Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 7, 1996, Pages 845-848

  Jew, Sang Sup ^a   Kim, Hee Jin ^a   Kim, Myoung Goo ^a   Roh, Eun Young ^a   Cho, Youn Sang ^a   Kim, Joon Kyum ^b   Cha, Kyung Hoe ^b   Lee, Kang Keun ^b   Han, Hyun Jung ^b   Choi, Jae Young ^c   Lee, Heesoon ^c  

^a Seoul National University   (South Korea)

^b Chong Kun Dang Research Institute   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE;

ANIMAL MODEL; ARTICLE; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA L 1210; MOUSE; NONHUMAN; TUMOR CELL;

EID: 18344413733     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00131-X     Document Type: Article

References (10)

1. Wall, M. E.; Wani, M. C.; Cook, C. E.; Palmer, K. H.; McPhail, A. T.; Sim, G. A. J. Am. Chem. Soc. 1966, 88, 3888.
2. Gottilieb, J. A.; Luce, J. K. Cancer Chemother. Rep. 1972, 56, 103.
3. Wall, M. E.; Wani, M. C. Human Medicinal Agents from Plants, Chapter 11. "Camptothecin and Analogue"; in Kinghorn, A. D. and Balandrin, M. F., Ed.; ACS Symposium Series 534, Am. Chem. Soc.: Washington, DC, 1993; pp. 149-169, and literature cited therein.
4. Jew, S. S.; Ok, K. D.; Kim, H. J.; Kim, M. G.; Kim, J. M.; Hah, J. M.; Cho, Y. S. Tetrahedron: Asymmetry 1995, 6, 1245.
5. Kingsbury, W. D.; Boehm, J. C.; Jakas, D. R.; Holden, K. G.; Hecht, S. M.; Gallagher, G.; Caranfa, M. J.; McCabe, F. L.; Faucette, L. F.; Johnson, R. K.; Hertzberg, R. P. J. Med. Chem. 1991, 34, 98.
6. Wall, M. E.; Wani, M. C.; Natschke, S. M.; Nicholas, A. W. J. Med. Chem. 1986, 29, 1553.
7. 50, μM).
8. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenny, S.; Boyd, M. R. J. Natl. Canc. Inst. 1990, 82, 1107.
9. All new compounds gave satisfactory spectroscopic data consistent with the proposed structures.
10. 6) were transplanted intraperitoneally (i.p.) into BDF1 mice on day 0; compounds were administered i.p. on day 1; T/C = (median survival time of treated/control animals) × 100 %.