Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2308-2318

  Sugimori, Masamichi ^a   Ejima, Akio ^a   Ohsuki, Satoru ^a   Uoto, Kouichi ^a   Mitsui, Ikuo ^a   Kawato, Yasuyoshi ^a   Hirota, Yasuhide ^a   Sato, Keiki ^a   Terasawa, Hirofumi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 9 AMINOCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; IRINOTECAN; LURTOTECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL DIVISION; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; LEUKEMIA P388; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032543522     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970765q     Document Type: Article

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