Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 742-748

  Wu, Jiaxi ^a   Yin, Ming Biao ^a   Hapke, Gunnar ^a   Tóth, Károly ^a   Rustum, Youcef M ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; APHIDICOLIN; DNA DEPENDENT PROTEIN KINASE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; DRUG METABOLITE; ENZYME INHIBITOR; IRINOTECAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DNA REPAIR; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

APHIDICOLIN; APOPTOSIS; CAMPTOTHECIN; CELL DIVISION; DNA DAMAGE; DNA FRAGMENTATION; DNA LIGASES; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DNA-DIRECTED DNA POLYMERASE; DRUG INTERACTIONS; ELECTROPHORESIS, GEL, PULSED-FIELD; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; PHOSPHORYLATION; TUMOR CELLS, CULTURED;

EID: 0036211833     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.742     Document Type: Article

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