The mechanism of topoisomerase I poisoning by a camptothecin analog

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 24, 2002, Pages 15387-15392

  Staker, Bart L ^a   Hjerrild, Kathryn ^a   Feese, Michael D ^a   Behnke, Craig A ^b   Burgin Jr , Alex B ^a   Stewart, Lance ^a  

^a DeCODE Chemistry & Biostructures   (United States)

^b Takeda San Diego Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; TOPOTECAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; COVALENT BOND; CRYSTAL STRUCTURE; DNA CLEAVAGE; DRUG BINDING SITE; DRUG MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; INTERCALATION COMPLEX; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INTERCALATING AGENTS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOTECAN;

EID: 0037180432     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.242259599     Document Type: Article

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