Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: Synthesis, inhibitory activity against topoisomerase I, and biological evaluation

Journal of Medicinal Chemistry

Volumn 39, Issue 5, 1996, Pages 1049-1055

  Xie, Guojian ^a   Gupta, Rajan ^a   Atchison, Kevin ^b   Lown, J William ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NAEJA Pharmaceutical Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 INDOLYL) 3 [1 [[[[1 METHYL 2 [[[1 METHYL 2 [[[1 METHYL 2 [[[3 (N,N DIMETHYLAMINO)PROPYL]AMINO]CARBONYL] 4 PYRROLYL]AMINO]CARBONYL] 4 PYRROLYL]AMINO]CARBONYL] 4 PYRROLYL]AMINO]CARBONYL]METHYL] 3 INDOLYL] 1H PYRROLE 2,5 DIONE; GYRASE INHIBITOR; MALEIMIDE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY TEST; DNA BINDING; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

ANTINEOPLASTIC AGENTS; BINDING SITES; DNA; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; ELECTROCHEMISTRY; ELECTROPHORESIS, AGAR GEL; ENZYME INHIBITORS; ETHIDIUM; INDOLES; MALEIMIDES; MOLECULAR STRUCTURE; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029974583     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950465d     Document Type: Article

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