Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5129-5140

  Nagarajan, Muthukaman ^a   Morrell, Andrew ^a   Antony, Smitha ^b   Kohlhagen, Glenda ^b   Agama, Keli ^b   Pommier, Yves ^b   Ragazzon, Patricia A ^c   Garbett, Nichola C ^c   Chaires, Jonathan B ^c   Hollingshead, Melinda ^d   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c University of Louisville School of Medicine   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS 1,2 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 (ETHYLAMINO)ETHANETETRAKIS(TRIFLUOROACETATE); BIS 1,2 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 ETHYLAMINO]ETHANEBIS(TRIFLUOROACETATE); BIS 1,2 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYLAMINO]ETHANEBIS(TRIFLUOROACETATE); BIS 1,2 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)(6 PROPYL TERT BUTOXYCARBONYLAMINO)]ETHANE; BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 ETHYLAMINO]PROPANEBIS(TRIFLUOROACETATE); BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYLAMINO]PROPANE; BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)(6 ETHYL TERT BUTOXYCARBONYLAMINO)]PROPANE; BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)(6 PROPYL TERT BUTOXYCARBONYLAMINO)]PROPANE; BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 2,3 DIMETHOXY 11H INDENO [1,2 C]ISOQUINOLINE) 6 PROPYLAMINO]PROPANEBIS(TRIFLUOROACETATE); BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 2,3 DIMETHOXY 11H INDENO[1,2 C]ISOQUINOLINE) 6 ETHYLAMINO]PROPANEBIS(TRIFLUOROACETATE); BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 3 NITRO 11H INDENO[1,2 C]ISOQUINOLINE) 6 ETHYLAMINO]PROPANEBIS(TRIFLUOROACETATE); BIS 1,3 [(5,6 DIHYDRO 5,11 DIKETO 3 NITRO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYLAMINO]PROPANEBIS(TRIFLUOROACETATE); BIS 1,4 [(5,6 DIHYDRO 5,11 DIKETO 11H [INDENO[1,2 C]ISOQUINOLINE) 6 PROPYLAMINO]BUTANE; BIS 1,4 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYL]PIPERAZINEBIS(TRIFLUOROACETATE); BIS 1,4 [(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)(6 PROPYL TERT BUTOXYCARBONYLAMINO)]BUTANE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 ETHYL]AMINE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYL]AMINE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 PROPYL]METHYLAMINE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)](6 ETHYL,6' PROPYL)AMINE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)](6 ETHYL,6' PROPYL)AMMONIUM TRIFLUOROACETATE; BIS[(5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE)](6 PROPYL,6' BUTYL)AMINE; BIS[(DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE) 6 (ETHYLAMINO)ETHYL]AMINE; CAMPTOTHECIN DERIVATIVE; CARBON; DNA TOPOISOMERASE INHIBITOR; ISOQUINOLINE DERIVATIVE; NITROGEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CYTOTOXICITY; DNA SUPERCOILING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LABELING INDEX; PROTEIN DNA BINDING; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INDENES; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747470312     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060046o     Document Type: Article

References (48)

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