Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex

Biochemistry

Volumn 38, Issue 14, 1999, Pages 4374-4381

  Wang, Xiangyang ^a   Zhou, Xiang ^a   Hecht, Sidney M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 AMINOCAMPTOTHECIN; 20 AZIDOCAMPTOTHECIN; 20 BROMOCAMPTOTHECIN; 20 CHLOROCAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; HYDROXYL GROUP; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DNA CLEAVAGE; DNA DRUG COMPLEX; DNA PROTEIN COMPLEX; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; YEAST;

BASE SEQUENCE; BINDING SITES; CAMPTOTHECIN; DNA LIGASES; DNA TOPOISOMERASES, TYPE I; ENZYME STABILITY; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0033528709     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982708k     Document Type: Article

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