DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: The lack of this suppression in p53MUT cells contributes to apoptosis

Journal of Biological Chemistry

Volumn 281, Issue 13, 2006, Pages 8675-8685

  Bhonde, Mandar R ^a   Hanski, Marie Luise ^a   Budczies, Jan ^b   Cao, Minh ^a   Gillissen, Bernd ^a   Moorthy, Dhatchana ^a   Simonetta, Federico ^c   Scherübl, Hans ^a   Truss, Matthias ^d   Hagemeier, Christian ^d   Mewes, Hans Werner ^b   Daniel, Peter T ^a   Zeitz, Martin ^a   Hanski, Christoph ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; ONCOLOGY; PATIENT TREATMENT; TUMORS;

APOPTOSIS; KINASE; TOPOISOMERASE;

ENZYME INHIBITION;

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CHECKPOINT KINASE 1; IRINOTECAN; MESSENGER RNA; PROTEIN HMPS1; PROTEIN P53; UNCLASSIFIED DRUG; 7-ETHYL-10-HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CELL CYCLE PROTEIN; DRUG DERIVATIVE; PROTEIN SERINE THREONINE KINASE; TTK PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; ENZYME REPRESSION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOLOGICAL MODEL; CARCINOMA; CELL STRAIN HCT116; CELL STRAIN HT29; COLON TUMOR; COMPARATIVE STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOVIRIDAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CAMPTOTHECIN; CARCINOMA; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA DAMAGE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HELA CELLS; HT29 CELLS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33646843583     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511333200     Document Type: Article

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