Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I

Cancer Research

Volumn 64, Issue 18, 2004, Pages 6679-6683

  Wadkins, Randy M ^a   Bearss, David ^c,d   Manikumar, Govindarajan ^b   Wani, Mansukhlal C ^b   Wall, Monroe E ^b   Von Hoff, Daniel D ^c  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b RTI INTERNATIONAL   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d Montigen Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10,11 METHYLENEDIOXYCAMPTOTHECIN DERIVATIVE; 7 DIHYDROXYMETHYLAMINOMETHYL 10,11 METHYLENEDIOXYCAMPTOTHECIN DERIVATIVE; 7 HYDROXYMETHYLAMINOMETHYL 10,11 METHYLENEDIOXYCAMPTOTHECIN DERIVATIVE; 7 TRIHYDROXYMETHYLAMINOMETHYL 10,11 METHYLENEDIOXYCAMPTOTHECIN DERIVATIVE; CAMPTOTHECIN DERIVATIVE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; HYDROXYL GROUP; METHYL GROUP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DNA BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; STRUCTURE ANALYSIS; TUMOR CELL LINE; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; FEMALE; HELA CELLS; HT29 CELLS; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MICE; MICE, SCID; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 4644248597     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1885     Document Type: Article

References (19)

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