Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues

Journal of Medicinal Chemistry

Volumn 41, Issue 27, 1998, Pages 5410-5419

  Lavergne, Olivier ^a   Lesueur Ginot, Laurence ^a   Rodas, Francesc Pla ^b   Kasprzyk, Philip G ^c   Pommier, Jacques ^a   Demarquay, Danièle ^a   Prévost, Grégoire ^a   Ulibarri, Gérard ^a   Rolland, Alain ^a   Schiano Liberatore, Anne Marie ^a   Harnett, Jeremiah ^a   Pons, Dominique ^a   Camara, José ^a   Bigg, Dennis C H ^a  

^a Institut Henri Beaufour   (France)

^b Laboratorios Lasa   (Spain)

^c Biomeasure Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; HOMOCAMPTOTHECIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOXEPINS; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; P-GLYCOPROTEIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0032585548     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980400l     Document Type: Article

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