Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 4, Issue 4, 2004, Pages 327-334

  Wadkins, Randy M ^a   Bearss, David ^b,c   Manikumar, Govindarajan ^d   Wani, Mansukhlal C ^d   Wall, Monroe E ^d   Von Hoff, Daniel D ^b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Montigen Pharmaceuticals   (United States)

^d RTI INTERNATIONAL   (United States)

Author keywords

Camptothecin; Cleavable complex; Entropic control; Kinetics; Stability; Topoisomerase 1; Water solubility

Indexed keywords

10 AMINOCAMPTOTHECIN; 10 HYDROXYCAMPTOTHECIN; 10 METHOXYCAMPTOTHECIN; 10,11 ETHYLENEDIOXYCAMPTOTHECIN; 10,11 METHYLENEDIOXYCAMPTOTHECIN; 7 BUTYLCAMPTOTHECIN; 7 SEC BUTYLCAMPTOTHECIN; 7 TERT BUTYLCAMPTOTHECIN; 9 AMINOCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA; DNA TOPOISOMERASE; EXATECAN; IRINOTECAN; METHYLCELLULOSE; POLYSORBATE 80; SOLVENT; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CHEMICAL REACTION KINETICS; CLINICAL TRIAL; COLORECTAL CANCER; CORRELATION ANALYSIS; CYTOTOXICITY; DNA DAMAGE; DRUG ACTIVITY; DRUG FORMULATION; DRUG POTENCY; DRUG STRUCTURE; ENTROPY; GENE REPLICATION; HUMAN; LETHAL GENE; LIPOPHILICITY; MOLECULAR STABILITY; NONHUMAN; PROTEIN DNA INTERACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; COLORECTAL NEOPLASMS; DNA TOPOISOMERASES, TYPE I; ENZYME STABILITY; FEMALE; HELA CELLS; HUMANS; MICE; MICE, SCID; PLASMIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 3142753018     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011043352894     Document Type: Review

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