-
1
-
-
0001086027
-
Structure and synthesis of distamycin A
-
Arcamone F., Nicolell V., Penco S., Orezzi P., Pirelli A. Structure and synthesis of distamycin A. Nature. 203:1964;1064.
-
(1964)
Nature
, vol.203
, pp. 1064
-
-
Arcamone, F.1
Nicolell, V.2
Penco, S.3
Orezzi, P.4
Pirelli, A.5
-
2
-
-
0001015292
-
Structural characterization of a 2:1 distamycin A·D(CGCAAATTGGC) complex by two-dimensional NMR
-
Pelton J.G., Wemmer D.E. Structural characterization of a 2:1 distamycin A·D(CGCAAATTGGC) complex by two-dimensional NMR. Proc. Natl. Acad. Sci. U.S.A. 86:1989;5723-5727.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 5723-5727
-
-
Pelton, J.G.1
Wemmer, D.E.2
-
4
-
-
0034830898
-
Molecular recognition of DNA by small molecules
-
A personal essay recounting the development of the field of DNA recognition in the minor groove by Py-Im polyamides.
-
Dervan P.B. Molecular recognition of DNA by small molecules. Bioorg. Med. Chem. 9:2001;2215-2235 A personal essay recounting the development of the field of DNA recognition in the minor groove by Py-Im polyamides.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2215-2235
-
-
Dervan, P.B.1
-
5
-
-
0032576722
-
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands
-
White S., Szewczyk J.W., Turner J.M., Baird E.E., Dervan P.B. Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature. 391:1998;468-471.
-
(1998)
Nature
, vol.391
, pp. 468-471
-
-
White, S.1
Szewczyk, J.W.2
Turner, J.M.3
Baird, E.E.4
Dervan, P.B.5
-
6
-
-
0342987251
-
Design of peptides that bind in the minor groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif
-
Wade W.S., Mrksich M., Dervan P.B. Design of peptides that bind in the minor groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif. J. Am. Chem. Soc. 114:1992;8783-8794.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 8783-8794
-
-
Wade, W.S.1
Mrksich, M.2
Dervan, P.B.3
-
7
-
-
0026661689
-
Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin
-
Mrksich M., Wade W.S., Dwyer T.J., Geierstanger B.H., Wemmer D.E., Dervan P.B. Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7586-7590.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 7586-7590
-
-
Mrksich, M.1
Wade, W.S.2
Dwyer, T.J.3
Geierstanger, B.H.4
Wemmer, D.E.5
Dervan, P.B.6
-
9
-
-
0033573863
-
The thermodynamics of polyamide-DNA recognition: Hairpin polyamide binding in the minor groove of duplex DNA
-
Pilch D.S., Poklar N., Baird E.E., Dervan P.B., Breslauer K.J. The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA. Biochemistry. 38:1999;2143-2151.
-
(1999)
Biochemistry
, vol.38
, pp. 2143-2151
-
-
Pilch, D.S.1
Poklar, N.2
Baird, E.E.3
Dervan, P.B.4
Breslauer, K.J.5
-
10
-
-
0032475994
-
A structural basis for recognition of A·T and T·A base pairs in the minor groove of B-DNA
-
Kielkopf C.L., White S., Szewczyk J.W., Turner J.M., Baird E.E., Dervan P.B., Rees D.C. A structural basis for recognition of A·T and T·A base pairs in the minor groove of B-DNA. Science. 282:1998;111-115.
-
(1998)
Science
, vol.282
, pp. 111-115
-
-
Kielkopf, C.L.1
White, S.2
Szewczyk, J.W.3
Turner, J.M.4
Baird, E.E.5
Dervan, P.B.6
Rees, D.C.7
-
11
-
-
0034695413
-
Structural effects of DNA sequence on T·A recognition by hydroxypyrrole/pyrrole pairs in the minor groove
-
Kielkopf C.L., Bremer R.E., White S., Szewczyk J.W., Turner J.M., Baird E.E., Dervan P.B., Rees D.C. Structural effects of DNA sequence on T·A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J. Mol. Biol. 295:2000;557-567.
-
(2000)
J. Mol. Biol.
, vol.295
, pp. 557-567
-
-
Kielkopf, C.L.1
Bremer, R.E.2
White, S.3
Szewczyk, J.W.4
Turner, J.M.5
Baird, E.E.6
Dervan, P.B.7
Rees, D.C.8
-
12
-
-
0037471666
-
Hydration of hydroxypyrrole influences binding of ImHpPyPy-β-Dp polyamide to DNA
-
Wellenzohn B., Loferer M.J., Trieb M., Rauch C., Winger R.H., Mayer E., Liedl K.R. Hydration of hydroxypyrrole influences binding of ImHpPyPy-β-Dp polyamide to DNA. J. Am. Chem. Soc. 125:2003;1088-1095.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 1088-1095
-
-
Wellenzohn, B.1
Loferer, M.J.2
Trieb, M.3
Rauch, C.4
Winger, R.H.5
Mayer, E.6
Liedl, K.R.7
-
13
-
-
0027970146
-
Hairpin peptide motif. A new class of oligopeptides for sequence-specific recognition in the minor-groove of double-helical DNA
-
Mrksich M., Parks M.E., Dervan P.B. Hairpin peptide motif. A new class of oligopeptides for sequence-specific recognition in the minor-groove of double-helical DNA. J. Am. Chem. Soc. 116:1994;7983-7988.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 7983-7988
-
-
Mrksich, M.1
Parks, M.E.2
Dervan, P.B.3
-
14
-
-
0029786013
-
Recognition of DNA by designed ligands at subnanomolar concentrations
-
Trauger J.W., Baird E.E., Dervan P.B. Recognition of DNA by designed ligands at subnanomolar concentrations. Nature. 382:1996;559-561.
-
(1996)
Nature
, vol.382
, pp. 559-561
-
-
Trauger, J.W.1
Baird, E.E.2
Dervan, P.B.3
-
15
-
-
0030758956
-
NMR characterization of hairpin polyamide complexes with the minor groove of DNA
-
deClairac R.P.L., Geierstanger B.H., Mrksich M., Dervan P.B., Wemmer D.E. NMR characterization of hairpin polyamide complexes with the minor groove of DNA. J. Am. Chem. Soc. 119:1997;7909-7916.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 7909-7916
-
-
DeClairac, R.P.L.1
Geierstanger, B.H.2
Mrksich, M.3
Dervan, P.B.4
Wemmer, D.E.5
-
16
-
-
0030813474
-
Orientation preferences of pyrrole-imidazole polyamides in the minor groove of DNA
-
White S., Baird E.E., Dervan P.B. Orientation preferences of pyrrole-imidazole polyamides in the minor groove of DNA. J. Am. Chem. Soc. 119:1997;8756-8765.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 8756-8765
-
-
White, S.1
Baird, E.E.2
Dervan, P.B.3
-
18
-
-
0032564881
-
Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove
-
Herman D.M., Baird E.E., Dervan P.B. Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove. J. Am. Chem. Soc. 120:1998;1382-1391.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 1382-1391
-
-
Herman, D.M.1
Baird, E.E.2
Dervan, P.B.3
-
19
-
-
0037070591
-
Hairpin versus extended DNA binding of a substituted β-alanine linked polyamide
-
Woods C.R., Ishii T., Wu B., Bair K.W., Boger D.L. Hairpin versus extended DNA binding of a substituted β-alanine linked polyamide. J. Am. Chem. Soc. 124:2002;2148-2152.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 2148-2152
-
-
Woods, C.R.1
Ishii, T.2
Wu, B.3
Bair, K.W.4
Boger, D.L.5
-
21
-
-
0034671363
-
Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif
-
Melander C., Herman D.M., Dervan P.B. Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif. Chem. Eur. J. 6:2000;4487-4497.
-
(2000)
Chem. Eur. J.
, vol.6
, pp. 4487-4497
-
-
Melander, C.1
Herman, D.M.2
Dervan, P.B.3
-
22
-
-
0035830369
-
Kinetic consequences of covalent linkage of DNA binding polyamides
-
Baliga R., Baird E.E., Herman D.M., Melander C., Dervan P.B., Crothers D.M. Kinetic consequences of covalent linkage of DNA binding polyamides. Biochemistry. 40:2001;3-8.
-
(2001)
Biochemistry
, vol.40
, pp. 3-8
-
-
Baliga, R.1
Baird, E.E.2
Herman, D.M.3
Melander, C.4
Dervan, P.B.5
Crothers, D.M.6
-
23
-
-
0031782431
-
A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA
-
Greenberg W.A., Baird E.E., Dervan P.B. A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA. Chem. Eur. J. 4:1998;796-805.
-
(1998)
Chem. Eur. J.
, vol.4
, pp. 796-805
-
-
Greenberg, W.A.1
Baird, E.E.2
Dervan, P.B.3
-
24
-
-
0037462098
-
Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase
-
Olenyuk B., Jitianu C., Dervan P.B. Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase. J. Am. Chem. Soc. 125:2003;4741-4751.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 4741-4751
-
-
Olenyuk, B.1
Jitianu, C.2
Dervan, P.B.3
-
25
-
-
0030847647
-
A pyrrole-imidazole polyamide motif for recognition of eleven base pair sequences in the minor groove of DNA
-
Swalley S.E., Baird E.E., Dervan P.B. A pyrrole-imidazole polyamide motif for recognition of eleven base pair sequences in the minor groove of DNA. Chem. Eur. J. 3:1997;1600-1607.
-
(1997)
Chem. Eur. J.
, vol.3
, pp. 1600-1607
-
-
Swalley, S.E.1
Baird, E.E.2
Dervan, P.B.3
-
26
-
-
0032126854
-
Aliphatic/aromatic amino acid pairings for polyamide recognition in the minor groove of DNA
-
Turner J.M., Swalley S.E., Baird E.E., Dervan P.B. Aliphatic/aromatic amino acid pairings for polyamide recognition in the minor groove of DNA. J. Am. Chem. Soc. 120:1998;6219-6226.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 6219-6226
-
-
Turner, J.M.1
Swalley, S.E.2
Baird, E.E.3
Dervan, P.B.4
-
27
-
-
0035105078
-
Expanding the recognition of the minor groove of DNA by incorporation of β-alanine in hairpin polyamides
-
Wang C.C.C., Ellervik U., Dervan P.B. Expanding the recognition of the minor groove of DNA by incorporation of β-alanine in hairpin polyamides. Bioorg. Med. Chem. 9:2001;653-657.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 653-657
-
-
Wang, C.C.C.1
Ellervik, U.2
Dervan, P.B.3
-
28
-
-
0029957034
-
Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif
-
Kelly J.J., Baird E.E., Dervan P.B. Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif. Proc. Natl. Acad. Sci. U.S.A. 93:1996;6981-6985.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6981-6985
-
-
Kelly, J.J.1
Baird, E.E.2
Dervan, P.B.3
-
29
-
-
0032486215
-
Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides
-
Trauger J.W., Baird E.E., Dervan P.B. Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides. Angew. Chem. Int. Ed. Engl. 37:1998;1421-1423.
-
(1998)
Angew. Chem. Int. Ed. Engl.
, vol.37
, pp. 1421-1423
-
-
Trauger, J.W.1
Baird, E.E.2
Dervan, P.B.3
-
30
-
-
0037134919
-
Recognition of ten base pairs of DNA by head-to-head hairpin dimers
-
Weyermann P., Dervan P.B. Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J. Am. Chem. Soc. 124:2002;6872-6878.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 6872-6878
-
-
Weyermann, P.1
Dervan, P.B.2
-
31
-
-
0032986773
-
Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole-imidazole polyamides
-
Herman D.M., Baird E.E., Dervan P.B. Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem. Eur. J. 5:1999;975-983.
-
(1999)
Chem. Eur. J.
, vol.5
, pp. 975-983
-
-
Herman, D.M.1
Baird, E.E.2
Dervan, P.B.3
-
32
-
-
0036335992
-
Search for the optimal linker in tandem hairpin polyamides
-
Kers I., Dervan P.B. Search for the optimal linker in tandem hairpin polyamides. Bioorg. Med. Chem. 10:2002;3339-3349.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 3339-3349
-
-
Kers, I.1
Dervan, P.B.2
-
33
-
-
0035875667
-
Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides
-
Fluorescently labeled tandem hairpin polyamides stain vertebrate and insect telomeres, and allow rapid estimation of relative telomere length.
-
Maeshima K., Janssen S., Laemmli U.K. Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. EMBO J. 20:2001;3218-3228 Fluorescently labeled tandem hairpin polyamides stain vertebrate and insect telomeres, and allow rapid estimation of relative telomere length.
-
(2001)
EMBO J.
, vol.20
, pp. 3218-3228
-
-
Maeshima, K.1
Janssen, S.2
Laemmli, U.K.3
-
34
-
-
0035185484
-
Alternative heterocycles for DNA recognition: An N-methylpyrazole/N-methylpyrrole pair specifies for A·T/T·A base pairs
-
Nguyen D.H., Szewczyk J.W., Baird E.E., Dervan P.B. Alternative heterocycles for DNA recognition: an N-methylpyrazole/N-methylpyrrole pair specifies for A·T/T·A base pairs. Bioorg. Med. Chem. 9:2001;7-17.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 7-17
-
-
Nguyen, D.H.1
Szewczyk, J.W.2
Baird, E.E.3
Dervan, P.B.4
-
35
-
-
0036959797
-
Toward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides
-
Marques M.A., Doss R.M., Urbach A.R., Dervan P.B. Toward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides. Helv. Chim. Acta. 85:2002;4485-4517.
-
(2002)
Helv. Chim. Acta.
, vol.85
, pp. 4485-4517
-
-
Marques, M.A.1
Doss, R.M.2
Urbach, A.R.3
Dervan, P.B.4
-
36
-
-
0033790763
-
Molecular recognition of DNA by Hoechst benzimidazoles: Exploring beyond the pyrrole-imidazole-hydroxypyrrole polyamide-pairing code
-
Minehan T.G., Gottwald K., Dervan P.B. Molecular recognition of DNA by Hoechst benzimidazoles: exploring beyond the pyrrole-imidazole-hydroxypyrrole polyamide-pairing code. Helv. Chim. Acta. 83:2000;2197-2213.
-
(2000)
Helv. Chim. Acta.
, vol.83
, pp. 2197-2213
-
-
Minehan, T.G.1
Gottwald, K.2
Dervan, P.B.3
-
37
-
-
0002861252
-
DNA sequence recognition altered bis-benzimidazole minor-groove binders
-
Edited by Jones GB. London: JAI Press Inc.
-
Lown JW: DNA sequence recognition altered bis-benzimidazole minor-groove binders. In Advances in DNA Sequence-Specific Agents. Edited by Jones GB. London: JAI Press Inc.; 1998:67-95.
-
(1998)
Advances in DNA Sequence-Specific Agents
, pp. 67-95
-
-
Lown, J.W.1
-
38
-
-
0037687485
-
Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition
-
Hydroxybenzimidazole (Hz) was incorporated into a hairpin polyamide and the Hz/Py pair is shown to distinguish T·A from A·T.
-
Renneberg D., Dervan P.B. Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J. Am. Chem. Soc. 125:2003;5707-5716 Hydroxybenzimidazole (Hz) was incorporated into a hairpin polyamide and the Hz/Py pair is shown to distinguish T·A from A·T.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 5707-5716
-
-
Renneberg, D.1
Dervan, P.B.2
-
39
-
-
0030059085
-
Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
-
Baird E.E., Dervan P.B. Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids. J. Am. Chem. Soc. 118:1996;6141-6146.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 6141-6146
-
-
Baird, E.E.1
Dervan, P.B.2
-
40
-
-
0035912351
-
Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids
-
Wurtz N.R., Turner J.M., Baird E.E., Dervan P.B. Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids. Org. Lett. 3:2001;1201-1203.
-
(2001)
Org. Lett.
, vol.3
, pp. 1201-1203
-
-
Wurtz, N.R.1
Turner, J.M.2
Baird, E.E.3
Dervan, P.B.4
-
41
-
-
0037156336
-
A practical approach to the synthesis of hairpin polyamide-peptide conjugates through the use of a safety-catch linker
-
Fattori D., Kinzel O., Ingallinella P., Bianchi E., Pessi A. A practical approach to the synthesis of hairpin polyamide-peptide conjugates through the use of a safety-catch linker. Bioorg. Med. Chem. Lett. 12:2002;1143-1147.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1143-1147
-
-
Fattori, D.1
Kinzel, O.2
Ingallinella, P.3
Bianchi, E.4
Pessi, A.5
-
42
-
-
0033577001
-
Effects of γ-turn and β-tail amino acids on sequence-specific recognition of DNA by hairpin polyamides
-
Swalley S.E., Baird E.E., Dervan P.B. Effects of γ-turn and β-tail amino acids on sequence-specific recognition of DNA by hairpin polyamides. J. Am. Chem. Soc. 121:1999;1113-1120.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 1113-1120
-
-
Swalley, S.E.1
Baird, E.E.2
Dervan, P.B.3
-
44
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell J.E. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer. 2:2002;740-749.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 740-749
-
-
Darnell, J.E.1
-
45
-
-
0030951207
-
Regulation of gene expression by small molecules
-
Gottesfeld J.M., Neely L., Trauger J.W., Baird E.E., Dervan P.B. Regulation of gene expression by small molecules. Nature. 387:1997;202-205.
-
(1997)
Nature
, vol.387
, pp. 202-205
-
-
Gottesfeld, J.M.1
Neely, L.2
Trauger, J.W.3
Baird, E.E.4
Dervan, P.B.5
-
46
-
-
0031566037
-
Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex
-
Neely L., Trauger J.W., Baird E.E., Dervan P.B., Gottesfeld J.M. Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex. J. Mol. Biol. 274:1997;439-445.
-
(1997)
J. Mol. Biol.
, vol.274
, pp. 439-445
-
-
Neely, L.1
Trauger, J.W.2
Baird, E.E.3
Dervan, P.B.4
Gottesfeld, J.M.5
-
47
-
-
0032573224
-
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
-
Dickinson L.A., Gulizia R.J., Trauger J.W., Baird E.E., Mosier D.E., Gottesfeld J.M., Dervan P.B. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl. Acad. Sci. U.S.A. 95:1998;12890-12895.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 12890-12895
-
-
Dickinson, L.A.1
Gulizia, R.J.2
Trauger, J.W.3
Baird, E.E.4
Mosier, D.E.5
Gottesfeld, J.M.6
Dervan, P.B.7
-
48
-
-
0033525806
-
Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand
-
McBryant S.J., Baird E.E., Trauger J.W., Dervan P.B., Gottesfeld J.M. Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand. J. Mol. Biol. 286:1999;973-981.
-
(1999)
J. Mol. Biol.
, vol.286
, pp. 973-981
-
-
McBryant, S.J.1
Baird, E.E.2
Trauger, J.W.3
Dervan, P.B.4
Gottesfeld, J.M.5
-
49
-
-
0036183456
-
Promoter scanning for transcription inhibition with DNA-binding polyamides
-
This paper uses the strategy of promoter scanning to identify important protein-DNA contacts within the HIV-1 promoter.
-
Ehley J.A., Melander C., Herman D., Baird E.E., Ferguson H.A., Goodrich J.A., Dervan P.B., Gottesfeld J.M. Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol. Cell Biol. 22:2002;1723-1733 This paper uses the strategy of promoter scanning to identify important protein-DNA contacts within the HIV-1 promoter.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 1723-1733
-
-
Ehley, J.A.1
Melander, C.2
Herman, D.3
Baird, E.E.4
Ferguson, H.A.5
Goodrich, J.A.6
Dervan, P.B.7
Gottesfeld, J.M.8
-
50
-
-
0034622572
-
Asymmetric DNA binding by a homodimeric bHLH protein
-
Winston R.L., Ehley J.A., Baird E.E., Dervan P.B., Gottesfeld J.M. Asymmetric DNA binding by a homodimeric bHLH protein. Biochemistry. 39:2000;9092-9098.
-
(2000)
Biochemistry
, vol.39
, pp. 9092-9098
-
-
Winston, R.L.1
Ehley, J.A.2
Baird, E.E.3
Dervan, P.B.4
Gottesfeld, J.M.5
-
51
-
-
0033617408
-
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-κB, and DNA by a designed DNA-binding ligand
-
Dickinson L.A., Trauger J.W., Baird E.E., Dervan P.B., Graves B.J., Gottesfeld J.M. Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-κB, and DNA by a designed DNA-binding ligand. J. Biol. Chem. 274:1999;12765-12773.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12765-12773
-
-
Dickinson, L.A.1
Trauger, J.W.2
Baird, E.E.3
Dervan, P.B.4
Graves, B.J.5
Gottesfeld, J.M.6
-
52
-
-
0034637562
-
Targeting the Ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides
-
Chiang S.Y., Burli R.W., Benz C.C., Gawron L., Scott G.K., Dervan P.B., Beerman T.A. Targeting the Ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides. J. Biol. Chem. 275:2000;24246-24254.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24246-24254
-
-
Chiang, S.Y.1
Burli, R.W.2
Benz, C.C.3
Gawron, L.4
Scott, G.K.5
Dervan, P.B.6
Beerman, T.A.7
-
53
-
-
0033609767
-
The Tax protein-DNA interaction is essential for HTLV-I transactivation in vitro
-
Lenzmeier B.A., Baird E.E., Dervan P.B., Nyborg J.K. The Tax protein-DNA interaction is essential for HTLV-I transactivation in vitro. J. Mol. Biol. 291:1999;731-744.
-
(1999)
J. Mol. Biol.
, vol.291
, pp. 731-744
-
-
Lenzmeier, B.A.1
Baird, E.E.2
Dervan, P.B.3
Nyborg, J.K.4
-
54
-
-
0034647098
-
Selective inhibition of DNA gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration
-
Simon H., Kittler L., Baird E., Dervan P., Zimmer C. Selective inhibition of DNA gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration. FEBS Lett. 471:2000;173-176.
-
(2000)
FEBS Lett.
, vol.471
, pp. 173-176
-
-
Simon, H.1
Kittler, L.2
Baird, E.3
Dervan, P.4
Zimmer, C.5
-
55
-
-
0037129975
-
Inhibition of DNA binding by NF-κB with pyrrole-imidazole polyamides
-
Wurtz N.R., Pomerantz J.L., Baltimore D., Dervan P.B. Inhibition of DNA binding by NF-κB with pyrrole-imidazole polyamides. Biochemistry. 41:2002;7604-7609.
-
(2002)
Biochemistry
, vol.41
, pp. 7604-7609
-
-
Wurtz, N.R.1
Pomerantz, J.L.2
Baltimore, D.3
Dervan, P.B.4
-
56
-
-
0032033739
-
Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch
-
Bremer R.E., Baird E.E., Dervan P.B. Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch. Chem. Biol. 5:1998;119-133.
-
(1998)
Chem. Biol.
, vol.5
, pp. 119-133
-
-
Bremer, R.E.1
Baird, E.E.2
Dervan, P.B.3
-
57
-
-
0034903074
-
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides
-
Bremer R.E., Wurtz N.R., Szewczyk J.W., Dervan P.B. Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides. Bioorg. Med. Chem. 9:2001;2093-2103.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2093-2103
-
-
Bremer, R.E.1
Wurtz, N.R.2
Szewczyk, J.W.3
Dervan, P.B.4
-
58
-
-
0038375540
-
Allosteric inhibition of protein-DNA complexes by polyamide-intercalator conjugates
-
in press
-
Fechter EJ, Dervan PB: Allosteric inhibition of protein-DNA complexes by polyamide-intercalator conjugates. J Am Chem Soc 2003, in press.
-
(2003)
J Am Chem Soc
-
-
Fechter, E.J.1
Dervan, P.B.2
-
59
-
-
0033635255
-
Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster
-
Py-Im polyamides targeted to DNA satellite regions cause gain- and loss-of-function phenotypes when fed to developing Drosophila flies.
-
Janssen S., Cuvier O., Muller M., Laemmli U.K. Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster. Mol. Cell. 6:2000;1013-1024 Py-Im polyamides targeted to DNA satellite regions cause gain- and loss-of-function phenotypes when fed to developing Drosophila flies.
-
(2000)
Mol. Cell
, vol.6
, pp. 1013-1024
-
-
Janssen, S.1
Cuvier, O.2
Muller, M.3
Laemmli, U.K.4
-
60
-
-
0033578354
-
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides
-
Dickinson L.A., Trauger J.W., Baird E.E., Ghazal P., Dervan P.B., Gottesfeld J.M. Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. Biochemistry. 38:1999;10801-10807.
-
(1999)
Biochemistry
, vol.38
, pp. 10801-10807
-
-
Dickinson, L.A.1
Trauger, J.W.2
Baird, E.E.3
Ghazal, P.4
Dervan, P.B.5
Gottesfeld, J.M.6
-
61
-
-
0036889182
-
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides
-
Coull J.J., He G.C., Melander C., Rucker V.C., Dervan P.B., Margolis D.M. Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J. Virol. 76:2002;12349-12354.
-
(2002)
J. Virol.
, vol.76
, pp. 12349-12354
-
-
Coull, J.J.1
He, G.C.2
Melander, C.3
Rucker, V.C.4
Dervan, P.B.5
Margolis, D.M.6
-
62
-
-
0036898867
-
Modular design of artificial transcription factors
-
Ansari A.Z., Mapp A.K. Modular design of artificial transcription factors. Curr. Opin. Chem. Biol. 6:2002;765-772.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 765-772
-
-
Ansari, A.Z.1
Mapp, A.K.2
-
63
-
-
0034635990
-
Activation of gene expression by small molecule transcription factors
-
An artificial TF, consisting of a minor groove-binding polyamide tethered to a designed peptide activation domain, mediates transcriptional activation in vitro.
-
Mapp A.K., Ansari A.Z., Ptashne M., Dervan P.B. Activation of gene expression by small molecule transcription factors. Proc. Natl. Acad. Sci. U.S.A. 97:2000;3930-3935 An artificial TF, consisting of a minor groove-binding polyamide tethered to a designed peptide activation domain, mediates transcriptional activation in vitro.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 3930-3935
-
-
Mapp, A.K.1
Ansari, A.Z.2
Ptashne, M.3
Dervan, P.B.4
-
64
-
-
0034976453
-
Towards a minimal motif for artificial transcriptional activators
-
Ansari A.Z., Mapp A.K., Nguyen D.H., Dervan P.B., Ptashne M. Towards a minimal motif for artificial transcriptional activators. Chem. Biol. 8:2001;583-592.
-
(2001)
Chem. Biol.
, vol.8
, pp. 583-592
-
-
Ansari, A.Z.1
Mapp, A.K.2
Nguyen, D.H.3
Dervan, P.B.4
Ptashne, M.5
-
65
-
-
0037032308
-
Design of artificial transcriptional activators with rigid poly-L-proline linkers
-
Arora P.S., Ansari A.Z., Best T.P., Ptashne M., Dervan P.B. Design of artificial transcriptional activators with rigid poly-L-proline linkers. J. Am. Chem. Soc. 124:2002;13067-13071.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 13067-13071
-
-
Arora, P.S.1
Ansari, A.Z.2
Best, T.P.3
Ptashne, M.4
Dervan, P.B.5
-
66
-
-
0035827139
-
Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides
-
Gottesfeld J.M., Melander C., Suto R.K., Raviol H., Luger K., Dervan P.B. Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. J. Mol. Biol. 309:2001;615-629.
-
(2001)
J. Mol. Biol.
, vol.309
, pp. 615-629
-
-
Gottesfeld, J.M.1
Melander, C.2
Suto, R.K.3
Raviol, H.4
Luger, K.5
Dervan, P.B.6
-
67
-
-
0037436337
-
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands
-
The high-resolution X-ray crystal structures of three nucleosome core particles in complex with hairpin polyamides are described.
-
Suto R.K., Edayathumangalam R.S., White C.L., Melander C., Gottesfeld J.M., Dervan P.B., Luger K. Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J. Mol. Biol. 326:2003;371-380 The high-resolution X-ray crystal structures of three nucleosome core particles in complex with hairpin polyamides are described.
-
(2003)
J. Mol. Biol.
, vol.326
, pp. 371-380
-
-
Suto, R.K.1
Edayathumangalam, R.S.2
White, C.L.3
Melander, C.4
Gottesfeld, J.M.5
Dervan, P.B.6
Luger, K.7
-
68
-
-
0036384345
-
Blocking transcription through a nucleosome with synthetic DNA ligands
-
Hairpin polyamides can inhibit nucleosome repositioning as well as transcription through a nucleosome in vitro.
-
Gottesfeld J.M., Belitsky J.M., Melander C., Dervan P.B., Luger K. Blocking transcription through a nucleosome with synthetic DNA ligands. J. Mol. Biol. 321:2002;249-263 Hairpin polyamides can inhibit nucleosome repositioning as well as transcription through a nucleosome in vitro.
-
(2002)
J. Mol. Biol.
, vol.321
, pp. 249-263
-
-
Gottesfeld, J.M.1
Belitsky, J.M.2
Melander, C.3
Dervan, P.B.4
Luger, K.5
-
69
-
-
0036339597
-
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates
-
Nuclear uptake of hairpin polyamide-bodipy conjugates is shown to be cell-type dependent.
-
Belitsky J.M., Leslie S.J., Arora P.S., Beerman T.A., Dervan P.B. Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg. Med. Chem. 10:2002;3313-3318 Nuclear uptake of hairpin polyamide-bodipy conjugates is shown to be cell-type dependent.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 3313-3318
-
-
Belitsky, J.M.1
Leslie, S.J.2
Arora, P.S.3
Beerman, T.A.4
Dervan, P.B.5
-
70
-
-
12444266726
-
Controlling the intracellular localization of fluorescent polyamide analogs in cultured cells
-
Crowley K.S., Phillion D.P., Woodard S.S., Schweitzer B.A., Singh M., Shabany H., Burnette B., Hippenmeyer P., Heitmeier M., Bashkin J.K. Controlling the intracellular localization of fluorescent polyamide analogs in cultured cells. Bioorg. Med. Chem. Lett. 13:2003;1565-1570.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1565-1570
-
-
Crowley, K.S.1
Phillion, D.P.2
Woodard, S.S.3
Schweitzer, B.A.4
Singh, M.5
Shabany, H.6
Burnette, B.7
Hippenmeyer, P.8
Heitmeier, M.9
Bashkin, J.K.10
-
71
-
-
18444416042
-
Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry
-
Gygi M.P., Ferguson M.D., Mefford H.C., Lund K.P., O'Day C., Zhou P., Friedman C., van den Engh G., Stolowitz M.L., Trask B.J. Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry. Nucleic Acids Res. 30:2002;2790-2799.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 2790-2799
-
-
Gygi, M.P.1
Ferguson, M.D.2
Mefford, H.C.3
Lund, K.P.4
O'Day, C.5
Zhou, P.6
Friedman, C.7
Van Den Engh, G.8
Stolowitz, M.L.9
Trask, B.J.10
-
73
-
-
0035989998
-
Genomic effects of polyamide/DNA interactions on mRNA expression
-
Supekova L., Pezacki J.P., Su A.I., Loweth C.J., Riedl R., Geierstanger B., Schultz P.G., Wemmer D.E. Genomic effects of polyamide/DNA interactions on mRNA expression. Chem. Biol. 9:2002;821-827.
-
(2002)
Chem. Biol.
, vol.9
, pp. 821-827
-
-
Supekova, L.1
Pezacki, J.P.2
Su, A.I.3
Loweth, C.J.4
Riedl, R.5
Geierstanger, B.6
Schultz, P.G.7
Wemmer, D.E.8
-
74
-
-
0036899212
-
RNAi and related mechanisms and their potential use for therapy
-
Agami R. RNAi and related mechanisms and their potential use for therapy. Curr. Opin. Chem. Biol. 6:2002;829-834.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 829-834
-
-
Agami, R.1
-
75
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M.et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature. 421:2003;231-237.
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
Fraser, A.G.2
Dong, Y.3
Poulin, G.4
Durbin, R.5
Gotta, M.6
Kanapin, A.7
Le Bot, N.8
Moreno, S.9
Sohrmann, M.10
-
76
-
-
0035850505
-
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates
-
Wang C.C.C., Dervan P.B. Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. J. Am. Chem. Soc. 123:2001;8657-8661.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 8657-8661
-
-
Wang, C.C.C.1
Dervan, P.B.2
-
77
-
-
0034212441
-
Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells
-
Malik S., Roeder R.G. Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells. Trends Biochem. Sci. 25:2000;277-283.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 277-283
-
-
Malik, S.1
Roeder, R.G.2
|