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Volumn 134, Issue 3, 1996, Pages 757-770

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE;

EID: 0029738086     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.134.3.757     Document Type: Article
Times cited : (288)

References (73)
  • 1
    • 0028834192 scopus 로고
    • L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation
    • Basma, A.N., E.J. Morris, W.J. Nicklas, and H.M. Geller. 1995. L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation. J. Neurochem. 64:825-832.
    • (1995) J. Neurochem. , vol.64 , pp. 825-832
    • Basma, A.N.1    Morris, E.J.2    Nicklas, W.J.3    Geller, H.M.4
  • 2
    • 0026046948 scopus 로고
    • Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity
    • Batistatou, A., and L.A. Greene. 1991. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol. 115:461-471.
    • (1991) J. Cell Biol. , vol.115 , pp. 461-471
    • Batistatou, A.1    Greene, L.A.2
  • 3
    • 0025335205 scopus 로고
    • Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription
    • Bendixen, C., B. Thomsen, J. Alsner, and O. Westergaard. 1990. Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription. Biochemistry. 29:5613-5619.
    • (1990) Biochemistry , vol.29 , pp. 5613-5619
    • Bendixen, C.1    Thomsen, B.2    Alsner, J.3    Westergaard, O.4
  • 4
    • 0027168859 scopus 로고
    • Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
    • Bertrand, R., E. Solary, J. Jenkins, and Y. Pommier. 1993. Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Exp. Cell Res. 207:388-397.
    • (1993) Exp. Cell Res. , vol.207 , pp. 388-397
    • Bertrand, R.1    Solary, E.2    Jenkins, J.3    Pommier, Y.4
  • 5
    • 0026975785 scopus 로고
    • Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases
    • Bruno, S., P. Lassota, W. Giaretti, and Z. Darzynkiewicz. 1992. Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases. Oncol. Res. 4:29-35.
    • (1992) Oncol. Res. , vol.4 , pp. 29-35
    • Bruno, S.1    Lassota, P.2    Giaretti, W.3    Darzynkiewicz, Z.4
  • 6
    • 0024836733 scopus 로고
    • Camptothecin hypersensitivity in poly(adenosine diphosphate-ribose) polymerase-deficient cell lines
    • Chatterjee, S., M.F. Cheng, D. Trivedi, S.J. Petzold, and N.A. Berger. 1989. Camptothecin hypersensitivity in poly(adenosine diphosphate-ribose) polymerase-deficient cell lines. Cancer Commun. 1:389-394.
    • (1989) Cancer Commun. , vol.1 , pp. 389-394
    • Chatterjee, S.1    Cheng, M.F.2    Trivedi, D.3    Petzold, S.J.4    Berger, N.A.5
  • 7
    • 0028174984 scopus 로고
    • DNA topoisomerases: Essential enzymes and lethal targets
    • Chen, A.Y., and L.F. Liu. 1994. DNA topoisomerases: essential enzymes and lethal targets. Annu. Rev. Pharmacol. Toxicol. 34:191-218.
    • (1994) Annu. Rev. Pharmacol. Toxicol. , vol.34 , pp. 191-218
    • Chen, A.Y.1    Liu, L.F.2
  • 8
    • 0024561487 scopus 로고
    • 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
    • Chodosh, L.A., A. Fire, M. Samuels, and P.A. Sharp. 1989. 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro. J. Biol. Chem. 264:2250-2257.
    • (1989) J. Biol. Chem. , vol.264 , pp. 2250-2257
    • Chodosh, L.A.1    Fire, A.2    Samuels, M.3    Sharp, P.A.4
  • 9
    • 0029972658 scopus 로고    scopus 로고
    • DNA damage and repair in central nervous system injury. National Institute of Neurological Disorders and Stroke Workshop Summary
    • Chopp, M., P.H. Chan, Y.H. Chung, M.E. Cheung, and T.P. Jacobs. 1996. DNA damage and repair in central nervous system injury. National Institute of Neurological Disorders and Stroke Workshop Summary. Stroke. 27:363-369.
    • (1996) Stroke , vol.27 , pp. 363-369
    • Chopp, M.1    Chan, P.H.2    Chung, Y.H.3    Cheung, M.E.4    Jacobs, T.P.5
  • 10
    • 0022152964 scopus 로고
    • Insulin stimulates macromolecular synthesis in cultured glial cells from rat brain
    • Clarke, D.W., F.T. Boyd, Jr., M.S. Kappy, and M.K. Raizada. 1985. Insulin stimulates macromolecular synthesis in cultured glial cells from rat brain. Am. J. Physiol. 249:C484-489.
    • (1985) Am. J. Physiol. , vol.249
    • Clarke, D.W.1    Boyd Jr., F.T.2    Kappy, M.S.3    Raizada, M.K.4
  • 12
    • 0026712192 scopus 로고
    • The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle
    • Cotter, T.G., J.M. Glynn, F. Echeverri, and D.R. Green. 1992. The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Res. 12:773-780.
    • (1992) Anticancer Res. , vol.12 , pp. 773-780
    • Cotter, T.G.1    Glynn, J.M.2    Echeverri, F.3    Green, D.R.4
  • 13
    • 0005127448 scopus 로고
    • Determinants of cellular sensitivity to topoisomerase-targeting antitumor drugs
    • L.F. Liu, editor. Academic Press, San Diego
    • D'Arpa, P. 1994. Determinants of cellular sensitivity to topoisomerase-targeting antitumor drugs. In DNA Topoisomerases: Topoisomerase Targeting Drugs. L.F. Liu, editor. Academic Press, San Diego. 12-143.
    • (1994) DNA Topoisomerases: Topoisomerase Targeting Drugs , pp. 12-143
    • D'Arpa, P.1
  • 14
    • 0025133118 scopus 로고
    • Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
    • D'Arpa, P., C. Beardmore, and L.F. Liu. 1990. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res. 50:6919-6924.
    • (1990) Cancer Res. , vol.50 , pp. 6919-6924
    • D'Arpa, P.1    Beardmore, C.2    Liu, L.F.3
  • 15
    • 0027483920 scopus 로고
    • Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
    • D'Mello, S.R., C. Galli, T. Ciotti, and P. Calissano. 1993. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA. 90: 10989-10993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10989-10993
    • D'Mello, S.R.1    Galli, C.2    Ciotti, T.3    Calissano, P.4
  • 16
    • 0027485950 scopus 로고
    • Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
    • Deckwerth, T.L., and E.M. Johnson, Jr. 1993. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123:1207-1222.
    • (1993) J. Cell Biol. , vol.123 , pp. 1207-1222
    • Deckwerth, T.L.1    Johnson Jr., E.M.2
  • 17
    • 9444284069 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof.
  • 18
    • 0026489662 scopus 로고
    • Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation
    • Del Bino, G., S. Bruno, P.N. Yi, and Z. Darzynkiewicz. 1992. Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation. Cell Prolif. 25:537-548.
    • (1992) Cell Prolif. , vol.25 , pp. 537-548
    • Del Bino, G.1    Bruno, S.2    Yi, P.N.3    Darzynkiewicz, Z.4
  • 20
    • 0029036445 scopus 로고
    • The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors
    • Dubrez, L., F. Goldwasser, P. Genne, Y. Pommier, and E. Solary. 1995. The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia. 9:1013-1024.
    • (1995) Leukemia , vol.9 , pp. 1013-1024
    • Dubrez, L.1    Goldwasser, F.2    Genne, P.3    Pommier, Y.4    Solary, E.5
  • 21
    • 0028929896 scopus 로고
    • Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody - Response to oxidative stress
    • Dwyer, B.E., R.N. Nishimura, and S.Y. Lu. 1995. Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody - response to oxidative stress. Mol. Brain Res. 30:37-47.
    • (1995) Mol. Brain Res. , vol.30 , pp. 37-47
    • Dwyer, B.E.1    Nishimura, R.N.2    Lu, S.Y.3
  • 22
    • 0024229066 scopus 로고
    • Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
    • Eng, W.K., L. Faucette, R.K. Johnson, and R. Sternglanz. 1988. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol. 34:755-760.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 755-760
    • Eng, W.K.1    Faucette, L.2    Johnson, R.K.3    Sternglanz, R.4
  • 23
    • 0014837677 scopus 로고
    • Differential metabolism of RNA in neuronal-enriched and glial-enriched fractions of rat cerebrum
    • Flangas, A.L., and R.E. Bowman. 1970. Differential metabolism of RNA in neuronal-enriched and glial-enriched fractions of rat cerebrum. J. Neurochem. 17:1237-1245.
    • (1970) J. Neurochem. , vol.17 , pp. 1237-1245
    • Flangas, A.L.1    Bowman, R.E.2
  • 24
    • 9444236482 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof.
  • 25
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
    • Gorczyca, W., J. Gong, and Z. Darzynkiewicz. 1993. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 53:1945-1951.
    • (1993) Cancer Res. , vol.53 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 26
    • 84975751684 scopus 로고
    • Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
    • Hartley, A., J.M. Stone, C. Heron, J.M. Cooper, and A.H. Schapira. 1994. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63:1987-1990.
    • (1994) J. Neurochem. , vol.63 , pp. 1987-1990
    • Hartley, A.1    Stone, J.M.2    Heron, C.3    Cooper, J.M.4    Schapira, A.H.5
  • 27
    • 0025006831 scopus 로고
    • DNA repair in radiation sensitive mutants of mammalian cells: Possible involvement of DNA topoisomerases
    • Hickson, I.D., S.L. Davies, S.M. Davies, and C.N. Robson. 1990. DNA repair in radiation sensitive mutants of mammalian cells: possible involvement of DNA topoisomerases. Int. J. Rad. Biol. 58:561-568.
    • (1990) Int. J. Rad. Biol. , vol.58 , pp. 561-568
    • Hickson, I.D.1    Davies, S.L.2    Davies, S.M.3    Robson, C.N.4
  • 28
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang, Y.H., R. Hertzberg, S. Hecht, and L.F. Liu. 1985. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260:14873-14878.
    • (1985) J. Biol. Chem. , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 29
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang, Y.H., M.G. Lihou, and L.F. Liu. 1989. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49:5077-5082.
    • (1989) Cancer Res. , vol.49 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 30
    • 0028719175 scopus 로고
    • Cellular regulation of mammalian DNA topoisomerases
    • L.F. Liu, editor. Academic Press, San Diego
    • Hwang, J., and C.L. Hwong. 1994. Cellular regulation of mammalian DNA topoisomerases. In DNA Topoisomerases: Biochemistry and Molecular Biology. L.F. Liu, editor. Academic Press, San Diego. 167-189.
    • (1994) DNA Topoisomerases: Biochemistry and Molecular Biology , pp. 167-189
    • Hwang, J.1    Hwong, C.L.2
  • 31
    • 0027396983 scopus 로고
    • Molecular mechanisms of developmental neuronal death
    • Johnson, E.M., Jr., and T.L. Deckwerth. 1993. Molecular mechanisms of developmental neuronal death. Annu. Rev. Neurosci 16:31-46.
    • (1993) Annu. Rev. Neurosci , vol.16 , pp. 31-46
    • Johnson Jr., E.M.1    Deckwerth, T.L.2
  • 32
    • 0015241290 scopus 로고
    • Effects of camptothecin on RNA synthesis in leukemia L1210 cells
    • Kessel, D. 1971. Effects of camptothecin on RNA synthesis in leukemia L1210 cells. Biochim. Biophys. Acta. 246:225-232.
    • (1971) Biochim. Biophys. Acta , vol.246 , pp. 225-232
    • Kessel, D.1
  • 34
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond). 227:680-685.
    • (1970) Nature (Lond) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 35
    • 0027379353 scopus 로고
    • Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome
    • Leadon, S.A., and P.K. Cooper. 1993. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl. Acad. Sci. USA. 90:10499-10503.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10499-10503
    • Leadon, S.A.1    Cooper, P.K.2
  • 36
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., H.E. Ruley, T. Jacks, and D.E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74: 957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 37
    • 0026503077 scopus 로고
    • Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin
    • Madden, K.R., and J.J. Champoux. 1992. Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin. Cancer Res. 52:525-532.
    • (1992) Cancer Res. , vol.52 , pp. 525-532
    • Madden, K.R.1    Champoux, J.J.2
  • 38
    • 0023851503 scopus 로고
    • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    • Martin, D.P., R.E. Schmidt, P.S. DiStefano, O.H. Lowry, J.G. Carter, and E.M. Johnson, Jr. 1988. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:829-844.
    • (1988) J. Cell Biol. , vol.106 , pp. 829-844
    • Martin, D.P.1    Schmidt, R.E.2    DiStefano, P.S.3    Lowry, O.H.4    Carter, J.G.5    Johnson Jr., E.M.6
  • 39
    • 0028263919 scopus 로고
    • Expression of Bcl-2 protein in murine neural cells in culture
    • Mizuguchi, M., K. Ikeda, M. Asada, S. Mizutani, and S. Kamoshita. 1994. Expression of Bcl-2 protein in murine neural cells in culture. Brain Res. 649:197-202.
    • (1994) Brain Res. , vol.649 , pp. 197-202
    • Mizuguchi, M.1    Ikeda, K.2    Asada, M.3    Mizutani, S.4    Kamoshita, S.5
  • 40
    • 0019638515 scopus 로고
    • Growth of purified astrocytes in a chemically defined medium
    • Morrison, R.S., and J. deVellis. 1981. Growth of purified astrocytes in a chemically defined medium. Proc. Natl. Acad. Sci. USA. 78:7205-7209.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7205-7209
    • Morrison, R.S.1    Devellis, J.2
  • 41
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 42
    • 0022067647 scopus 로고
    • Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA
    • Muller, M.T., W.P. Pfund, V.B. Mehta, and D.K. Trask. 1985. Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA. EMBO (Eur. Mol. Biol. Organ.) J. 4:1237-1243.
    • (1985) EMBO (Eur. Mol. Biol. Organ.) J. , vol.4 , pp. 1237-1243
    • Muller, M.T.1    Pfund, W.P.2    Mehta, V.B.3    Trask, D.K.4
  • 43
    • 0028314235 scopus 로고
    • Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system
    • Nakajima, M., K. Kashiwagi, J. Ohta, S. Furukawa, K. Hayashi, T. Kawashima, and Y. Hayashi. 1994. Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system. Brain Res. 641:350-352.
    • (1994) Brain Res. , vol.641 , pp. 350-352
    • Nakajima, M.1    Kashiwagi, K.2    Ohta, J.3    Furukawa, S.4    Hayashi, K.5    Kawashima, T.6    Hayashi, Y.7
  • 44
    • 0028064510 scopus 로고
    • Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: Distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor
    • Nakajima, M., K. Kashiwagi, J. Ohta, S. Furukawa, K. Hayashi, T. Kawashima, and Y. Hayashi. 1994. Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor. Neurosci. Lett. 176:161-164.
    • (1994) Neurosci. Lett. , vol.176 , pp. 161-164
    • Nakajima, M.1    Kashiwagi, K.2    Ohta, J.3    Furukawa, S.4    Hayashi, K.5    Kawashima, T.6    Hayashi, Y.7
  • 45
    • 0000536643 scopus 로고
    • DNA topoisomerase-targeting antitumor drugs can be studied in yeast
    • Nitiss, J., and J.C. Wang. 1988. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA. 85:7501-7505.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7501-7505
    • Nitiss, J.1    Wang, J.C.2
  • 46
    • 0025689565 scopus 로고
    • 10,11-methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells
    • O'Connor, P.M., D. Kerrigan, R. Bertrand, K.W. Kohn, and Y. Pommier. 1990. 10,11-methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells. Cancer Commun. 2:395-400.
    • (1990) Cancer Commun. , vol.2 , pp. 395-400
    • O'Connor, P.M.1    Kerrigan, D.2    Bertrand, R.3    Kohn, K.W.4    Pommier, Y.5
  • 47
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim, R.W. 1991. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14:453-501.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 48
    • 0028067913 scopus 로고
    • Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types
    • Perego, P., G. Capranico, R. Supino, and F. Zunino. 1994. Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types. Anti-Cancer Drugs. 5:645-649.
    • (1994) Anti-Cancer Drugs , vol.5 , pp. 645-649
    • Perego, P.1    Capranico, G.2    Supino, R.3    Zunino, F.4
  • 49
    • 0014859062 scopus 로고
    • Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species
    • Perry, R.P., and D.E. Kelley. 1970. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. J. Cell Physiol. 76:127-139.
    • (1970) J. Cell Physiol. , vol.76 , pp. 127-139
    • Perry, R.P.1    Kelley, D.E.2
  • 50
    • 0028237732 scopus 로고
    • Selective labeling of embryonic neurons cultured on astrocyte monolayers with 5(6)-carboxyfluorescein diacetate (CFDA)
    • Petroski, R.E., and H.M. Geller. 1994. Selective labeling of embryonic neurons cultured on astrocyte monolayers with 5(6)-carboxyfluorescein diacetate (CFDA). J. Neurosci. Methods. 52:23-32.
    • (1994) J. Neurosci. Methods , vol.52 , pp. 23-32
    • Petroski, R.E.1    Geller, H.M.2
  • 51
    • 0028677817 scopus 로고
    • Mechanisms of topoisomerase I inhibition by anticancer drugs
    • L.F. Liu, editor. Academic Press, San Diego
    • Pommier, Y., A. Tanizawa, and K.W. Kohn. 1994. Mechanisms of topoisomerase I inhibition by anticancer drugs. In DNA Topoisomerases: Topoisomerase-targeting Drugs. L.F. Liu, editor. Academic Press, San Diego. 73-93.
    • (1994) DNA Topoisomerases: Topoisomerase-targeting Drugs , pp. 73-93
    • Pommier, Y.1    Tanizawa, A.2    Kohn, K.W.3
  • 52
    • 0028095981 scopus 로고
    • Oxidative stress induces apoptosis in embryonic cortical neurons
    • Ratan, R.R., T.H. Murphy, and J.M. Baraban. 1994. Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62:376-379.
    • (1994) J. Neurochem. , vol.62 , pp. 376-379
    • Ratan, R.R.1    Murphy, T.H.2    Baraban, J.M.3
  • 53
    • 0017843257 scopus 로고
    • Studies on the regulation of RNA synthesis in neuronal and glial nuclei isolated from rat brain
    • Sarkander, H.I., and H.J. Dulce. 1978. Studies on the regulation of RNA synthesis in neuronal and glial nuclei isolated from rat brain. Exp. Brain Res. 31:317-327.
    • (1978) Exp. Brain Res. , vol.31 , pp. 317-327
    • Sarkander, H.I.1    Dulce, H.J.2
  • 54
    • 0018732978 scopus 로고
    • Cockayne syndrome: Unusual neuropathological findings and review of the literature
    • Soffer, D., H.W. Grotsky, I. Rapin, and K. Suzuki. 1979. Cockayne syndrome: unusual neuropathological findings and review of the literature. Ann. Neurol. 6:340-348.
    • (1979) Ann. Neurol. , vol.6 , pp. 340-348
    • Soffer, D.1    Grotsky, H.W.2    Rapin, I.3    Suzuki, K.4
  • 55
    • 0027403207 scopus 로고
    • Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors
    • Solary, E., R. Bertrand, K.W. Kohn, and Y. Pommier. 1993. Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors. Blood. 5:1359-1368.
    • (1993) Blood , vol.5 , pp. 1359-1368
    • Solary, E.1    Bertrand, R.2    Kohn, K.W.3    Pommier, Y.4
  • 56
    • 0027173884 scopus 로고
    • Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA
    • Squires, S., A.J. Ryan, H.L. Strutt, and R.T. Johnson. 1993. Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA. Cancer Res. 53:2012-2019.
    • (1993) Cancer Res. , vol.53 , pp. 2012-2019
    • Squires, S.1    Ryan, A.J.2    Strutt, H.L.3    Johnson, R.T.4
  • 57
    • 0028175464 scopus 로고
    • 2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons
    • 2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons. Brain Res. 652:65-70.
    • (1994) Brain Res. , vol.652 , pp. 65-70
    • Takei, N.1    Endo, Y.2
  • 58
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science (Wash. DC). 267:1456-1462.
    • (1995) Science (Wash. DC) , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 59
    • 0027212267 scopus 로고
    • Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
    • Tishler, R.B., S.K. Calderwood, C.N. Coleman, and B.D. Price. 1993. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res. 53:2212-2216.
    • (1993) Cancer Res. , vol.53 , pp. 2212-2216
    • Tishler, R.B.1    Calderwood, S.K.2    Coleman, C.N.3    Price, B.D.4
  • 60
    • 0028206102 scopus 로고
    • Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF
    • Tomkins, C.E., S.N. Edwards, and A.M. Tolkovsky. 1994. Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF. J. Cell Sci 107:1499-1507.
    • (1994) J. Cell Sci , vol.107 , pp. 1499-1507
    • Tomkins, C.E.1    Edwards, S.N.2    Tolkovsky, A.M.3
  • 61
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications
    • Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 62
    • 0025341294 scopus 로고
    • The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA
    • Venema, J., L.H.F. Mullenders, A.T. Natarajan, A.A. van Zeeland, and L.V. Mayne. 1990. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl. Acad. Sci. USA. 87:4707-4711.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4707-4711
    • Venema, J.1    Mullenders, L.H.F.2    Natarajan, A.T.3    Van Zeeland, A.A.4    Mayne, L.V.5
  • 63
    • 0023470216 scopus 로고
    • Cell types and cell-substrate interactions in serum-free dissociated cultures of rat hypothalamus
    • Ventimiglia, R., and H.M. Geller. 1987. Cell types and cell-substrate interactions in serum-free dissociated cultures of rat hypothalamus. Brain Res. 436:339-351.
    • (1987) Brain Res. , vol.436 , pp. 339-351
    • Ventimiglia, R.1    Geller, H.M.2
  • 64
    • 0027475980 scopus 로고
    • Filamentous degeneration of neurons. A possible feature of cytosine arabinoside neurotoxicity
    • Vogel, H., and D.S. Horoupian. 1993. Filamentous degeneration of neurons. A possible feature of cytosine arabinoside neurotoxicity. Cancer. 71:1303-1308.
    • (1993) Cancer , vol.71 , pp. 1303-1308
    • Vogel, H.1    Horoupian, D.S.2
  • 65
    • 7144248725 scopus 로고
    • The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
    • Wall, M.E., M.C. Wani, C.E. Cook, K.H. Palmer, A.T. McPhail, and G.A. Sim. 1966. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 83:3888-3890.
    • (1966) J. Am. Chem. Soc. , vol.83 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3    Palmer, K.H.4    McPhail, A.T.5    Sim, G.A.6
  • 66
    • 0027196091 scopus 로고
    • Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis
    • Walton, M.I., D. Whysong, P.M. O'Connor, D. Hockenberry, S.J. Korsmeyer, and K.W. Kohn. 1993. Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res. 53:1853-1861.
    • (1993) Cancer Res. , vol.53 , pp. 1853-1861
    • Walton, M.I.1    Whysong, D.2    O'Connor, P.M.3    Hockenberry, D.4    Korsmeyer, S.J.5    Kohn, K.W.6
  • 67
    • 0021891888 scopus 로고
    • DNA topoisomerases
    • Wang, J.C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665-697.
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 665-697
    • Wang, J.C.1
  • 68
    • 0018358511 scopus 로고
    • DNA polymerase beta from brain neurons is a repair enzyme
    • Waser, J., U. Hubscher, C.C. Kuenzle, and S. Spadari. 1979. DNA polymerase beta from brain neurons is a repair enzyme. Eur. J. Biochem. 97: 361-368.
    • (1979) Eur. J. Biochem. , vol.97 , pp. 361-368
    • Waser, J.1    Hubscher, U.2    Kuenzle, C.C.3    Spadari, S.4
  • 69
    • 0021030155 scopus 로고
    • Cerebellar degeneration caused by high-dose cytosine arabinoside: A clinicopathological study
    • Winkelman, M.D., and J.D. Hines. 1983. Cerebellar degeneration caused by high-dose cytosine arabinoside: a clinicopathological study. Ann. Neurol. 14:520-527.
    • (1983) Ann. Neurol. , vol.14 , pp. 520-527
    • Winkelman, M.D.1    Hines, J.D.2
  • 70
    • 0029086989 scopus 로고
    • The role of free radicals and p53 in neuron apoptosis in vivo
    • Wood, K.A., and R.J. Youle. 1995. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:5851-5857.
    • (1995) J. Neurosci. , vol.15 , pp. 5851-5857
    • Wood, K.A.1    Youle, R.J.2
  • 71
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie, A.H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond.). 284:555-556.
    • (1980) Nature (Lond.) , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 72
    • 0021346318 scopus 로고
    • Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
    • Wyllie, A.H., R.G. Morris, A.L. Smith, and D. Dunlop. 1984. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142:67-77.
    • (1984) J. Pathol. , vol.142 , pp. 67-77
    • Wyllie, A.H.1    Morris, R.G.2    Smith, A.L.3    Dunlop, D.4
  • 73
    • 0023958908 scopus 로고
    • Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes
    • Zhang, H., J.C. Wang, and L.F. Liu. 1988. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc. Natl. Acad. Sci. USA. 85:1060-1064.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1060-1064
    • Zhang, H.1    Wang, J.C.2    Liu, L.F.3


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