Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks

Biochemistry

Volumn 38, Issue 47, 1999, Pages 15556-15563

  Bailly, Christian ^a   Lansiaux, Amélie ^a   Dassonneville, Laurent ^a   Demarquay, Danièle ^b   Coulomb, Hélène ^b   Huchet, Marion ^b   Lavergne, Olivier ^b   Bigg, Dennis C H ^b  

^a INSERM   (France)

^b Institut Henri Beaufour   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; HOMOCAMPTOTHECIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA STRUCTURE; DRUG DNA BINDING; ENZYME INHIBITION; IMMUNOBLOTTING; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; LEUKEMIA P388; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033598698     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990947h     Document Type: Article

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