Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

British Journal of Cancer

Volumn 84, Issue 1, 2001, Pages 106-112

  Bowman, K J ^a   Newell, D R ^a   Calvert, A H ^a   Curtin, N J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cytotoxicity; DNA damage; Poly(ADP ribose) polymerase; Topoisomerase I; Topoisomerase II

Indexed keywords

8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; 8 HYDROXY 2 METHYLQUINAZOLIN 4 ONE; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; ENZYME INHIBITOR; ETOPOSIDE; GYRASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER; CANCER COMBINATION CHEMOTHERAPY; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA METHYLATION; DNA REPAIR; DNA STRAND BREAKAGE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME INHIBITORS; ETOPOSIDE; LEUKEMIA L1210; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEINS; QUINAZOLINES;

EID: 0035137364     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1555     Document Type: Article

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