Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 18, 2006, Pages 6202-6212

  Tangirala, Raghuram S ^a   Antony, Smitha ^b   Agama, Keli ^b   Pommier, Yves ^b   Anderson, Bradley D ^c   Bevins, Robert ^d   Curran, Dennis P ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Anti cancer agents; Camptothecin; Cascade radical annulation; Topoisomerase 1

Indexed keywords

12 [TERT BUTYL(DIMETHYL)SILYL] 5 ETHYL 1,13 DIHYDRO 3H,15H OXEPINO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLINE 3,15 DIONE; 12 [TERT BUTYL(DIMETHYL)SILYL] 5 ETHYL 10 FLUORO 1,13 DIHYDRO 3H,15H OXEPINO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLINE 3,15 DIONE; 2 [12 [TERT BUTYL(DIMETHYL)SILYL 2 HYDROXY 8 METHYL 9 OXO 9,11 DIHYDROINDOLIZINO[1,2 B]QUINOLIN 7 YL] 2 HYDROXYBUTANOIC ACID; 2 [12 [TERT BUTYL(DIMETHYL)SILYL] 2 HYDROXY 8 (HYDROXYMETHYL) 9 OXO 9,11 DIHYDROINDOLIZINO[1,2 B]QUINOLIN 7 YL] 2 HYDROXYBUTANOHYDRAZIDE; 2 HYDROXY 2 (8 METHYL 9 OXO 9,11 DIHYDROINDOLIZINO[1,2 B]QUINOLIN 7 YL)BUTANOIC ACID METHYL ESTER; 2 HYDROXY 2 [8 (HYDROXYMETHYL) 9 OXO 9,11 DIHYDROINDOLIZINO[1,2 B]QUINOLIN 7 YL]BUTANOHYDRAZIDE; 5 ETHYL 1,13 DIHYDRO 3H,15H OXEPINO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLINE 3,15 DIONE; 5 ETHYL 10 FLUORO 1,13 DIHYDRO 3H,15H OXEPINO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLINE 3,15 DIONE; AMIDE; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; ETHER; HOMOCAMPTOTHECIN; HYDRAZIDE; LACTONE; METHYL (3 ETHYL 13 OXO 11,13 DIHYDRO 1H,3H FURO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLIN 3 YL)ACETATE; METHYL (3 ETHYL 8 FLUORO 13 OXO 11,13 DIHYDRO 1H,3H FURO[3',4':6,7] INDOLIZINO[1,2 B]QUINOLIN 3 YL)ACETATE; METHYL [10 [TERT BUTYL(DIMETHYL)SILYL] 3 ETHYL 13 OXO 11,13 DIHYDRO 1H,3H FURO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLIN 3 YL]ACETATE; METHYL [10 [TERT BUTYL(DIMETHYL)SILYL] 3 ETHYL 8 FLUORO 13 OXO 11,13 DIHYDRO 1H,3H FURO[3',4':6,7]INDOLIZINO[1,2 B]QUINOLIN 3 YL]ACETATE; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CELL ASSAY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY;

ANTINEOPLASTIC AGENTS; BIOLOGICAL ASSAY; CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747129180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.073     Document Type: Article

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