
-
33747600400
-
Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11diketo- 11H-indeno{1,2-}isoquinoline)-6-propylamino} propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity
-
Antony S., Agama K.K., Miao Z.H., et al. Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11diketo- 11H-indeno{1,2-}isoquinoline)-6-propylamino} propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006, 70:1109-1120.
-
(2006)
Mol Pharmacol.
, vol.70
, pp. 1109-1120
-
-
Antony, S.1
Agama, K.K.2
Miao, Z.H.3
-
5
-
-
0033303826
-
Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin
-
Arimondo P.B., Bailly C., Boutorine A., et al. Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin. C. R. Acad. Sci. III 1999, 322:785-790.
-
(1999)
C. R. Acad. Sci. III
, vol.322
, pp. 785-790
-
-
Arimondo, P.B.1
Bailly, C.2
Boutorine, A.3
-
6
-
-
0034924635
-
Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase Imediated DNA cleavage to a specific site
-
Arimondo P.B., Bailly C., Boutorine A. Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase Imediated DNA cleavage to a specific site. Bioconj. Chem. 2001, 12:501-509.
-
(2001)
Bioconj. Chem.
, vol.12
, pp. 501-509
-
-
Arimondo, P.B.1
Bailly, C.2
Boutorine, A.3
-
7
-
-
0035902786
-
Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands
-
Arimondo P.B., Bailly C., Boutorine A.S. Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands. Angew. Chem. Intl Ed. Engl. 2001, 40:3045-3048.
-
(2001)
Angew. Chem. Intl Ed. Engl.
, vol.40
, pp. 3045-3048
-
-
Arimondo, P.B.1
Bailly, C.2
Boutorine, A.S.3
-
8
-
-
0036479132
-
Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I
-
Arimondo P.B., Boutorine A., Baldeyrou B. Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I. J. Biol. Chem.; 2002, 277:3132-3140.
-
(2002)
J. Biol. Chem.;
, vol.277
, pp. 3132-3140
-
-
Arimondo, P.B.1
Boutorine, A.2
Baldeyrou, B.3
-
9
-
-
0242317688
-
Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin- oligonucleotide conjugates
-
Arimondo P.B., Angenault S., Halby L. Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin- oligonucleotide conjugates. Nucleic Acids Res. 2003, 31:4031-4040.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 4031-4040
-
-
Arimondo, P.B.1
Angenault, S.2
Halby, L.3
-
10
-
-
20144383102
-
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides
-
Arimondo P.B., Laco G.S., Thomas C.J. Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides. Biochemistry 2005, 44:4171-4180.
-
(2005)
Biochemistry
, vol.44
, pp. 4171-4180
-
-
Arimondo, P.B.1
Laco, G.S.2
Thomas, C.J.3
-
11
-
-
33645220275
-
Exploring the cellular activity of camptothecin- triple-helix-forming oligonucleotide conjugates
-
Arimondo P.B., Thomas C.J., Oussedik K. Exploring the cellular activity of camptothecin- triple-helix-forming oligonucleotide conjugates. Mol. Cell.; Biol. 2006, 26:324-333.
-
(2006)
Mol. Cell.; Biol.
, vol.26
, pp. 324-333
-
-
Arimondo, P.B.1
Thomas, C.J.2
Oussedik, K.3
-
12
-
-
0035853295
-
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
-
Arnaudeau C., Lundin C., Helleday T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J. Mol. Biol. 2001, 307:1235-1245.
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 1235-1245
-
-
Arnaudeau, C.1
Lundin, C.2
Helleday, T.3
-
13
-
-
0037212083
-
Homocamptothecins: potent topoisomerase I inhibitors and promising anti-Cancer drugs
-
Bailly C. Homocamptothecins: potent topoisomerase I inhibitors and promising anti-Cancer drugs. Crit. Rev. Oncol. Hematol. 2003, 45:91-108.
-
(2003)
Crit. Rev. Oncol. Hematol.
, vol.45
, pp. 91-108
-
-
Bailly, C.1
-
14
-
-
3142764930
-
Lamellarins, from A to Z: a family of antiCancer marine pyrrole alkaloids
-
Bailly C. Lamellarins, from A to Z: a family of antiCancer marine pyrrole alkaloids. Curr. Med. Chem. AntiCancer Agents 2004, 4:363-378.
-
(2004)
Curr. Med. Chem. AntiCancer Agents
, vol.4
, pp. 363-378
-
-
Bailly, C.1
-
15
-
-
0033598698
-
Homocamptothecin, an E-ring modifi ed camptothecin analog, generates new topoisomerase Imediated DNA breaks
-
Bailly C., Lansiaux A., Dassonneville L., et al. Homocamptothecin, an E-ring modifi ed camptothecin analog, generates new topoisomerase Imediated DNA breaks. Biochemistry 1999, 38:15,556-15,563.
-
(1999)
Biochemistry
, vol.38
, pp. 15556-15563
-
-
Bailly, C.1
Lansiaux, A.2
Dassonneville, L.3
-
16
-
-
33750552551
-
Mechanisms of cellular resistance to camptothecins
-
Beretta G.L., Perego P., Zunino F. Mechanisms of cellular resistance to camptothecins. Curr Med Chem. 2006, 13:3291-3305.
-
(2006)
Curr Med Chem.
, vol.13
, pp. 3291-3305
-
-
Beretta, G.L.1
Perego, P.2
Zunino, F.3
-
17
-
-
33845344031
-
Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring
-
Beretta G.L., Petrangolini G., de Cesare M., et al. Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring. Cancer Res. 2006, 66:10,976-10,982.
-
(2006)
Cancer Res.
, vol.66
, pp. 10976-10982
-
-
Beretta, G.L.1
Petrangolini, G.2
de Cesare, M.3
-
18
-
-
0037413560
-
Synthesis and in vivo anti-tumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin
-
Bhatt R., de Vries P., Tulinsky J. Synthesis and in vivo anti-tumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin. J. Med. Chem.; 2003, 46:190-193.
-
(2003)
J. Med. Chem.;
, vol.46
, pp. 190-193
-
-
Bhatt, R.1
de Vries, P.2
Tulinsky, J.3
-
19
-
-
30544446125
-
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumor growth
-
Bhonde M.R., Hanski M.L., Notter M. Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumor growth. Oncogene; 2006, 25:165-175.
-
(2006)
Oncogene;
, vol.25
, pp. 165-175
-
-
Bhonde, M.R.1
Hanski, M.L.2
Notter, M.3
-
20
-
-
33745714060
-
Inhibition of DNA topoisomerases I and II, and growth inhibition of breast Cancer MCF-7 cells by ouabain, digoxin and proscillaridin A
-
Bielawski K., Winnicka K., Bielawska A. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast Cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. Biol. Pharm. Bull. 2006, 29:1493-1497.
-
(2006)
Biol. Pharm. Bull.
, vol.29
, pp. 1493-1497
-
-
Bielawski, K.1
Winnicka, K.2
Bielawska, A.3
-
21
-
-
33646843583
-
DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis
-
Bhonde M.R., Hanski M.L., Budczies J. DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis. J. Biol. Chem.; 2006, 281:8675-8685.
-
(2006)
J. Biol. Chem.;
, vol.281
, pp. 8675-8685
-
-
Bhonde, M.R.1
Hanski, M.L.2
Budczies, J.3
-
22
-
-
33750564495
-
Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate
-
Binaschi M., Parlani M., Bellarosa D. Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate. AntiCancer Drugs 2006, 17:1119-1126.
-
(2006)
AntiCancer Drugs
, vol.17
, pp. 1119-1126
-
-
Binaschi, M.1
Parlani, M.2
Bellarosa, D.3
-
23
-
-
0033549870
-
Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities
-
Bom D., Curran D.P., Chavan A.J. Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities. J. Med. Chem.; 1999, 42:3018-3022.
-
(1999)
J. Med. Chem.;
, vol.42
, pp. 3018-3022
-
-
Bom, D.1
Curran, D.P.2
Chavan, A.J.3
-
24
-
-
0035137364
-
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro
-
Bowman K.J., Newell D.R., Calvert A.H., Curtin N.J. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br. J. Cancer 2001, 84:106-112.
-
(2001)
Br. J. Cancer
, vol.84
, pp. 106-112
-
-
Bowman, K.J.1
Newell, D.R.2
Calvert, A.H.3
Curtin, N.J.4
-
25
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., Sweeney L.B., Sturgill J.F. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science; 2004, 303:2011-2015.
-
(2004)
Science;
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
-
26
-
-
16244413613
-
Phase II trial of oral rubitecan in previously treated pancreatic Cancer patients
-
Burris H.A., Rivkin S., Reynolds R. Phase II trial of oral rubitecan in previously treated pancreatic Cancer patients. Oncologist 2005, 10:183-190.
-
(2005)
Oncologist
, vol.10
, pp. 183-190
-
-
Burris, H.A.1
Rivkin, S.2
Reynolds, R.3
-
27
-
-
1842640171
-
Synthesis and biochemical properties of E-ring modified luotonin A derivatives
-
Cagir A., Jones S.H., Eisenhauer B.M. Synthesis and biochemical properties of E-ring modified luotonin A derivatives. Bioorg. Med. Chem.; Lett.; 2004, 14:2051-2054.
-
(2004)
Bioorg. Med. Chem.; Lett.;
, vol.14
, pp. 2051-2054
-
-
Cagir, A.1
Jones, S.H.2
Eisenhauer, B.M.3
-
28
-
-
9244251096
-
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma
-
Catley L., Tai Y.T., Shringarpure R. Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma. Cancer Res.; 2004, 64:8746-8753.
-
(2004)
Cancer Res.;
, vol.64
, pp. 8746-8753
-
-
Catley, L.1
Tai, Y.T.2
Shringarpure, R.3
-
29
-
-
2942633704
-
Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory Cancer patients in a Phase I dose escalation study
-
Chatterjee A., Digumarti R., Mamidi R.N. Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory Cancer patients in a Phase I dose escalation study. J. Clin. Pharmacol. 2004, 44:723-736.
-
(2004)
J. Clin. Pharmacol.
, vol.44
, pp. 723-736
-
-
Chatterjee, A.1
Digumarti, R.2
Mamidi, R.N.3
-
30
-
-
20144387082
-
Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory Cancer patients in a bridging Phase I study
-
Chatterjee A., Digumarti R., Katneni K. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory Cancer patients in a bridging Phase I study. J. Clin. Pharmacol. 2005, 45:453-460.
-
(2005)
J. Clin. Pharmacol.
, vol.45
, pp. 453-460
-
-
Chatterjee, A.1
Digumarti, R.2
Katneni, K.3
-
31
-
-
0034509642
-
Kinetics of in vitro hydrolysis of homocamptothecins as measured by fl uorescence
-
Chauvier D., Chourpa I., Bigg D.C.H., Manfait M. Kinetics of in vitro hydrolysis of homocamptothecins as measured by fl uorescence. Ann. NY Acad. Sci.; 2000, 922:314-316.
-
(2000)
Ann. NY Acad. Sci.;
, vol.922
, pp. 314-316
-
-
Chauvier, D.1
Chourpa, I.2
Bigg, D.C.H.3
Manfait, M.4
-
32
-
-
12444272662
-
14-Azacamptothecin: a potent water-soluble topoisomerase I poison
-
Cheng K., Rahier N.J., Eisenhauer B.M. 14-Azacamptothecin: a potent water-soluble topoisomerase I poison. J. Am. Chem. Soc.; 2005, 127:838-839.
-
(2005)
J. Am. Chem. Soc.;
, vol.127
, pp. 838-839
-
-
Cheng, K.1
Rahier, N.J.2
Eisenhauer, B.M.3
-
33
-
-
2542425518
-
Mechanisms of camptothecin resistance by human topoisomerase I mutations
-
Chrencik J.E., Staker B.L., Burgin A.B., Pourquier P., Pommier Y., Stewart L., Redinbo M.R. Mechanisms of camptothecin resistance by human topoisomerase I mutations. J. Mol. Biol. 2004, 339:773-784.
-
(2004)
J. Mol. Biol.
, vol.339
, pp. 773-784
-
-
Chrencik, J.E.1
Staker, B.L.2
Burgin, A.B.3
Pourquier, P.4
Pommier, Y.5
Stewart, L.6
Redinbo, M.R.7
-
34
-
-
1542330612
-
Subcellular localization of the camptothecin analogues, topotecan and gimatecan
-
Croce A.C., Bottiroli G., Supino R. Subcellular localization of the camptothecin analogues, topotecan and gimatecan. Biochem. Pharmacol. 2004, 67:1035-1045.
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 1035-1045
-
-
Croce, A.C.1
Bottiroli, G.2
Supino, R.3
-
35
-
-
1642434056
-
CKD-602. Chong Kun Dang
-
Crul M. CKD-602. Chong Kun Dang. Curr. Opin. Invest. Drug 2003, 4:1455-1459.
-
(2003)
Curr. Opin. Invest. Drug
, vol.4
, pp. 1455-1459
-
-
Crul, M.1
-
36
-
-
0035328584
-
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition
-
Cusack J.C., Liu R., Houston M., et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res.; 2001, 61:3535-3540.
-
(2001)
Cancer Res.;
, vol.61
, pp. 3535-3540
-
-
Cusack, J.C.1
Liu, R.2
Houston, M.3
-
37
-
-
33747475241
-
Synthesis and cytotoxic activity of polyamine analogues of camptothecin
-
Dallavalle S., Giannini G., Alloatti D. Synthesis and cytotoxic activity of polyamine analogues of camptothecin. J. Med. Chem.; 2006, 49:5177-5186.
-
(2006)
J. Med. Chem.;
, vol.49
, pp. 5177-5186
-
-
Dallavalle, S.1
Giannini, G.2
Alloatti, D.3
-
38
-
-
0033198919
-
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
-
d'Amours D., Desnoyers S., d'Silva I., Poirier G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 1999, 342:249-268.
-
(1999)
Biochem. J.
, vol.342
, pp. 249-268
-
-
d'Amours, D.1
Desnoyers, S.2
d'Silva, I.3
Poirier, G.G.4
-
39
-
-
20144370552
-
Randomized trial of two intravenous schedules of the topoisomerase I inhibitor liposomal lurtotecan in women with relapsed epithelial ovarian Cancer: a trial of the national Cancer institute of Canada clinical trials group
-
Dark G.G., Calvert A.H., Grimshaw R. Randomized trial of two intravenous schedules of the topoisomerase I inhibitor liposomal lurtotecan in women with relapsed epithelial ovarian Cancer: a trial of the national Cancer institute of Canada clinical trials group. J. Clin. Oncol.; 2005, 23:1859-1866.
-
(2005)
J. Clin. Oncol.;
, vol.23
, pp. 1859-1866
-
-
Dark, G.G.1
Calvert, A.H.2
Grimshaw, R.3
-
40
-
-
20244372117
-
Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study
-
Daud A., Valkov N., Centeno B. Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study. Clin. Cancer Res.; 2005, 11:3009-3016.
-
(2005)
Clin. Cancer Res.;
, vol.11
, pp. 3009-3016
-
-
Daud, A.1
Valkov, N.2
Centeno, B.3
-
41
-
-
0024536961
-
Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant
-
Davies S.M., Harris A.L., Hickson I.D. Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant. Nucleic Acids Res. 1989, 17:1337-1351.
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 1337-1351
-
-
Davies, S.M.1
Harris, A.L.2
Hickson, I.D.3
-
42
-
-
8444222650
-
Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models
-
de Cesare M., Pratesi G., Veneroni S. Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models. Clin. Cancer Res.; 2004, 10:7357-7364.
-
(2004)
Clin. Cancer Res.;
, vol.10
, pp. 7357-7364
-
-
de Cesare, M.1
Pratesi, G.2
Veneroni, S.3
-
43
-
-
33846486810
-
Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series
-
de Cesare M., Beretta G.L., Tinelli S. Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series. Biochem Pharmacol. 2006, 73:656-664.
-
(2006)
Biochem Pharmacol.
, vol.73
, pp. 656-664
-
-
de Cesare, M.1
Beretta, G.L.2
Tinelli, S.3
-
44
-
-
0035122238
-
The homocamptothecin BN809l5 is a highly potent orally active topoisomerase I poison
-
Demarquay D., Huchet M., Coulomb H. The homocamptothecin BN809l5 is a highly potent orally active topoisomerase I poison. AntiCancer Drugs 2001, 12:9-19.
-
(2001)
AntiCancer Drugs
, vol.12
, pp. 9-19
-
-
Demarquay, D.1
Huchet, M.2
Coulomb, H.3
-
45
-
-
3142686746
-
BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo
-
Demarquay D., Huchet M., Coulomb H. BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo. Cancer Res.; 2004, 64:4942-4949.
-
(2004)
Cancer Res.;
, vol.64
, pp. 4942-4949
-
-
Demarquay, D.1
Huchet, M.2
Coulomb, H.3
-
46
-
-
0037832279
-
Recognition of the DNA minor groove by pyrrole-imidazole polyamides
-
Dervan P.B., Edelson B.S. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr. Opin. Struct. Biol. 2003, 13:284-299.
-
(2003)
Curr. Opin. Struct. Biol.
, vol.13
, pp. 284-299
-
-
Dervan, P.B.1
Edelson, B.S.2
-
47
-
-
0030854371
-
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the anti-tumor drug camptothecin
-
Desai S.D., Liu L.F., Vazquez-Abad D., d'Arpa P. Ubiquitin-dependent destruction of topoisomerase I is stimulated by the anti-tumor drug camptothecin. J. Biol. Chem. 1997, 272:24,159-24,164.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24159-24164
-
-
Desai, S.D.1
Liu, L.F.2
Vazquez-Abad, D.3
d'Arpa, P.4
-
48
-
-
0036131937
-
Synthesis and evaluation of a novel E-ring modifi ed alpha-hydroxy keto ether analogue of camptothecin
-
Du W., Curran D.P., Bevins R.L. Synthesis and evaluation of a novel E-ring modifi ed alpha-hydroxy keto ether analogue of camptothecin. Bioorg. Med. Chem.; 2002, 10:103-110.
-
(2002)
Bioorg. Med. Chem.;
, vol.10
, pp. 103-110
-
-
Du, W.1
Curran, D.P.2
Bevins, R.L.3
-
49
-
-
9644281612
-
Phase II study of OSI211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck. An EORTC New Drug Development Group study
-
and the EORTC-New Drug Development Group/New Drug Development Program
-
Duffaud F., Borner M., Chollet P., et al. Phase II study of OSI211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck. An EORTC New Drug Development Group study. Eur. J. Cancer 2004, 40:2748-2752. and the EORTC-New Drug Development Group/New Drug Development Program.
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 2748-2752
-
-
Duffaud, F.1
Borner, M.2
Chollet, P.3
-
50
-
-
0024433890
-
Synthesis and anti-leukemic activity of (9/)-20-deoxyaminocamptothecin analogues
-
Tokyo
-
Ejima A., Terasawa H., Sugimori M., et al. Synthesis and anti-leukemic activity of (9/)-20-deoxyaminocamptothecin analogues. Chem. Pharm. Bull. 1989, 37:2253-2255. Tokyo.
-
(1989)
Chem. Pharm. Bull.
, vol.37
, pp. 2253-2255
-
-
Ejima, A.1
Terasawa, H.2
Sugimori, M.3
-
51
-
-
0026507242
-
Anti-tumor agents. V. Synthesis and anti-leukemic activity of E-ring-modified (RS)-camptothecin analogues
-
Tokyo
-
Ejima A., Terasawa H., Sugimori M., et al. Anti-tumor agents. V. Synthesis and anti-leukemic activity of E-ring-modified (RS)-camptothecin analogues. Chem. Pharm. Bull. 1992, 40:683-688. Tokyo.
-
(1992)
Chem. Pharm. Bull.
, vol.40
, pp. 683-688
-
-
Ejima, A.1
Terasawa, H.2
Sugimori, M.3
-
52
-
-
33747291417
-
Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin
-
Elban M.A., Sun W., Eisenhauer B.M. Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org. Lett. 2006, 8:3513-3516.
-
(2006)
Org. Lett.
, vol.8
, pp. 3513-3516
-
-
Elban, M.A.1
Sun, W.2
Eisenhauer, B.M.3
-
53
-
-
0024229066
-
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
-
Eng W.K., Faucette L., Johnson R.K., Sternglanz R. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol. 1988, 34:755-760.
-
(1988)
Mol. Pharmacol.
, vol.34
, pp. 755-760
-
-
Eng, W.K.1
Faucette, L.2
Johnson, R.K.3
Sternglanz, R.4
-
54
-
-
0242526064
-
Lamellarin D: a novel potent inhibitor of topoisomerase I
-
Facompré M., Tardy C., Bal-Mahieu C., et al. Lamellarin D: a novel potent inhibitor of topoisomerase I. Cancer Res. 2003, 63:7392-7399.
-
(2003)
Cancer Res.
, vol.63
, pp. 7392-7399
-
-
Facompré, M.1
Tardy, C.2
Bal-Mahieu, C.3
-
55
-
-
0027096415
-
A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
-
Fassberg J., Stella V.J. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J. Pharm. Sci. 1992, 81:676-684.
-
(1992)
J. Pharm. Sci.
, vol.81
, pp. 676-684
-
-
Fassberg, J.1
Stella, V.J.2
-
56
-
-
33749249529
-
Irinotecan in the treatment of colorectal Cancer
-
Fuchs C., Mitchell E.P., Hoff P.M. Irinotecan in the treatment of colorectal Cancer. Cancer Treat. Rev. 2006, 32:491-503.
-
(2006)
Cancer Treat. Rev.
, vol.32
, pp. 491-503
-
-
Fuchs, C.1
Mitchell, E.P.2
Hoff, P.M.3
-
57
-
-
20044379959
-
MEN4901/ T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent anti-tumor activities in a panel of human tumor xenografts in nude mice
-
Fujita F., Koike M., Fujita M. MEN4901/ T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent anti-tumor activities in a panel of human tumor xenografts in nude mice. Clin. Cancer Res. 2005, 11:1650-1657.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1650-1657
-
-
Fujita, F.1
Koike, M.2
Fujita, M.3
-
58
-
-
33646691757
-
P21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine
-
Furuta T., Hayward R.L., Meng L.H. p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. Oncogene 2006, 25:2839-2849.
-
(2006)
Oncogene
, vol.25
, pp. 2839-2849
-
-
Furuta, T.1
Hayward, R.L.2
Meng, L.H.3
-
59
-
-
0037019171
-
Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis
-
Fusaro G., Wang S., Chellappan S. Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. Oncogene 2002, 21:4539-4548.
-
(2002)
Oncogene
, vol.21
, pp. 4539-4548
-
-
Fusaro, G.1
Wang, S.2
Chellappan, S.3
-
60
-
-
0347481379
-
Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling
-
Fusaro G., Dasgupta P., Rastogi S., et al. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J. Biol. Chem. 2003, 278:47,853-47,861.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47853-47861
-
-
Fusaro, G.1
Dasgupta, P.2
Rastogi, S.3
-
61
-
-
20444410402
-
Synthesis and anti-tumor activity of the hexacyclic camptothecin derivatives
-
Gao H., Zhang X., Chen Y. Synthesis and anti-tumor activity of the hexacyclic camptothecin derivatives. Bioorg. Med. Chem.; Lett. 2005, 15:3233-3236.
-
(2005)
Bioorg. Med. Chem.; Lett.
, vol.15
, pp. 3233-3236
-
-
Gao, H.1
Zhang, X.2
Chen, Y.3
-
62
-
-
33644927601
-
P53 in recombination and repair
-
Gatz S.A., Wiesmuller L. p53 in recombination and repair. Cell Death Diff. 2006, 13:1003-1016.
-
(2006)
Cell Death Diff.
, vol.13
, pp. 1003-1016
-
-
Gatz, S.A.1
Wiesmuller, L.2
-
63
-
-
0141455147
-
Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ringmodified camptothecin analogue in adults with solid tumors
-
Gelderblom H., Salazar R., Verweij J. Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ringmodified camptothecin analogue in adults with solid tumors. Clin. Cancer Res. 2003, 9:4101-4107.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4101-4107
-
-
Gelderblom, H.1
Salazar, R.2
Verweij, J.3
-
64
-
-
0042477712
-
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
-
Gilley J., Coffer P.J., Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 2003, 162:613-622.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 613-622
-
-
Gilley, J.1
Coffer, P.J.2
Ham, J.3
-
65
-
-
0036134605
-
Preclinical evaluation of the anti-Cancer activity and toxicity of 9-nitro-20(S)-camptothecin (rubitecan)
-
Giovanella B.C., Stehlin J.S., Hinz H.R. Preclinical evaluation of the anti-Cancer activity and toxicity of 9-nitro-20(S)-camptothecin (rubitecan). Intl J. Oncol. 2002, 20:81-88.
-
(2002)
Intl J. Oncol.
, vol.20
, pp. 81-88
-
-
Giovanella, B.C.1
Stehlin, J.S.2
Hinz, H.R.3
-
66
-
-
9244260553
-
Kinetics of Smac/DIABLO release from mitochondria during apoptosis of MCF-7 breast Cancer cells
-
Gorka M., Godlewski M.M., Gajkowska B. Kinetics of Smac/DIABLO release from mitochondria during apoptosis of MCF-7 breast Cancer cells. Cell Biol. Intl 2004, 28:741-754.
-
(2004)
Cell Biol. Intl
, vol.28
, pp. 741-754
-
-
Gorka, M.1
Godlewski, M.M.2
Gajkowska, B.3
-
67
-
-
0016018735
-
Mappicine, a minor alkaloid from Mappia foetida Miers
-
Govindachari T.R., Ravindranath K.R., Viswanathan N. Mappicine, a minor alkaloid from Mappia foetida Miers. J. Chem. Soc. Perkin Trans. 1974, 11:1215-1217.
-
(1974)
J. Chem. Soc. Perkin Trans.
, vol.11
, pp. 1215-1217
-
-
Govindachari, T.R.1
Ravindranath, K.R.2
Viswanathan, N.3
-
68
-
-
2542449068
-
Enhanced chemosensitivity to irinotecan by RNA interferencemediated down-regulation of the nuclear factorkappaB p65 subunit
-
Guo J., Verma U.N., Gaynor R.B. Enhanced chemosensitivity to irinotecan by RNA interferencemediated down-regulation of the nuclear factorkappaB p65 subunit. Clin. Cancer Res. 2004, 10:3333-3341.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3333-3341
-
-
Guo, J.1
Verma, U.N.2
Gaynor, R.B.3
-
69
-
-
0038149018
-
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
-
É.A.
-
Hautefaye P., Cimetière B., É A., et al. Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin. Bioorg. Med. Chem.; Lett. 2003, 13:2731-2735.
-
(2003)
Bioorg. Med. Chem.; Lett.
, vol.13
, pp. 2731-2735
-
-
Hautefaye, P.1
Cimetière, B.2
-
71
-
-
0024537205
-
Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity
-
Hertzberg R.P., Caranfa M.J., Holden K.G. Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. J. Med. Chem. 1989, 32:715-720.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 715-720
-
-
Hertzberg, R.P.1
Caranfa, M.J.2
Holden, K.G.3
-
72
-
-
0033760496
-
Lack of efficacy of 9-aminocamptothecin in patients with newly diagnosed glioblastoma multiforma and recurrent high-grade astrocytoma
-
Hochberg F., Grossman S.A., Mikkelsen T. Lack of efficacy of 9-aminocamptothecin in patients with newly diagnosed glioblastoma multiforma and recurrent high-grade astrocytoma. Neuro-Oncol. 2002, 2:29-33.
-
(2002)
Neuro-Oncol.
, vol.2
, pp. 29-33
-
-
Hochberg, F.1
Grossman, S.A.2
Mikkelsen, T.3
-
73
-
-
10044219980
-
Biweekly 72-h 9-aminocamptothecin infusion as second- line therapy for ovarian carcinoma: Phase II study of the New York Gynecologic Oncology Group and the Eastern Cooperative Oncology Group
-
Hochster H., Plimack E.R., Runowicz C.D. Biweekly 72-h 9-aminocamptothecin infusion as second- line therapy for ovarian carcinoma: Phase II study of the New York Gynecologic Oncology Group and the Eastern Cooperative Oncology Group. J. Clin. Oncol. 2004, 22:120-126.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 120-126
-
-
Hochster, H.1
Plimack, E.R.2
Runowicz, C.D.3
-
74
-
-
0037079237
-
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin
-
Horie K., Tomida A., Sugimoto Y. SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin. Oncogene 2002, 21:7913-7922.
-
(2002)
Oncogene
, vol.21
, pp. 7913-7922
-
-
Horie, K.1
Tomida, A.2
Sugimoto, Y.3
-
75
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
Hsiang Y.H., Hertzberg R., Hecht S., Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 1985, 260:14,873-14,878.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
76
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hsiang Y.H., Lihou M.G., Liu L.F. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 1989, 49:5077-5082.
-
(1989)
Cancer Res.
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
77
-
-
33750032892
-
CDK2dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
-
Huang H., Regan K.M., Lou Z., et al. CDK2dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 2006, 314:294-297.
-
(2006)
Science
, vol.314
, pp. 294-297
-
-
Huang, H.1
Regan, K.M.2
Lou, Z.3
-
78
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal Cancer
-
Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal Cancer. N. Engl. J. Med. 2004, 350:2335-2342.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
80
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to anti-tumor activity
-
Jaxel C., Kohn K.W., Wani M.C. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to anti-tumor activity. Cancer Res. 1989, 49:1465-1469.
-
(1989)
Cancer Res.
, vol.49
, pp. 1465-1469
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
-
81
-
-
0025719903
-
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin
-
Jaxel C., Capranico G., Kerrigan D., et al. Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. J. Biol. Chem. 1991, 266:20,418-20,423.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 20418-20423
-
-
Jaxel, C.1
Capranico, G.2
Kerrigan, D.3
-
82
-
-
18344413733
-
Synthesis and anti-tumor activity of 7-substituted 20(RS)-camptothecin analogues
-
Jew S.S., Kim H.J., Kim M.G. Synthesis and anti-tumor activity of 7-substituted 20(RS)-camptothecin analogues. Bioorg. Med. Chem. Lett. 1996, 6:845-848.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 845-848
-
-
Jew, S.S.1
Kim, H.J.2
Kim, M.G.3
-
83
-
-
0034630167
-
Induction of apoptosis by Cancer chemotherapy
-
Kaufmann S.H., Earnshaw W.C. Induction of apoptosis by Cancer chemotherapy. Exper. Cell Res. 2000, 256:42-49.
-
(2000)
Exper. Cell Res.
, vol.256
, pp. 42-49
-
-
Kaufmann, S.H.1
Earnshaw, W.C.2
-
84
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the anti-tumor effect of CPT-11
-
Kawato Y., Aonuma M., Hirota Y. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the anti-tumor effect of CPT-11. Cancer Res. 1991, 51:4187-4191.
-
(1991)
Cancer Res.
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
-
85
-
-
0026099599
-
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity
-
Kingsbury W.D., Boehm J.C., Jakas D.R. Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J. Med. Chem. 1991, 34:98-107.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 98-107
-
-
Kingsbury, W.D.1
Boehm, J.C.2
Jakas, D.R.3
-
86
-
-
33645527573
-
Cancer cell mitochondria are direct pro-apoptotic targets for the marine anti-tumor drug lamellarin D
-
Kluza J., Gallego M.A., Loyens A., et al. Cancer cell mitochondria are direct pro-apoptotic targets for the marine anti-tumor drug lamellarin D. Cancer Res. 2006, 66:3177-3187.
-
(2006)
Cancer Res.
, vol.66
, pp. 3177-3187
-
-
Kluza, J.1
Gallego, M.A.2
Loyens, A.3
-
87
-
-
1642527105
-
DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f: potent anti-tumor activities in various murine tumor models
-
Kumazawa E., Ochi Y. DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f: potent anti-tumor activities in various murine tumor models. Cancer Sci. 2004, 95:168-175.
-
(2004)
Cancer Sci.
, vol.95
, pp. 168-175
-
-
Kumazawa, E.1
Ochi, Y.2
-
88
-
-
0033894570
-
Phase II trial of 9-aminocamptothecin in patients with advanced squamous cell head and neck
-
Lad T., Rosen F., Sciortino D., et al. Phase II trial of 9-aminocamptothecin in patients with advanced squamous cell head and neck. Cancer. Invest. New Drugs 2000, 18:261-263.
-
(2000)
Cancer. Invest. New Drugs
, vol.18
, pp. 261-263
-
-
Lad, T.1
Rosen, F.2
Sciortino, D.3
-
89
-
-
0034858967
-
Apoptosis induced by the homocamptothecin antiCancer drug BN80915 in HL-60 cells
-
Lansiaux A., Facompré M., Wattez N., et al. Apoptosis induced by the homocamptothecin antiCancer drug BN80915 in HL-60 cells. Mol. Pharmacol. 2001, 60:450-461.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 450-461
-
-
Lansiaux, A.1
Facompré, M.2
Wattez, N.3
-
90
-
-
0030931517
-
BN80245: an E-ring modifi ed camptothecin with potent antiproliferative and topoisomerase I inhibitory activities
-
Lavergne O., Lesueur-Ginot L., Pla Rodas F., Bigg D.C.H. BN80245: an E-ring modifi ed camptothecin with potent antiproliferative and topoisomerase I inhibitory activities. Bioorg. Med. Chem. 1997, 7:2235-2238.
-
(1997)
Bioorg. Med. Chem.
, vol.7
, pp. 2235-2238
-
-
Lavergne, O.1
Lesueur-Ginot, L.2
Pla Rodas, F.3
Bigg, D.C.H.4
-
91
-
-
0033530146
-
BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II
-
Lavergne O., Harnett J., Rolland A. BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II. Bioorg. Med. Chem.; Lett. 1999, 9:2599-2602.
-
(1999)
Bioorg. Med. Chem.; Lett.
, vol.9
, pp. 2599-2602
-
-
Lavergne, O.1
Harnett, J.2
Rolland, A.3
-
92
-
-
0032585548
-
Homocamptothecins: synthesis and anti-tumor activity of novel E-ring modifi ed camptothecin analogues
-
Lavergne O., Lesueur-Ginot L., Pla Rodas F. Homocamptothecins: synthesis and anti-tumor activity of novel E-ring modifi ed camptothecin analogues. J. Med. Chem. 1998, 41:5410-5419.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5410-5419
-
-
Lavergne, O.1
Lesueur-Ginot, L.2
Pla Rodas, F.3
-
93
-
-
7744226289
-
Novel vitamin E analogue and 9-nitrocamptothecin administered as liposome aerosols decrease syngenic mouse mammary tumor burden and inhibit metastasis
-
Lawson K.A., Anderson K., Snyder R.M., et al. Novel vitamin E analogue and 9-nitrocamptothecin administered as liposome aerosols decrease syngenic mouse mammary tumor burden and inhibit metastasis. Cancer Chemother. Pharmacol. 2004, 54:421-431.
-
(2004)
Cancer Chemother. Pharmacol.
, vol.54
, pp. 421-431
-
-
Lawson, K.A.1
Anderson, K.2
Snyder, R.M.3
-
94
-
-
33750737700
-
New molecular mechanisms of action of camptothecin-type drugs
-
Legarza K., Yang L.X. New molecular mechanisms of action of camptothecin-type drugs. AntiCancer Res. 2006, 26:3301-3305.
-
(2006)
AntiCancer Res.
, vol.26
, pp. 3301-3305
-
-
Legarza, K.1
Yang, L.X.2
-
95
-
-
0033564494
-
Homocamptothecin, an E-ring modifi ed camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and anti-tumor properties
-
Lesueur-Ginot L., Demarquay D., Kiss R. Homocamptothecin, an E-ring modifi ed camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and anti-tumor properties. Cancer Res. 1999, 59:2939-2943.
-
(1999)
Cancer Res.
, vol.59
, pp. 2939-2943
-
-
Lesueur-Ginot, L.1
Demarquay, D.2
Kiss, R.3
-
96
-
-
33748754360
-
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues
-
Li Q., Zu Y., Shi R. Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. Bioorg. Med. Chem. 2006, 14:7175-7182.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 7175-7182
-
-
Li, Q.1
Zu, Y.2
Shi, R.3
-
97
-
-
33745737662
-
Review camptothecin: current perspectives
-
Q.Y.Li, Zu Y.G., Shi R.Z., Yao L.P. Review camptothecin: current perspectives. Curr. Med. Chem. 2006, 13:2021-2039.
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 2021-2039
-
-
Li, Q.Y.1
Zu, Y.G.2
Shi, R.Z.3
Yao, L.P.4
-
98
-
-
0346365368
-
Characterization of ARC-111 as a novel topoisomerase I-targeting anti-Cancer drug
-
Li T.K., Houghton P.J., Desai S.D. Characterization of ARC-111 as a novel topoisomerase I-targeting anti-Cancer drug. Cancer Res. 2003, 63:8400-8407.
-
(2003)
Cancer Res.
, vol.63
, pp. 8400-8407
-
-
Li, T.K.1
Houghton, P.J.2
Desai, S.D.3
-
99
-
-
4944264246
-
Camptothecin, over four decades of surprising findings
-
Lorence A., Nessler C.L. Camptothecin, over four decades of surprising findings. Phytochem. 2004, 65:2735-2749.
-
(2004)
Phytochem.
, vol.65
, pp. 2735-2749
-
-
Lorence, A.1
Nessler, C.L.2
-
100
-
-
33646546660
-
Potent anti-tumor activity of 10-methoxy-9-nitrocamptothecin
-
Luo P., He Q., He X. Potent anti-tumor activity of 10-methoxy-9-nitrocamptothecin. Mol. Cancer Ther. 2006, 5:962-968.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 962-968
-
-
Luo, P.1
He, Q.2
He, X.3
-
101
-
-
1242339684
-
Poly(ADPribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing
-
Malanga M., Althaus F.R. Poly(ADPribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing. J. Biol. Chem. 2004, 279:5244-5248.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5244-5248
-
-
Malanga, M.1
Althaus, F.R.2
-
102
-
-
33644970269
-
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
-
Marchand C., Antony S., Kohn K.W. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol. Cancer Ther. 2006, 5:287-295.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 287-295
-
-
Marchand, C.1
Antony, S.2
Kohn, K.W.3
-
103
-
-
20144369676
-
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure activity relationships
-
Marco E., Laine W., Tardy C. Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure activity relationships. J. Med. Chem. 2005, 48:3796-3807.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3796-3807
-
-
Marco, E.1
Laine, W.2
Tardy, C.3
-
104
-
-
2642579273
-
Pharmacokinetics of DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f, in tumor-bearing mice
-
Masubuchi N. Pharmacokinetics of DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f, in tumor-bearing mice. Pharmazie 2004, 59:374-377.
-
(2004)
Pharmazie
, vol.59
, pp. 374-377
-
-
Masubuchi, N.1
-
105
-
-
0030878687
-
Sequence specific targeting of duplex DNA using a camptothecin-triple helix forming oligonucleotide conjugate and topoisomerase I
-
Matteucci M., Lin K.Y., Huang T. Sequence specific targeting of duplex DNA using a camptothecin-triple helix forming oligonucleotide conjugate and topoisomerase I. J. Am. Chem. Soc. 1997, 119:6939-6940.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 6939-6940
-
-
Matteucci, M.1
Lin, K.Y.2
Huang, T.3
-
106
-
-
12944259142
-
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors
-
Megonigal M.D., Cheung N.K., Rappaport E.F., et al. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. Proc. Natl Acad. Sci. USA 2000, 97:2814-2819.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2814-2819
-
-
Megonigal, M.D.1
Cheung, N.K.2
Rappaport, E.F.3
-
108
-
-
0028844445
-
Reduced albumin binding promotes the stability and activity of topotecan in human blood
-
Mi Z., Malak H., Burke T.G. Reduced albumin binding promotes the stability and activity of topotecan in human blood. Biochemistry 1995, 34:13,722-13,728.
-
(1995)
Biochemistry
, vol.34
, pp. 13722-13728
-
-
Mi, Z.1
Malak, H.2
Burke, T.G.3
-
109
-
-
0030966954
-
Sensitization of Cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity
-
Micheau O., Solary E., Hammann A., et al. Sensitization of Cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity. J. Natl Cancer Inst. 1997, 89:783-789.
-
(1997)
J. Natl Cancer Inst.
, vol.89
, pp. 783-789
-
-
Micheau, O.1
Solary, E.2
Hammann, A.3
-
110
-
-
0037349289
-
P53 has a direct apoptogenic role at the mitochondria
-
Mihara M., Erster S., Zaika A. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell. 2003, 11:577-590.
-
(2003)
Mol. Cell.
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
-
111
-
-
0242588748
-
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
-
Miknyoczki S.J., Jones-Bolin S., Pritchard S. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol. Cancer Ther. 2003, 2:371-382.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 371-382
-
-
Miknyoczki, S.J.1
Jones-Bolin, S.2
Pritchard, S.3
-
112
-
-
18844391011
-
Phase II trial of karenitecin in patients with relapsed or refractory non-small cell lung Cancer (CALGB 30004)
-
Miller A.A., Herndon J.E., Gub L., Green M.R. Phase II trial of karenitecin in patients with relapsed or refractory non-small cell lung Cancer (CALGB 30004). Lung Cancer 2005, 48:399-407.
-
(2005)
Lung Cancer
, vol.48
, pp. 399-407
-
-
Miller, A.A.1
Herndon, J.E.2
Gub, L.3
Green, M.R.4
-
113
-
-
10044237834
-
Phase II evaluation of 9-aminocamptothecin (9- AC, NSC 603071) in platinum-resistant ovarian and primary peritoneal carcinoma: a Gynecologic Oncology Group study
-
Miller D.S., Blessing J.A., Waggoner S. Phase II evaluation of 9-aminocamptothecin (9- AC, NSC 603071) in platinum-resistant ovarian and primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol. Oncol. 2005, 96:67-71.
-
(2005)
Gynecol. Oncol.
, vol.96
, pp. 67-71
-
-
Miller, D.S.1
Blessing, J.A.2
Waggoner, S.3
-
114
-
-
0029150444
-
A new water-soluble camptothecin derivative, DX-8951f, exhibits potent anti-tumor activity against human tumors in vitro and in vivo
-
Mitsui I., Kumazawa E., Hirota Y. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent anti-tumor activity against human tumors in vitro and in vivo. Jpn J. Cancer Res. 1995, 86:776-782.
-
(1995)
Jpn J. Cancer Res.
, vol.86
, pp. 776-782
-
-
Mitsui, I.1
Kumazawa, E.2
Hirota, Y.3
-
115
-
-
0037169534
-
Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein
-
Mo Y.Y., Yu Y., Shen Z., Beck W.T. Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein. J. Biol. Chem. 2002, 277:2958-2964.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2958-2964
-
-
Mo, Y.Y.1
Yu, Y.2
Shen, Z.3
Beck, W.T.4
-
116
-
-
0015291595
-
Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal Cancer
-
Moertel C.G., Schutt A.J., Reitemeier R.J., Hahn R.G. Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal Cancer. Cancer Chemother. Rep. 1972, 56:95-101.
-
(1972)
Cancer Chemother. Rep.
, vol.56
, pp. 95-101
-
-
Moertel, C.G.1
Schutt, A.J.2
Reitemeier, R.J.3
Hahn, R.G.4
-
117
-
-
33845955224
-
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor
-
Morrell A., Antony S., Kohlhagen G. A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor. J. Med. Chem. 2006, 49:7740-7753.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7740-7753
-
-
Morrell, A.1
Antony, S.2
Kohlhagen, G.3
-
118
-
-
0029738086
-
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
-
Morris E.J., Geller H.M. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J. Cell Biol. 1996, 134:757-770.
-
(1996)
J. Cell Biol.
, vol.134
, pp. 757-770
-
-
Morris, E.J.1
Geller, H.M.2
-
119
-
-
0015378084
-
Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies
-
Muggia F.M., Creaven P.J., Hansen H.H. Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies. Cancer Chemother. Rep. 1972, 56:515-521.
-
(1972)
Cancer Chemother. Rep.
, vol.56
, pp. 515-521
-
-
Muggia, F.M.1
Creaven, P.J.2
Hansen, H.H.3
-
120
-
-
33747470312
-
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
-
Nagarajan M., Morrell A., Antony S. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors. J. Med. Chem. 2006, 49:5129-5140.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 5129-5140
-
-
Nagarajan, M.1
Morrell, A.2
Antony, S.3
-
121
-
-
33750142705
-
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles
-
Nagarajan M., Morrell A., Ioanoviciu A. Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles. J. Med. Chem. 2006, 49:6283-6289.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6283-6289
-
-
Nagarajan, M.1
Morrell, A.2
Ioanoviciu, A.3
-
122
-
-
0025219608
-
Plant anti-tumor agents
-
Nicholas A.W., Wani M.C., Manikumar G. Plant anti-tumor agents. 29, Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. J. Med. Chem. 1990, 33:972-978.
-
(1990)
29, Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. J. Med. Chem.
, vol.33
, pp. 972-978
-
-
Nicholas, A.W.1
Wani, M.C.2
Manikumar, G.3
-
123
-
-
21344446130
-
Gimatecan (sigmatau industrie farmaceutiche riunite/novartis)
-
Nitiss J.L., Nitiss K.C. Gimatecan (sigmatau industrie farmaceutiche riunite/novartis). IDrugs 2005, 8:578-588.
-
(2005)
IDrugs
, vol.8
, pp. 578-588
-
-
Nitiss, J.L.1
Nitiss, K.C.2
-
124
-
-
0000536643
-
DNA topoisomerasetargeting anti-tumor drugs can be studied in yeast
-
Nitiss J.L., Wang J.C. DNA topoisomerasetargeting anti-tumor drugs can be studied in yeast. Proc. Natl Acad. Sci. USA 1988, 85:7501-7505.
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 7501-7505
-
-
Nitiss, J.L.1
Wang, J.C.2
-
125
-
-
15044344371
-
A possible mechanism for the long-lasting anti-tumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951
-
Ochi Y., Shiose Y., Kumazawa E. A possible mechanism for the long-lasting anti-tumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951. Cancer Chemother. Pharmacol. 2005, 55:323-332.
-
(2005)
Cancer Chemother. Pharmacol.
, vol.55
, pp. 323-332
-
-
Ochi, Y.1
Shiose, Y.2
Kumazawa, E.3
-
126
-
-
24144457231
-
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy
-
Onishi H., Machida Y. Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy. Curr. Drug Discov. Technol. 2005, 1:169-183.
-
(2005)
Curr. Drug Discov. Technol.
, vol.1
, pp. 169-183
-
-
Onishi, H.1
Machida, Y.2
-
127
-
-
39049182648
-
Exatecan and gemcitabine: no better than gemcitabine only
-
Owen O.G. Exatecan and gemcitabine: no better than gemcitabine only. Lancet Oncol. 2006, 7:891.
-
(2006)
Lancet Oncol.
, vol.7
, pp. 891
-
-
Owen, O.G.1
-
128
-
-
18644376106
-
Caspase- and mitochondrial dysfunctiondependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis
-
Paquet C., Sane A.T., Beauchemin M., Bertrand R. Caspase- and mitochondrial dysfunctiondependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis. Leukemia 2005, 19:784-791.
-
(2005)
Leukemia
, vol.19
, pp. 784-791
-
-
Paquet, C.1
Sane, A.T.2
Beauchemin, M.3
Bertrand, R.4
-
129
-
-
0030856927
-
Phase II trial of 9-aminocamptothecin administered as a 72-h continuous infusion in metastatic colorectal carcinoma
-
Pazdur R., Diaz-Canton E., Ballard W.P. Phase II trial of 9-aminocamptothecin administered as a 72-h continuous infusion in metastatic colorectal carcinoma. J. Clin. Oncol. 1997, 15:2905-2909.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 2905-2909
-
-
Pazdur, R.1
Diaz-Canton, E.2
Ballard, W.P.3
-
130
-
-
0032457859
-
Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-h continuous infusion weekly for three weeks in metastatic colorectal carcinoma
-
Pazdur R., Medgyesy D.C., Winn R.J., et al. Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-h continuous infusion weekly for three weeks in metastatic colorectal carcinoma. Invest. New Drugs 1999, 16:341-346.
-
(1999)
Invest. New Drugs
, vol.16
, pp. 341-346
-
-
Pazdur, R.1
Medgyesy, D.C.2
Winn, R.J.3
-
131
-
-
0034049602
-
Homocamptothecin, an E-ring-modifi ed camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon Cancers obtained from surgery and maintained in vitro under histotypical culture conditions
-
Philippart P., Harper L., Chaboteaux C. Homocamptothecin, an E-ring-modifi ed camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon Cancers obtained from surgery and maintained in vitro under histotypical culture conditions. Clin. Cancer Res. 2000, 6:1557-1562.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1557-1562
-
-
Philippart, P.1
Harper, L.2
Chaboteaux, C.3
-
132
-
-
0029997148
-
Topoisomerase poisons activate the transcription factor NF-kappaB in ACH2 and CEM cells
-
Piret B., Piette J. Topoisomerase poisons activate the transcription factor NF-kappaB in ACH2 and CEM cells. Nucleic Acids Res. 1996, 24:4242-4248.
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 4242-4248
-
-
Piret, B.1
Piette, J.2
-
133
-
-
0034667850
-
A north central Cancer treatment group Phase II trial of 9-aminocamptothecin in previously untreated patients with measurable metastatic colorectal carcinoma
-
Pitot H.C., Knost J.A., Mahoney M.R., et al. A north central Cancer treatment group Phase II trial of 9-aminocamptothecin in previously untreated patients with measurable metastatic colorectal carcinoma. Cancer 2000, 89:1699-1705.
-
(2000)
Cancer
, vol.89
, pp. 1699-1705
-
-
Pitot, H.C.1
Knost, J.A.2
Mahoney, M.R.3
-
134
-
-
33749034730
-
Topoisomerase I inhibitors: camptothecins and beyond
-
Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Natl Rev. Cancer 2006, 6:789-802.
-
(2006)
Natl Rev. Cancer
, vol.6
, pp. 789-802
-
-
Pommier, Y.1
-
135
-
-
0028567795
-
DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region
-
Pommier Y., Poddevin B., Gupta M., Jenkins J. DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region. Biochem. Biophys. Res. Commun. 1994, 205:1601-1609.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.205
, pp. 1601-1609
-
-
Pommier, Y.1
Poddevin, B.2
Gupta, M.3
Jenkins, J.4
-
136
-
-
10744233671
-
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
-
Pommier Y., Redon C., Rao V.A. Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat. Res. 2003, 532:173-203.
-
(2003)
Mutat. Res.
, vol.532
, pp. 173-203
-
-
Pommier, Y.1
Redon, C.2
Rao, V.A.3
-
137
-
-
27744554658
-
Phase I study of weekly polyethylene glycol- camptothecin in patients with advanced solid tumors and lymphomas
-
Posey J.A., Saif M.W., Carlisle R., et al. Phase I study of weekly polyethylene glycol- camptothecin in patients with advanced solid tumors and lymphomas. Clin. Cancer Res. 2005, 11:7866-7871.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 7866-7871
-
-
Posey, J.A.1
Saif, M.W.2
Carlisle, R.3
-
139
-
-
0036898629
-
Pattern of anti-tumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts
-
Pratesi G., de Cesare M., Carenini N. Pattern of anti-tumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts. Clin. Cancer Res. 2002, 8:3904-3909.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3904-3909
-
-
Pratesi, G.1
de Cesare, M.2
Carenini, N.3
-
140
-
-
0037294445
-
Rebeccamycin analogues as anti-Cancer agents
-
Prudhomme M. Rebeccamycin analogues as anti-Cancer agents. Eur. J. Med. Chem. 2003, 38:123-140.
-
(2003)
Eur. J. Med. Chem.
, vol.38
, pp. 123-140
-
-
Prudhomme, M.1
-
141
-
-
15044352473
-
Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison
-
Rahier N.J., Cheng J.C., Gao R. Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison. Org. Lett. 2005, 7:835-837.
-
(2005)
Org. Lett.
, vol.7
, pp. 835-837
-
-
Rahier, N.J.1
Cheng, J.C.2
Gao, R.3
-
142
-
-
33646381128
-
Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism
-
Rastogi S., Joshi B., Fusaro G., Chellappan S. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. J. Biol. Chem. 2006, 281:2951-2959.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2951-2959
-
-
Rastogi, S.1
Joshi, B.2
Fusaro, G.3
Chellappan, S.4
-
143
-
-
0041633807
-
Apoptosis induction in prostate Cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor- related apoptosis-inducing ligand and CPT-11
-
Ray S., Almasan A. Apoptosis induction in prostate Cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor- related apoptosis-inducing ligand and CPT-11. Cancer Res. 2003, 63:4713-4723.
-
(2003)
Cancer Res.
, vol.63
, pp. 4713-4723
-
-
Ray, S.1
Almasan, A.2
-
144
-
-
0032489634
-
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
-
Redinbo M.R., Stewart L., Kuhn P. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science 1998, 279:1504-1513.
-
(1998)
Science
, vol.279
, pp. 1504-1513
-
-
Redinbo, M.R.1
Stewart, L.2
Kuhn, P.3
-
145
-
-
31444457080
-
Nuclear caspase-3 and caspase- 7 activation, and Poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis
-
Rodriguez-Hernandez A., Brea-Calvo G., Fernandez-Ayala D.J. Nuclear caspase-3 and caspase- 7 activation, and Poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Apoptosis 2006, 11:131-139.
-
(2006)
Apoptosis
, vol.11
, pp. 131-139
-
-
Rodriguez-Hernandez, A.1
Brea-Calvo, G.2
Fernandez-Ayala, D.J.3
-
146
-
-
0030667871
-
9- Aminocamptothecin by 72-h continuous intravenous infusion is inactive in the treatment of patients with 5-fl uorouracil-refractory colorectal carcinoma
-
Saltz L.B., Kemeny N.E., Tong W. 9- Aminocamptothecin by 72-h continuous intravenous infusion is inactive in the treatment of patients with 5-fl uorouracil-refractory colorectal carcinoma. Cancer 2000, 80:1727-1732.
-
(2000)
Cancer
, vol.80
, pp. 1727-1732
-
-
Saltz, L.B.1
Kemeny, N.E.2
Tong, W.3
-
147
-
-
0033694728
-
Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells
-
Sanchez-Alcazar J.A., Ault J.G., Khodjakov A., Schneider E. Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells. Cell Death. Diff. 2000, 7:1090-1100.
-
(2000)
Cell Death. Diff.
, vol.7
, pp. 1090-1100
-
-
Sanchez-Alcazar, J.A.1
Ault, J.G.2
Khodjakov, A.3
Schneider, E.4
-
148
-
-
33645087362
-
Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple Cancer models
-
Schluep T., Hwang J., Cheng J. Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple Cancer models. Clin. Cancer Res. 2006, 12:1606-1614.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 1606-1614
-
-
Schluep, T.1
Hwang, J.2
Cheng, J.3
-
149
-
-
1842425347
-
A Phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian Cancer
-
Seiden M.V., Muggia F., Astrow A. A Phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian Cancer. Gynecol. Oncol. 2004, 93:229-232.
-
(2004)
Gynecol. Oncol.
, vol.93
, pp. 229-232
-
-
Seiden, M.V.1
Muggia, F.2
Astrow, A.3
-
150
-
-
12544256413
-
Toxicity of the topoisomerase I inhibitors
-
Seiter K. Toxicity of the topoisomerase I inhibitors. Expert Opin. Drug Safety 2005, 4:45-53.
-
(2005)
Expert Opin. Drug Safety
, vol.4
, pp. 45-53
-
-
Seiter, K.1
-
151
-
-
0033104517
-
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
-
Shao R.G., Cao C.X., Zhang H. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 1999, 18:1397-1406.
-
(1999)
EMBO J.
, vol.18
, pp. 1397-1406
-
-
Shao, R.G.1
Cao, C.X.2
Zhang, H.3
-
152
-
-
28544441999
-
The novel poly(ADP-ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks
-
Smith L.M., Willmore E., Austin C.A., Curtin N.J. The novel poly(ADP-ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin. Cancer Res. 2005, 11:8449-8457.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8449-8457
-
-
Smith, L.M.1
Willmore, E.2
Austin, C.A.3
Curtin, N.J.4
-
153
-
-
0028113185
-
Synthesis of 18-nonanhydrocamptothecin analogs which retain topoisomerase I inhibitory function
-
Snyder L., Shen W., Bornmann W.G., Danishefsky S.J. Synthesis of 18-nonanhydrocamptothecin analogs which retain topoisomerase I inhibitory function. J. Org. Chem. 1994, 59:7033-7037.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 7033-7037
-
-
Snyder, L.1
Shen, W.2
Bornmann, W.G.3
Danishefsky, S.J.4
-
155
-
-
17144371295
-
Structures of three classes of anti-Cancer agents bound to the human topoisomerase I-DNA covalent complex
-
Staker B.L., Feese M.D., Cushman M. Structures of three classes of anti-Cancer agents bound to the human topoisomerase I-DNA covalent complex. J. Med. Chem. 2005, 48:2336-2345.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 2336-2345
-
-
Staker, B.L.1
Feese, M.D.2
Cushman, M.3
-
158
-
-
0032543522
-
Synthesis and anti-tumor activity of ring A- and F-modified hexacyclic camptothecin analogues
-
Sugimori M., Ejima A., Ohsuki S. Synthesis and anti-tumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J. Med. Chem. 1998, 41:2308-2318.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2308-2318
-
-
Sugimori, M.1
Ejima, A.2
Ohsuki, S.3
-
159
-
-
33845650679
-
A conjugate of camptothecin and a somatostatin analog against prostate Cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alpha V-beta3/ alpha Vbeta5 and MMP-2/-9
-
Sun L.C., Luo J., Mackey L.V. A conjugate of camptothecin and a somatostatin analog against prostate Cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alpha V-beta3/ alpha Vbeta5 and MMP-2/-9. Cancer Lett 2007, 246:157-166.
-
(2007)
Cancer Lett
, vol.246
, pp. 157-166
-
-
Sun, L.C.1
Luo, J.2
Mackey, L.V.3
-
160
-
-
33747129180
-
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
-
Tangirala R.S., Antony S., Agama K. Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin. Bioorg. Med. Chem. 2006, 14:6202-6212.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 6202-6212
-
-
Tangirala, R.S.1
Antony, S.2
Agama, K.3
-
161
-
-
33845672155
-
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma
-
Tentori L., Leonetti C., Scarsella M. Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. FASEB J. 2006, 20:1709-1711.
-
(2006)
FASEB J.
, vol.20
, pp. 1709-1711
-
-
Tentori, L.1
Leonetti, C.2
Scarsella, M.3
-
163
-
-
9744230672
-
PRb2/ p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol
-
Tonini T., Gabellini C., Bagella L. pRb2/ p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol. Clin. Cancer Res. 2004, 10:8085-8093.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8085-8093
-
-
Tonini, T.1
Gabellini, C.2
Bagella, L.3
-
164
-
-
33645744463
-
Phase I dose-finding study and a pharmacokinetic/ pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumors
-
Troconiz I.F., Garrido M.J., Segura C. Phase I dose-finding study and a pharmacokinetic/ pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumors. Cancer Chemother. Pharmacol. 2006, 57:727-735.
-
(2006)
Cancer Chemother. Pharmacol.
, vol.57
, pp. 727-735
-
-
Troconiz, I.F.1
Garrido, M.J.2
Segura, C.3
-
165
-
-
18944373328
-
Highly efficient endogenous human gene correction using designed zinc-fi nger nucleases
-
Urnov F.D., Miller J., Lee Y.-L. Highly efficient endogenous human gene correction using designed zinc-fi nger nucleases. Nature 2005, 435:646-651.
-
(2005)
Nature
, vol.435
, pp. 646-651
-
-
Urnov, F.D.1
Miller, J.2
Lee, Y.-L.3
-
166
-
-
0034875942
-
A Phase II trial of 9-aminocamptothecin as a 120-h infusion in patients with non-small cell lung Cancer
-
Vokes E.E., Gordon G.S., Rudin C.M. A Phase II trial of 9-aminocamptothecin as a 120-h infusion in patients with non-small cell lung Cancer. Invest. New Drugs 2001, 19:329-333.
-
(2001)
Invest. New Drugs
, vol.19
, pp. 329-333
-
-
Vokes, E.E.1
Gordon, G.S.2
Rudin, C.M.3
-
167
-
-
4644248597
-
Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I
-
Wadkins R.M., Bearss D., Manikumar G. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004, 64:6679-6683.
-
(2004)
Cancer Res.
, vol.64
, pp. 6679-6683
-
-
Wadkins, R.M.1
Bearss, D.2
Manikumar, G.3
-
168
-
-
3142753018
-
Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity
-
Wadkins R.M., Bearss D., Manikumar G. Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity. Curr. Med. Chem. Anti-Cancer Agents 2004, 4:327-334.
-
(2004)
Curr. Med. Chem. Anti-Cancer Agents
, vol.4
, pp. 327-334
-
-
Wadkins, R.M.1
Bearss, D.2
Manikumar, G.3
-
169
-
-
7144248725
-
Plant anti-tumor agents
-
Wall M.E., Wani M.C., Cook C.E., et al. Plant anti-tumor agents. 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 1966, 88:3888-3890.
-
(1966)
1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc.
, vol.88
, pp. 3888-3890
-
-
Wall, M.E.1
Wani, M.C.2
Cook, C.E.3
-
170
-
-
0027196091
-
Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis
-
Walton M.I., Whysong D., O'Connor P.M., et al. Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res. 1993, 53:1853-1861.
-
(1993)
Cancer Res.
, vol.53
, pp. 1853-1861
-
-
Walton, M.I.1
Whysong, D.2
O'Connor, P.M.3
-
171
-
-
0035850505
-
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates
-
Wang C.C., Dervan P.B. Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. J. Am. Chem. Soc. 2001, 123:8657-8661.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 8657-8661
-
-
Wang, C.C.1
Dervan, P.B.2
-
172
-
-
0032508414
-
NF-kappaB anti-apoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and
-
Wang C.Y., Mayo M.W., Korneluk R.G. NF-kappaB anti-apoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase8 activation. Science 1998, 281:1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
-
173
-
-
0030014783
-
DNA topoisomerases
-
Wang J.C. DNA topoisomerases. Annu. Rev. Biochem. 1996, 65:635-692.
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 635-692
-
-
Wang, J.C.1
-
174
-
-
0033542425
-
Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function
-
Wang S., Nath N., Adlam M., Chellappan S. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene 1999, 18:3501-3510.
-
(1999)
Oncogene
, vol.18
, pp. 3501-3510
-
-
Wang, S.1
Nath, N.2
Adlam, M.3
Chellappan, S.4
-
175
-
-
0033528709
-
Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex
-
Wang X., Zhou X., Hecht S.M. Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex. Biochemistry 1999, 38:4374-4381.
-
(1999)
Biochemistry
, vol.38
, pp. 4374-4381
-
-
Wang, X.1
Zhou, X.2
Hecht, S.M.3
-
177
-
-
0346753588
-
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing
-
Whitmarsh R.J., Saginario C., Zhuo Y. Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Oncogene 2003, 22:8448-8459.
-
(2003)
Oncogene
, vol.22
, pp. 8448-8459
-
-
Whitmarsh, R.J.1
Saginario, C.2
Zhuo, Y.3
-
178
-
-
0036211833
-
Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin
-
Wu J., Yin M.B., Hapke G. Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin. Mol. Pharmacol. 2002, 61:742-748.
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 742-748
-
-
Wu, J.1
Yin, M.B.2
Hapke, G.3
-
179
-
-
27744466429
-
Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: a quantum mechanics treatment
-
Xiao X., Cushman M. Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: a quantum mechanics treatment. J. Org. Chem. 2005, 70:9584-9587.
-
(2005)
J. Org. Chem.
, vol.70
, pp. 9584-9587
-
-
Xiao, X.1
Cushman, M.2
-
180
-
-
19544383968
-
Dihydroin denoisoquinolines function as pro-drugs of indenoisoquinolines
-
Xiao X., Miao Z.H., Antony S. Dihydroin denoisoquinolines function as pro-drugs of indenoisoquinolines. Bioorg. Med. Chem.; Lett. 2005, 15:2795-2798.
-
(2005)
Bioorg. Med. Chem.; Lett.
, vol.15
, pp. 2795-2798
-
-
Xiao, X.1
Miao, Z.H.2
Antony, S.3
-
181
-
-
33144456499
-
Total synthesis and biological evaluation of 22-hydroxyacuminatine
-
Xiao X., Antony S., Pommier Y., Cushman M. Total synthesis and biological evaluation of 22-hydroxyacuminatine. J. Med. Chem. 2006, 49:1408-1412.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1408-1412
-
-
Xiao, X.1
Antony, S.2
Pommier, Y.3
Cushman, M.4
-
182
-
-
0029974583
-
Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation
-
Xie G., Gupta R., Atchison K., Lown J.W. Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation. J. Med. Chem. 1996, 39:1049-1055.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1049-1055
-
-
Xie, G.1
Gupta, R.2
Atchison, K.3
Lown, J.W.4
-
183
-
-
33746893366
-
Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis
-
Xu M.L., Li G., Moon D.C. Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis. Arch. Pharm. Res. 2006, 29:541-547.
-
(2006)
Arch. Pharm. Res.
, vol.29
, pp. 541-547
-
-
Xu, M.L.1
Li, G.2
Moon, D.C.3
-
185
-
-
0032054504
-
DNA interaction of two clinical camptothecin drugs stabilize their active lactone forms
-
Yang D., Strode J.T., Spielman H.P. DNA interaction of two clinical camptothecin drugs stabilize their active lactone forms. J. Am. Chem. Soc. 1998, 120:2979-2980.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 2979-2980
-
-
Yang, D.1
Strode, J.T.2
Spielman, H.P.3
-
186
-
-
0033199091
-
Mode of action of a new indolocarbazole anti-Cancer agent, J-107088, targeting topoisomerase I
-
Yoshinari T., Ohkubo M., Fukasawa K. Mode of action of a new indolocarbazole anti-Cancer agent, J-107088, targeting topoisomerase I. Cancer Res. 1999, 59:4271-4275.
-
(1999)
Cancer Res.
, vol.59
, pp. 4271-4275
-
-
Yoshinari, T.1
Ohkubo, M.2
Fukasawa, K.3
-
187
-
-
10644271506
-
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity
-
Yu D., Khan E., Khaleque M.A., et al. Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity. J. Biol. Chem.. J. Biol. Chem.. J. Biol. Chem. 2004, 279:861-951.
-
(2004)
J. Biol. Chem.. J. Biol. Chem.. J. Biol. Chem.
, vol.279
, pp. 861-951
-
-
Yu, D.1
Khan, E.2
Khaleque, M.A.3
-
188
-
-
18144416611
-
The transcriptional targets of p53 in apoptosis control
-
Yu J., Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem. Biophys. Res. Commun. 2005, 331:851-858.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.331
, pp. 851-858
-
-
Yu, J.1
Zhang, L.2
-
189
-
-
0031033311
-
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anti-Cancer cytotoxicity in vitro
-
Zhao R., al-Said N.H., Sternbach D.L., Lown J.W. Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anti-Cancer cytotoxicity in vitro. J. Med. Chem. 1997, 40:216-225.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 216-225
-
-
Zhao, R.1
al-Said, N.H.2
Sternbach, D.L.3
Lown, J.W.4
|